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  • Open Access


    Fabrication of Crack-Free Flattened Bamboo and Its Macro-/Micro-Morphological and Mechanical Properties

    Zhichao Lou1,2, Tiancheng Yuan1, Qiuyi Wang1, Xinwu Wu1, Shouheng Hu1, Xiaomeng Hao1, Xianmiao Liu3,*, Yanjun Li1,*

    Journal of Renewable Materials, Vol.9, No.5, pp. 959-977, 2021, DOI:10.32604/jrm.2021.014285

    Abstract This work aimed to help the bamboo industry develop methodology for producing imperfection-free bamboo boards that can serve either decorative or structural benefit to consumers seeking to engage with the bioeconomy. Specifi- cally, softened and slotted bamboo tubes were handled by a roller device with nails to render crack-free flattened bamboo board. Softening temperature and time were optimized herein according to findings regarding chemical composition and board mechanical properties. The optimal softening parameters for saturated steam heat treatment is proved to be 160°C for 8 minutes. The flattened bamboo board possesses an increased bending strength of 101.5 MPa and a… More >

  • Open Access


    Investigation on Energy Characteristic of RBCs Deformability: A Quantitative Analysis of Extending and Retracting Curves Based on AFM

    Dong Chen1, Xiang Wang1,*, Fuzhou Tang2, Yajin Zhao1

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 150-150, 2019, DOI:10.32604/mcb.2019.07071

    Abstract Deformability is a fundamental property of the cells and tissues of living organisms, which is commonly detected to indicate the state of the cells. And the cell deformability usually depends on the methods that we used, which is easy to be confused. The present research is designed to explore the energy characteristic of red blood cell deformability, based on a quantitative analysis of extending-retracting curves acquired from atomic force microscopy. ATP-depleted red blood cells are prepared by treatment with free-glucose Ringer solution. Our results clearly show that the Youngs’ modulus of erythrocyte is closely depended on the concentration of intracellular… More >

  • Open Access


    Contour-Based Data Analysis: Loading Rate Dependence in Dynamic Catch of Integrin-Ligand Bonds

    Xueyi Yang1, Yue Xu1, Chun Yang1,*

    Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 101-101, 2019, DOI:10.32604/mcb.2019.07117

    Abstract Cell-matrix interactions guide various cell behaviors, including proliferation, differentiation, migration, etc. Integrins, as a known transmembrane mechanosensor, undergo conformational changes in response to mechanical stimuli, and manipulate cell-matrix chemical-mechanical coupled signaling transduction [1]. The integrin-ligand bond kinetics has gain increasing attention among researchers. Independent studies showed that the integrin-ligand bond has been reported to be reinforced by the applied force f, while the loading rate df/dt had little effect on the bond lifetime [2].
    We previously observed a dramatic increase in bond lifetime beyond a loading rate threshold for the integrin α2β1-DGEA bond, by introducing AFM (Atomic Force Microscopy)… More >

  • Open Access


    Mechanical Strength and Structural Basis of β2 Integrin to Mediate Neutrophil Accumulation on Liver Sinusoidal Endothelial Cells: A Study Using Atomic Force Microscopy and Molecular Dynamics Simulations

    Ning Li1, 2, 3, Xiao Zhang1, 2, Peiwen Li1, 2, Hao Yang1, 2, Chunfang Tong1, 2, Shouqin Lü1, 2, Yan Zhang1, 2, Zhiyi Ye3, Jun Pan3, *, Mian Long1, 2, *

    CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 263-279, 2018, DOI:10.31614/cmes.2018.04079

    Abstract Neutrophil (PMN) accumulation on liver sinusoidal endothelial cells (LSECs) is crucial to pathogen clearance and tissue damage in the liver sinusoids and controlled by a series of adhesion molecules expressed on the surface of PMNs and LSECs. The role of lymphocyte function-associated antigen-1 (LFA-1) and macrophage-1 antigen (Mac-1) in this process is still contentious. Here we compared the dynamic force spectra of the binding of β2 integrin to intercellular adhesion molecule-1 (ICAM-1) on LSECs using atomic force microscopy (AFM) and performed free and steered molecular dynamics (MD) simulations to analyze their structural bases of LFA-1- or Mac-1-I-domain and ICAM-1-D1 or… More >

  • Open Access


    Direct Observation of the p188 Mediated Membrane Sealing with Atomic Force Microscopy

    R. C. Lee1, F. Despa1, X. Tang1, I. Titushkin2, M. Cho2

    Molecular & Cellular Biomechanics, Vol.3, No.4, pp. 185-186, 2006, DOI:10.32604/mcb.2006.003.185

    Abstract This article has no abstract. More >

  • Open Access


    Experimental Characterization of MCF-10A Normal Cells Using AFM: Comparison with MCF-7 Cancer Cells

    Moharam Habibnejad Korayem1,*, Zahra Rastegar2

    Molecular & Cellular Biomechanics, Vol.16, No.2, pp. 109-122, 2019, DOI:10.32604/mcb.2019.04706

    Abstract The mechanical properties of single cells have been recently identified as the basis of an emerging approach in medical applications since they are closely related to the biological processes of cells and human health conditions. The problem in hand is how to measure mechanical properties in order to obtain them more accurately and applicably. Some of the cell’s properties such as elasticity module and adhesion have been measured before using various methods; nevertheless, comprehensive tests for two healthy and cancerous cells have not been performed simultaneously. As a Nanoscale device, AFM has been used for some biological cells, however for… More >

  • Open Access


    Biophysical approaches for studying the integrity and function of tight junctions

    S.R.K. Vedula1, T.S. Lim2, P.J. Kausalya3, W. Hunziker3, G. Rajagopal2, C.T. Lim1,4

    Molecular & Cellular Biomechanics, Vol.2, No.3, pp. 105-124, 2005, DOI:10.3970/mcb.2005.002.105

    Abstract Cell-cell adhesion is an extremely important phenomenon as it influences several biologically important processes such as inflammation, cell migration, proliferation, differentiation and even cancer metastasis. Furthermore, proteins involved in cell-cell adhesion are also important from the perspective of facilitating better drug delivery across epithelia. The adhesion forces imparted by proteins involved in cell-cell adhesion have been the focus of research for sometime. However, with the advent of nanotechnological techniques such as the atomic force microscopy (AFM), we can now quantitatively probe these adhesion forces not only at the cellular but also molecular level. Here, we review the structure and function… More >

  • Open Access


    High Magnetic Field Annealing Dependent the Morphology and Microstructure of Nanocrystalline Co/Ni Bilayered Films

    Donggang Li1,2, Alexandra Levesque2, Qiang Wang1,3,2, Agnieszka Franczak2, Chun Wu1, Jean-Paul Chopart2, Jicheng He1

    CMC-Computers, Materials & Continua, Vol.30, No.3, pp. 207-218, 2012, DOI:10.3970/cmc.2012.030.207

    Abstract Co/Ni bilayered films were prepared on ITO glass by electrodeposition assisted with a magnetic field up to 0.5T aligned parallel to the electrode surface. The effect of a high magnetic field annealing up to 12T on morphology and microstructure of the post-deposited films was investigated by field emission scanning electronic microscopy (FE-SEM), X-ray diffraction (XRD) and atomic force microscopy (AFM). Grain shape and grain boundary in the Co/Ni morphology were modified dramatically when the high magnetic field was applied during the annealing process. Magnetic anisotropy appeared in the films due to the preferential orientation of fcc-CoNi alloy in comparison with… More >

  • Open Access


    Simulation Analysis and Experiment Study of Nanocutting with AFM Probe on the Surface of Sapphire Substrate by Using Three Dimensional Quasi-steady Molecular Statics Nanocutting Model

    Zone-Ching Lin1, Ying-Chih Hsu1

    CMC-Computers, Materials & Continua, Vol.25, No.1, pp. 75-106, 2011, DOI:10.3970/cmc.2011.025.075

    Abstract The three-dimensional quasi-steady molecular statics nanocutting model is used by this paper to carry out simulation analysis of nanocutting of sapphire in order to explore the effects of conical tools with different tip radii of probe and straight-line cutting at different cutting depths, on cutting force. Meanwhile, this paper uses a cutting tool of atomic force microscopy (AFM) with a probe tip similar to a semisphere to conduct nanocutting experiment of sapphire substrate. Furthermore, from the experimental results of nanocutting sapphire substrate, this paper innovatively proposes the theoretical model and equation that the specific down force energy (SDFE) during nanocutting… More >

  • Open Access


    Modelling of Nanoscale Friction using Network Simulation Method

    F. Marín1, F. Alhama1, J.A. Moreno1

    CMC-Computers, Materials & Continua, Vol.43, No.1, pp. 1-20, 2014, DOI:10.3970/cmc.2014.043.001

    Abstract The field of nanotribology in the last decades was established through the introduction of Atomic Force/Friction Force Microscopes. However, our theoretical understanding of the individual processes involved in friction force microscopy is limited. This work designs a reliable and efficient model for the stickslip phenomenon, following the rules of network simulation. The model is able to manage different types of potential between the tip and the sample surface, allowing different kinds of sample material and microscope tip properties to be simulated with only minor changes in the code. The most analysed tribological materials in technical literature are simulated to test… More >

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