Mohammad Izadifar^a,b,*, Xiongbiao Chen^a,b

Frontiers in Heat and Mass Transfer, Vol.3, No.4, pp. 1-7, 2012, DOI:10.5098/hmt.v3.4.3004

Abstract Heat can be potentially used for accelerating biodegradation of implanted tissue engineered scaffolds. Cyclic and continuous radio frequency (RF) heating was applied to implanted chitosan and alginate scaffolds at 4 applied voltages, 3 frequencies, and 2 thermally conditioning environments. A 3D finite element model was developed to simulate the RF treatment. A uniform RF heating was achieved at the scaffold top. For alginate, voltage was the only significant RF heating factor while both frequency and voltage significantly affected RF heating of chitosan. Less temperature gradient across the scaffold was achieved at a conditioning environment at <30°C. Surrounding tissue was insignificantly… More >

AAYUSHI RANDHAWA^1,2, SAYAN DEB DUTTA¹, KEYA GANGULY¹, TEJAL V. PATIL^1,2, RACHMI LUTHFIKASARI¹, KI-TAEK LIM^1,2,*

BIOCELL, Vol.47, No.4, pp. 789-808, 2023, DOI:10.32604/biocell.2023.026217

Abstract Tissues are made up of cells and the extracellular matrix (ECM) which surrounds them. These cells and tissues are actively adaptable to enduring significant stress that occurs in daily life. This astonishing mechanical stress develops due to the interaction between the live cells and the non-living ECM. Cells in the matrix microenvironment can sense the signals and forces produced and initiate a signaling cascade that plays a crucial role in the body’s normal functioning and influences various properties of the native cells, including growth, proliferation, and differentiation. However, the matrix’s characteristic features also impact the repair and regeneration of the… More >

SUKUMARAN ANIL^1,2,*, RAMYA RAMADOSS³, NEBU G. THOMAS⁴, JASMIN M. GEORGE⁴, VISHNUPRIYA K. SWEETY⁴

BIOCELL, Vol.47, No.1, pp. 71-80, 2023, DOI:10.32604/biocell.2023.024334

Abstract Exfoliated deciduous or an extracted healthy adult tooth can be used to harvest, process, and cryogenically preserve dental pulp stem cells. Future stem cell-based regenerative medicine methods could benefit significantly from these mesenchymal stem cells. Teeth serve as a substantial source of mesenchymal stem cells, otherwise disposed of as medical waste. Care should be taken to store this treasure trove of stem cells. Collective responsibility of patients, dentists, and physicians is necessary to ensure that this valuable resource is not wasted and that every possible dental pulp stem cell is available for use in the future. The dental pulp stem… More >

Andrea Morelli, Dario Puppi, Federica Chiellini^*

Journal of Renewable Materials, Vol.1, No.2, pp. 83-112, 2013, DOI:10.7569/JRM.2012.634106

Abstract Polymers, particularly those susceptible to undergoing biodegradation under physiological environments, can be considered the materials of choice for biomedical applications such as tissue engineering, regenerative medicine, and controlled and targeted drug delivery. The development of these relatively new fi elds of biomedical research represents the driving force towards the exploitation of renewable resources for the obtainment of biobased polymeric biomaterials. This perspective article reports on the biomedical applications of three major categories of biobased polymeric materials obtained from renewable resources, namely, polysaccharides, proteins and polyesters of natural origins. Particular emphasis is given to biobased polymers that display only minor modifi… More >

Soliman Abdalla^1,2,*, Shiref Kandil²

Journal of Renewable Materials, Vol.10, No.11, pp. 2699-2716, 2022, DOI:10.32604/jrm.2022.022334

Abstract In order to obtain larger, clinical-scale and practical-scale bone grafts, we have designed both tailored scaffolds and tailored bio incubator with optimal bio-production characteristics. Using DIC files to Simpleware Scan-IP (Simple-ware-exeter United Kingdom), we have digitally reconstructed segmental additive bone-tissue in order to perform images processing. Both hydroxyapatite and tannin composites have been used in order to get the final bone modules combined for retexturing of segmental bone defect. We have found that sectioning of bone segment deficiency reorganizations into well disk-shaped design permits one to standardize the cell culture and seeding protocol, to get better products. The present study… More >

FABIANO BINI^1,*, ANDRADA PICA¹, ANDREA MARINOZZI², FRANCO MARINOZZI¹

BIOCELL, Vol.46, No.10, pp. 2225-2229, 2022, DOI:10.32604/biocell.2022.021150

Abstract Bone tissue is a hierarchical material characterized at nanoscale by the mineralized collagen fibril, a recurring structure mainly composed of apatite minerals, collagen and water. Bone nanostructure has a fundamental role in determining the mechanical behavior of the tissue and its mass transport properties. Diffusion phenomenon allows to maintain an adequate supply of metabolites in the mechanisms of bone remodeling, adaptation and repair. Several analytical and computational models have been developed to analyze and predict bone tissue behavior. However, the fine replication of the natural tissue still represents a challenge. Insights on the structural organization at nanoscale and on the… More >

Mahmood Hameed Majeed^*, Nabeel Kadhem Abd Alsaheb

Journal of Renewable Materials, Vol.10, No.9, pp. 2391-2408, 2022, DOI:10.32604/jrm.2022.019887

Abstract Tissue engineering’s main goal is to regenerate or replace tissues or organs that have been destroyed by disease, injury, or congenital disabilities. Tissue engineering now uses artificial supporting structures called scaffolds to restore damaged tissues and organs. These are utilized to attach the right cells and then grow them. Rapid prototyping appears to be the most promising technology due to its high level of precision and control. Bone tissue replacement “scaffolding” is a common theme discussed in this article. The fused deposition technique was used to construct our scaffold, and a polymer called polylactic acids and soybean oil resin were… More > Graphic Abstract

XIAOFANG WANG¹, XIAOLIN TU^1,2,*, YUFEI MA¹, JIE CHEN¹, YANG SONG³, GUANGLIANG LIU¹

BIOCELL, Vol.46, No.9, pp. 2089-2099, 2022, DOI:10.32604/biocell.2022.020069

Abstract The limited bioactivity of scaffold materials is an important factor that restricts the development of bone tissue engineering. Wnt3a activates the classic Wnt/β-catenin signaling pathway which effects bone growth and development by the accumulation of β-catenin in the nucleus. In this study, we fabricated 3D printed PCL scaffold with Wnt3a-induced murine bone marrow-derived stromal cell line ST2 decellularized matrix (Wnt3a-ST2-dCM-PCL) and ST2 decellularized matrix (ST2-dCM-PCL) by freeze-thaw cycle and DNase decellularization treatment which efficiently decellularized >90% DNA while preserved most protein. Compared to ST2-dCM-PCL, Wnt3a-ST2-dCM-PCL significantly enhanced newly-seeded ST2 proliferation, osteogenic differentiation and upregulated osteogenic marker genes alkaline phosphatase (Alp),… More >

W. BENTON SWANSON, YUJI MISHINA^*

BIOCELL, Vol.46, No.6, pp. 1445-1451, 2022, DOI:10.32604/biocell.2022.018781

Abstract Mesenchymal stem cells (MSCs) have long been regarded as critical components of regenerative medicine strategies, given their multipotency and persistence in a variety of tissues. Recently, the specific role of MSCs in mediating regenerative outcomes has been attributed (in part) to secreted factors from transplanted cells, namely extracellular vesicles. This viewpoint manuscript highlights the promise of cell-derived extracellular vesicles as agents of regeneration, enhanced by synergy with appropriate biomaterials platforms. Extracellular vesicles are a potentially interesting regenerative tool to enhance the synergy between MSCs and biomaterials. As a result, we believe these technologies will improve patient outcomes through efficient therapeutic… More >

ODIN RAMIREZ-FERNANDEZ^1,2, ESMERALDA ZUÑIGA-AGUILAR^3,*

BIOCELL, Vol.46, No.2, pp. 325-338, 2022, DOI:10.32604/biocell.2022.016892

Abstract This review aims to offer a vision of the clinical reality of cell therapy today in intensive medicine. For this, it has been carried out a description of the properties, functions, and Mesenchymal Stem Cells (MSCS) sources to subsequently address the evidence in preclinical models and studies clinical trials with whole cells and models attributed to small extracellular vesicles (sEVs), nanoparticles made up of microvesicles secreted by cells with an effect on the extracellular matrix, and their impact as an alternative towards cell-free regenerative medicine. MSCs are cells that enhance the regenerative capacity which can be differentiated typically in different… More >