SHAN OU^#, YUN XU^#, QINGLAN LIU, TIANWEN YANG, WEI CHEN, XIU YUAN, XIN ZUO, PENG SHI^*, JIE YAO^*

BIOCELL, Vol.48, No.3, pp. 415-429, 2024, DOI:10.32604/biocell.2024.046178

Abstract Background: The interrelation between intestinal polyps, metabolic syndrome (MetS), and colorectal cancer (CRC) is a critical area of study. This research focuses on pinpointing potential molecular targets to understand the link between intestinal polyp formation, metabolic irregularities, and CRC progression. Methods: We examined clinical samples from patients with intestinal polyps coexisting with MetS and compared them with samples from patients with standard intestinal polyps. Transcriptome sequencing and public database analysis were employed to identify significant pathways and genes. These targets were then validated through immunohistochemistry (IHC). Following the RNA interference of key target expression, a series of experiments, including the… More > Graphic Abstract

YAN LI¹, HUZHI CAI², XIAOLING PENG³, YOUHUI LIU⁴, QINGYANG CHEN⁴, XIANGDONG LIN⁵, XINYU CHEN^6,*

BIOCELL, Vol.48, No.3, pp. 501-511, 2024, DOI:10.32604/biocell.2023.030854

Abstract Background: Renal fibrosis is an important process in the development of chronic kidney disease. Understanding the pathogenesis and finding effective treatments for renal fibrosis is crucial. This study aims to investigate whether a newly discovered long non-coding RNA (lncRNA) called LOC103694972 could be a potential target for treating fibrosis of NRK-49F cells. Methods:: LncRNA Chip was used to identify differentially expressed lncRNAs between TGF-β1-induced NRK-49F cells and normal cells. The dual-luciferase assay confirmed the binding between miR-29c-3p and signal transducer and activator of transcription (STAT3), as well as between miR-29c-3p and lncRNA LOC103694972. Si-LOC103694972 and miR-29c-3p mimic were then transfected… More > Graphic Abstract

Zhonghao Guo^*, Xinyue Xu, Xiangxian Chen

Computer Systems Science and Engineering, Vol.48, No.2, pp. 479-509, 2024, DOI:10.32604/csse.2023.043932

Abstract In software testing, the quality of test cases is crucial, but manual generation is time-consuming. Various automatic test case generation methods exist, requiring careful selection based on program features. Current evaluation methods compare a limited set of metrics, which does not support a larger number of metrics or consider the relative importance of each metric to the final assessment. To address this, we propose an evaluation tool, the Test Case Generation Evaluator (TCGE), based on the learning to rank (L2R) algorithm. Unlike previous approaches, our method comprehensively evaluates algorithms by considering multiple metrics, resulting in a more reasoned assessment. The… More >

Nasser Alshammari¹, Shumaila Shahzadi², Saad Awadh Alanazi^1,*, Shahid Naseem³, Muhammad Anwar³, Madallah Alruwaili⁴, Muhammad Rizwan Abid⁵, Omar Alruwaili⁴, Ahmed Alsayat¹, Fahad Ahmad^6,7

Computer Systems Science and Engineering, Vol.48, No.2, pp. 363-394, 2024, DOI:10.32604/csse.2023.040721

Abstract Software Defined Network (SDN) and Network Function Virtualization (NFV) technology promote several benefits to network operators, including reduced maintenance costs, increased network operational performance, simplified network lifecycle, and policies management. Network vulnerabilities try to modify services provided by Network Function Virtualization MANagement and Orchestration (NFV MANO), and malicious attacks in different scenarios disrupt the NFV Orchestrator (NFVO) and Virtualized Infrastructure Manager (VIM) lifecycle management related to network services or individual Virtualized Network Function (VNF). This paper proposes an anomaly detection mechanism that monitors threats in NFV MANO and manages promptly and adaptively to implement and handle security functions in order… More >

Pranab Kumar Mondal^*, Sanchayan Mukherjee

Frontiers in Heat and Mass Transfer, Vol.3, No.3, pp. 1-6, 2012, DOI:10.5098/hmt.v3.3.3004

Abstract The present paper deals with the analytical investigation for the limiting value of Nusselt number, including the effect of viscous dissipation on heat transfer for a laminar shear driven flow between two infinite parallel plates, where the bottom plate is fixed and the top plate is moving in an axial direction at a constant speed. The study concentrates on hydro-dynamically fully developed flow of a Newtonian fluid of constant properties without considering the axial conduction in the fluid. To investigate the effect of viscous dissipation on heat transfer by defining the limiting Nusselt number, plates are kept at constant equal… More >

Melanie Patrick^a, Messiha Saad^a,*

Frontiers in Heat and Mass Transfer, Vol.3, No.4, pp. 1-8, 2012, DOI:10.5098/hmt.v3.4.3007

Abstract Thermal characterization is essential to the proper assignment of composites to specific applications. Specific heat, thermal diffusivity, and thermal conductivity are critical in the engineering design process and in the analysis of aerospace vehicles, space systems, power generation, transportation systems, and energy storage devices including fuel cells. This paper examines the thermal properties through the thickness of Carbon-Carbon and the impact of Graphitization is explored. Following ASTM standards, the Flash Method and Differential Scanning Calorimetry measured thermal diffusivity and specific heat respectively. These measurements and density data allowed for the computation of thermal conductivity. More >

Long Chen¹, Ting Li¹, Liang Liu¹, Wenshuo Wang^2,*, Xiaoxiao Du³, Wei Wang³

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2773-2806, 2024, DOI:10.32604/cmes.2024.046641

Abstract This study explores the implementation of computed tomography (CT) reconstruction and simulation techniques for patient-specific valves, aiming to dissect the mechanical attributes of calcified valves within transcatheter heart valve replacement (TAVR) procedures. In order to facilitate this exploration, it derives pertinent formulas for 3D multi-material isogeometric hyperelastic analysis based on Hounsfield unit (HU) values, thereby unlocking foundational capabilities for isogeometric analysis in calcified aortic valves. A series of uniaxial and biaxial tensile tests is executed to obtain an accurate constitutive model for calcified active valves. To mitigate discretization errors, methodologies for reconstructing volumetric parametric models, integrating both geometric and material… More > Graphic Abstract

Yanzhong Sun¹, Xiaoni Du^1,*, Shufen Niu², Xiaodong Yang²

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 3287-3310, 2024, DOI:10.32604/cmes.2023.043589

Abstract Traditional email systems can only achieve one-way communication, which means only the receiver is allowed to search for emails on the email server. In this paper, we propose a blockchain-based certificateless bidirectional authenticated searchable encryption model for a cloud email system named certificateless authenticated bidirectional searchable encryption (CL-BSE) by combining the storage function of cloud server with the communication function of email server. In the new model, not only can the data receiver search for the relevant content by generating its own trapdoor, but the data owner also can retrieve the content in the same way. Meanwhile, there are dual… More >

S. Dickson¹, S. Padmasekaran¹, Pushpendra Kumar^2,*, Kottakkaran Sooppy Nisar³, Hamidreza Marasi⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2265-2287, 2024, DOI:10.32604/cmes.2023.030286

Abstract This research examines the transmission dynamics of the Omicron variant of COVID-19 using SEIQI_cRVW and SQIRV models, considering the delay in converting susceptible individuals into infected ones. The significant delays eventually resulted in the pandemic’s containment. To ensure the safety of the host population, this concept integrates quarantine and the COVID-19 vaccine. We investigate the stability of the proposed models. The fundamental reproduction number influences stability conditions. According to our findings, asymptomatic cases considerably impact the prevalence of Omicron infection in the community. The real data of the Omicron variant from Chennai, Tamil Nadu, India, is used to validate the… More >

Ruirui Zhang¹, Xuguang Zhang², Minxin Yang³, Haoran Zhang^4,5,*

International Journal of Mental Health Promotion, Vol.26, No.2, pp. 117-126, 2024, DOI:10.32604/ijmhp.2023.045819

Abstract Contingent self-esteem captures the fragile nature of self-esteem and is often regarded as suboptimal to psychological functioning. Self-compassion is another important self-related concept assumed to promote mental health and well-being. However, research on the relation of self-compassion to contingent self-esteem is lacking. Two studies were conducted to explore the role of self-compassion, either as a personal characteristic or an induced mindset, in influencing the effects of contingent self-esteem on well-being. Study 1 recruited 256 Chinese college students (30.4% male, mean age = 21.72 years) who filled out measures of contingent self-esteem, self-compassion, and well-being. The results found that self-compassion moderated… More >