Jamal N. Al Abbasi¹, Ahmed Z. Afify^2,*, Badr Alnssyan^3,*, Mustafa S. Shama^4,5

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 513-536, 2024, DOI:10.32604/cmes.2024.046533

Abstract This study proposes a new flexible family of distributions called the Lambert-G family. The Lambert family is very flexible and exhibits desirable properties. Its three-parameter special sub-models provide all significant monotonic and non-monotonic failure rates. A special sub-model of the Lambert family called the Lambert-Lomax (LL) distribution is investigated. General expressions for the LL statistical properties are established. Characterizations of the LL distribution are addressed mathematically based on its hazard function. The estimation of the LL parameters is discussed using six estimation methods. The performance of this estimation method is explored through simulation experiments. The usefulness and flexibility of the… More >

FREDERICK H. SILVER^1,2,*, TANMAY DESHMUKH²

BIOCELL, Vol.48, No.4, pp. 525-540, 2024, DOI:10.32604/biocell.2024.047965

Abstract All tissues in the body are subjected externally to gravity and internally by collagen fibril and cellular retractive forces that create stress and energy equilibrium required for homeostasis. Mechanotransduction involves mechanical work (force through a distance) and energy storage as kinetic and potential energy. This leads to changes in cell mitosis or apoptosis and the synthesis or loss of tissue components. It involves the application of energy directly to cells through integrin-mediated processes, cell-cell connections, stretching of the cell cytoplasm, and activation of the cell nucleus via yes-associated protein (YAP) and transcriptional coactivator with PDZ-motif (TAZ). These processes involve numerous… More >

Honghui Sun^1,2,#, Ruichao Liu^1,2,#, Yueting Qi¹, Hongsheng Gao¹, Xueting Wang¹, Ning Jiang^1,2, Xiaotong Guo^1,2, Hongxia Zhang¹, Chunyan Yu^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.3, pp. 533-549, 2024, DOI:10.32604/phyton.2024.049417

Abstract Grapes, one of the oldest tree species globally, are rich in vitamins. However, environmental conditions such as low temperature and soil salinization significantly affect grape yield and quality. The glutamate receptor (GLR) family, comprising highly conserved ligand-gated ion channels, regulates plant growth and development in response to stress. In this study, 11 members of the VvGLR gene family in grapes were identified using whole-genome sequence analysis. Bioinformatic methods were employed to analyze the basic physical and chemical properties, phylogenetic trees, conserved domains, motifs, expression patterns, and evolutionary relationships. Phylogenetic and collinear analyses revealed that the VvGLRs were divided into three… More >

KUNLUN LI¹, DANDAN LI², BARBOD HAFEZ^3,*, MOUNIR M. SALEM BEKHIT⁴, YOUSEF A. BIN JARDAN⁴, FARS KAED ALANAZI⁴, EHAB I. TAHA⁴, SAYED H. AUDA⁴, FAIQAH RAMZAN^5,*, MUHAMMAD JAMIL⁶

Oncology Research, Vol.32, No.4, pp. 737-752, 2024, DOI:10.32604/or.2023.042925

Abstract Kidney Renal Clear Cell Carcinoma (KIRC) is a malignant tumor that carries a substantial risk of morbidity and mortality. The MMP family assumes a crucial role in tumor invasion and metastasis. This study aimed to uncover the mechanistic relevance of the MMP gene family as a therapeutic target and diagnostic biomarker in Kidney Renal Clear Cell Carcinoma (KIRC) through a comprehensive approach encompassing both computational and molecular analyses. STRING, Cytoscape, UALCAN, GEPIA, OncoDB, HPA, cBioPortal, GSEA, TIMER, ENCORI, DrugBank, targeted bisulfite sequencing (bisulfite-seq), conventional PCR, Sanger sequencing, and RT-qPCR based analyses were used in the present study to analyze MMP… More >

Liping Yang^1,#, Xin Wan^2,3,#, Runyang Zhou¹, Yingdan Yuan^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 81-96, 2024, DOI:10.32604/phyton.2023.045389

Abstract As one of the main active components of Dendrobium catenatum, alkaloids have high medicinal value. The physicochemical properties, conserved domains and motifs, phylogenetic analysis, and cis-acting elements of the gene family members in the alkaloid biosynthesis pathway of D. catenatum were analyzed by bioinformatics, and the expression of the genes in different years and tissues was analyzed by qRT-PCR. There are 16 gene families, including 25 genes, in the D. catenatum alkaloid biosynthesis pathway. The analysis of conserved domains and motifs showed that the types, quantities, and orders of domains and motifs were similar among members of the same family,… More >

Yanhuan Lin^1,#, Hua Du^2,#, Zhitao Ye², Shuqi Wang², Zhen Wang², Xiaojuan Liu^2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 137-150, 2024, DOI:10.32604/phyton.2023.044996

Abstract PDI is a molecular chaperone and plays an important role in Endoplasmic Reticulum quality control (ERQC). PDI participates in the refolding of the misfolded/unfolded proteins to maintain cellular homeostasis under different stresses. However, bioinformatic characteristics and potential functions of PDIs in diatom Phaeodactylum tricornutum (Pt) are still unknown so far. Hence, the genome-wide characteristics of PtPDI proteins in P. tricornutum were first studied via bioinformatic and transcriptomic methods. 42 PtPDI genes were identified from the genome of P. tricornutum. The motif, protein structure, classification, number of introns, phylogenetic relationship, and the expression level of 42 PtPDI genes under the tunicamycin… More >

Mingda Yin^1,#, Rui Luo^1,#, Tana Liang¹, Qi Wen¹, Xiaotian Liang¹, Yanpeng Wen¹, Xuemei Hu¹, Zhiyan Wang¹, Chang Gao¹, Wenjing Ren¹, Fenglan Huang^1,2,3,4,5,*

Phyton-International Journal of Experimental Botany, Vol.93, No.1, pp. 97-117, 2024, DOI:10.32604/phyton.2023.031228

Abstract Castor is one of the top 10 oil crops in the world and has extremely valuable uses. Castor inflorescences directly affect yield, so the study of inflorescence development is very important in increasing castor yield. Our previous studies have shown that the PIP5K gene family (PIP5Ks) is associated with inflorescence development. In this study, to determine the function of each PIP5K gene in castor, a female Lm-type castor line, aLmAB2, was used to determine the relative expression levels of the PIP5Ks in castor inflorescences. Six PIP5K genes were heterologously overexpressed in Arabidopsis thaliana, the relative expression of each gene and… More >

Cong Liu¹, Mohd Nazri Abdul Rahman^1,*, Nur Eva²

International Journal of Mental Health Promotion, Vol.25, No.11, pp. 1161-1172, 2023, DOI:10.32604/ijmhp.2023.030324

Abstract The implementation of China’s three-child fertility policy has led to a notable increase in multiple-child families. Notably, firstborn children experience a significant transition from being an only child to a non-only child. This transition is associated with problematic behaviors, affecting their social adjustment, sibling relationships, and family harmony. Although several studies have examined the relationship between parent-child attachment and problem behaviors exhibited by firstborn children during family transitions, the findings have been inconsistent. Hence, a meta-analytic study was undertaken to elucidate the inconsistencies in this relationship and explore the moderating factors that may contribute to these discrepancies. Using a systematic… More >

KUO-SHYANG JENG¹, PO-YU CHENG², YUEH-HSIEN LIN², PO-CHUN LIU², PING-HUI TSENG³, YU-CHAO WANG⁴, CHIUNG-FANG CHANG⁵, CHUEN-MIIN LEU^2,*

Oncology Research, Vol.32, No.1, pp. 163-174, 2024, DOI:10.32604/or.2023.030975

Abstract Hepatocellular carcinoma (HCC) is a leading cause of death worldwide. Current therapies are effective for HCC patients with early disease, but many patients suffer recurrence after surgery and have a poor response to chemotherapy. Therefore, new therapeutic targets are needed. We analyzed gene expression profiles between HCC tissues and normal adjacent tissues from public databases and found that the expression of genes involved in lipid metabolism was significantly different. The analysis showed that AKR1C3 was upregulated in tumors, and high AKR1C3 expression was associated with a poorer prognosis in HCC patients. In vitro, assays demonstrated that the knockdown of AKR1C3… More >

ZIPENG LIN^1,#, CHUXI TANG^1,#, LE KANG², GUANXI LAI¹, SHIWEN LIU¹, YIXIANG WU¹, HUIQUN TIAN^3,*, SONG LIU^1,4,5,*

BIOCELL, Vol.47, No.10, pp. 2217-2232, 2023, DOI:10.32604/biocell.2023.030233

Abstract The multiple roles of the tumor necrosis factor (TNF)-α-inducible protein 8 (TNFAIP8), also named TIPE family of proteins have been shown in tumor and inflammation progression and regulation of cellular autophagy and apoptosis. In this review, we found that the TIPE family showed highly homologous sequences and conserved functional domains, such as the death effector domain (DED)-like domain but displayed different roles and mechanisms in different biological activities. For example, while TIPE is primarily associated with tumor progression and antitumor drug resistance, TIPE1 suppresses tumor progression in most instances. TIPE2 has multiple roles in tumor progression regulation, and antitumor drug… More > Graphic Abstract