YUN ZHANG^1,2,#, SHALING TANG^1,2,#, YUBO GAO^1,2, ZHONGTING LU^1,2, YUAN YANG^1,2, JING CHEN³, TAO LI^4,*

Oncology Research, Vol.32, No.1, pp. 61-71, 2024, DOI:10.32604/or.2023.043481

Abstract Colorectal cancer (CRC) is a major global health problem with high morbidity and mortality rates. Surgical resection is the main treatment for early-stage CRC, but detecting it early is challenging. Therefore, effective therapeutic targets for advanced patients are still lacking. Exosomes, tiny vesicles in body fluids, play a crucial role in tumor metastasis, immune regulation, and drug resistance. Interestingly, they can even serve as a biomarker for cancer diagnosis and prognosis. Studies have shown that exosomes can carry miRNA, mediate the polarization of M1/M2 macrophages, promote the proliferation and metastasis of cancer cells, and affect the prognosis of CRC. Since… More > Graphic Abstract

QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

ABHISHEK WAHI¹, MAMTA BISHNOI², NEHA RAINA¹, MEGHNA AMRITA SINGH¹, PIYUSH VERMA¹, PIYUSH KUMAR GUPTA^3,4, GINPREET KAUR⁵, HARDEEP SINGH TULI^6,*, MADHU GUPTA^1,*

Oncology Research, Vol.32, No.1, pp. 19-47, 2024, DOI:10.32604/or.2023.042228

Abstract Cancer is a leading cause of death globally, with limited treatment options and several limitations. Chemotherapeutic agents often result in toxicity which long-term conventional treatment. Phytochemicals are natural constituents that are more effective in treating various diseases with less toxicity than the chemotherapeutic agents providing alternative therapeutic approaches to minimize the resistance. These phytoconstituents act in several ways and deliver optimum effectiveness against cancer. Nevertheless, the effectiveness of phyto-formulations in the management of cancers may be constrained due to challenges related to inadequate solubility, bioavailability, and stability. Nanotechnology presents a promising avenue for transforming current cancer treatment methods through the… More > Graphic Abstract

Suprapto Suprapto, Putri Augista Nur Azizah, Yatim Lailun Ni’mah^*

Journal of Renewable Materials, Vol.11, No.12, pp. 4007-4023, 2023, DOI:10.32604/jrm.2023.031210

Abstract This research focuses on the effective removal of methylene blue dye using silica gel synthesized from chemical glass bottle waste as an environmentally friendly and cost-effective adsorbent. The adsorption process was optimized using Box-Behnken Design (BBD) and Response Surface Methodology (RSM) to investigate the influence of pH (6; 8 and 10), contact time (15; 30 and 45 min), adsorbent mass (30; 50 and 70 mg), and initial concentration (20; 50 and 80 mg/L) of the adsorbate on the adsorption efficiency. The BBD was conducted using Google Colaboratory software, which encompassed 27 experiments with randomly assigned combinations. The silica gel synthesized… More > Graphic Abstract

XIANGYU QUAN¹, XUETING MA¹, GUODONG LI², XUEQI FU¹, JIANGTAO LI¹, LINLIN ZENG^1,*

BIOCELL, Vol.47, No.10, pp. 2163-2176, 2023, DOI:10.32604/biocell.2023.031226

Abstract Exosomes are extracellular vesicles with a 30–150 nm diameter originating from endosomes. In recent years, scientists have regarded exosomes as an ideal small molecule carrier for the targeted treatment of Alzheimer’s disease (AD) across the blood-brain barrier due to their nanoscale size and low immunogenicity. A large amount of evidence shows that exosomes are rich in biomarkers, and it has been found that the changes in biomarker content in blood, cerebrospinal fluid, and urine are often associated with the onset of AD patients. In this paper, some recent advances in the use of exosomes in the treatment of AD are… More > Graphic Abstract

Yueying Liu^#, Yuqing Wang^#, Lijiao Gu^*

Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2937-2946, 2023, DOI:10.32604/phyton.2023.043306

Abstract WRKY transcription factors play important roles in plant growth, development, and stress responses. Our previous research has shown that the GhWRKY91 gene can delay age-, abscisic acid (ABA)-, and drought-induced leaf senescence when overexpressed in transgenic Arabidopsis plants. To explore in more depth the biological functions of the GhWRKY91 gene, we further observed the root growth of overexpressing transgenic Arabidopsis thaliana under ABA and drought treatment. In this study, we transplanted the germinated seeds of wild-type (WT) and three transgenic lines (OE-12, OE-13 and OE-20) to 1/2 MS solid medium containing ABA and different concentrations of mannitol (simulated drought treatment)… More >

Huiru Zhao¹, Manyu Yao^1,*, Zhenqi Bai¹, Yue Zhang², Zhihua Ding³, Zhenda Hu⁴

Energy Engineering, Vol.120, No.10, pp. 2211-2231, 2023, DOI:10.32604/ee.2023.029371

Abstract As an essential infrastructure, the rural power grid is vital in promoting agricultural and rural carbon sequestration and improving rural energy electrification. It is necessary to carry out in-depth research on its comprehensive efficiency. Based on the requirements of “double carbon” and rural revitalization strategy for the rural Power Grid, this paper focuses on the modernization and low-carbon transformation of the rural Power Grid. It constructs an input-output index system for the investment efficiency of the rural Power Grid in China under the new situation. It uses the primary data of the rural Power Grid of 30 prefecture-level cities in… More >

Shun Ma¹, Na Yu¹, Xiuna Wang², Shiyan Mei¹, Mingrui Zhao^2,*, Xiaoyu Han²

Energy Engineering, Vol.120, No.10, pp. 2369-2392, 2023, DOI:10.32604/ee.2023.028727

Abstract Using the improved prospect theory with the linear transformations of rewarding good and punishing bad (RGPBIT), a new investment ranking model for power grid construction projects (PGCPs) is proposed. Given the uncertainty of each index value under the market environment, fuzzy numbers are used to describe qualitative indicators and interval numbers are used to describe quantitative ones. Taking into account decision-maker’s subjective risk attitudes, a multi-criteria decision-making (MCDM) method based on improved prospect theory is proposed. First, the [−1, 1] RGPBIT operator is proposed to normalize the original data, to obtain the best and worst schemes of PGCPs. Furthermore, the… More >

LU SUN^1,2, HUAICHENG TAN¹, TING YU³, RUICHAO LIANG^4,*

Oncology Research, Vol.31, No.6, pp. 967-988, 2023, DOI:10.32604/or.2023.042309

Abstract Lung adenocarcinoma (LUAD) is the most common and deadliest subtype of lung cancer. To select more targeted and effective treatments for individuals, further advances in classifying LUAD are urgently needed. The number, type, and function of T cells in the tumor microenvironment (TME) determine the progression and treatment response of LUAD. Long noncoding RNAs (lncRNAs), may regulate T cell differentiation, development, and activation. Thus, our aim was to identify T cell-related lncRNAs (T cell-Lncs) in LUAD and to investigate whether T cell-Lncs could serve as potential stratifiers and therapeutic targets. Seven T cell-Lncs were identified to further establish the T… More >

Zhaoli Chen, Ying Liu^*, Bingshan Zeng, Qingbin Jiang, Shengkun Wang, Xiangyang Li

Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2891-2906, 2023, DOI:10.32604/phyton.2023.030664

Abstract Michelia macclurei Dandy is a significant tree species that has extensive cultivation for forestry and horticulture purposes in southern China, owing to its economic and practical importance. Light quality influences plantlet growth and development during tissue culture. However, the growth characteristic and molecular regulation of M. macclurei under different light quality conditions are not well understood yet. In this study, we investigated the morphological, chlorophyll content, and transcriptomic responses of M. macclurei plantlets under different light-emitting diode (LED) qualities, including white, blue, and red light. The results showed that blue light significantly increased plant height (21.29%) and leaf number (18.65%),… More >