Megan G. Paradzinsky^1,*, Mukul Sharda¹, Arya R. Anvar¹, Travis W. Groth²

Canadian Journal of Urology, Vol.32, No.3, pp. 213-217, 2025, DOI:10.32604/cju.2025.063777 - 27 June 2025

Abstract Polyorchidism is a rare anomaly of the male urogenital tract characterized by the presence of one or more extra testes. Supernumerary testes can often present with coexistent conditions, including cryptorchidism, inguinal hernia, and torsion. We report a case of a pediatric patient with initial concern for intra-scrotal left testicular torsion on ultrasonography who was ultimately found to have torsion of an intra-abdominal supernumerary testis. He underwent scrotal exploration with bilateral orchiopexy and laparoscopic excision of the torsed gonad. This case highlights a unique presentation of polyorchidism with incongruent descent of an ipsilateral supernumerary testis. More >

JUN-JIE YU, WAN-XI YANG^*

BIOCELL, Vol.49, No.1, pp. 93-107, 2025, DOI:10.32604/biocell.2024.058299 - 24 January 2025

Abstract Hedgehog (HH) signaling has been researched for decades and Hedgehog has 3 homologs: Sonic Hedgehog (Shh), Indian Hedgehog (Ihh), and Desert Hedgehog (Dhh). Dhh is the one involved in male gonad and germ cell development. The distribution of molecules in Hedgehog signaling in testis indicated that Hedgehog signaling executes important functions during testis development. The patients with Dhh signaling deficiency develop dysgenesis of gonads and hormone production which demands further exploration of gonad HH signaling. Some results proved the indispensable roles of HH signaling in gonad and germ cell development and the interaction with More > Graphic Abstract

Sarah Azari, Darcy Wolfman², Armine Smith³

Canadian Journal of Urology, Vol.31, No.2, pp. 11854-11857, 2024

Abstract The majority of solid testicular tumors are treated with orchiectomy given the high risk of malignancy. We present a case of a testicular mass in an adult patient in the setting of recent hand, foot, and mouth disease that was managed conservatively with serial ultrasounds. Even though cases of viral-associated testicular masses are rare, this differential diagnosis should be considered in patients with a new testicular mass in the setting of recent viral infection and negative tumor markers. For these patients, observation may be an option instead of immediate orchiectomy. More >

AMOURA M. ABOU-EL-NAGA¹, SHAKER A. MOUSA², FAYEZ ALTHOBAITI³, EMAN FAYAD^3,*, ENGY S. FAHIM¹

BIOCELL, Vol.46, No.2, pp. 535-545, 2022, DOI:10.32604/biocell.2022.017739 - 20 October 2021

Abstract Testicular damage is one of the most hazardous effects as it’s associated with azoospermia. Busulfan (Bu) is a highly toxic chemotherapeutic drug that affects testis. Thirty male Swiss albino mice divided into six groups of 5 animals each. Control (oral 0.9% saline daily for 75 days); Mel (20 mg/kg/day orally for 30 days); ZnO NPs (5 mg/kg/day i.p. for 30 days); BU (single i.p. injection of 40 mg/kg and then left for 45 days); BU + Mel (single 40 mg/kg dose of BU and left for 45 days followed by 20 mg/kg/day Mel for 30 More >

YONG LIU^1,2,#, ZHIHUA JU^1,#, QIANG JIANG¹, WENHAO LIU¹, CHUNHONG YANG¹, YARAN ZHANG¹, XIUGE WANG¹, YAPING GAO¹, XIAOCHAO WEI¹, YAN SUN¹, JINPENG WANG¹, MINGHAI HOU¹, LING YANG², JINMING HUANG^1,*

BIOCELL, Vol.45, No.1, pp. 79-87, 2021, DOI:10.32604/biocell.2021.013583 - 26 January 2021

Abstract F-box and WD-40 domain protein 11 (FBXW11) is an important component of the E3 ubiquitin-ligase enzyme that plays a key role in the ubiquitin-dependent regulation of spermatogenesis. In our previous research, the mRNA expression of FBXW11 in bull sperm with high motility is significantly higher than that with low motility. In the present study, the protein expression levels of FBXW11 in bull testicular tissues with low-performance sperm quality groups were significantly higher than those in normal performance groups. The immunohistochemistry result demonstrated that FBXW11 protein was located in the periphery of Leydig cells and seminiferous… More >

Alexander H. Wu¹, Supreet Kaur², Sharon Peng², Ashima Kapoor¹, Michael Maroules²

Canadian Journal of Urology, Vol.26, No.3, pp. 9799-9801, 2019

Abstract Most germ cell tumors are located in the gonads however there are instances where these tumors are located elsewhere in which are termed extragonadal germ cell tumors. When primary lesion of the testicular tumor has regressed, the term “burned-out testicular tumor” has been proposed. We herein report the first case of burned-out seminoma of the testis presenting as a cervical spinal mass causing cord compression with bone metastasis. More >

Claudio Spinelli¹, Silvia Strambi¹, Marga Busetto¹, Leonardo Rossi¹, Jessica Piscioneri¹, Angela Pucci², Francesco Bianco³

Canadian Journal of Urology, Vol.23, No.2, pp. 8254-8259, 2016

Abstract Introduction: The aim of our study is to compare two different surgical procedures, lymphatic vessels and arterioles sparing microsurgical inguinal varicocelectomy (LASMIV) without delivery of the testis and LASMIV with delivery of the testis and ligature of collateral and gubernacular veins.
Materials and methods: Seventy adolescents suffering from varicocele and reduction of the ipsilateral testicular volume greater than 20% were prospectively assigned to two homogenous groups according to age and Tanner stage. The patients, operated from 2008 to 2013, were randomized to undergo either LASMIV without delivery of the testis or LASMIV with delivery and ligature of… More >

Adam S. Howe, Lane S. Palmer

Canadian Journal of Urology, Vol.23, No.6, pp. 8602-8602, 2016

Abstract This article has no abstract. More >

Dwayne Tun Soong Chang¹, Isaac Andrew Thyer^1,2, Dickon Hayne^1,3, Darren Jonathan Katz⁴

Canadian Journal of Urology, Vol.22, No.4, pp. 7935-7937, 2015

Abstract We report the case of a man with idiopathic lymphocytic orchitis (LO) manifested by undifferentiated testicular pain and atrophy. Conventional investigation results were unremarkable. Oral ciprofloxacin only improved the pain temporarily. Scrotal exploration surgery was performed to exclude acute testicular torsion and a biopsy was taken during surgery for histological examination. Histology revealed severe LO with reduced spermatogenesis. A trial of oral steroids was initially effective but the effect was temporary. Due to chronic pain, he eventually underwent unilateral orchidectomy. Histology confirmed the initial diagnosis of LO. He was pain-free postoperatively. Idiopathic LO is a More >

Leslie Nicolay, Jordan Gitlin, Lane S. Palmer

Canadian Journal of Urology, Vol.20, No.3, pp. 6805-6807, 2013

Abstract We present the first case of torsion of an appendix testis in a cryptorchid testicle. The difficulties in history, physical examination and imaging posed by such a presentation are presented as well as management considerations. More >