FABIANO BINI^1,*, ANDRADA PICA¹, ANDREA MARINOZZI², FRANCO MARINOZZI¹

BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150 - 13 June 2022

Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization More >

Mahmood Hameed Majeed^*, Nabeel Kadhem Abd Alsaheb

Journal of Renewable Materials, Vol.10, No.9, pp. 2391-2408, 2022, DOI:10.32604/jrm.2022.019887 - 30 May 2022

Abstract Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease, injury, or congenital disabilities. Tissue engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and organs. These are utilized to attach the right cells and then grow them. Rapid prototyping appears to be the most promising technology due to its high level of precision and control. Bone tissue replacement “scaffolding” is a common theme discussed in this article. The fused deposition technique was used to construct our scaffold, and a polymer called polylactic acids… More > Graphic Abstract

XIAOFANG WANG¹, XIAOLIN TU^1,2,*, YUFEI MA¹, JIE CHEN¹, YANG SONG³, GUANGLIANG LIU¹

BIOCELL, Vol.46, No.9, pp. 2089-2099, 2022, DOI:10.32604/biocell.2022.020069 - 18 May 2022

Abstract The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering. Wnt3a activates the classic Wnt/β-catenin signaling pathway which effects bone growth and development by the accumulation of β-catenin in the nucleus. In this study, we fabricated 3D printed PCL scaffold with Wnt3a-induced murine bone marrow-derived stromal cell line ST2 decellularized matrix (Wnt3a-ST2-dCM-PCL) and ST2 decellularized matrix (ST2-dCM-PCL) by freeze-thaw cycle and DNase decellularization treatment which efficiently decellularized >90% DNA while preserved most protein. Compared to ST2-dCM-PCL, Wnt3a-ST2-dCM-PCL significantly enhanced newly-seeded ST2 proliferation, osteogenic differentiation and upregulated osteogenic More >

W. BENTON SWANSON, YUJI MISHINA^*

BIOCELL, Vol.46, No.6, pp. 1445-1451, 2022, DOI:10.32604/biocell.2022.018781 - 07 February 2022

Abstract Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve More >

ODIN RAMIREZ-FERNANDEZ^1,2, ESMERALDA ZUÑIGA-AGUILAR^3,*

BIOCELL, Vol.46, No.2, pp. 325-338, 2022, DOI:10.32604/biocell.2022.016892 - 20 October 2021

Abstract This review aims to offer a vision of the clinical reality of cell therapy today in intensive medicine. For this, it has been carried out a description of the properties, functions, and Mesenchymal Stem Cells (MSCS) sources to subsequently address the evidence in preclinical models and studies clinical trials with whole cells and models attributed to small extracellular vesicles (sEVs), nanoparticles made up of microvesicles secreted by cells with an effect on the extracellular matrix, and their impact as an alternative towards cell-free regenerative medicine. MSCs are cells that enhance the regenerative capacity which can… More >

Qingxi Hu^1,2,3, Yiming Wang¹, Dongchao Yang⁴, Haiguang Zhang^1,2,3,*, Zhicheng Song⁴, Yan Gu^4,*

Journal of Renewable Materials, Vol.9, No.1, pp. 1-16, 2021, DOI:10.32604/jrm.2021.013319 - 30 November 2020

Abstract Acellular dermal matrix (ADM) as a biomaterial is currently believed to be promising tissue repair improvement. With the development of tissue engineering, ADM is increasingly used as biological scaffolds. We explored the feasibility and performance of ADM biological scaffolds that fabricated by 3D printing. This paper presented our study on the printability of 3D printed ADM scaffolds, with a focus on identifying the influence of printing parameters/conditions on printability. To characterize the printability, we examined the fiber morphology, pore size, strand diameter, and mechanical property of the printed scaffolds. Our results revealed that the printability… More >

Marcia Cristina Branciforti^1,*, Caroline Faria Bellani², Carolina Lipparelli Morelli², Alice Ferrand³, Nadia Benkirane-Jessel³, Rosario Elida Suman Bretas²

Journal of Renewable Materials, Vol.7, No.3, pp. 269-277, 2019, DOI:10.32604/jrm.2019.01833

Abstract Although nanocomposites have recently attracted special interest in the tissue engineering area, due to their potential to reinforce scaffolds for hard tissues applications, a number of variables must be set prior to any clinical application. This manuscript addresses the evaluation of thermo-mechanical properties and of cell proliferation of cellulose nanocrystals (CNC), poly(butylene adipate-co-terephthalate) (PBAT), poly(ε-caprolactone) (PCL) films and their bionanocomposites with 2 wt% of CNC obtained by casting technique. Cellulose nanocrystals extracted from Balsa wood by acid hydrolysis were used as a reinforcing phase in PBAT and PCL matrix films. The films and pure CNC… More >

Shu Chien^*

Molecular & Cellular Biomechanics, Vol.16, No.3, pp. 163-178, 2019, DOI:10.32604/mcb.2019.07689

Abstract Professor Y.C. Fung has made tremendous impacts on science, engineering and humanity through his research and its applications, by setting the highest standards, through educating many students and their students, and providing his exemplary leadership. He has applied his profound knowledge and elegant analytical methods to the study of biomedical problems with rigor and excellence. He established the foundations of biomechanics in living tissues and organs. Through his vision of the power of “making models” to explain and predict biological phenomena, Dr. Fung opened up new vista for bioengineering, from organs-systems to molecules-genes, and has More >

Pranav S. Sapkal^1,*, Abhaykumar M. Kuthe¹, Shantanu Mathankar², Akash A. Deshmukh

Molecular & Cellular Biomechanics, Vol.14, No.2, pp. 125-136, 2017, DOI:10.3970/mcb.2017.014.123

Abstract β-TCP-Zirconia scaffolds with different architectures were fabricated by means of 3D-Bioplotting in order to enhance the mechanical and in-vitro ability of the scaffold to heal large size bone defects. In the present study scaffold architecture with different strand orientations (0°-90°, 0°-45°-135°-180°, 0°-108°-216° and 0°-72°-144°-36°-108°) were fabricated, characterized and evaluated for mechanical strength and cell proliferation ability. β-TCP powder (25 µm) and PVA (Polyvinyl Alcohol) was acquired from Fisher Scientific, India. Zirconia (18 to 32 µm) was procured from Lobachemie, India. In brief 7.5%, PVA in distilled water was used as a binder and was mixed… More >

M. L. Lambri^1,2, E. D. Giordano^2,3, P. B. Bozzano⁴, F. G. Bonifacich², J. I. Pérez-Landazábal^5,6, G. I. Zelada², D. Gargicevich², V. Recarte^5,6, O. A. Lambri^2*

Journal of Renewable Materials, Vol.4, No.4, pp. 251-257, 2016, DOI:10.7569/JRM.2016.634111

Abstract The denaturation processes of collagen in the temperature range between 450 K and 670 K are revealed through studies performed on cow rib bones by means of mechanical spectroscopy, differential scanning calorimetry, thermogravimetry, scanning electron microscopy and infrared spectroscopy. The conformational change of the collagen molecules from a triple helix structure to a random coil was found at around 510 K. It was determined that the transformation is developed through the viscous movement of fibrils with an activation energy of (127 ± 8) kJ/mol. The second stage of massive bulk deterioration of the collagen was More >