WEN GE^1,2,#, YA LI^1,2,#, YUTING RUAN^1,2, NINGXIA WU^1,2, PEI MA^3,4, TONGPENG XU^3,4, YONGQIAN SHU^3,4, YINGWEI WANG^1,2, WEN QIU^1,2, CHENHUI ZHAO^3,4,*

Oncology Research, Vol.32, No.4, pp. 625-641, 2024, DOI:10.32604/or.2023.031053

Abstract The cancer cell metastasis is a major death reason for patients with non-small cell lung cancer (NSCLC). Although researchers have disclosed that interleukin 17 (IL-17) can increase matrix metalloproteinases (MMPs) induction causing NSCLC cell metastasis, the underlying mechanism remains unclear. In the study, we found that IL-17 receptor A (IL-17RA), p300, p-STAT3, Ack-STAT3, and MMP19 were up-regulated both in NSCLC tissues and NSCLC cells stimulated with IL-17. p300, STAT3 and MMP19 overexpression or knockdown could raise or reduce IL-17-induced p-STAT3, Ack-STAT3 and MMP19 level as well as the cell migration and invasion. Mechanism investigation revealed that STAT3 and p300 bound… More > Graphic Abstract

Amr Ismail¹, Walid Hamdy^1,2, Aya M. Al-Zoghby³, Wael A. Awad³, Ahmed Ismail Ebada³, Yunyoung Nam⁴, Byeong-Gwon Kang^4,*, Mohamed Abouhawwash^5,6

Computer Systems Science and Engineering, Vol.48, No.2, pp. 273-285, 2024, DOI:10.32604/csse.2023.038192

Abstract Deep learning (DL) plays a critical role in processing and converting data into knowledge and decisions. DL technologies have been applied in a variety of applications, including image, video, and genome sequence analysis. In deep learning the most widely utilized architecture is Convolutional Neural Networks (CNN) are taught discriminatory traits in a supervised environment. In comparison to other classic neural networks, CNN makes use of a limited number of artificial neurons, therefore it is ideal for the recognition and processing of wheat gene sequences. Wheat is an essential crop of cereals for people around the world. Wheat Genotypes identification has… More >

Sherly Alphonse^*, Harshit Verma

CMC-Computers, Materials & Continua, Vol.78, No.2, pp. 2067-2086, 2024, DOI:10.32604/cmc.2024.046070

Abstract Although lots of research has been done in recognizing facial expressions, there is still a need to increase the accuracy of facial expression recognition, particularly under uncontrolled situations. The use of Local Directional Patterns (LDP), which has good characteristics for emotion detection has yielded encouraging results. An innovative end-to-end learnable High Response-based Local Directional Pattern (HR-LDP) network for facial emotion recognition is implemented by employing fixed convolutional filters in the proposed work. By combining learnable convolutional layers with fixed-parameter HR-LDP layers made up of eight Kirsch filters and derivable simulated gate functions, this network considerably minimizes the number of network… More >

Eduardo Burgos-Valencia^1,#, Federico García-Laynes^1,#, Ileana Echevarría-Machado¹, Fatima Medina-Lara¹, Miriam Monforte-González¹, José Narváez-Zapata^2,*, Manuel Martínez-Estévez^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 151-183, 2024, DOI:10.32604/phyton.2023.046943

Abstract Habanero pepper (Capsicum chinense Jacq.) is a crop of economic relevance in the Peninsula of Yucatan. Its fruits have a high level of capsaicinoids compared to peppers grown in other regions of the world, which gives them industrial importance. Soil is an important factor that affects pepper development, nutritional quality, and capsaicinoid content. However, the effect of soil type on fruit development and capsaicinoid metabolism has been little understood. This work aimed to compare the effect of soils with contrasting characteristics, black soil (BS) and red soil (RS), on the expression of genes related to the development of fruits, and… More >

Zhifen Shi^1,3, Fumei Pan^1,3, Xiaotian Kong², Jiaqi Lang³, Mingyan Ye³, Qian Wu⁴, Guangzhi Wang^1,*, Liang Han^5,*, Nong Zhou^3,*

Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 247-260, 2024, DOI:10.32604/phyton.2024.046452

Abstract Fritillaria taipaiensis P. Y. Li is a widely used medicinal herb in treating pulmonary diseases. In recent years, its wild resources have become scarce, and the demand for efficient artificial cultivation has significantly increased. This article is the first to apply phosphate solubilizing bacteria isolated from the rhizosphere soil of F. taipaiensis P. Y. Li to the cultivation process of F. taipaiensis P. Y. Li. The aim is to identify suitable reference strains for the artificial cultivation and industrial development of F. taipaiensis P. Y. Li by examining the effects of various phosphate solubilizing bacteria and their combinations on photosynthesis,… More >

CHAO LIU^*

BIOCELL, Vol.48, No.2, pp. 339-351, 2024, DOI:10.32604/biocell.2023.047044

Abstract Introduction: Osteoarthritis (OA) is still an important health problem, and understanding its pathological mechanisms is essential for its diagnosis and treatment. There is evidence that autophagy may play a role in OA progression, but the exact mechanism remains unclear. Methods: In this study, we adopted a multi-prong approach to systematically identify the key autophagy-related genes (ARGs) associated with OA. Through weighted gene co-expression network analysis, we initially identified significant gene modules associated with OA. Subsequent differential gene analysis performed on normal and OA specimens. Further analysis later using the MCC algorithm highlighted hub ARGs. These genes were then incorporated into… More >

QINGJIAN HE¹, HUIXIN ZHU^2,3, SHANHONG FANG^4,5,*

BIOCELL, Vol.48, No.2, pp. 205-216, 2024, DOI:10.32604/biocell.2023.045109

Abstract Introduction: Dexamethasone (Dex) caused impaired osteoblast differentiation and oxidative stress (OS) in bone marrow mesenchymal stem cells (BMSCs). This work sought to elucidate the precise molecular pathway through which Dex influences osteogenic differentiation (OD) and OS in BMSCs. Methods: The expression of Runt-related transcription factor 1 (RUNX1) and alpha-2 macroglobulin (A2M) was assessed in Dex-treated BMSCs using qRT-PCR and Western Blot. Following the functional rescue experiments, cell proliferation was determined by MTT assay, reactive oxygen species (ROS) expression by DCFH-DA fluorescent probe, lactate dehydrogenase (LDH), superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (Gpx) expression by kits, OD by alkaline… More >

JIECHUAN QIU¹, TIANMIN YANG¹, YANNING SUN², KAI SUN², YINGKUN XU³, QINGHUA XIA^1,*

Oncology Research, Vol.32, No.3, pp. 545-561, 2024, DOI:10.32604/or.2023.030462

Abstract This research aims to identify the key fatty acid beta-oxidation (FAO) genes that are altered in kidney renal clear cell carcinoma (KIRC) and to analyze the role of these genes in KIRC. The Gene Expression Omnibus (GEO) and FAO datasets were used to identify these key genes. Wilcoxon rank sum test was used to assess the levels of acyl-CoA dehydrogenase medium chain (ACADM) between KIRC and non-cancer samples. The logistic regression and Wilcoxon rank sum test were used to explore the association between ACADM and clinical features. The diagnostic performance of ACADM for KIRC was assessed using a diagnostic receiver… More >

Mingda Yin^1,#, Rui Luo^1,#, Tana Liang¹, Qi Wen¹, Xiaotian Liang¹, Yanpeng Wen¹, Xuemei Hu¹, Zhiyan Wang¹, Chang Gao¹, Wenjing Ren¹, Fenglan Huang^1,2,3,4,5,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 97-117, 2024, DOI:10.32604/phyton.2023.031228

Abstract Castor is one of the top 10 oil crops in the world and has extremely valuable uses. Castor inflorescences directly affect yield, so the study of inflorescence development is very important in increasing castor yield. Our previous studies have shown that the PIP5K gene family (PIP5Ks) is associated with inflorescence development. In this study, to determine the function of each PIP5K gene in castor, a female Lm-type castor line, aLmAB2, was used to determine the relative expression levels of the PIP5Ks in castor inflorescences. Six PIP5K genes were heterologously overexpressed in Arabidopsis thaliana, the relative expression of each gene and… More >

Ziguang Song^1,2, Jiangbo Yu¹, Mengmeng Wang³, Weitao Shen⁴, Chengcheng Wang¹, Tianyi Lu¹, Gaojun Shan¹, Guo Dong¹, Yiru Wang¹, Jiyi Zhao^1,*

Congenital Heart Disease, Vol.18, No.6, pp. 693-701, 2023, DOI:10.32604/chd.2024.048081

Abstract CHDTEPDB (URL: ) is a manually integrated database for congenital heart disease (CHD) that stores the expression profiling data of CHD derived from published papers, aiming to provide rich resources for investigating a deeper correlation between human CHD and aberrant transcriptome expression. The development of human diseases involves important regulatory roles of RNAs, and expression profiling data can reflect the underlying etiology of inherited diseases. Hence, collecting and compiling expression profiling data is of critical significance for a comprehensive understanding of the mechanisms and functions that underpin genetic diseases. CHDTEPDB stores the expression profiles of over 200 sets of 7… More >