GIULIA CHIABOTTO^1,*, STEFANIA BRUNO^2,*

BIOCELL, Vol.47, No.7, pp. 1499-1508, 2023, DOI:10.32604/biocell.2023.028121

Abstract Renal fibrosis and inflammation are common pathological features of chronic kidney disease (CKD). Since currently available treatments can only delay the progression of CKD, the outcome of patients with CKD is still poor. One therapeutic option for the prevention of CKD-related complications could be the use of mesenchymal stromal cells (MSCs), which have shown beneficial effects in tissue fibrosis and regeneration after damage. However, safety issues, such as cellular rejection and carcinogenicity, limit their clinical application. Among the bioactive factors secreted by MSCs, extracellular vesicles (EVs) have shown the same beneficial effect of MSCs, without any notable side effects. This… More > Graphic Abstract

ABDELAZIZ ADAM IDRISS ARBAB^1,3,#, CHUNQING YIN^4,#, XUBIN LU¹, YAN LIANG¹, ISMAIL MOHAMED ABDALLA¹, AMER ADAM IDRIS³, TIANLE XU^1,2, YONGJIANG MAO¹, ZHANGPING YANG^1,2,*

BIOCELL, Vol.46, No.11, pp. 2443-2454, 2022, DOI:10.32604/biocell.2022.020865

Abstract Mastitis is a common inflammatory cow mammary infection; that causes significant economic loss in dairy industry. Given the interesting connection between metformin’s anti-inflammatory function and mastitis model induced by LTA in pbMECs, our objective was to prove that metformin was beneficial in suppressing proinflammatory response induced by LTA through modulation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways and activation of peroxisome proliferator-activated receptor-γ (PPARγ) in pbMECs. The proliferation of cells and mRNA expression were measured using EdU assay and quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Immunoblotting and immunofluorescence analysis were conducted to evaluate the… More >

Hyun-Jung Moon,1 So-Young Park,1 Su-Hoon Lee, Chi-Dug Kang, Sun-Hee Kim

Oncology Research, Vol.27, No.7, pp. 835-847, 2019, DOI:10.3727/096504019X15517850319579

Abstract Recently, novel therapeutic strategies have been designed with the aim of killing cancer stem-like cells (CSCs), and considerable interest has been generated in the development of specific therapies that target stemnessrelated marker of CSCs. In this study, nonsteroidal anti-inflammatory drugs (NSAIDs) significantly potentiated Hsp90 inhibitor 17-allylamino-17-demethoxygeldanamycin (17-AAG)-mediated cytotoxicity through apoptotic and autophagic cell death induction, but COX-2-inhibitory function was not required for NSAIDinduced autophagy in CD44-overexpressing human chronic myeloid leukemia K562 (CD44^highK562) cells. Importantly, we found that treatment with NSAIDs resulted in a dose-dependent increase in LC3-II level and decrease in p62 level and simultaneous reduction in multiple stemness-related markers… More >

María Janeth Rodríguez-Roque¹, Carmen Lizette Del-Toro-Sánchez^2,*, Janet Madeline Chávez-Ayala¹, Ricardo Iván González-Vega², Liliana Maribel Pérez-Pérez², Esteban Sánchez-Chávez³, Nora Aideé Salas-Salazar¹, Juan Manuel Soto-Parra¹, Rey David Iturralde-García², María Antonia Flores-Córdova^1,*

Journal of Renewable Materials, Vol.10, No.10, pp. 2569-2580, 2022, DOI:10.32604/jrm.2022.021163

Abstract Phenolic compounds are related to high biological activity, avoiding oxidation in food and human systems. Nutshells are by-products derived from the pecan nut processing that contain important amounts of phenols which biological activity must be studied. This research aimed to evaluate the antioxidant (DPPH, ABTS, FRAP and hemolysis) and anti-inflammatory activities of shell extracts from pecan nuts harvested during the crop production cycle 2018 and 2019, as well as the in vitro digestibility of their phenolic compounds, including flavonoids. Results showed that extracts from the crop production cycle 2018 obtained the highest yield, while those from 2019 contained the highest… More > Graphic Abstract

Heba I. Mohamed^1,*, Eman M. Fawzi¹, Abdul Basit², Kaleemullah³, Rafiq Lone⁴, Mahmoud R. Sofy⁵

Phyton-International Journal of Experimental Botany, Vol.91, No.7, pp. 1303-1325, 2022, DOI:10.32604/phyton.2022.020642

Abstract After wheat, rice, maize, and barley, sorghum is the fifth most widely grown cereal on the planet. Due to its high production, drought resistance, and heat tolerance, this crop is replacing maize in some areas. Sorghum is available in a variety of colors, including cream, lemon-yellow, red, and even black. The principal grain anatomical components are pericarp, germ or embryo and endosperm. This review provides an overview of key sorghum grain components, including starches, fiber, proteins, lipids, and vitamins. Also, we summarized phenolic compounds, flavonoids, tannins, carotenoids, vitamin E, amines, Policosanols and Phytosterols in sorghum grains. Sorghum is used to… More >

FEI CHENG^1,#, YIQIAN DING^2,#, QING XU³, WEI ZHANG³, YULAN ZHEN⁴, JING LIU⁵, SHICHENG LI¹, CHANG TU¹, GUOHUA LAI¹, JUN LAN^1,*, JINGFU CHEN^1,*

BIOCELL, Vol.46, No.4, pp. 1053-1066, 2022, DOI:10.32604/biocell.2021.012901

Abstract Previous reports have suggested that Ang-(1-7) may have a protective effect in endothelial cells against high glucose (HG)-induced cell injury thanks to a modulatory mechanism in the NF-κB signaling pathway. In this study, we have examined whether NF-κB-IL-1β and Heme oxygenase-1 (HO-1) pathways contribute to the protection of Ang-(1-7) against hyperglycemia-induced inflammation and oxidative stress in human umbilical vein endothelial cells (HUVECs). Our results indicate that time-varying exposures of HUVECs, from 1 h to 24 h, to high glucose concentrations result in an increased expression of phosphorylated (p)-p65 and HO-1 in a time-dependent manner. As an inhibitor of NF-κB, pyrrolidinedithiocarbamic… More >

SHADY G. EL-SAWAH^1,*, FAYEZ ALTHOBAITI², HANAN M. RASHWAN¹, ADIL ALDHAHRANI³, MARWA A. ABDEL-DAYEM⁴, EMAN FAYAD², REHAB M. AMEN⁵, EL SHAIMAA SHABANA⁶, EHAB I. EL-HALLOUS⁷

BIOCELL, Vol.46, No.3, pp. 745-757, 2022, DOI:10.32604/biocell.2022.017853

Abstract Since Type 1 diabetes (T1DM) occurs when β-cells mass is reduced to less than 20% of the normal level due to autoimmune destruction of cells resulting in the inability to secrete insulin, preservation or replenishment of the functional β-cells mass has become a major therapeutic focus for this diabetic type treatment. Thus, this 4-week work plan was designed to determine which mesenchymal stem cells (MSCs) type is more appropriate to alleviate pancreatic hazards resulting from diabetes induction; via tracking a comparative study between MSCs derived from adipose tissue (AD-MSCs) and from bone marrow (BM-MSCs) in management of T1DM considering their… More >

Farnaz Nabiya¹, Anchana Devi Chenniappan^1,*, Rajamiriyam Marichamy¹, MubarakAli Davoodbasha^2,3, Jung-Wan Kim^3,*

Phyton-International Journal of Experimental Botany, Vol.91, No.3, pp. 569-582, 2022, DOI:10.32604/phyton.2022.017390

Abstract Endometriosis is a chronic inflammatory disease that occurs due to the presence of endometrial tissue outside the uterine cavity. It affects from 5% to 10% of women of reproductive age. High levels of matrix metalloproteinase (especially MMP-9) have been observed in women suffering from endometriosis. Thus, the aim of this study was to investigate the naturally anti-inflammatory compounds available from an algal source that can target the MMP-9 by various in silico approaches. The target 1L6J (Crystal structure of human matrix metalloproteinase MMP-9) structure was retrieved from the PDB database. Five compounds such as Eckol, Sargafuran, Vitamin E, Docosahexaenoic acid,… More >

LINMEI ZHENG¹, RONG TANG², ^1,*, ZHONGYI ZHOU³

BIOCELL, Vol.45, No.5, pp. 1231-1240, 2021, DOI:10.32604/biocell.2021.015752

Abstract Pre-eclampsia is characterized by an excessive maternal inflammatory response. The cholinergic anti-inflammatory pathway (CAP) has been shown as the efferent arm of a vagal reflex with the potential to limit inflammatory responses. Therefore, in this study, the CAP regulation through the nervous vagal stimulation (VNS) reduced the severity of NG-nitro-L-arginine methyl ester (L-NAME)-induced pre-eclampsia was determined in a rat model. Rats were given 125 mg/kg/day of L-NAME via subcutaneous injection on gestational day (GD) 10–16. In addition, the rats were treated by active or sham electrical stimulation once a day during GD 13–19. Systolic blood pressure (SBP), urinary albumin, and… More >

Fahad Alotaibi¹, Muhammad Attique^2,3, Yaser Daanial Khan^2,*

CMC-Computers, Materials & Continua, Vol.69, No.1, pp. 1039-1055, 2021, DOI:10.32604/cmc.2021.017297

Abstract Several autoimmune ailments and inflammation-related diseases emphasize the need for peptide-based therapeutics for their treatment and established substantial consideration. Though, the wet-lab experiments for the investigation of anti-inflammatory proteins/peptides (“AIP”) are usually very costly and remain time-consuming. Therefore, before wet-lab investigations, it is essential to develop in-silico identification models to classify prospective anti-inflammatory candidates for the facilitation of the drug development process. Several anti-inflammatory prediction tools have been proposed in the recent past, yet, there is a space to induce enhancement in prediction performance in terms of precision and efficiency. An exceedingly accurate anti-inflammatory prediction model is proposed, named AntiFlamPred… More >