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  • Open Access


    Retraction: miR-148b Functions as a Tumor Suppressor by Targeting Endoplasmic Reticulum Metallo Protease 1 in Human Endometrial Cancer Cells

    Oncology Research Editorial Office

    Oncology Research, Vol.32, No.8, pp. 1379-1379, 2024, DOI:10.32604/or.2024.055034

    Abstract This article has no abstract. More >

  • Open Access


    The Downregulation of MicroRNA-10b and its Role in Cervical Cancer

    Dongling Zou*, Qi Zhou, Dong Wang, Lili Guan*, Li Yuan*†, Shaolin Li*

    Oncology Research, Vol.24, No.2, pp. 99-108, 2016, DOI:10.3727/096504016X14611963142173

    Abstract It has been demonstrated that microRNAs (miRNAs) act as oncogenes or tumor suppressors in a variety of cancers. Our previous work suggested that miR-10a/b functioned as a tumor suppressor in gastric cancer, and miR-10b was also reported to be significantly downregulated in advanced stage cervical cancer tissues. However, the aberrant expression of miR-10b in cervical cancer and its possible role in cervical carcinogenesis was largely unknown. In this study, we investigated the expression of miR-10b in cervical cancer tissues, carcinoma in situ tissues, mild dysplasia, moderate dysplasia, severe dysplasia tissues, and normal controls. We found More >

  • Open Access


    Function of miR-152 as a Tumor Suppressor in Human Breast Cancer by Targeting PIK3CA

    Shuke Ge*, Dan Wang, Qinglong Kong, Wei Gao*, Jiayi Sun*

    Oncology Research, Vol.25, No.8, pp. 1363-1371, 2017, DOI:10.3727/096504017X14878536973557

    Abstract miR-152, as a tumor suppressor, has been reported to be downregulated in a number of cancer cell lines and tumor tissues, including breast cancer. This study aimed to investigate the role of miR-152 in human breast cancer and its underlying mechanisms. Human breast cancer cell line HCC1806 was transfected with hsa-miR- 152-3p mimic, inhibitor, or scrambled negative controls. The efficiency of miR-152-3p transfection was evaluated by quantitative real-time PCR, and the effects on cell viability and apoptosis as well as on the PI3K/AKT signaling pathway were investigated by MTT assay, flow cytometry, and Western blot… More >

  • Open Access


    MicroRNA-148a Acts as a Tumor Suppressor in Osteosarcoma via Targeting Rho-Associated Coiled-Coil Kinase

    HaiYan Yang*†, ZhiGang Peng, ZhenZhen Da*, Xin Li, YeXiao Cheng*, BinBin Tan§, Xin Xiang, HaiPing Zheng, Yan Li*, LanHua Chen*, Ning Mo, XueXin Yan, Xiaolin Li*, XiaoHua Hu

    Oncology Research, Vol.25, No.8, pp. 1231-1243, 2017, DOI:10.3727/096504017X14850134190255

    Abstract MicroRNAs (miRs) have been demonstrated to be involved in the development and progression of osteosarcoma (OS), but the molecular mechanism still remains to be fully investigated. The present study investigated the function of miR-148a in OS, as well as its underlying mechanism. Our data showed that miR-148a was significantly downregulated in OS tissues compared to their matched adjacent normal tissues, and also in OS cell lines compared to normal human osteoblast cells. Low expression of miR-148a was significantly associated with tumor progression and a poor prognosis for OS patients. Rho-associated coiled-coil kinase 1 (ROCK1) was… More >

  • Open Access


    Long Noncoding RNA LINC0086 Functions as a Tumor Suppressor in Nasopharyngeal Carcinoma by Targeting miR-214

    Jie Guo*†, Jinqi Ma, Guosheng Zhao, Guocai Li, Yunfeng Fu, Yanwei Luo, Rong Gui

    Oncology Research, Vol.25, No.7, pp. 1189-1197, 2017, DOI:10.3727/096504017X14865126670075

    Abstract Nasopharyngeal carcinoma (NPC) is a distinct head and neck cancer, which is occurring at a high frequency in Southern China. Emerging studies have shown that long noncoding RNAs (lncRNAs) play a critical role in carcinogenesis and progression. In this study, we established a comprehensive lncRNA profile in NPC and found that 35 lncRNAs were differentially expressed in NPC. We found that LINC0086 was decreased in NPC patient serum samples and tissues. The Kaplan–Meier survival curve showed that patients with high LINC0086 expression had a higher survival rate than those with low LINC0086 expression. LINC0086 expression… More >

  • Open Access


    MicroRNA-98 Plays a Suppressive Role in Non-Small Cell Lung Cancer Through Inhibition of SALL4 Protein Expression

    Wenliang Liu*, Peng Xiao, Han Wu*, Li Wang*, Demiao Kong*, Fenglei Yu*

    Oncology Research, Vol.25, No.6, pp. 975-988, 2017, DOI:10.3727/096504016X14791726591124

    Abstract MicroRNAs (miRs) have been demonstrated to be significantly associated with the development and progression of non-small cell lung cancer (NSCLC). However, the underlying mechanism of miR-98 in mediating the malignant phenotypes of NSCLC cells remains obscure. In this study, we found that miR-98 was significantly downregulated in NSCLC tissues compared to nontumor lung tissues. Downregulation of miR-98 was significantly associated with poor differentiation and advanced clinical stage. Restoration of miR-98 expression significantly decreased the proliferation, migration, and invasion of NSCLC A549 and H1229 cells. SALL4 was identified as a target gene of miR-98, and the… More >

  • Open Access


    Overexpression of MicroRNA-27b Inhibits Proliferation, Migration, and Invasion via Suppression of MET Expression

    Hui Zhou*†, Yanglin Liu, Ling Xiao, Zhengmao Hu*, Kun Xia

    Oncology Research, Vol.25, No.1, pp. 147-154, 2017, DOI:10.3727/096504016X14732772150505

    Abstract MicroRNA-27b (miR-27b) was recently found to be significantly downregulated in different human cancers. However, evidence of the function of miR-27b in non-small cell lung cancer (NSCLC) remains limited. In this study, we aimed to investigate novel miR-27b-mediated targets or signaling pathways associated with the tumorigenesis and metastasis of NSCLC. Real-time (RT) PCR was performed to examine miR-27b expression in NSCLC specimens. MTT assay, wound-healing assay, and Transwell assay were used to determine cell proliferation, migration, and invasion. Our data indicated that the miR-27b levels were significantly decreased in NSCLC specimens and cell lines (SK-MES-1, H358,… More >

  • Open Access


    miR-126 Functions as a Tumor Suppressor by Targeting SRPK1 in Human Gastric Cancer

    Qiaorong Li*, Geng Wang, Hong Wang

    Oncology Research, Vol.26, No.9, pp. 1345-1353, 2018, DOI:10.3727/096504018X15180508535835

    Abstract The expression of miR-126 and serine–arginine protein kinase 1 (SRPK1) are linked to tumor development; nevertheless, its role in the tumor growth and invasion of gastric cancer (GC) and the underlying mechanism have not been clarified. Here the expression and role of miR-126 and SRPK1 were investigated in GC tissues and cells by in vitro assay, and then targets of miR-126 were identified by dual-luciferase reporter assay. In this study, miR-126 expression was downregulated and associated with lymph node metastasis and poor prognosis as well as SRPK1 expression. In vitro assay revealed that miR-126 obviously More >

  • Open Access


    miR-641 Functions as a Tumor Suppressor by Targeting MDM2 in Human Lung Cancer

    Qinglong Kong, Nan Shu, Jun Li, Ning Xu

    Oncology Research, Vol.26, No.5, pp. 735-741, 2018, DOI:10.3727/096504017X15021536183490

    Abstract Lung cancer is the leading cause of deaths due to cancer. Studies suggest an important role of microRNAs (miRNAs) in a variety of cancers, including lung cancer. In the present study, we evaluated the role of miR- 641 in human lung cancer A549 cells. Quantitative RT-PCR and Western blot were used to measure mRNA and protein expression, respectively. Cell viability and cell apoptosis were respectively measured by MTT assay and flow cytometry. In addition, luciferase activity assay was used to identify the target of miR-641. The expression of miR-641 was downregulated in lung cancer tissues More >

  • Open Access


    MicroRNA-520b Functions as a Tumor Suppressor in Colorectal Cancer by Inhibiting Defective in Cullin Neddylation 1 Domain Containing 1 (DCUN1D1)

    Jing Xiao*, Guang Li, Jingyu Zhou, Shalong Wang, Dongcai Liu, Guoshun Shu, Jianping Zhou, Feng Ren

    Oncology Research, Vol.26, No.4, pp. 593-604, 2018, DOI:10.3727/096504017X14920318811712

    Abstract MicroRNAs (miRs), a class of small noncoding RNAs, are important regulators for gene expression through directly binding to the 3'-untranslated region (3'-UTR) of their target mRNA. Recently, downregulation of miR-520b has been observed in several common human cancers. However, the exact role of miR-520b in colorectal cancer (CRC) has not previously been studied. In this study, our data showed that miR-520b was significantly downregulated in CRC and cell lines when compared with adjacent normal tissues and a normal intestinal epithelial cell line. Low expression of miR-520b was notably associated with the malignant progress and a… More >

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