Young Mae Ko, Tae Hyon Kim^*

BIOCELL, Vol.49, No.7, pp. 1141-1168, 2025, DOI:10.32604/biocell.2025.065464 - 25 July 2025

Abstract Ginsenosides, the bioactive saponins primary found in Panax ginseng, possess a complex structure that underlies their diverse pharmacological properties. Ginsenoside Rg3 stands out for its broad therapeutic potential, including anticancer, anti-inflammatory, neuroprotective, and cardiovascular effects. This review provides a comprehensive overview of the cellular and molecular mechanisms of Rg3, emphasizing its roles in regulating apoptosis, inflammation, oxidative stress, and metabolic pathways relevant to skincare and anticancer applications. The unique biological activities of its isomeric forms, 20(S)-Rg3 and 20(R)-Rg3, are highlighted, alongside strategies to enhance its bioavailability, such as nanoencapsulation and prodrug design. Additionally, the synergistic effects More >

Ammar Attar^*

Phyton-International Journal of Experimental Botany, Vol.94, No.4, pp. 1225-1237, 2025, DOI:10.32604/phyton.2025.063207 - 30 April 2025

Abstract Artemisia dracunculus L., or tarragon, is a perennial herb from the Asteraceae family that is extensively cultivated for its aromatic leaves, which are valued for its preventative and therapeutic properties in both cookery and traditional medicine. This study aims to investigate the antibacterial, antioxidant, and anti-inflammatory properties of A. dracunculus (tarragon) essential oil (ADEO), with estragole (57.23%) identified as the major compound through gas chromatography-mass spectrometry (GC-MS) analysis. ADEO exhibited varying degrees of antibacterial activity, with Escherichia coli showing higher resistance (inhibition zone (IZ) = 14.7 ± 0.58 mm, minimum inhibitory concentration (MIC) = 2% and minimum bactericidal… More >

Giuseppe Carota¹, Lucia Di Pietro^2,3, Vincenzo Cardaci⁴, Anna Privitera^1,2, Francesco Bellia¹, Valentina Di Pietro⁵, Giuseppe Lazzarino¹, Barbara Tavazzi⁶, Angela Maria Amorini¹, Giacomo Lazzarino⁶, Giuseppe Caruso^6,7,*

BIOCELL, Vol.49, No.4, pp. 563-578, 2025, DOI:10.32604/biocell.2025.062176 - 30 April 2025

Abstract Carnosine (β-alanyl-L-histidine) is a naturally occurring endogenous peptide widely distributed in excitable tissues, such as the heart and brain. Over the years, several beneficial effects of carnosine have been discussed well in scientific literature. In particular, this dipeptide is well-known for its antioxidant, anti-inflammatory, and anti-aggregation activities. It is of great interest in the context of numerous systemic and neurodegenerative diseases, besides performing important “side activities” such as metal chelation and pH-buffering. Despite a plethora of preclinical and clinical data supporting carnosine’s therapeutic potential, researchers are still searching for new pharmacological targets that better highlight More >

Chen Chen^#,*, Chunli Li^#, Tengfei Li, Qianhong Li, Luyao Li, Fengqin Liu

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 793-807, 2025, DOI:10.32604/phyton.2025.063549 - 31 March 2025

Abstract Lycium ruthenicum Murray, a plant widely cultivated in northwestern China, is integral to traditional Chinese medicine, with applications in treating menstrual disorders, cardiovascular diseases, and menopausal symptoms. Despite its recognized medicinal value and use as a functional food, comprehensive knowledge of its metabolites and their pharmacological effects remains limited. This study presents an innovative approach using ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (UPLC–QTOF/MS) to conduct a detailed analysis of both wild and cultivated L. ruthenicum samples. A total of 62 peaks were detected in the total ion current profile, with 59 metabolites identified based… More >

Mohamed reda Kachmar^1,2, Toufik Bouddine³, Abdelaziz Ed-dra^4,5, Safaâ Kachmar⁶, Hammou Anarghou^7,8, Sulaiman Mohammed Alnasser⁹, Fahad M. Alshabrmi¹⁰, Samiah Hamad Al-Mijalli^11,*, Emad M. Abdallah^12,*, Nidal Naceiri Mrabti¹³, Abdelmounaim Laabar¹⁴, Mourad Chikhaoui¹⁵, Galman Aziz^1,4, Lhoussain Hajji³, Said Chakir²

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 657-677, 2025, DOI:10.32604/phyton.2025.062289 - 31 March 2025

Abstract Juniperus oxycedrus (J. oxycedrus) is a traditional culinary spice and medicinal herb with a longstanding history of ethnopharmacological applications across diverse cultures. While prior research has explored the biological activities and phytochemical constituents of extracts derived from its leaves and seed cones, the present study systematically investigates their mineral and phenolic profiles alongside their multifunctional bioactive potential. Inductively coupled plasma-atomic emission spectroscopy (ICP-AES) analysis revealed a substantial abundance of essential macro- and microelements. Reversed-phase high-performance liquid chromatography (RP-HPLC) further identified high concentrations of phenolic acids (e.g., p-coumaric acid) and flavonoids (e.g., rutin and quercetin). The extracts exhibited More >

Samiah Hamad Al-Mijalli¹, Hanae Naceiri Mrabti², Amine Elbouzidi^3,*, Naglaa S. Ashmawy^4,5, Amine Batbat⁶, Emad M. Abdallah⁷, Wafa Laaboudi⁸, Mohammed Aladhadh⁹, Fahad M. Alshabrmi¹⁰, Sulaiman Mohammed Alnasser¹¹, Mohamed Addi³, Naoufal El Hachlafi¹²

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 209-227, 2025, DOI:10.32604/phyton.2025.060438 - 24 January 2025

Abstract Thymus serpyllum L., often known as wild thyme, has been used since ancient times due to its multifaceted culinary and medicinal attributes. It is usually utilized in folk medicine to manage different health issues. This work aimed to investigate the chemical composition and biological characteristics of T. serpyllum essential oil (EO), including its antimicrobial, antioxidant, and anti-inflammatory capabilities. Moreover, we have prompted an in-silico simulation to reveal the underlying mode of action of these properties. The chemical characterization of T. serpyllum (EO) by Gas Chromatography-Mass Spectrometry (GC-MS) indicated sabinene (17.33%), terpinen-4-ol (11.73%), phellandral (13.18%), and thymol (10.54%) as main… More >

Yan Wu¹, Xuerui An¹, Haofan Lv¹, Zhiqiang Zhao¹, Wei Liu^1,2,*, Chunpeng Wan^1,3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 199-207, 2025, DOI:10.32604/phyton.2025.059581 - 24 January 2025

Abstract A novel pair of oleanane nor-triterpenes, with compound 1 featuring a unique 18α-H structure, was isolated from mastic, and this compound represents a noteworthy new entity not previously reported in the literature. The absolute configurations of their structures were further determined using a combination of different analytical methods such as NMR, high-resolution mass spectrometry (HR-MS), ultraviolet (UV), infrared (IR) and single-crystal X-ray diffraction (SXRD). The compound actively mitigated inflammations by efficiently quenching nitric oxide (NO) synthesis within an ex vivo system using lipopolysaccharide activated murine macrophage RAW264.7 cells. Moreover, compound 1 exhibit a better IC₅₀ concentration of More >

Yurii Hrytsyk¹, Oleh Koshovyi^2,3, Martin Lepiku⁴, Valdas Jakštas⁵, Vaidotas Žvikas⁵, Tetiana Matus¹, Mariia Melnyk¹, Lyubov Grytsyk¹, Ain Raal^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.9, pp. 2303-2315, 2024, DOI:10.32604/phyton.2024.055117 - 30 September 2024

Abstract Canadian goldenrod (Solidago canadensis L.) is a rhizomatous plant of the Asteraceae family. In folk medicine, Solidago galenic remedies are used for diseases of the kidneys, urinary tract, liver, etc. Externally, goldenrod is used to treat purulent wounds, furunculosis, and gum abscesses as washes and compresses. The aims of this research were to study the yield and chemical composition of essential oil (EO), the anti-inflammatory activity of S. canadensis dry extracts based on its decoction and tincture. In EO (2.8 mL/kg) of S. canadensis were identified and quantified 34 compounds. The principal compounds of the EO from flowering tops… More > Graphic Abstract

GIULIA CHIABOTTO^1,*, STEFANIA BRUNO^2,*

BIOCELL, Vol.47, No.7, pp. 1499-1508, 2023, DOI:10.32604/biocell.2023.028121 - 21 June 2023

Abstract Renal fibrosis and inflammation are common pathological features of chronic kidney disease (CKD). Since currently available treatments can only delay the progression of CKD, the outcome of patients with CKD is still poor. One therapeutic option for the prevention of CKD-related complications could be the use of mesenchymal stromal cells (MSCs), which have shown beneficial effects in tissue fibrosis and regeneration after damage. However, safety issues, such as cellular rejection and carcinogenicity, limit their clinical application. Among the bioactive factors secreted by MSCs, extracellular vesicles (EVs) have shown the same beneficial effect of MSCs, without More > Graphic Abstract

ABDELAZIZ ADAM IDRISS ARBAB^1,3,#, CHUNQING YIN^4,#, XUBIN LU¹, YAN LIANG¹, ISMAIL MOHAMED ABDALLA¹, AMER ADAM IDRIS³, TIANLE XU^1,2, YONGJIANG MAO¹, ZHANGPING YANG^1,2,*

BIOCELL, Vol.46, No.11, pp. 2443-2454, 2022, DOI:10.32604/biocell.2022.020865 - 07 July 2022

Abstract Mastitis is a common inflammatory cow mammary infection; that causes significant economic loss in dairy industry. Given the interesting connection between metformin’s anti-inflammatory function and mastitis model induced by LTA in pbMECs, our objective was to prove that metformin was beneficial in suppressing proinflammatory response induced by LTA through modulation of mitogen-activated protein kinase (MAPK) and nuclear factor kappa B (NF-κB) signaling pathways and activation of peroxisome proliferator-activated receptor-γ (PPARγ) in pbMECs. The proliferation of cells and mRNA expression were measured using EdU assay and quantitative reverse transcriptase-polymerase chain reaction (qRT-PCR). Immunoblotting and immunofluorescence analysis… More >