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  • Open Access


    A Systematic Literature Review of Deep Learning Algorithms for Segmentation of the COVID-19 Infection

    Shroog Alshomrani*, Muhammad Arif, Mohammed A. Al Ghamdi

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 5717-5742, 2023, DOI:10.32604/cmc.2023.038059

    Abstract Coronavirus has infected more than 753 million people, ranging in severity from one person to another, where more than six million infected people died worldwide. Computer-aided diagnostic (CAD) with artificial intelligence (AI) showed outstanding performance in effectively diagnosing this virus in real-time. Computed tomography is a complementary diagnostic tool to clarify the damage of COVID-19 in the lungs even before symptoms appear in patients. This paper conducts a systematic literature review of deep learning methods for classifying the segmentation of COVID-19 infection in the lungs. We used the methodology of systematic reviews and meta-analyses (PRISMA) flow method. This research aims… More >

  • Open Access


    Deep Learning ResNet101 Deep Features of Portable Chest X-Ray Accurately Classify COVID-19 Lung Infection

    Sobia Nawaz1, Sidra Rasheed2, Wania Sami3, Lal Hussain4,5,*, Amjad Aldweesh6,*, Elsayed Tag eldin7, Umair Ahmad Salaria8,9, Mohammad Shahbaz Khan10

    CMC-Computers, Materials & Continua, Vol.75, No.3, pp. 5213-5228, 2023, DOI:10.32604/cmc.2023.037543

    Abstract This study is designed to develop Artificial Intelligence (AI) based analysis tool that could accurately detect COVID-19 lung infections based on portable chest x-rays (CXRs). The frontline physicians and radiologists suffer from grand challenges for COVID-19 pandemic due to the suboptimal image quality and the large volume of CXRs. In this study, AI-based analysis tools were developed that can precisely classify COVID-19 lung infection. Publicly available datasets of COVID-19 (N = 1525), non-COVID-19 normal (N = 1525), viral pneumonia (N = 1342) and bacterial pneumonia (N = 2521) from the Italian Society of Medical and Interventional Radiology (SIRM), Radiopaedia, The… More >

  • Open Access


    Identification of Resistance to Pathogenesis Related Protein GmPR1L in Tobacco Botrytis cinerea Infection

    Yeyao Du1,#, Ye Zhang2,#, Yang Song1, Zhuo Zhang1, Sujie Fan1, Hanzhu Zhang1, Piwu Wang1,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.6, pp. 1907-1920, 2023, DOI:10.32604/phyton.2023.027607

    Abstract Soybean (Glycine max (Linn.) Merr.) annual leguminous crop is cultivated all over the world. The occurrence of diseases has a great impact on the yield and quality of soybean. In this study, based on the RNA-seq of soybean variety M18, a complete CDS (Coding sequence) GmPR1L of the pathogenesis-related protein 1 family was obtained, which has the ability to resist fungal diseases. The overexpression vector and interference expression vector were transferred into tobacco NC89, and the resistance of transgenic tobacco (Nicotiana tabacum L.) to Botrytis cinerea infection was identified. The results show that: Compared with the control, the activities of… More >

  • Open Access


    Study of Fractional Order Dynamical System of Viral Infection Disease under Piecewise Derivative

    Kamal Shah1,2, Hafsa Naz2, Thabet Abdeljawad1,3,*, Bahaaeldin Abdalla1

    CMES-Computer Modeling in Engineering & Sciences, Vol.136, No.1, pp. 921-941, 2023, DOI:10.32604/cmes.2023.025769

    Abstract This research aims to understand the fractional order dynamics of the deadly Nipah virus (NiV) disease. We focus on using piecewise derivatives in the context of classical and singular kernels of power operators in the Caputo sense to investigate the crossover behavior of the considered dynamical system. We establish some qualitative results about the existence and uniqueness of the solution to the proposed problem. By utilizing the Newtonian polynomials interpolation technique, we recall a powerful algorithm to interpret the numerical findings for the aforesaid model. Here, we remark that the said viral infection is caused by an RNA type virus… More > Graphic Abstract

    Study of Fractional Order Dynamical System of Viral Infection Disease under Piecewise Derivative

  • Open Access


    The microRNA pathway activation in insect cell model upon Autographa californica multiple nucleopolyhedrovirus infection


    BIOCELL, Vol.47, No.3, pp. 627-645, 2023, DOI:10.32604/biocell.2023.026182

    Abstract Background: The immune system of insects exerts fundamentally different antiviral mechanisms than mammals. MicroRNAs (miRNAs) play vital roles in developing insect antiviral immunity. MiRNAs expression profiles of insects changed significantly during baculovirus infection. Methods: Differential expression profiles of miRNAs in Spodoptera frugiperda were monitored by next-generation sequencing (NGS) and RT-qPCR during Autographa californica multiple nucleopolyhedrovirus (AcMNPV) infection. The transcription levels of genes were detected by RT-qPCR. The 50% tissue culture infective dose (TCID50) endpoint dilution assay was used to determine the proliferation of progeny virus. Results: NGS revealed that 49 miRNAs were differentially expressed in Sf9 cells, and 10 of… More >

  • Open Access


    Numerical Procedure for Fractional HBV Infection with Impact of Antibody Immune

    Sakda Noinang1, Zulqurnain Sabir2, Muhammad Asif Zahoor Raja3, Soheil Salahshour4, Wajaree Weera5,*, Thongchai Botmart5

    CMC-Computers, Materials & Continua, Vol.74, No.2, pp. 2575-2588, 2023, DOI:10.32604/cmc.2023.029046

    Abstract The current investigations are presented to solve the fractional order HBV differential infection system (FO-HBV-DIS) with the response of antibody immune using the optimization based stochastic schemes of the Levenberg-Marquardt backpropagation (LMB) neural networks (NNs), i.e., LMBNNs. The FO-HBV-DIS with the response of antibody immune is categorized into five dynamics, healthy hepatocytes (H), capsids (D), infected hepatocytes (I), free virus (V) and antibodies (W). The investigations for three different FO variants have been tested numerically to solve the nonlinear FO-HBV-DIS. The data magnitudes are implemented 75% for training, 10% for certification and 15% for testing to solve the FO-HBV-DIS with… More >

  • Open Access


    Transcriptome Analysis of a Wild Eggplant Germplasm M239 in Response to Verticillium dahliae Infection

    Liyan Wu1, Jie Cheng1,2, Yaju Gong1, Rui Bao1, Zhibin Li1, Min Gui1,*, Guanghui Du2,*

    Phyton-International Journal of Experimental Botany, Vol.92, No.2, pp. 591-609, 2023, DOI:10.32604/phyton.2022.023481

    Abstract In this study, wild eggplant germplasm No. M239, which is highly susceptible to Verticillium wilt, was used as the experimental material. The physiological and biochemical indices (SOD, PAL, MDA and soluble protein) of M239 roots were measured at different times (0, 12, 24, 36, 48, 60 and 72 h) post inoculation with Verticillium dahliae, and the key time points for the M239 response to Verticillium wilt infection were screened. Then, RNA-Seq technology was used to screen the differentially expressed genes (DEGs) in M239 roots at 0, 12 and 48 h post-inoculation (hpi). The transcriptional results of M239 were also compared… More >

  • Open Access


    The Presence of Human Papillomavirus and Epstein-Barr Virus Infection in Gastric Cancer: A Systematic Study

    Abolfazl Jafari-Sales1, Afsoon Shariat1,*, Hossein Bannazadeh Baghi2, Behzad Baradaran3, Behboud Jafari4

    Oncologie, Vol.24, No.3, pp. 413-426, 2022, DOI:10.32604/oncologie.2022.024161

    Abstract Background and Aim: Gastric cancer (GC) is one of the most common infection-related malignancies worldwide. Human Papillomavirus (HPV) and Epstein-Barr virus (EBV) are among the most important viruses affecting many people worldwide. The potential role of these viruses in gastric tissue may explain the possibility of GC, as seen in Helicobacter pylori (H. pylori). This study aimed to systematically investigate the presence of HPV and EBV in GC. Methods: According to the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) guidelines, this study is a systematic review based on reported cases. The keywords HPV, EBV and GC, were searched… More >

  • Open Access


    Characterization and Pathogenicity of Pseudopestalotiopsis vietnamensis Causing Gray Blight of Wuyi Rock Tea (Camellia sinensis) in China and Specific Mechanisms of Disease Infection

    Guangheng Wu1,#,*, Lu Rui2,3,#, Xiang Lu4, Libo Han2, Gan Lv1, Xianyu Fu5, Jinxian Liu5, Nong Zhou3, Chuanhai Zhang1

    Phyton-International Journal of Experimental Botany, Vol.92, No.1, pp. 131-147, 2023, DOI:10.32604/phyton.2022.021919

    Abstract Gray blight disease (GBD) causes significant losses in tea production in China. Although genes and biological processes involved in resistance to fungal disease in tea plants have been identified, specific mechanisms of the GBD infection process remain unknown. In this study, morphological and multi-gene (TEF-TUB-ITS) phylogenetic characteristics were used to identify isolate CLBB1 of Pseudopestalotiopsis vietnamensis. Pathogenicity tests confirmed that isolate CLBB1 from tea leaves caused GBD in the susceptible tea cultivar Wuyi Rock (Camellia sinensis var. sinensis cv. Shuixian). Spores began to germinate 24 h after infection (hai), and after 48 h, elongated fungal hyphae formed from a single conidium. Transcriptome… More >

  • Open Access


    Long term immunological perturbations post DAA therapy in chronic HCV/HIV co-infected patients


    BIOCELL, Vol.46, No.12, pp. 2695-2699, 2022, DOI:10.32604/biocell.2022.022257

    Abstract Direct-acting antiviral (DAA) therapies are efficacious for the achievement of sustained virologic response (SVR) in almost all treated hepatitis C virus (HCV)-infected patients. However, the impacts of HCV eradication on immune function and chronic immune activation in the long-term remain controversial and limited, especially in patients co-infected with human immunodeficiency virus (HIV). Indeed, although restoration of many immune responses clearly can be observed, several features of immune perturbations persist over time after HCV clearance. Understanding the degree and reasons of the partial recovery of the immune system in chronic HCV/HIV co-infection after HCV elimination is pivotal to avoid disease progression… More >

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