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Search Results (116)
  • Open Access

    ARTICLE

    Numerical Treatments for Crossover Cancer Model of Hybrid Variable-Order Fractional Derivatives

    Nasser Sweilam1, Seham Al-Mekhlafi2,*, Aya Ahmed3, Ahoud Alsheri4, Emad Abo-Eldahab3

    CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.2, pp. 1619-1645, 2024, DOI:10.32604/cmes.2024.047896

    Abstract In this paper, two crossover hybrid variable-order derivatives of the cancer model are developed. Grünwald-Letnikov approximation is used to approximate the hybrid fractional and variable-order fractional operators. The existence, uniqueness, and stability of the proposed model are discussed. Adams Bashfourth’s fifth-step method with a hybrid variable-order fractional operator is developed to study the proposed models. Comparative studies with generalized fifth-order Runge-Kutta method are given. Numerical examples and comparative studies to verify the applicability of the used methods and to demonstrate the simplicity of these approximations are presented. We have showcased the efficiency of the proposed method and garnered robust empirical… More >

  • Open Access

    ARTICLE

    LA-D-B1, a novel Abemaciclib derivative, exerts anti-breast cancer effects through CDK4/6

    LING MA1,#, ZIRUI JIANG1,#, XIAO HOU1, YUTING XU1, ZIYUN CHEN1, SIYI ZHANG1, HANXUE LI1, SHAOJIE MA1, GENG ZHANG2, XIUJUN WANG1,*, JING JI1,*

    BIOCELL, Vol.48, No.5, pp. 847-860, 2024, DOI:10.32604/biocell.2024.050868

    Abstract Background: Regulatory proteins involved in human cellular division and proliferation, cyclin-dependent kinases 4 and 6 (CDK4/6) are overexpressed in numerous cancers, including triple-negative breast cancer (TNBC). TNBC is a common pathological subtype of breast cancer that is prone to recurrence and metastasis, and has a single treatment method. As one of the CDK4/6 inhibitors, abemaciclib can effectively inhibit the growth of breast tumors. In this study, we synthesized LA-D-B1, a derivative of Abemaciclib, and investigated its anti-tumor effects in breast cancer. Methods: Cellular viability was assessed using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Cell cloning and migration abilities were determined by… More >

  • Open Access

    ARTICLE

    Sepsis Prediction Using CNNBDLSTM and Temporal Derivatives Feature Extraction in the IoT Medical Environment

    Sapiah Sakri1, Shakila Basheer1, Zuhaira Muhammad Zain1, Nurul Halimatul Asmak Ismail2,*, Dua’ Abdellatef Nassar1, Manal Abdullah Alohali1, Mais Ayman Alharaki1

    CMC-Computers, Materials & Continua, Vol.79, No.1, pp. 1157-1185, 2024, DOI:10.32604/cmc.2024.048051

    Abstract Background: Sepsis, a potentially fatal inflammatory disease triggered by infection, carries significant health implications worldwide. Timely detection is crucial as sepsis can rapidly escalate if left undetected. Recent advancements in deep learning (DL) offer powerful tools to address this challenge. Aim: Thus, this study proposed a hybrid CNNBDLSTM, a combination of a convolutional neural network (CNN) with a bi-directional long short-term memory (BDLSTM) model to predict sepsis onset. Implementing the proposed model provides a robust framework that capitalizes on the complementary strengths of both architectures, resulting in more accurate and timelier predictions. Method: The sepsis prediction method proposed here utilizes… More >

  • Open Access

    ARTICLE

    Renewable Bis-benzoxazine Monomers from Lignin Derivatives: Synthesis, Characterization and Studies on Curing Behavior

    CHUNYAN LIU*, YUNHE LIU, ZIHAN PAN, QIUTING LI, HAN XU, TAO LIU

    Journal of Polymer Materials, Vol.36, No.1, pp. 87-99, 2019, DOI:10.32381/JPM.2019.36.01.7

    Abstract In this work, a series of novel lignin-based bis-benzoxazine monomers were efficiently synthesized by the reaction of renewable phenols: guaiacol, vanillyl alcohol, eugenol, vanillin with ethylene diamine and paraformaldehyde. The chemical structures of these lignin-based bis-benzoxazine monomers were confirmed by 1H-NMR, 13C-NMR and FTIR, indicating the formation of benzoxazine ring. The obtained bis-benzoxazine monomers were cured via thermal treatment. The curing behavior of these lignin-based bis-benzoxazine monomers were compared and analyzed via differential scanning calorimetry (DSC), showing that Va-e possessed higher ring-opening polymerization activity than G-e, while E-e and V-e had lower curing activity than G-e. More >

  • Open Access

    ARTICLE

    Novel Investigation of Stochastic Fractional Differential Equations Measles Model via the White Noise and Global Derivative Operator Depending on Mittag-Leffler Kernel

    Saima Rashid1,2,*, Fahd Jarad3,4

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.3, pp. 2289-2327, 2024, DOI:10.32604/cmes.2023.028773

    Abstract Because of the features involved with their varied kernels, differential operators relying on convolution formulations have been acknowledged as effective mathematical resources for modeling real-world issues. In this paper, we constructed a stochastic fractional framework of measles spreading mechanisms with dual medication immunization considering the exponential decay and Mittag-Leffler kernels. In this approach, the overall population was separated into five cohorts. Furthermore, the descriptive behavior of the system was investigated, including prerequisites for the positivity of solutions, invariant domain of the solution, presence and stability of equilibrium points, and sensitivity analysis. We included a stochastic element in every cohort and… More >

  • Open Access

    ARTICLE

    Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

    Flavia Oliveira Monteiro da Silva Abreu1,2,*, Taysse Holanda1, Joice Farias do Nascimento1, Henety Nascimento Pinheiro1, Rachel Menezes Castelo1, Hélcio Silva dos Santos3, Thais Benincá4, Patrícia da Silva Malheiros4, Júlio César Sousa Prado5, Raquel de Oliveira Fontenelle5, Maria Madalena de Camargo Forte2

    Journal of Renewable Materials, Vol.12, No.2, pp. 285-304, 2024, DOI:10.32604/jrm.2023.043919

    Abstract With the increase in antimicrobial resistance, it has become necessary to explore alternative approaches for combating and preventing diseases. DB-cinnamaldehyde (CNM) and Benzyl4-amino (B4AM) are bioactive compounds derived from chalcones but with restricted solubility in aqueous media. Nanoemulsions can enhance the solubility of compounds and can be a promising alternative in the development of novel antimicrobials, with reduced side effects and prolonged release. The objective of this study was to evaluate the stability of oil-in-water nanoemulsions loaded with two distinct types of chalcones at two different dosages, to propose a stable formulation with antimicrobial properties. Results showed that nanoemulsions presented… More > Graphic Abstract

    Evaluation of the Antibacterial and Antifungal Capacity of Nanoemulsions Loaded with Synthetic Chalcone Derivatives Di-Benzyl Cinnamaldehyde and Benzyl 4-Aminochalcone

  • Open Access

    ARTICLE

    High-Value-Added Utilization of Turpentine: Screening of Anti-Influenza Virus Agents from β-Pinene Derivatives

    Yiwen Li1,#, Hongyan Si1,#, Peng Wang1, Hai Luo1, Minggui Shen2, Xiaoping Rao3, Zhanqian Song2, Shibin Shang2, Zongde Wang1,*, Shengliang Liao1,*

    Journal of Renewable Materials, Vol.12, No.1, pp. 45-56, 2024, DOI:10.32604/jrm.2023.031089

    Abstract Turpentine is a renewable and resourceful forest product. The deep processing and utilization of turpentine, particularly its primary component β-pinene, has garnered widespread attention. This study aimed to synthesize 40 derivatives of β-pinene, including nopinone, 3-cyanopyridines of nopinone, myrtanyl acid, myrtanyl acylthioureas, and myrtanyl amides. We assessed the antiviral activities of these β-pinene derivatives against influenza virus A/Puerto Rico/8/34 (H1N1) using the 3-(4,5-dimetylthiazol-2-yl)-2,5-diphenyltetrazolium bromide method. The β-pinene derivatives were used before and after cellular infection with the influenza virus to evaluate their preventive and therapeutic effects against the H1N1 virus. The results showed that only compound 10o exhibited a preventive… More > Graphic Abstract

    High-Value-Added Utilization of Turpentine: Screening of Anti-Influenza Virus Agents from <i>β</i>-Pinene Derivatives

  • Open Access

    ARTICLE

    Prediction and Output Estimation of Pattern Moving in Non-Newtonian Mechanical Systems Based on Probability Density Evolution

    Cheng Han1,*, Zhengguang Xu1,2

    CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.1, pp. 515-536, 2024, DOI:10.32604/cmes.2023.043464

    Abstract A prediction framework based on the evolution of pattern motion probability density is proposed for the output prediction and estimation problem of non-Newtonian mechanical systems, assuming that the system satisfies the generalized Lipschitz condition. As a complex nonlinear system primarily governed by statistical laws rather than Newtonian mechanics, the output of non-Newtonian mechanics systems is difficult to describe through deterministic variables such as state variables, which poses difficulties in predicting and estimating the system’s output. In this article, the temporal variation of the system is described by constructing pattern category variables, which are non-deterministic variables. Since pattern category variables have… More >

  • Open Access

    REVIEW

    Realizing the potential of exploiting human IPSCs and their derivatives in research of Down syndrome

    YAFEI WANG1,2,#, JIELEI NI1,#, YUHAN LIU2, DINGYING LIAO3, QIANWEN ZHOU1, XIAOYANG JI2, GANG NIU2, YANXIANG NI1,*

    BIOCELL, Vol.47, No.12, pp. 2567-2578, 2023, DOI:10.32604/biocell.2023.043781

    Abstract Down syndrome (DS) is a genetic condition characterized by intellectual disability, delayed brain development, and early onset Alzheimer’s disease. The use of primary neural cells and tissues is important for understanding this disease, but there are ethical and practical issues, including availability from patients and experimental manipulability. Moreover, there are significant genetic and physiological differences between animal models and humans, which limits the translation of the findings in animal studies to humans. Advancements in induced pluripotent stem cells (iPSC) technology have revolutionized DS research by providing a valuable tool for studying the cellular and molecular pathologies associated with DS. Induced… More >

  • Open Access

    ARTICLE

    Research on Stick-Slip Vibration Suppression Method of Drill String Based on Machine Learning Optimization

    Kanhua Su, Jian Wei*, Meng Li, Hao Li, Wenghao Da, Lang Zhang

    Sound & Vibration, Vol.57, pp. 97-117, 2023, DOI:10.32604/sv.2023.043734

    Abstract During the drilling process, stick-slip vibration of the drill string is mainly caused by the nonlinear friction generated by the contact between the drill bit and the rock. To eliminate the fatigue wear of downhole drilling tools caused by stick-slip vibrations, the Fractional-Order Proportional-Integral-Derivative (FOPID) controller is used to suppress stick-slip vibrations in the drill string. Although the FOPID controller can effectively suppress the drill string stick-slip vibration, its structure is flexible and parameter setting is complicated, so it needs to use the corresponding machine learning algorithm for parameter optimization. Based on the principle of torsional vibration, a simplified model… More > Graphic Abstract

    Research on Stick-Slip Vibration Suppression Method of Drill String Based on Machine Learning Optimization

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