Francesco Triggiano^#, Giusy Diella^#, Mara Lorusso, Paolo Veneziani^*, Marilena D’Ambrosio, Daniela Nesta, Luigi Santacroce^*

BIOCELL, Vol.49, No.2, pp. 199-220, 2025, DOI:10.32604/biocell.2025.059322 - 28 February 2025

Abstract The composition of the vaginal microbiota (VMB) influences the health of the female reproductive tract. Several studies have shown how the absence of lactobacilli causes an imbalance in the vaginal microbial community, favoring the development of infections. The present study aims to evaluate the relationship between the VMB and human papillomavirus (HPV) infection to clarify the role of the vaginal microbiota in the persistence and clearance of HPV. Many researchers have provided the scientific community with information on the composition of the microbiota and how it may also influence HPV infection and the development of… More >

Muhammad Imran^1,*, Brett McKinney¹, Azhar Iqbal Kashif Butt²

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1899-1931, 2025, DOI:10.32604/cmes.2024.059552 - 27 January 2025

Abstract The co-infection of corona and influenza viruses has emerged as a significant threat to global public health due to their shared modes of transmission and overlapping clinical symptoms. This article presents a novel mathematical model that addresses the dynamics of this co-infection by extending the SEIR (Susceptible-Exposed-Infectious-Recovered) framework to incorporate treatment and hospitalization compartments. The population is divided into eight compartments, with infectious individuals further categorized into influenza infectious, corona infectious, and co-infection cases. The proposed mathematical model is constrained to adhere to fundamental epidemiological properties, such as non-negativity and boundedness within a feasible region.… More >

Ghaliah Alhamzi¹, Badr Saad T. Alkahtani², Ravi Shanker Dubey³, Mati ur Rahman^4,5,*

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.1, pp. 609-633, 2025, DOI:10.32604/cmes.2024.056604 - 17 December 2024

Abstract This study directs the discussion of HIV disease with a novel kind of complex dynamical generalized and piecewise operator in the sense of classical and Atangana Baleanu (AB) derivatives having arbitrary order. The HIV infection model has a susceptible class, a recovered class, along with a case of infection divided into three sub-different levels or categories and the recovered class. The total time interval is converted into two, which are further investigated for ordinary and fractional order operators of the AB derivative, respectively. The proposed model is tested separately for unique solutions and existence on… More >

Shira Cohen Rubin^1,*, Nadav Zacks¹, Ori Wand², Ophir Freund³, Evgeni Gershman³, Anna Breslavsky², Rotem Givoli-Vilensky¹, Anat Tzurel Ferber², Natalya Bilenko^1,4, Amir Bar-Shai³

European Cytokine Network, Vol.35, No.1, pp. 13-19, 2024, DOI:10.1684/ecn.2024.0494

Abstract COVID-19 vaccination and acute infection result in cellular and humoral immune responses with various degrees of protection. While most studies have addressed the difference in humoral response between vaccination and acute infection, studies on the cellular response are scarce. We aimed to evaluate differences in immune response among vaccinated patients versus those who had recovered from COVID-19. Materials and Methods: This was a prospective study in a tertiary medical centre. The vaccinated group included health care workers, who had received a second dose of the BNT162b2 vaccine 30 days ago. The recovered group included adults… More >

Sarah Azari, Darcy Wolfman², Armine Smith³

Canadian Journal of Urology, Vol.31, No.2, pp. 11854-11857, 2024

Abstract The majority of solid testicular tumors are treated with orchiectomy given the high risk of malignancy. We present a case of a testicular mass in an adult patient in the setting of recent hand, foot, and mouth disease that was managed conservatively with serial ultrasounds. Even though cases of viral-associated testicular masses are rare, this differential diagnosis should be considered in patients with a new testicular mass in the setting of recent viral infection and negative tumor markers. For these patients, observation may be an option instead of immediate orchiectomy. More >

Qinghao Zhang¹, Yijie Yang¹, Jiong Wu¹, Hongru Li¹, Yuan Li¹, Zuran Li^2,*, Yongmei He^1,*

Phyton-International Journal of Experimental Botany, Vol.93, No.10, pp. 2613-2628, 2024, DOI:10.32604/phyton.2024.056014 - 30 October 2024

Abstract In the present study, an indoor potting experiment was conducted to study the effects of enhanced UV-B radiation and Magnaporthe oryzae on the growth, stomatal structure, photosynthesis, and endogenous hormone contents of a traditional rice cultivar Baijiaolaojing in the Yuanyang terraces of Yunnan Province. In addition, the relationships between these parameters and disease indices were analyzed. We aimed to clarify the response of the photosynthetic physiology of rice under the combined stress of UV-B radiation and M. oryzae. Compared with the M. oryzae infection treatment, all the treatments, including M. oryzae infection before (MBR), simultaneously with (MSR), and after… More >

KERAN JIA¹, YANHAO ZHANG¹, MENGYU JIANG², MENGGE CUI², JIA WANG², JIAJIA ZHANG², HUIHAI ZHAO², MENGYAN LI², HUA WANG², QUANMING ZOU^1,#,*, HAO ZENG^1,#,*

BIOCELL, Vol.48, No.9, pp. 1355-1368, 2024, DOI:10.32604/biocell.2024.051383 - 04 September 2024

Abstract Objective: Candida albicans is a common fungal pathogen that triggers complex host defense mechanisms, including coordinated innate and adaptive immune responses, to neutralize invading fungi effectively. Exploring the immune microenvironment has the potential to inform the development of therapeutic strategies for fungal infections. Methods: The study analyzed individual immune cell profiles in peripheral blood mononuclear cells from Candida albicans-infected mice and healthy control mice using single-cell transcriptomics, fluorescence quantitative PCR, and Western blotting. We investigated intergroup differences in the dynamics of immune cell subpopulation infiltration, pathway enrichment, and differentiation during Candida albicans infection. Results: Our findings indicate that infiltration… More >

Javaid Ali¹, Armando Ciancio², Kashif Ali Khan³, Nauman Raza^4,5, Haci Mehmet Baskonus^6,*, Muhammad Luqman¹, Zafar-Ullah Khan⁷

CMES-Computer Modeling in Engineering & Sciences, Vol.140, No.3, pp. 2275-2296, 2024, DOI:10.32604/cmes.2024.046923 - 08 July 2024

Abstract This study proposes a structure-preserving evolutionary framework to find a semi-analytical approximate solution for a nonlinear cervical cancer epidemic (CCE) model. The underlying CCE model lacks a closed-form exact solution. Numerical solutions obtained through traditional finite difference schemes do not ensure the preservation of the model’s necessary properties, such as positivity, boundedness, and feasibility. Therefore, the development of structure-preserving semi-analytical approaches is always necessary. This research introduces an intelligently supervised computational paradigm to solve the underlying CCE model’s physical properties by formulating an equivalent unconstrained optimization problem. Singularity-free safe Padé rational functions approximate the mathematical More >

Jiehao Ye, Wen Cheng, Xiaolong Liu, Wenyi Zhu, Xuan’ang Wu, Shigen Shen^*

CMC-Computers, Materials & Continua, Vol.79, No.2, pp. 2743-2769, 2024, DOI:10.32604/cmc.2024.049985 - 15 May 2024

Abstract The Internet of Things (IoT) has characteristics such as node mobility, node heterogeneity, link heterogeneity, and topology heterogeneity. In the face of the IoT characteristics and the explosive growth of IoT nodes, which brings about large-scale data processing requirements, edge computing architecture has become an emerging network architecture to support IoT applications due to its ability to provide powerful computing capabilities and good service functions. However, the defense mechanism of Edge Computing-enabled IoT Nodes (ECIoTNs) is still weak due to their limited resources, so that they are susceptible to malicious software spread, which can compromise… More >

YAO FANG^1,2,#, FEI XIA^1,#, FEIFEI TIAN³, LEI QU¹, FANG YANG¹, JUAN FANG^1,2, ZHENHONG HU^1,*, HAICHAO LIU^1,*

BIOCELL, Vol.48, No.4, pp. 613-621, 2024, DOI:10.32604/biocell.2024.031539 - 09 April 2024

Abstract Objective: In the realm of Class I pathogens, Burkholderia pseudomallei (BP) stands out for its propensity to induce severe pathogenicity. Investigating the intricate interactions between BP and host cells is imperative for comprehending the dynamics of BP infection and discerning biomarkers indicative of the host cell response process. Methods: mRNA extraction from BP-infected mouse macrophages constituted the initial step of our study. Employing gene expression arrays, the extracted RNA underwent conversion into digital signals. The percentile shift method facilitated data processing, with the identification of genes manifesting significant differences accomplished through the application of the t-test. Subsequently,… More >