A.V. Ekhlakov², O.M. Khay², Ch. Zhang², J. Sladek³, V. Sladek³

Structural Durability & Health Monitoring, Vol.6, No.3&4, pp. 329-350, 2010, DOI:10.3970/sdhm.2010.006.329

Abstract In this paper, transient crack analysis in two-dimensional, isotropic, continuously non-homo -ge -neous and linear elastic functionally graded materials is presented. A boundary-domain element method based on boundary-domain integral representations is developed. The Laplace-transform technique is utilized to eliminate the dependence on time. Laplace-transformed fundamental solutions of linear coupled thermoelasticity for isotropic, homogeneous and linear elastic solids are applied to derive boundary-domain integral equations. The numerical implementation is performed by using a collocation method for the spatial discretization. The time-dependent numerical solutions are obtained by the Stehfest's inversion algorithm. For an edge crack in a finite domain under thermal shock,… More >

Yan Zu^1,2, Qiang Li¹, Chun Yang^2,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 106-106, 2019, DOI:10.32604/mcb.2019.07132

Abstract Extracellular matrix (ECM) elasticity affects the function of a variety of cells. Integrins are transmembrane receptors that considered to be a sensor of cellular mechanical stimulation. The activity of integrins is strongly influenced by glycans through glycosylation events and the establishment of glycan-mediated interactions. Our study found that the level of β1 integrin N-linked glycosylation was significantly down-regulated on softer ECM. Further, sialic acid is a common monosaccharide modified at the end of the sugar chain during N-glycosylation. We subjected the enriched sialylated glycoproteins to gel-based proteomic identification by tandem mass spectrometry and found that the chondrocytes seeded on stiff… More >

Hao Sun¹, Timothy Eswothy¹, Kerlin P. Robert¹, Jiaoyan Li², L. G. Zhang¹, James D. Lee^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 75-75, 2019, DOI:10.32604/mcb.2019.07090

Abstract Most biological phenomena commonly involve with mechanics. In this work, we proposed an innovative model that tumor is considered as a pyroelastic medium consisting of two parts: solid and fluid. The variation of solid part depends on whether the drug has been effectively delivered to the tumor site. We derived the governing equations of the tumor, in which large deformation is incorporated. Meanwhile, the finite element equations for coupled displacement field and pressure field are formulated. We proposed two sets of porosity and growth tensor. In both cases the continuum theory and FEM are accompanied by accurate numerical simulations. To… More >

Kerlin P. Robert¹, Jiaoyan Li², James D. Lee^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 74-74, 2019, DOI:10.32604/mcb.2019.07125

Abstract This presentation focuses on the new and upcoming concept of 4D printing and its vast scope and importance in the research and development in industry. The 3D printing object is considered as a layered structure. Each layer may have different orientation. Therefore each layer may behave differently under the change of its environment. We formulate the theoretical shape changing process of 4D printing resulted from (I) the biological growth or swelling, (II) the change of temperature, and (III) the effect of electric field on piezoelectric material of the 3D printing product. Then we illustrate this theory visually through finite element… More >

Sevan Goenezen^1,*, Ping Luo¹, Baik Jin Kim¹, Maulik Kotecha¹, Yue Mei^2,3

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 46-48, 2019, DOI:10.32604/mcb.2019.07348

Abstract It is well known that the mechanical properties of tissues may vary spatially due to changing tissue types or due to inherent tissue disease. For example, the biomechanical properties are known to vary throughout blood vessels [1]. Diseases such as cancers may also lead to locally altered mechanical properties, thus allow a preliminary diagnosis via finger palpation. Quantifying the mechanical property distribution of tissues for a given constitutive equation will allow to characterize the biomechanical response of tissues. This may help to 1) predict disease progression, 2) diagnose diseases that alter the biomechanics of the tissue, e.g., skin cancers, breast… More >

Navid Mohammad Mirzaei¹, Pak-Wing Fok^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.2, pp. 32-33, 2019, DOI:10.32604/mcb.2019.07088

Abstract Atherosclerosis is a disease considered to be one of the leading causes of death. Understanding the behavior and dynamics of the vessel wall before and after atherosclerosis has been a motivation for many studies. We investigate this phenomenon as a combination of mechanical deformation of the vessel wall along with cell and chemical dynamics that occur within. We consider the vessel wall as a growing hyperelastic material with three layers; intima,media and adventitia. Each of these layers have a different set of mechanical properties [1]. To describe tissue growth, we use morphoelasticity as the mathematical framework. The growth tensor in… More >

Kyousuke Yamaguchi¹, Nao-Aki Noda², Ker-Kong Chen³, Kiyoshi Tajima³, Seiji Harada¹, Xin Lan¹

Structural Durability & Health Monitoring, Vol.5, No.3, pp. 191-200, 2009, DOI:10.3970/sdhm.2009.005.191

Abstract Wedge-shaped defects are frequently observed on the cervical region of the human tooth. Previously, most studies explained that improper tooth-brushing causes such defects. However, recent clinical observation suggested that the repeated stress due to occlusal force may induce the formation of these wedge-shaped defects. In this study, a two-dimensional human tooth model after a wedge-shaped defect is restored with the composite resin is analyzed by using the finite element method. To obtain the intensity of the singular stress accurately, a method of analysis is discussed for calculating generalized stress intensity factors, which control the singular stress around the corner of… More >

C. Colombo¹, M. Guagliano^1,2, L. Vergani¹

Structural Durability & Health Monitoring, Vol.4, No.2, pp. 67-76, 2008, DOI:10.3970/sdhm.2008.004.067

Abstract With the aim of experimentally assessing the stress intensity factors under mixed-mode loading along a crack front, the case of an internal elliptical crack is analyzed. An experimental test is performed on a three-dimensional photoelastic model made in epoxy resin. This model contains an inner natural crack, created by thermal shock. The crack is inclined in the cylindrical model, loaded with a tensile stress field.
Exploiting the characteristics of the epoxy resin, and using the stress freezing technique, it is possible to keep memory of the stresses near to the crack tip, once the specimen is unloaded. The final specimen… More >

P.D. Shah¹, Ch. Song², C.L. Tan¹, X. Wang¹

Structural Durability & Health Monitoring, Vol.2, No.4, pp. 225-238, 2006, DOI:10.3970/sdhm.2006.002.225

Abstract Numerical T-stress solutions in two dimensional anisotropic cracked bodies are very scarce in the literature. Schemes to evaluate this fracture parameter in anisotropy have been reported only fairly recently. Among them are those developed in conjunction with two different computational techniques, namely, the Boundary Element Method (BEM) and the Scaled Boundary Finite-Element Method (SBFEM). This paper provides a review of the respective schemes using these techniques and demonstrates their efficacy with three examples. These examples, which are of engineering importance, involve cracks lying in a homogeneous medium as well as at the interface between dissimilar media. The numerical T-stress solutions… More >

J. Sladek¹, V. Sladek, Ch.Zhang²

Structural Durability & Health Monitoring, Vol.1, No.2, pp. 131-144, 2005, DOI:10.3970/sdhm.2005.001.131

Abstract A meshless method based on the local Petrov-Galerkin approach is proposed for crack analysis in two-dimensional (2-d), anisotropic and linear elastic solids with continuously varying material properties. Both quasi-static and transient elastodynamic problems are considered. For time-dependent problems, the Laplace-transform technique is utilized. A unit step function is used as the test function in the local weak-form. It is leading to local boundary integral equations (LBIEs) involving only a domain-integral in the case of transient dynamic problems. The analyzed domain is divided into small subdomains with a circular shape. The moving least-squares (MLS) method is adopted for approximating the physical… More >