WENXI GAO^1,2,#, QIANQIAN MA^3,#, CHENYU TANG^2,#, YUELI ZHAN⁴, YINONG DUAN², HUIHUA NI^5,*, YUNZHAO XU^5,6,*

BIOCELL, Vol.44, No.4, pp. 597-605, 2020, DOI:10.32604/biocell.2020.011328

Abstract Cervical cancer (CESC) is one of the most common cancers and affects the female genital tract. Consistent HPV infection status has been determined to be a vital cause of tumorigenesis. HPV infection may induce changes to the immune system and limit the host’s immune response. Immunotherapy is therefore essential to improving the overall survival of both locally advanced and recurrent CESC patients. Using 304 relevant samples from TCGA, we assessed immune cell function in CESC patients to better understand the status of both tumor micro-environment cells and immune cells in CESC. Functional enrichment analysis, pathway enrichment analysis, and PPI network… More >

Wan Azani Mustafa^1,*, Afiqah Halim¹, Khairul Shakir Ab Rahman²

Oncologie, Vol.22, No.2, pp. 53-63, 2020, DOI:10.32604/oncologie.2020.013660

Abstract Cervical cancer develops as cells transformation in the cervix of a female that connects the uterus to the vagina. This cancer may impact the columnal epithelial cells of the cervix and therefore can be expanded to the lymphatic and circulatory system (metastasize), sometimes the kidneys, liver, prostate, vagina, and rectum. Many of the cervical cancer patients survived by taking early prevention by undergoing a Pap Smear Test. However, the result of the test usually takes a few weeks which is extremely time-consuming especially at the government hospital. The purpose of this research was to study the detection and classification method… More >

K. HIDALGO¹, I. G. ROJAS², A. B. PENISSI³, M. I. RUDOLPH¹

BIOCELL, Vol.29, No.3, pp. 303-311, 2005, DOI:10.32604/biocell.2005.29.303

Abstract TNFα has been associated with both, tumor survival and apoptosis. This cytokine is also involved in promoting cell migration during wound healing and tumorigenesis. SW756 is a HPV18-positive cervical carcinoma cell line, which has been used to study different mechanisms of cervical cancer progression. An in vitro assay of scratch wound healing onto monolayers of SW756 cells was used to assess the effect of TNFα on cell migration into a wound space. It was found that SW756 cells have the ability to migrate, but not proliferate in response to scratch wounding in a serum-free medium supplemented with TNFα. RT-PCR analysis… More >

M. ISOLDE RUDOLPH¹, I. GINA ROJAS², ALICIA B. PENISSI³

BIOCELL, Vol.28, No.1, pp. 1-11, 2004, DOI:10.32604/biocell.2004.28.001

Abstract Birth is the result of complex, well-defined, and coordinated events, that are tightly regulated by endocrine, nervous, and immune responses, and take place primarily in the female reproductive tract. Various mechanisms and mediators involved in pregnancy, labor, and delivery, are highly conserved among different mammalian species and mast cells emerge as potential and crucial participants in these processes, as it is discussed in this review. More >

Yanhong ZHEN¹, Li HAN², Kailai CAI¹, Lijun HUO¹, Hasan RIAZ¹, Canjie WU¹, Aixin LIANG¹ , Lei SANG¹, Liguo YANG^{1 *}

BIOCELL, Vol.38, No.1, pp. 17-24, 2014, DOI:10.32604/biocell.2014.38.017

Abstract Inhibins play important roles in the reproductive system. To evaluate whether inhibin α (1-32) fusion protein plays a role in cervical cancer growth, the plasmid pVAX-inhα was constructed and its effect on proliferation and apoptosis of the human cervical cancer cell line (Hela) was checked by flow cytometry and real-time PCR. The expression and localization of inhibin α protein were detected by RT-PCR and confocal microscopy which showed that inhibin α protein was expressed and localized in the nucleus of Hela cells. Over expression of inhibin α gene significantly induced cell apoptosis and ceased S phase of cell cycle. Furthermore,… More >

Tong MA^{1, §}, Fafen WANG^{2, §}, Xiaohui WANG¹

BIOCELL, Vol.43, No.3, pp. 191-198, 2019, DOI:10.32604/biocell.2019.06989

Abstract Cervical cancer (CC), has been identified as one of the most frequent malignant tumors all over the world, with high mortality in females. A growing number of investigations have confirmed that long noncoding RNAs (lncRNAs) play a crucial role in the progression of multiple cancers. Nonetheless, the biological function and regulatory mechanism of LINC01772 in CC haven’t been explored so far. In this study, LINC01772 expression was found to be upregulated in tissues and cells of CC. Knocking down LINC01772 suppressed CC cell proliferation, migration and epithelial-mesenchymal transition (EMT) process. Through molecular mechanism assays, LINC01772 was verified to be bound… More >