WAN AZANI MUSTAFA^1,2,*, AFIQAH HALIM², MOHD WAFI NASRUDIN², KHAIRUL SHAKIR AB RAHMAN³

BIOCELL, Vol.46, No.2, pp. 367-381, 2022, DOI:10.32604/biocell.2022.016814 - 20 October 2021

Abstract Cervix cancer is one of Malaysia’s most significant cancers for women (around 12.9%, with an age-standardised incidence rate of 19.7 per 100,000). It was higher than other Asian, West, and even worldwide nations. The National Strategic Plan for Cancer Control Program 2016–2020 (Health Ministry) was presented to minimize cancer and mortality. The high incidence of cervical cancer in Malaysia is mainly due to women’s insufficient knowledge about its prevention and importance. Compared with traditional literature reviews, the systemic analysis provides many advantages. A clearer review process, a more prominent field of study, and essential priorities More >

Mohamed Ibrahim Waly¹, Mohamed Yacin Sikkandar¹, Mohamed Abdelkader Aboamer¹, Seifedine Kadry², Orawit Thinnukool^3,*

CMC-Computers, Materials & Continua, Vol.70, No.2, pp. 3295-3309, 2022, DOI:10.32604/cmc.2022.020713 - 27 September 2021

Abstract Biomedical imaging is an effective way of examining the internal organ of the human body and its diseases. An important kind of biomedical image is Pap smear image that is widely employed for cervical cancer diagnosis. Cervical cancer is a vital reason for increased women’s mortality rate. Proper screening of pap smear images is essential to assist the earlier identification and diagnostic process of cervical cancer. Computer-aided systems for cancerous cell detection need to be developed using deep learning (DL) approaches. This study introduces an intelligent deep convolutional neural network for cervical cancer detection and… More >

Ali Raza¹, Muhammad Rafiq², Dalal Alrowaili³, Nauman Ahmed⁴, Ilyas Khan^5,*, Kottakkaran Sooppy Nisar⁶, Muhammad Mohsin⁷

CMC-Computers, Materials & Continua, Vol.70, No.1, pp. 1649-1666, 2022, DOI:10.32604/cmc.2022.019148 - 07 September 2021

Abstract Nonlinear modelling has a significant role in different disciplines of sciences such as behavioral, social, physical and biological sciences. The structural properties are also needed for such types of disciplines, as dynamical consistency, positivity and boundedness are the major requirements of the models in these fields. One more thing, this type of nonlinear model has no explicit solutions. For the sake of comparison its computation will be done by using different computational techniques. Regrettably, the aforementioned structural properties have not been restored in the existing computational techniques in literature. Therefore, the construction of structural preserving… More >

NUR AIN ALIAS¹, WAN AZANI MUSTAFA^1,2,*, MOHD AMINUDIN JAMLOS³, AHMED ALKHAYYAT⁴, KHAIRUL SHAKIR AB RAHMAN⁵, RAMI Q. MALIK⁶

Oncology Research, Vol.29, No.5, pp. 365-376, 2021, DOI:10.32604/or.2022.025897 - 10 October 2022

Abstract Cervical cancer is a prevalent and deadly cancer that affects women all over the world. It affects about 0.5 million women anually and results in over 0.3 million fatalities. Diagnosis of this cancer was previously done manually, which could result in false positives or negatives. The researchers are still contemplating how to detect cervical cancer automatically and how to evaluate Pap smear images. Hence, this paper has reviewed several detection methods from the previous researches that has been done before. This paper reviews pre-processing, detection method framework for nucleus detection, and analysis performance of the… More >

NIMA HEMMAT¹, MOHAMMAD AMIN DOUSTVANDI¹, ZAHRA ASADZADEH¹, AHAD MOKHTARZADEH¹, BEHZAD BARADARAN^1,4,*, HOSSEIN BANNAZADEH BAGHI^1,2,3,*

Oncology Research, Vol.29, No.2, pp. 141-148, 2021, DOI:10.32604/or.2022.023346 - 13 July 2022

Abstract Cervical cancer is a growing global disease in developing countries. Persistent infection with human papillomaviruses (HPV) is an essential causative agent in this type of cancer. Several studies demonstrate HPV E5 oncoprotein can impress the normal life cycle of HPV-infected cells by targeting some pivotal cellular signaling pathways, such as the epidermal growth factor receptor (EGFR) signaling pathway. In this study, we used E5-siRNA to knockdown that essential oncogene and considered the effect of E5 silencing on proliferation, apoptosis, cell cycle, apoptosis-related gene expression, and the initiator of the EGFR signaling pathway in cervical cancer More >

TING LAN, SHENG QIN, XIAOJIN GONG, PING ZHENG, JIAXIN YAN, YANG LIU^*

BIOCELL, Vol.45, No.5, pp. 1313-1319, 2021, DOI:10.32604/biocell.2021.015923 - 12 July 2021

Abstract Invasive stratified mucin-producing carcinoma (ISMC) is a recently described histologic variant of high-risk human papillomavirus (HPV)-associated endocervical adenocarcinoma, as the putative invasive counterpart of the stratified mucin-producing intraepithelial lesion (SMILE). ISMC can display variable architectural patterns and usually coexists with other more conventional types of HPV-associated carcinomas, which makes diagnosis and differential diagnosis of ISMC is difficult for pathologists. Moreover, the prognosis of ISMC is still controversial. We analyzed 6 ISMCs with detailed pathological and clinical information. Intraepithelial lesion, including 1 high-grade squamous intraepithelial lesion and 1 SMILE, was found. Various architectures were observed (including… More >

Madhumitha Kedhari Sundaram¹, Abdulmajeed G. Almutary², Shafiul Haque³, Faheem SM¹, Arif Hussain^1,*

Oncologie, Vol.23, No.2, pp. 269-277, 2021, DOI:10.32604/Oncologie.2021.016002 - 22 June 2021

Abstract Cervical cancer is the neoplasm of the uterine cervix in women, which is highly preventable. With the advent of vaccination against HPV infection, a gradual decline in the incidence of cervical cancer cases has been observed in developing countries. The developing nations bear the brunt of cervical cancer incidence due to low acceptance of vaccination. This survey-based study was designed to assess the awareness and opinions of female university students regarding human papilloma virus, vaccination and cervical cancer. A survey questionnaire was distributed among female expatriate students (18 to 26 years of age) of a… More >

Kalaivani Muniandy¹, Zuhaida Asra Ahmad^1,4, Sylvia Annabel Dass¹, Shaharum Shamsuddin², Nethia Mohana Kumaran³, Venugopal Balakrishnan^1,*

Oncologie, Vol.23, No.2, pp. 279-291, 2021, DOI:10.32604/Oncologie.2021.015969 - 22 June 2021

Abstract Spheroids are generally self-assembled cells with the ability to generate their extracellular matrix, including the complex cell-matrix and the cell-cell interactions that resemble the functional characteristics of the corresponding tissue in vivo. The study aimed to develop a three-dimensional (3D) spheroid system for the cervical cancer cell lines, HeLa (HPV18), CaSki (HPV16), SiHa (HPV16), C33A (non-HPV), HT3 (non-HPV) as well as to identify its biological activity in the extracellular form. For the formation of the cervical cancer spheroids, the liquid overlay approach was applied, followed by embedding to the bovine collagen I matrix. Spheroid formation using More >

Afiqah Halim¹, Wan Azani Mustafa^1,2,*, Wan Khairunizam Wan Ahmad¹, Hasliza A. Rahim², Hamzah Sakeran³

Oncologie, Vol.23, No.1, pp. 73-88, 2021, DOI:10.32604/Oncologie.2021.015154 - 30 March 2021

Abstract Cervical cancer is a cell disease in the cervix that develops out of control in the female body. The cervix links the vagina (birth canal) with the upper section of the uterus, which can only be found in the female body. This is the second leading cause of death among women around the world. However, cervical cancer is currently one of the most preventable cancers if early detection is identified. The effect of unidentified cancer may increase the risk of death when the cell disease spreads to other parts of the female anatomy (metastasize). The… More >

Praveena Rajasekaran^*, Preetha Jaganathan, Anjali Annadurai

Computer Systems Science and Engineering, Vol.36, No.3, pp. 477-484, 2021, DOI:10.32604/csse.2021.014247 - 18 January 2021

Abstract The stabilizing mechanisms of cervical spine spondylosis are involved in the degenerating segmentation vertebra, which often causes pain. Health of the individual is affected, both physically and mentally. Due to depression, nervousness, and psychological damages occur thereby losing their human activity functions. The nucleus pulposus of spinal disc herniation is prolapsed through a deficiency of annulus fibrosus. A jelly-like core part of the disc contains proteins that cause the tissues to become swollen when it touches the nucleus pulposus. The proposed Gradient Linear Classification (GLC) algorithm is used for the efficient automatic classification of disc More >