MONA S. ABDELLATEIF^1,*, NAGLAA M. HASSAN², MAHMOUD M. KAMEL², YOMNA M. EL-MELIGUI²

Oncology Research, Vol.32, No.3, pp. 577-584, 2024, DOI:10.32604/or.2023.043026

Abstract Background: microRNA-34a (miR-34a) had been reported to have a diagnostic role in acute myeloid leukemia (AML). However, its value in the bone marrow (BM) of AML patients, in addition to its role in response to therapy is still unclear. The current study was designed to assess the diagnostic, prognostic, and predictive significance of miR-34a in the BM of AML patients. Methods: The miR-34a was assessed in BM aspirate of 82 AML patients in relation to 12 normal control subjects using qRT-PCR. The data were assessed for correlation with the relevant clinical criteria, response to therapy, disease-free survival (DFS), and overall… More >

Rong Fu^*, Luze Xie

International Journal of Mental Health Promotion, Vol.26, No.1, pp. 21-30, 2024, DOI:10.32604/ijmhp.2023.041730

Abstract COVID-19, as one of the most serious sudden public health problems in this century, is a serious threat to people’s mental health. College students, as a vulnerable group, are more likely to develop mental health problems. When the body is unable to adapt to new changes in the environment, the main mental health problem that arises is adjustment disorder. The aim of this study was to assess the prevalence and influencing factors of adjustment disorder among college students during the COVID-19 outbreak in China. Cross-sectional data collected by web-based questionnaires were obtained through convenience sampling and snowball sampling between March… More >

Jie Huang^*, Rongbin Jiang, Xiaobo Sun, Yingyong Shuai

Journal of Renewable Materials, Vol.12, No.1, pp. 187-201, 2024, DOI:10.32604/jrm.2023.044232

Abstract The reuse of waste recycled concrete from harsh environments has become a research hotspot in the field of construction. This study investigated the repair effect of carbonation treatment on second-generation recycled fine aggregate (SRFA) obtained from recycled fine aggregate concrete (RFAC) subjected to freeze-thaw (FT) cycles. Before and after carbonation, the properties of SRFA were evaluated. Carbonated second-generation recycled fine aggregate (CSRFA) at five substitution rates (0%, 25%, 50%, 75%, 100%) to replace SRFA was used to prepare carbonated second-generation recycled fine aggregate concrete (CSRFAC). The water absorption, porosity and mechanical properties of CSRFAC were tested, and its frost-resisting durability… More >

Kristi K. Westphaln^1,2,*, Karen Kay Imagawa^2,3, Lorena Espinosa Smith^1,4, Julia Srivastava⁵, Nancy A. Pike^1,5

Congenital Heart Disease, Vol.18, No.6, pp. 657-670, 2023, DOI:10.32604/chd.2023.044179

Abstract Background: Congenital heart disease (CHD) is a chronic medical condition often diagnosed at birth and requires surgical intervention, multiple hospitalizations, and lifelong care. This can put significant stress on the family, leading to altered maternal mental health, bonding and attachment issues, and the potential for child abuse. The purpose of this study is to explore the characteristics of a sample of young children with CHD who experienced hospitalization with concurrent concern for child abuse in a free-standing pediatric tertiary care hospital. Methods: Electronic medical records were reviewed for children aged 0–5 years old who were hospitalized with concern for child… More >

XIAOJIA HUANG^1,#, CAILU SONG^2,#, JINHUI ZHANG², LEWEI ZHU^3,*, HAILIN TANG^2,*

Oncology Research, Vol.32, No.2, pp. 241-249, 2024, DOI:10.32604/or.2023.046582

Abstract Breast cancer has surpassed lung cancer to become the most common malignancy worldwide. The incidence rate and mortality rate of breast cancer continue to rise, which leads to a great burden on public health. Circular RNAs (circRNAs), a new class of noncoding RNAs (ncRNAs), have been recognized as important oncogenes or suppressors in regulating cancer initiation and progression. In breast cancer, circRNAs have significant roles in tumorigenesis, recurrence and multidrug resistance that are mediated by various mechanisms. Therefore, circRNAs may serve as promising targets of therapeutic strategies for breast cancer management. This study reviews the most recent studies about the… More >

KEGANG JIA^1,#, YAWEI WANG^2,#, QI CAO^3,*, YOUYU WANG^1,*

Oncology Research, Vol.32, No.2, pp. 409-419, 2024, DOI:10.32604/or.2023.042863

Abstract Background: Lung cancer is the most prevalent cancer diagnosis and the leading cause of cancer death worldwide. Therapeutic failure in lung cancer (LUAD) is heavily influenced by drug resistance. This challenge stems from the diverse cell populations within the tumor, each having unique genetic, epigenetic, and phenotypic profiles. Such variations lead to varied therapeutic responses, thereby contributing to tumor relapse and disease progression. Methods: The Genomics of Drug Sensitivity in Cancer (GDSC) database was used in this investigation to obtain the mRNA expression dataset, genomic mutation profile, and drug sensitivity information of NSCLS. Machine Learning (ML) methods, including Random Forest… More >

FATEMEH HEIDARI^1,2, REIHANEH SEYEDEBRAHIMI^1,2, PIAO YANG³, MOHSEN ESLAMI FARSANI^1,2, SHIMA ABABZADEH^2,4, NASER KALHOR⁵, HAMED MANOOCHEHRI⁶, MOHSEN SHEYKHHASAN^7,*, MARYAM AZIMZADEH^8,9,*

BIOCELL, Vol.47, No.12, pp. 2597-2608, 2023, DOI:10.32604/biocell.2023.043351

Abstract Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV. Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity on how exosomes influence the… More >

KUAILU LIN^1,2, QIANYU GU², XIXI LAI^2,3,*

BIOCELL, Vol.47, No.12, pp. 2681-2696, 2023, DOI:10.32604/biocell.2023.043298

Abstract Objectives: Triple-negative breast cancer (TNBC) poses a significant challenge due to the lack of reliable prognostic gene signatures and an understanding of its immune behavior. Methods: We analyzed clinical information and mRNA expression data from 162 TNBC patients in TCGA-BRCA and 320 patients in METABRIC-BRCA. Utilizing weighted gene coexpression network analysis, we pinpointed 34 TNBC immune genes linked to survival. The least absolute shrinkage and selection operator Cox regression method identified key TNBC immune candidates for prognosis prediction. We calculated chemotherapy sensitivity scores using the “pRRophetic” package in R software and assessed immunotherapy response using the Tumor Immune Dysfunction and… More >

Na Yu¹, Changzheng Gao², Xiuna Wang², Dongwei Li^2,*, Weiyang You²

Energy Engineering, Vol.120, No.12, pp. 2879-2901, 2023, DOI:10.32604/ee.2023.029426

Abstract With the goal of “carbon peaking and carbon neutralization”, it is an inevitable trend for investing smart grid to promote the large-scale grid connection of renewable energy. Smart grid investment has a significant driving effect (derivative value), and evaluating this value can help to more accurately grasp the external effects of smart grid investment and support the realization of industrial linkage value with power grid investment as the core. Therefore, by analyzing the characterization of the derivative value of smart grid driven by investment, this paper constructs the evaluation index system of the derivative value of smart grid investment including… More >

Kun Zhang^*, Liang Bi Wang

Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-7, 2016, DOI:10.5098/hmt.7.18

Abstract Detailed numerical analysis is presented for the effect of spaceship orbital transfer on solution convection during protein crystal growth under microgravity. The results show that the flow and mass transfer during protein crystal growth are unsteady in the process of orbital transfer. For the case of quasi-steady acceleration, the flow is so weak that the effect of flow on concentration field can be negligible. For the case of position adjustment, the convection is enhanced with protein crystal diameter d_c > 0.2 mm and slightly alters the purely diffusive concentration distribution under zero gravity condition. For the case of motor working,… More >