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  • Open Access

    ARTICLE

    Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

    FEI SHA1, DAISHAN XIN2, JUN XU3, ZHIWEI ZHENG1, WENXIN LIN1, XIAORUI CAI1, FEI LIN3, MINGHAO ZHENG1,*, JIAOLING CHEN1,*

    BIOCELL, Vol.48, No.3, pp. 443-451, 2024, DOI:10.32604/biocell.2023.029188

    Abstract Background: Curcumin is a plant polyphenol with antitumor properties and inhibits the development of colorectal cancer (CRC). However, as the molecular mechanism associated is still unclear, our study aimed to explore the underlying molecular mechanisms by which curcumin inhibits CRC. Methods: HT29 and SW480 cells were treated with curcumin or/and Doxycycline (DOX), and cell viability, colony forming ability, migration and invasion were confirmed by cell counting kit-8 (CCK-8), colony forming, Transwell assays. And Yes-associated protein 1 (YAP) and PDZ-binding motif (TAZ) signaling-related genes or proteins were analyzed using reverse transcription quantitative real-time PCR (RT-qPCR), western blot, and immunofluorescence assays. Then… More > Graphic Abstract

    Curcumin inhibits colorectal cancer development by blocking the YAP/TAZ signaling axis

  • Open Access

    ARTICLE

    Congestion Control Using In-Network Telemetry for Lossless Datacenters

    Jin Wang1, Dongzhi Yuan1, Wangqing Luo1, Shuying Rao1, R. Simon Sherratt2, Jinbin Hu1,*

    CMC-Computers, Materials & Continua, Vol.75, No.1, pp. 1195-1212, 2023, DOI:10.32604/cmc.2023.035932

    Abstract In the Ethernet lossless Data Center Networks (DCNs) deployed with Priority-based Flow Control (PFC), the head-of-line blocking problem is still difficult to prevent due to PFC triggering under burst traffic scenarios even with the existing congestion control solutions. To address the head-of-line blocking problem of PFC, we propose a new congestion control mechanism. The key point of Congestion Control Using In-Network Telemetry for Lossless Datacenters (ICC) is to use In-Network Telemetry (INT) technology to obtain comprehensive congestion information, which is then fed back to the sender to adjust the sending rate timely and accurately. It is possible to control congestion… More >

  • Open Access

    ERRATUM

    Kallistatin Suppresses Cell Proliferation and Invasion and Promotes Apoptosis in Cervical Cancer Through Blocking NF-κB Signaling

    Tao Wang, Fan Shi, JiQuan Wang, Zi Liu, Jin Su

    Oncology Research, Vol.28, No.9, pp. 969-970, 2020, DOI:10.3727/096504022X16414984936773

    Abstract Kallistatin has been recognized as an endogenous angiogenesis inhibitor and exerts pleiotropic effects in inhibiting tumor growth, migration, apoptosis, and inflammation. The purpose of the present study was to investigate the potential role and mechanisms of kallistatin in cervical cancer. We demonstrated that kallistatin effectively inhibited cell proliferation and enhanced apoptosis in a dose-dependent manner. Additionally, kallistatin suppressed migration and invasion activities and markedly reduced the expression of matrix-degrading metalloproteinases, progelatinase (MMP-2), MMP-9, and urokinase-type PA (uPA). Kallistatin reversed the epithelial–mesenchymal transition (EMT) and caused the upregulation of epithelial markers such as E-cadherin and inhibited mesenchymal markers such as N-cadherin… More >

  • Open Access

    ARTICLE

    Influence of Blocking-Stressors on Post-90s Employees’ Occupational Mobility: The Chain Mediating Effect of Psychological Contracts and Negative Emotion

    Lixia Niu1,*, Ying Liu1, Jie Liu2, Rui Zhao1

    International Journal of Mental Health Promotion, Vol.24, No.4, pp. 527-538, 2022, DOI:10.32604/ijmhp.2022.017484

    Abstract To clarify the mechanism of blocking-stressors, psychological contracts, and negative emotions on post-90s employees’ occupational mobility, based on the literature study, a hypothetical model of the relationship was established. Using the blocking-stressor, psychological contract, negative emotion, and occupational mobility scales, 317 post-90s employees were selected to investigate their status. It used correlation analysis and intermediary effect tests to verify the hypothesis model. The results showed that: first, there were significant positive correlations between blocking-stressors, negative emotions, and occupational mobility, while indicating a significant negative correlation with the psychological contract; second, blocking-stressors can directly and significantly predict occupational mobility; and third,… More >

  • Open Access

    ARTICLE

    Early DDoS Detection and Prevention with Traced-Back Blocking in SDN Environment

    Sriramulu Bojjagani1, D. R. Denslin Brabin2,*, K. Saravanan2

    Intelligent Automation & Soft Computing, Vol.34, No.2, pp. 805-819, 2022, DOI:10.32604/iasc.2022.023771

    Abstract The flow of information is a valuable asset for every company and its consumers, and Distributed Denial-of-Service (DDoS) assaults pose a substantial danger to this flow. If we do not secure security, hackers may steal information flowing across a network, posing a danger to a business and society. As a result, the most effective ways are necessary to deal with the dangers. A DDoS attack is a well-known network infrastructure assault that prevents servers from servicing genuine customers. It is necessary to identify and block a DDoS assault before it reaches the server in order to avoid being refused services.… More >

  • Open Access

    ARTICLE

    Motion Features of Legs in Volleyball Block Jump Based on Biomechanical Analysis

    Zilin Li, Junjiang Wang, Yan Yang*

    Molecular & Cellular Biomechanics, Vol.18, No.2, pp. 87-97, 2021, DOI:10.32604/mcb.2021.014731

    Abstract Blocking technology is one of the most important means to obtain score in volleyball, which has a great influence on the victory of the game. In this study, the vertical jump was analyzed to understand the movement characteristics of legs during training time. The kinematics and dynamics data of the legs of 10 volleyball players after training for 0 h, 0.5 h, 1 h and 2 h were studied by using an infrared light point motion capture system and force measuring platform. The results showed that the joint angles of the players who had 1 h and 2 h of… More >

  • Open Access

    ARTICLE

    Fuzzy Based Adaptive Deblocking Filters at Low-Bitrate HEVC Videos for Communication Networks

    Anudeep Gandam1,*, Jagroop Singh Sidhu2

    CMC-Computers, Materials & Continua, Vol.66, No.3, pp. 3045-3063, 2021, DOI:10.32604/cmc.2021.013663

    Abstract In-loop filtering significantly helps detect and remove blocking artifacts across block boundaries in low bitrate coded High Efficiency Video Coding (HEVC) frames and improves its subjective visual quality in multimedia services over communication networks. However, on faster processing of the complex videos at a low bitrate, some visible artifacts considerably degrade the picture quality. In this paper, we proposed a four-step fuzzy based adaptive deblocking filter selection technique. The proposed method removes the quantization noise, blocking artifacts and corner outliers efficiently for HEVC coded videos even at low bit-rate. We have considered Y (luma), U (chroma-blue), and V (chroma-red) components… More >

  • Open Access

    ABSTRACT

    A Post-processing for the reduction of blocking artifact in mobile devices

    Dae-Hyun Park1, Hyun-Hee Park2, Yoon Kim1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.11, No.4, pp. 113-114, 2009, DOI:10.3970/icces.2009.011.113

    Abstract In this paper, we propose a post-processing visual enhancement technique to reduce the blocking artifacts in block based DCT decoded image for mobile devices that has allocation of the restricted resource. This algorithm uses the adaptive deblocking filter to remove grid noise and ringing noise in monotone areas. To decide whether monotone region or not, we introduce a notion of Flatness. Also, a new directional filter is utilized to get rid of staircase noise and preserve the original edge component. The directional filter is applied according to the direction of edge, which is corrected in the process of directional vector… More >

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