JINGJING CHEN¹, DAN WANG², ZEQUN WANG², MENGYUAN HAN⁴, HOUQING YIN², WENTING ZHOU⁴, RIBAI YAN⁵, YAN PAN^2,3,*

Oncology Research, Vol.32, No.5, pp. 911-923, 2024, DOI:10.32604/or.2023.042384

Abstract Photodynamic therapy (PDT) is a promising cancer treatment. This study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin (DTP) mediated PDT (DTP-PDT). Cell viability, reactive oxygen species (ROS), and apoptosis were measured with a Cell Counting Kit-8 assay, DCFH-DA fluorescent probe, and Hoechst staining, respectively. Cell apoptosis- and autophagy-related proteins were examined using western blotting. RNA sequencing was used to screen differentially expressed mRNAs (DERs), and bioinformatic analysis was performed to identify the major biological events after DTP-PDT. Our results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901… More > Graphic Abstract

Hao Jiang¹, Yuerong Liao¹, Dongdong Zhao², Wenjian Luo³, Xingyi Zhang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1045-1075, 2024, DOI:10.32604/cmes.2024.048653

Abstract Due to the presence of a large amount of personal sensitive information in social networks, privacy preservation issues in social networks have attracted the attention of many scholars. Inspired by the self-nonself discrimination paradigm in the biological immune system, the negative representation of information indicates features such as simplicity and efficiency, which is very suitable for preserving social network privacy. Therefore, we suggest a method to preserve the topology privacy and node attribute privacy of attribute social networks, called AttNetNRI. Specifically, a negative survey-based method is developed to disturb the relationship between nodes in the social network so that the… More >

Hasan J. Alyamani^*

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.1, pp. 1129-1142, 2024, DOI:10.32604/cmes.2024.047756

Abstract The evaluation of disease severity through endoscopy is pivotal in managing patients with ulcerative colitis, a condition with significant clinical implications. However, endoscopic assessment is susceptible to inherent variations, both within and between observers, compromising the reliability of individual evaluations. This study addresses this challenge by harnessing deep learning to develop a robust model capable of discerning discrete levels of endoscopic disease severity. To initiate this endeavor, a multi-faceted approach is embarked upon. The dataset is meticulously preprocessed, enhancing the quality and discriminative features of the images through contrast limited adaptive histogram equalization (CLAHE). A diverse array of data augmentation… More > Graphic Abstract

Cyril Enault^*

Revue Internationale de Géomatique, Vol.33, pp. 77-92, 2024, DOI:10.32604/rig.2024.046591

Abstract La théorie égocentrée est aujourd’hui bien connue des éthologues et des psychologues mais moins diffusée chez les géographes car elle reste encore à l’état de théorie abstraite. Ce papier se propose dans un premier temps de rendre opérationnel cette approche dans le cadre de travaux géographiques à l’échelle de l’individu. Puis, elle envisage d’établir le lien entre l’échelle individu et l’échelle de la ville avec comme objectif de produire des cartes déformées de la ville. More > Graphic Abstract

LIJUAN ZHANG^1,#, QINGYIN MENG^2,#, LI ZHUANG¹, QUAN GONG¹, XIANDA HUANG³, XUEQIN LI¹, SHIJUAN LI¹, GUOQIN WANG⁴, XICAI WANG^5,*

BIOCELL, Vol.48, No.4, pp. 581-590, 2024, DOI:10.32604/biocell.2024.047260

Abstract Background: Lung adenocarcinoma is a very pervasive histological form of lung cancers, and inhibiting metastasis is crucial for effective treatment. In this investigation, we explored the functional interaction of miR-30a-5p and the putative transcription factor 2 of the homeodomain (PHTF2) in dictating the aggressiveness and metastasis of lung adenocarcinoma. Method: We collected clinical samples to evaluate the expression patterns of miR-30a-5p and PHTF2 in lung adenocarcinoma along with normal tissues. Cellular experiments including cell count kit (CCK)-8 growth assay, apoptosis analysis, migration and invasion examinations were performed to assess the aggressiveness of lung adenocarcinoma cells. Furthermore, we examined tumorigenesis and… More > Graphic Abstract

YAO FANG^1,2,#, FEI XIA^1,#, FEIFEI TIAN³, LEI QU¹, FANG YANG¹, JUAN FANG^1,2, ZHENHONG HU^1,*, HAICHAO LIU^1,*

BIOCELL, Vol.48, No.4, pp. 613-621, 2024, DOI:10.32604/biocell.2024.031539

Abstract Objective: In the realm of Class I pathogens, Burkholderia pseudomallei (BP) stands out for its propensity to induce severe pathogenicity. Investigating the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response process. Methods: mRNA extraction from BP-infected mouse macrophages constituted the initial step of our study. Employing gene expression arrays, the extracted RNA underwent conversion into digital signals. The percentile shift method facilitated data processing, with the identification of genes manifesting significant differences accomplished through the application of the t-test. Subsequently, a comprehensive analysis… More >

Tatyana Lyubimova^1,*, Anatoly Lepikhin², Yanina Parshakova¹, Irina Zayakina³, Alibek Issakhov⁴

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.4, pp. 815-828, 2024, DOI:10.32604/fdmp.2024.048463

Abstract In the process of production or processing of materials by various methods, there is a need for a large volume of water of the required quality. Today in many regions of the world, there is an acute problem of providing industry with water of a required quality. Its solution is an urgent and difficult task. The water quality of surface water bodies is formed by a combination of a large number of both natural and anthropogenic factors, and is often significantly heterogeneous not only in the water area, but also in depth. As a rule, the water supply of large… More >

Xia Li¹, Zhanyou Ma^1,*, Zhibao Mian², Ziyuan Liu¹, Ruiqi Huang¹, Nana He¹

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 4129-4152, 2024, DOI:10.32604/cmc.2024.047168

Abstract Model checking is an automated formal verification method to verify whether epistemic multi-agent systems adhere to property specifications. Although there is an extensive literature on qualitative properties such as safety and liveness, there is still a lack of quantitative and uncertain property verifications for these systems. In uncertain environments, agents must make judicious decisions based on subjective epistemic. To verify epistemic and measurable properties in multi-agent systems, this paper extends fuzzy computation tree logic by introducing epistemic modalities and proposing a new Fuzzy Computation Tree Logic of Knowledge (FCTLK). We represent fuzzy multi-agent systems as distributed knowledge bases with fuzzy… More >

Arshiya S. Ansari^*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 2865-2892, 2024, DOI:10.32604/cmc.2024.045908

Abstract Image steganography is a technique of concealing confidential information within an image without dramatically changing its outside look. Whereas vehicular ad hoc networks (VANETs), which enable vehicles to communicate with one another and with roadside infrastructure to enhance safety and traffic flow provide a range of value-added services, as they are an essential component of modern smart transportation systems. VANETs steganography has been suggested by many authors for secure, reliable message transfer between terminal/hope to terminal/hope and also to secure it from attack for privacy protection. This paper aims to determine whether using steganography is possible to improve data security… More >

Xiaoyan Zhu¹, Ruchun Jia², Tingrui Zhang³, Song Yao^4,*

CMC-Computers, Materials & Continua, Vol.78, No.3, pp. 4363-4377, 2024, DOI:10.32604/cmc.2023.045615

Abstract The traditional air traffic control information sharing data has weak security characteristics of personal privacy data and poor effect, which is easy to leads to the problem that the data is usurped. Starting from the application of the ATC (automatic train control) network, this paper focuses on the zero trust and zero trust access strategy and the tamper-proof method of information-sharing network data. Through the improvement of ATC’s zero trust physical layer authentication and network data distributed feature differentiation calculation, this paper reconstructs the personal privacy scope authentication structure and designs a tamper-proof method of ATC’s information sharing on the… More >