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  • Open Access

    REVIEW

    Targeting Protein Arginine Deiminases in Rheumatoid Arthritis: Pathophysiology and Therapeutic Progress

    Yung-Chieh Huang1,2,3, Wen-Chien Cheng4,5, Ya-Hsuan Chao6, Tzu-Ting Chen7,*, Chi-Chen Lin8,9,10,11,*

    BIOCELL, Vol.50, No.4, 2026, DOI:10.32604/biocell.2025.072732 - 21 April 2026

    Abstract Protein arginine deiminases (PADs) are key enzymes in the development of rheumatoid arthritis (RA), catalyzing the conversion of arginine to citrulline in a process called citrullination. This post-translational modification is crucial to RA pathogenesis as it creates neo-antigens that trigger the production of anti-citrullinated protein antibodies (ACPAs). These ACPAs are highly specific to RA and often appear before clinical symptoms, making them valuable biomarkers for diagnosis and prognosis. Beyond ACPA production, PADs, particularly PAD4, play a vital role in forming neutrophil extracellular traps (NETs). NETs contribute to inflammation and joint damage, further highlighting the importance… More > Graphic Abstract

    Targeting Protein Arginine Deiminases in Rheumatoid Arthritis: Pathophysiology and Therapeutic Progress

  • Open Access

    ARTICLE

    Numerical and Experimental Investigation of Filament-End Dynamics in Negative-Pressure Pneumatic Transport

    Yisheng Liu*, Xufeng Sun, Zhifeng Chen

    FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.3, 2026, DOI:10.32604/fdmp.2026.077267 - 31 March 2026

    Abstract This study addresses the optimization of automated yarn handling in textile manufacturing by examining the related suction process through a combined numerical and experimental approach. In particular, a three-dimensional model of the suction nozzle was coupled with an equivalent linear-elastic beam representation of the yarn, and a Fluent–IDW–Abaqus weakly coupled fluid–structure interaction (FSI) framework was employed to capture the yarn’s release and dynamic response under negative-pressure suction. High-speed imaging experiments validated the simulations, demonstrating excellent agreement in displacements and velocities. According to the results, increasing the initial suction pressure from −0.04 MPa to −0.06 MPa More >

  • Open Access

    ARTICLE

    Large Language Model-Enabled Constitutive Modeling for Rate-Dependent Plasticity and Automatic UMAT Subroutine Generation

    Yuchuan Gu1,2, Lusheng Wang1,*, Jun Ding1, Yanhong Peng1, Changgeng Li3,*, Shaojie Gu4,5

    CMC-Computers, Materials & Continua, Vol.87, No.2, 2026, DOI:10.32604/cmc.2026.075939 - 12 March 2026

    Abstract In materials science and engineering design, high-fidelity and high-efficiency numerical simulation has become a driving force for innovation and practical implementation. To address longstanding bottlenecks in the development of conventional material constitutive models—such as lengthy modeling cycles and difficulties in numerical implementation—this study proposes an intelligent modeling and code generation approach powered by large language models. A structured knowledge base integrating constitutive theory, numerical algorithms, and UMAT (User Material) interface specifications is constructed, and a retrieval-augmented generation strategy is employed to establish an end-to-end workflow spanning experimental data parsing, constitutive model formulation, and automatic UMAT… More >

  • Open Access

    ARTICLE

    Effectiveness of an 8-Week Game-Based Physical Activity Program in Reducing Post-Traumatic Stress among Children Affected by the 2023 Kahramanmaraş Earthquakes

    Burak Canpolat1,*, Göktuğ Norman2, Cemal Gündoğdu2, Şakir Tüfekçi2, Yalın Aygün2, Taylan Akbuğa3

    International Journal of Mental Health Promotion, Vol.27, No.11, pp. 1781-1795, 2025, DOI:10.32604/ijmhp.2025.069852 - 28 November 2025

    Abstract Objectives: This study examines the effectiveness of an eight-week game-based physical activity program designed to reduce post-traumatic stress levels in children affected by the Kahramanmaraş-centered earthquakes that occurred in Turkey on 06 February 2023. Following the earthquake, millions of children experienced significant changes in their education and living conditions, adversely affecting their psychological health. Methods: The therapeutic effects of physical activity on post-traumatic stress disorder (PTSD) are frequently emphasized in the literature, and this study specifically focuses on the impact of game-based exercises. The research employed an experimental design, involving 80 earthquake-affected children aged 10 to… More >

  • Open Access

    PROCEEDINGS

    Electrochemical Pneumatic Battery for Compact, Efficient, and Silent Robotic Actuation

    Junyu Ge1, Yifan Wang1, Hong Li1,2,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.33, No.4, pp. 1-3, 2025, DOI:10.32604/icces.2025.011446

    Abstract The advancement of untethered and adaptive robotic systems necessitates the development of compact, efficient, and silent pneumatic power sources [1,2]. Traditional pneumatic actuation relies on bulky compressors or external gas reservoirs, limiting their practical applications in mobile and autonomous systems [3,4]. This work presents a novel electrochemical pneumatic battery (EPB) that exploits electrochemical driven gas generation to achieve controlled and energy-efficient pneumatic actuation, offering a viable alternative to conventional air supply methods. The EPB operates through an electrochemical redox mechanism based on a zinc-oxygen battery [5–7], enabling reversible gas storage and controlled pressure modulation. This… More >

  • Open Access

    REVIEW

    Eosinophils in Rheumatoid Arthritis: A Multifaceted Role in the Pathogenesis of the Disease

    Alexander Blagov1,*, Michael Bukrinsky2, Aleksandra Utkina3, Gulalek Babayeva4, Vasily Sukhorukov1, Alexander Orekhov5

    BIOCELL, Vol.49, No.7, pp. 1125-1140, 2025, DOI:10.32604/biocell.2025.062821 - 25 July 2025

    Abstract Eosinophils are multifunctional granulocytes that contribute to the initiation and modulation of inflammation. Accumulating evidence suggests that eosinophils are adaptable leukocytes that orchestrate the resolution of inflammatory responses. The most prevalent chronic inflammatory illness, rheumatoid arthritis (RA), is typified by persistent synovitis that makes it hard for the disease to go away on its own. Interestingly, a unique subset of eosinophils known as regulatory eosinophils has been found in RA patients’ synovium, especially while the disease is in remission. Pro-resolving signatures of regulatory eosinophils in the synovium are distinct from those of their lung counterparts. More >

  • Open Access

    ARTICLE

    Effects of the 9/11 Terrorist Attacks on Family Narratives and Family Systems

    Cesar E. Montelongo Hernandez1,*, Carol S. North1, E. Whitney Pollio2, David E. Pollio3

    International Journal of Mental Health Promotion, Vol.27, No.6, pp. 737-752, 2025, DOI:10.32604/ijmhp.2025.065317 - 30 June 2025

    Abstract Background: Disaster mental health outcomes of individuals may be affected by the families they inhabit, with effects rippling through the entire family system. Existing research on the experience of children in disasters has typically been limited to examining single individuals or, at most, family dyads. Research is needed to explore interactions within families as a whole, including interactions among multiple family members, as well as with community entities in a broad systems approach with dynamic analysis of family systems over time. The purpose of this study was to combine quantitative and qualitative data using structured… More >

  • Open Access

    ARTICLE

    Physical Fitness and Mental Health Three Months after COVID-19 Infection in Young and Elderly Women

    Meng Wang1, Onkei Lei1,2, Frankie U Kei Wong1, Water Soi Po Wong1, Walter Heung Chin Hui1, Gasper Chi Hong Leong1, Wenze Fang1,3, Zhaowei Kong1,*

    International Journal of Mental Health Promotion, Vol.27, No.3, pp. 363-378, 2025, DOI:10.32604/ijmhp.2025.060875 - 31 March 2025

    Abstract Background: This study evaluated physical fitness and mental health in young and elderly women 3 months after mild COVID-19 infection, and examined the impact of infection and age on long COVID occurrence and trajectory. Methods: There were 213 eligible female volunteers (107 young, 106 elderly) recruited approximately three months after the significant outbreak of COVID-19 in China. Participants completed a fitness test and mental health assessment using the Post-Traumatic Stress Disorder Self-Assessment Scale (PTSD) and the Pittsburgh Sleep Quality Inventory (PSQI). Results: Despite no significant difference in physical fitness, infected young and elderly females experienced poorer… More >

  • Open Access

    ARTICLE

    Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling

    Hsien-Tsung Lu1,2, Ching-Chi Hsu3,*, Qi-Quan Jian3, Wei-Ting Chen4

    CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1883-1898, 2025, DOI:10.32604/cmes.2025.057675 - 27 January 2025

    Abstract Reconstruction of a traumatic distal femur defect remains a therapeutic challenge. Bone defect implants have been proposed to substitute the bone defect, and their biomechanical performances can be analyzed via a numerical approach. However, the material assumptions for past computational human femur simulations were mainly homogeneous. Thus, this study aimed to design and analyze scaffolds for reconstructing the distal femur defect using a patient-specific finite element modeling technique. A three-dimensional finite element model of the human femur with accurate geometry and material distribution was developed using the finite element method and material mapping technique. An… More > Graphic Abstract

    Biomechanical Study of Different Scaffold Designs for Reconstructing a Traumatic Distal Femur Defect Using Patient-Specific Computational Modeling

  • Open Access

    ARTICLE

    Numerical Simulation of Gas-Solid Flow Processes in an Ash Conveying Pipeline with Multiple Feeds

    Kairuo Chen1, He Wang1,*, Xiangliang Wang2

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.12, pp. 2721-2739, 2024, DOI:10.32604/fdmp.2024.055174 - 23 December 2024

    Abstract Pneumatic conveying technology, as an efficient material transportation method, has been widely used in various industrial fields. To study the powder transportation in horizontal ash conveying pipes, this study relies on the Computational Particle Fluid Dynamics (CPFD) numerical method. The characteristics of the gas-solid two-phase flow under continuous air supply conditions are analyzed, and the effects on particle movement of factors such as feed port spacing, inlet air velocity, and the number of discharge ports are explored accordingly. The research results show that when the inlet velocity is 5 m/s, adjacent discharged particles come into More >

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