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  • Open Access

    ARTICLE

    Differential Activation of Defense Enzymes in Clonal Lines of Agave americana Derived from Chemical Mutagenesis in Response to Fusarium oxysporum Infection

    Sugey Vásquez-Hernández, Joaquín Adolfo Montes-Molina*, Federico Antonio Gutierrez-Miceli, Nancy Ruiz-Lau, Victor Manuel Ruiz-Valdiviezo, Carlos Alberto Lecona-Guzmán*

    Phyton-International Journal of Experimental Botany, Vol.95, No.3, 2026, DOI:10.32604/phyton.2026.076451 - 31 March 2026

    Abstract Agave americana L. is potentially a source of functional and nutritive compounds. However, its yield has been compromised by vascular wilt, which is associated with the presence of the Fusarium oxysporum. In response to this phytosanitary problem, the implementation of efficient methods to mitigate the damage. Biotechnological techniques offer a viable alternative to improve and increase the production of species of interest via genetic improvement. By use of mutagenic chemical agents, these techniques have been consolidated as a powerful tool to induce genetic variability and select genotypes with greater tolerance to pathogens. In this study, we evaluated… More >

  • Open Access

    ARTICLE

    Uretero-enteric strictures after cystectomy: revealing the modifiable risk factors

    Abdelkader Akkad, Franck Bruyere, Ali Bourgi*

    Canadian Journal of Urology, Vol.33, No.1, pp. 155-163, 2026, DOI:10.32604/cju.2025.069546 - 28 February 2026

    Abstract Objectives: Uretero-enteric strictures are feared complications following cystectomy. Despite surgical advancements, particularly the rise of robot-assisted approaches, the risk factors associated with these strictures remain poorly defined. This study aimed to identify the risk factors associated with uretero-enteric anastomotic strictures after cystectomy, according to the surgical approach and type of urinary diversion (extracorporeal vs. intracorporeal). Methods: We conducted a single-center retrospective study including 340 patients who underwent cystectomy between 2016 and 2024 at Tours University Hospital. Clinical, biological, perioperative, and postoperative data were analyzed. The occurrence of a uretero-ileal anastomotic stricture was defined radiologically by… More >

  • Open Access

    VIEWPOINT

    Mechanisms and Therapeutic Strategies for HCV/HBV-Associated B-Cell Non-Hodgkin’s Lymphomas: A Viewpoint

    Guido Carloni, Monica Rinaldi*

    Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.071847 - 24 February 2026

    Abstract Hepatitis C virus (HCV) and hepatitis B virus (HBV) infections are increasingly recognized as significant etiological factors in the pathogenesis of B-cell non-Hodgkin’s lymphomas (B-NHLs). Epidemiological and molecular studies have demonstrated a consistent association between chronic viral infection and B-NHLs. Multiple pathogenic mechanisms have been implicated in lymphomagenesis, both direct and indirect, including chronic antigenic stimulation, direct infection of B cells, and viral protein–mediated oncogenic signaling, It is likely that a combination of several pathogenic conditions is required to eventually lead to the development of lymphoma. The prevalence of B-cell lymphomas among individuals with chronic… More >

  • Open Access

    REVIEW

    Natural Killer Cell Cytotoxicity: STAT3 Interactions with NF-κB Dimer Composition Modulate Mitochondrial Melatonergic Pathway: Tumor, and Viral Infection Treatment Implications#

    George Anderson*

    BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.073221 - 14 February 2026

    Abstract As natural killer (NK) cells eliminate cancer cells and virus-infected cells, as well as modulate various other medical conditions, including aging-associated conditions such as neurodegenerative disorders, understanding NK cell regulation is of considerable clinical importance. This article reviews the role of circadian processes (melatonin and the cortisol system), aryl hydrocarbon receptor, and vagal nerve in the modulation of NK cell function, highlighting the importance of the endogenous mitochondrial melatonergic pathway in NK cells. As circadian and exogenous melatonin increase NK cell cytotoxicity, the presence of the endogenous melatonergic pathway may be of some importance not… More >

  • Open Access

    ARTICLE

    A Fractional-Order Study for Bicomplex Haemorrhagic Infection in Several Populations Conditions

    Muhammad Farman1,2,3,*, Muhammad Hashir Zubair4, Hua Li4, Kottakkaran Sooppy Nisar5,6, Mohamad Hafez7,8

    CMES-Computer Modeling in Engineering & Sciences, Vol.146, No.1, 2026, DOI:10.32604/cmes.2025.074160 - 29 January 2026

    Abstract Lassa Fever (LF) is a viral hemorrhagic illness transmitted via rodents and is endemic in West Africa, causing thousands of deaths annually. This study develops a dynamic model of Lassa virus transmission, capturing the progression of the disease through susceptible, exposed, infected, and recovered populations. The focus is on simulating this model using the fractional Caputo derivative, allowing both qualitative and quantitative analyses of boundedness, positivity, and solution uniqueness. Fixed-point theory and Lipschitz conditions are employed to confirm the existence and uniqueness of solutions, while Lyapunov functions establish the global stability of both disease-free and… More >

  • Open Access

    REVIEW

    Parasitic Infections and Carcinogenesis: Molecular Mechanisms, Immune Modulation, and Emerging Therapeutic Strategies

    Marta Pawłowska1,*, Dorian Jarek2, Jan Milanowski2, Karolina Szewczyk-Golec1

    Oncology Research, Vol.34, No.2, 2026, DOI:10.32604/or.2025.071891 - 19 January 2026

    Abstract Parasitic infections are increasingly recognized as contributors to cancer development, yet the underlying oncogenic mechanisms remain insufficiently understood. Growing evidence from molecular oncology, immunology, and microbiome research suggests that chronic parasitic infections may drive tumorigenesis through sustained inflammation, deregulated signaling pathways, genomic instability, and the release of parasite-derived exosomes that reshape the tumor microenvironment. These insights underscore the need to integrate parasitology with cancer biology to understand infection-associated malignancies better. The aim of this narrative review is to synthesize current knowledge on how selected parasites contribute to cancer development and to highlight emerging therapeutic and… More > Graphic Abstract

    Parasitic Infections and Carcinogenesis: Molecular Mechanisms, Immune Modulation, and Emerging Therapeutic Strategies

  • Open Access

    ARTICLE

    Determining the Emotions and Views of Patients with Post-Cesarean Surgical Site Infection: A Qualitative Study

    Elçin Alaçam1,*, Mualla Yılmaz2

    International Journal of Mental Health Promotion, Vol.27, No.12, pp. 1989-2005, 2025, DOI:10.32604/ijmhp.2025.071033 - 31 December 2025

    Abstract Background: Post-cesarean surgical site infection is a frequent complication with significant consequences for maternal, physical, and psychological well-being. This study explored women’s lived experiences of post-cesarean surgical site infection, focusing on emotional responses, treatment experiences, and perceived psychosocial impact. Methods: A qualitative study was conducted using thematic analysis of semi-structured interviews with 23 patients hospitalized due to post-cesarean surgical site infection, selected through purposeful sampling between 15 August 2022, and 15 January 2024. Results: The mean age of the participants in the study was 28.69 ± 5.07 years. Of them, 13 were high school graduates, and 22… More >

  • Open Access

    ARTICLE

    Association of urinary tract infection and low albumin/globulin ratio with chemoresistance to gemcitabine-cisplatin in advanced urothelial carcinoma

    Jingcheng Lyu1,2,#, Ruiyu Yue1,2,#, Yichen Zhu1,2, Ye Tian1,2,*, Xinyi Hu1,2,*

    Canadian Journal of Urology, Vol.32, No.5, pp. 411-422, 2025, DOI:10.32604/cju.2025.066758 - 30 October 2025

    Abstract Objective: Urothelial carcinoma (UC) remains a prevalent malignancy with high recurrence and chemoresistance rates despite gemcitabine-cisplatin (GC) chemotherapy. The study aimed to identify clinical risk factors for chemoresistance in advanced UC patients and develop a predictive model. Method: A retrospective analysis was conducted on 375 UC patients who received postoperative GC chemotherapy between 2013 and 2024. Patients were categorized into chemotherapy-resistant (CR, n = 91) and non-chemotherapy resistant (NCR, n = 284) groups based on tumor progression. Clinical, pathological, and laboratory variables were compared using t-tests and chi-square tests. Kaplan-Meier assessed overall survival (OS), and binary More >

  • Open Access

    ARTICLE

    Ventilation Velocity vs. Airborne Infection Risk: A Combined CFD and Field Study of CO2 and Viral Aerosols

    Chuhan Zhao1,*, Souad Morsli2, Laurent Caramelle3, Mohammed El Ganaoui3

    FDMP-Fluid Dynamics & Materials Processing, Vol.21, No.8, pp. 2001-2025, 2025, DOI:10.32604/fdmp.2025.068093 - 12 September 2025

    Abstract Carbon dioxide (CO2) is often monitored as a convenient yardstick for indoor air safety, yet its ability to stand in for pathogen-laden aerosols has never been settled. To probe the question, we reproduced an open-plan office at full scale (7.2 m 5.2 m 2.8 m) and introduced a breathing plume that carried 4% CO2, together with a polydisperse aerosol spanning 0.5–10 m (1320 particles s−1). Inlet air was supplied at 0.7, 1.4, and 2.1 m s−1, and the resulting fields were simulated with a Realisable – RANS model coupled to Lagrangian particle tracking. Nine strategically placed probes… More >

  • Open Access

    ARTICLE

    A Time-Continuous Model for an Untreated HIV-Infection and a Novel Non-Standard Finite-Difference-Method for Its Discretization

    Benjamin Wacker1, Jan Christian Schlüter2,3,*

    CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.2, pp. 2191-2229, 2025, DOI:10.32604/cmes.2025.067397 - 31 August 2025

    Abstract In this work, we re-investigate a classical mathematical model of untreated HIV infection suggested by Kirschner and introduce a novel non-standard finite-difference method for its numerical solution. As our first contribution, we establish non-negativity, boundedness of some solution components, existence globally in time, and uniqueness on a time interval for an arbitrary for the time-continuous problem which extends known results of Kirschner’s model in the literature. As our second analytical result, we establish different equilibrium states and examine their stability properties in the time-continuous setting or discuss some numerical tools to evaluate this question. Our More >

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