D. L. Butler¹, N. Juncosa-Melvin¹, G. P. Boivin¹, M. Galloway², C. Gooch¹, J. T. Shearn¹, V. S. Nirmalanandhan¹, S. A. Hunter¹, K. Chokalingam¹, C. Frede³, J. Florer³, R. Wenstrup³

Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 127-130, 2006, DOI:10.32604/mcb.2006.003.127

Abstract This article has no abstract. More >

Marcello Lappa¹

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.2, pp. 141-152, 2006, DOI:10.3970/fdmp.2006.002.141

Abstract Numerical simulations and computer-graphics animation can be used as useful tools to discern the physicochemical environmental factors affecting the surface kinetics of growing biological tissues as well as their relative importance in determining growth. A mathematical formalism for such kinetics is proposed through parametric investigation and validated through focused comparison with experimental results. The study relies on the application of a CFD moving boundary (Volume of Fluid) method specially conceived for the simulation of these problems. In the second part of the analysis the case of two samples hydrodynamically interacting in a rotating bioreactor is More >

Milica Radisic^1,2, Gordana Vunjak-Novakovic³

FDMP-Fluid Dynamics & Materials Processing, Vol.2, No.1, pp. 1-16, 2006, DOI:10.3970/fdmp.2006.002.001

Abstract To engineer cardiac tissue in vitro with properties approaching those of native tissue, it is necessary to reproduce many of the conditions found in vivo. In particular, cell density must be sufficiently high to enable contractility, which implies a three-dimensional culture with a sufficient oxygen and nutrient supply. In this review, hydrogels and scaffolds that support high cell densities are examined followed by a discussion on the utility of scaffold perfusion to satisfy high oxygen demand of cardiomyocytes and an overview of new bioreactors developed in our laboratory to accomplish this task more simply. More >

P. Yu¹, T. S. Lee¹, Y. Zeng¹, H. T. Low²

FDMP-Fluid Dynamics & Materials Processing, Vol.1, No.3, pp. 235-246, 2005, DOI:10.3970/fdmp.2005.001.235

Abstract A numerical model is developed for the investigation of flow field and mass transport in a micro-bioreactor, of working volume below 5 ml, in which medium mixing is generated by a magnetic stirrer-rod rotating on the bottom. The flow-field results show that a recirculation region exists above the stirrer rod and rotates with it; the related fluid mixing is characterized by a circulation coefficient of up to 0.2 which is about five times smaller than that of a one-litre stirred-tank bioreactor. The oxygen transfer coefficient is less than 5 h^-1 which is two orders smaller than… More >