Jingcheng Lyu^1,2,#, Ruiyu Yue^1,2,#, Yichen Zhu^1,2, Ye Tian^1,2,*, Xinyi Hu^1,2,*

Canadian Journal of Urology, Vol.32, No.5, pp. 411-422, 2025, DOI:10.32604/cju.2025.066758 - 30 October 2025

Abstract Objective: Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. Method: A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using t-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary More >

Chuhan Zhao^1,*, Souad Morsli², Laurent Caramelle³, Mohammed El Ganaoui³

FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.8, pp. 2001-2025, 2025, DOI:10.32604/fdmp.2025.068093 - 12 September 2025

Abstract Carbon dioxide (CO₂) is often monitored as a convenient yardstick for indoor air safety, yet its ability to stand in for pathogen-laden aerosols has never been settled. To probe the question, we reproduced an open-plan office at full scale (7.2 m 5.2 m 2.8 m) and introduced a breathing plume that carried 4% CO₂, together with a polydisperse aerosol spanning 0.5–10 m (1320 particles s⁻¹). Inlet air was supplied at 0.7, 1.4, and 2.1 m s⁻¹, and the resulting fields were simulated with a Realisable – RANS model coupled to Lagrangian particle tracking. Nine strategically placed probes… More >

Benjamin Wacker¹, Jan Christian Schlüter^2,3,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2191-2229, 2025, DOI:10.32604/cmes.2025.067397 - 31 August 2025

Abstract In this work, we re-investigate a classical mathematical model of untreated HIV infection suggested by Kirschner and introduce a novel non-standard finite-difference method for its numerical solution. As our first contribution, we establish non-negativity, boundedness of some solution components, existence globally in time, and uniqueness on a time interval for an arbitrary for the time-continuous problem which extends known results of Kirschner’s model in the literature. As our second analytical result, we establish different equilibrium states and examine their stability properties in the time-continuous setting or discuss some numerical tools to evaluate this question. Our More >

Hong Zhang^1,2,#, Ying Zhu^3,#, Xingyu Li^3,#, Zhonghua Liu^1,2, Guoliang Li^1,2, Zhaomiao Lin^1,2, Yongxiang Qiu^1,2, Yongqing Xu^1,2, Shimin Lyu³, Jiyang Wang³, Sixin Qiu^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2479-2498, 2025, DOI:10.32604/phyton.2025.064850 - 29 August 2025

Abstract Vascular wilt caused by Fusarium oxysporum f. sp. batatas (Fob) is a devastating disease threatening global sweet potato production. To elucidate Fob’s pathogenicity mechanisms and inform effective control strategies, we generated a green fluorescent protein (GFP)-tagged Fob strain to track infection dynamics in sweet potato susceptible cultivar Xinzhonghua and resistant cultivar Xiangshu75-55, respectively. Through cytological observation, we found in the susceptible Xinzhonghua, Fob predominantly colonized stem villi, injured root growth points, and directly invaded vascular bundles through stem wounds. Spore germination peaked at 2–3 h post-inoculation (hpi), followed by cyclical mycelial expansion and sporulation within vascular tissues… More >

Federico Licastro^*

BIOCELL, Vol.49, No.6, pp. 981-989, 2025, DOI:10.32604/biocell.2025.062303 - 24 June 2025

Abstract Alzheimer’s disease (AD) is a neurodegenerative disease causing the most frequent form of dementia in old age. AD etiology is still uncertain and deposition of abnormal proteins in the brain along with chronic neuroinflammation have been suggested as pathogenic mechanisms of neuronal death. Infections by exogenous neurotropic virus, endogenous retrovirus reactivation, infections by other microbes, and air pollutants may either induce neurodegeneration or activate brain inflammation. Up to 8% of the human genome has a retroviral origin. These ancient retroviruses, also called human endogenous retroviruses, are associated with a clinical history of several neurodegenerative diseases.… More >

Meng Wang¹, Onkei Lei^1,2, Frankie U Kei Wong¹, Water Soi Po Wong¹, Walter Heung Chin Hui¹, Gasper Chi Hong Leong¹, Wenze Fang^1,3, Zhaowei Kong^1,*

International Journal of Mental Health Promotion, Vol.27, No.3, pp. 363-378, 2025, DOI:10.32604/ijmhp.2025.060875 - 31 March 2025

Abstract Background: This study evaluated physical fitness and mental health in young and elderly women 3 months after mild COVID-19 infection, and examined the impact of infection and age on long COVID occurrence and trajectory. Methods: There were 213 eligible female volunteers (107 young, 106 elderly) recruited approximately three months after the significant outbreak of COVID-19 in China. Participants completed a fitness test and mental health assessment using the Post-Traumatic Stress Disorder Self-Assessment Scale (PTSD) and the Pittsburgh Sleep Quality Inventory (PSQI). Results: Despite no significant difference in physical fitness, infected young and elderly females experienced poorer… More >

Benjamin J. Lichtbroun^1,2,*, Mann Patel², Alexis Consalvo², Labeeqa Khizir², Munisa Said², Austin Chien², Kevin Chua^1,2, John Pfail^1,2, Rachel Passarelli^1,2, Vignesh T. Packiam¹, David Golombos¹, Sammy Elsamra², Thomas L. Jang¹, Arnav Srivastava^1,3, Saum Ghodoussipour¹

Canadian Journal of Urology, Vol.32, No.1, pp. 55-62, 2025, DOI:10.32604/cju.2025.064701 - 20 March 2025

Abstract Introduction: Infections are the most feared complication of transrectal prostate biopsies, along with growing concerns of antibiotic resistance. Our institution transitioned to a transperineal approach without use of perioperative antibiotics or bowel preparations. We aimed to compare the safety outcomes associated with transperineal and transrectal prostate biopsy techniques. Materials and Methods: A retrospective analysis of patients who underwent transrectal and transperineal prostate biopsies at our institution from 2019–2022 was performed. Results: We identified 319 patients—174 transrectal and 145 transperineal. 8 patients who had transperineal biopsy (5.5%) received peri-operative antibiotics, compared to 100% with transrectal biopsy. 35.86%… More >

Francesco Triggiano^#, Giusy Diella^#, Mara Lorusso, Paolo Veneziani^*, Marilena D’Ambrosio, Daniela Nesta, Luigi Santacroce^*

BIOCELL, Vol.49, No.2, pp. 199-220, 2025, DOI:10.32604/biocell.2025.059322 - 28 February 2025

Abstract The composition of the vaginal microbiota (VMB) influences the health of the female reproductive tract. Several studies have shown how the absence of lactobacilli causes an imbalance in the vaginal microbial community, favoring the development of infections. The present study aims to evaluate the relationship between the VMB and human papillomavirus (HPV) infection to clarify the role of the vaginal microbiota in the persistence and clearance of HPV. Many researchers have provided the scientific community with information on the composition of the microbiota and how it may also influence HPV infection and the development of… More >

Muhammad Imran^1,*, Brett McKinney¹, Azhar Iqbal Kashif Butt²

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1899-1931, 2025, DOI:10.32604/cmes.2024.059552 - 27 January 2025

Abstract The co-infection of corona and influenza viruses has emerged as a significant threat to global public health due to their shared modes of transmission and overlapping clinical symptoms. This article presents a novel mathematical model that addresses the dynamics of this co-infection by extending the SEIR (Susceptible-Exposed-Infectious-Recovered) framework to incorporate treatment and hospitalization compartments. The population is divided into eight compartments, with infectious individuals further categorized into influenza infectious, corona infectious, and co-infection cases. The proposed mathematical model is constrained to adhere to fundamental epidemiological properties, such as non-negativity and boundedness within a feasible region.… More >

Ghaliah Alhamzi¹, Badr Saad T. Alkahtani², Ravi Shanker Dubey³, Mati ur Rahman^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.1, pp. 609-633, 2025, DOI:10.32604/cmes.2024.056604 - 17 December 2024

Abstract This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu (AB) derivatives having arbitrary order. The HIV infection model has a susceptible class, a recovered class, along with a case of infection divided into three sub-different levels or categories and the recovered class. The total time interval is converted into two, which are further investigated for ordinary and fractional order operators of the AB derivative, respectively. The proposed model is tested separately for unique solutions and existence on… More >