Oncology Research Editorial Office

Oncology Research, Vol.33, No.7, pp. 1801-1802, 2025, DOI:10.32604/or.2025.068988 - 26 June 2025

Abstract This article has no abstract. More >

YA-LING YEH¹, YING-JAN WANG¹, SHOEI-YN LIN-SHIAU^2,3,*

Oncology Research, Vol.33, No.7, pp. 1781-1796, 2025, DOI:10.32604/or.2025.063717 - 26 June 2025

Abstract Background: The increasing incidence of cancers and infectious diseases worldwide presents a significant public health challenge that requires immediate intervention. Our strategy to tackle this issue involves the development of pharmaceutical formulations that combine phytopolyphenols (P), targeted drugs (T), and metal ions (M), collectively referred to as PTM regimens. The diverse pharmacological properties of PTM regimens are hypothesized to effectively reduce the risk factors associated with both cancers and infectious diseases. Methods: The effects of the pharmaceutical agents on the proliferation of cultured cancer cells and pathogens were assessed after 72 h and 48 h,… More >

LUIZ FERNANDO LOPES SILVA^1,#, JULIETE NATHALI SCHOLL^1,#, AUGUSTO FERREIRA WEBER¹, CAMILA KEHL DIAS¹, PAULINE RAFAELA PIZZATO², VINíCIUS PIERDONá LIMA¹, JEAN SÉVIGNY^3,4, ANA MARIA OLIVEIRA BATTASTINI¹, FABRÍCIO FIGUEIRÓ^1,2,*

Oncology Research, Vol.33, No.4, pp. 951-964, 2025, DOI:10.32604/or.2024.055508 - 19 March 2025

Abstract Objectives: Glioblastoma (GB) is a grade IV glial tumor characterized by high malignancy and dismal prognosis, primarily due to high recurrence rates and therapeutic resistance. The epidermal growth factor receptor (EGFR), a receptor tyrosine kinase (RTK), regulates signaling pathways, including cell growth, proliferation, survival, migration, and cell death. Many cancers utilize immune checkpoints (ICs) to attenuate immune responses. CD73 is an enzyme that functions as an IC by hydrolyzing AMP to adenosine, suppressing immune cells in the tumor microenvironment. However, the role of CD73 in resistance to EGFR inhibitors is poorly understood. This study aims… More >

YULIAN WANG¹, LIANLI ZHU¹, RONGHAO ZENG², YUNPING PU³, BAIJIAN CHEN³, YUWEI TAN³, MING HONG^2,*, WEIJIA WANG^1,2,*

Oncology Research, Vol.33, No.3, pp. 695-708, 2025, DOI:10.32604/or.2024.051746 - 28 February 2025

Abstract Background: The role of 1,25-dihydroxyvitamin D3 (1,25-(OH)₂D₃) in cancer prevention and treatment is an emerging topic of interest. However, its effects on the stemness of acute myeloid leukemia (AML) cells are poorly understood. Methods: The proliferation and differentiation of AML cells (HL60 and NB4) were investigated by the CCK-8 assay, immunocytochemical staining, and flow cytometry. The abilities of HL60 and NB4 cells to form spheres were examined by the cell sphere formation assay. In addition, the levels of stemness-associated markers (SOX2, Nanog, OCT4, and c-Myc) in HL60 and NB4 cells were measured by western blotting and… More >

HASSAN M. OTIFI^*

Oncology Research, Vol.33, No.1, pp. 235-243, 2025, DOI:10.32604/or.2024.055677 - 20 December 2024

Abstract Background: Gastric cancer (GC) remains a global health burden and is often characterized by heterogeneous molecular profiles and resistance to conventional therapies. The phosphoinositide 3-kinase and PI3K and Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathways play pivotal roles in GC progression, making them attractive targets for therapeutic interventions. Methods: This study applied a computational and molecular dynamics simulation approach to identify and characterize SBL-JP-0004 as a potential dual inhibitor of JAK2 and PI3KCD kinases. KATOIII and SNU-5 GC cells were used for in vitro evaluation. Results: SBL-JP-0004 exhibited a robust binding affinity for… More >

YAJUN CAO^1,2,3,#, SHUANG YIN^1,2,#, YIDAN FANG⁴, JIEXIAN ZHOU^3,*, YOUTAN LIU^1,2,*

BIOCELL, Vol.48, No.12, pp. 1773-1780, 2024, DOI:10.32604/biocell.2024.056374 - 30 December 2024

Abstract Background: De novo lipogenesis (DNL) is a critical event for the development of tumors, in the present work, we revealed the role of propofol in colorectal cancer (CRC) cell proliferation. Methods: Western blotting (WB), Real-time PCR, and luciferase combined with chromatin immunoprecipitation (ChIP) were used to identify the mechanism underlying propofol-modulated cell proliferation in CRC cells. Results: Herein, we showed that propofol suppressed cell proliferation, which was attributed to the inhibition of DNL characterized by reduced fatty acid synthase (FASN), acetyl-coA carboxylase alpha (ACCA), and stearoyl-coA desaturase-1 (SCD1) expression. Mechanically, propofol stimulation decreased sterol regulatory element-binding proteins-1c (SREBP-1c) More >

Xiayun Zhao^1,*, Yue Zhang¹, Heyang Zhang¹, Yousra Bensouda¹, Md Jahangir Alam¹, Haolin Zhang¹, Yiquan Wang¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.2, pp. 1-2, 2024, DOI:10.32604/icces.2024.011485

Abstract Vat photopolymerization (VPP) among other additive manufacturing (AM) processes have a great potential to rapidly print complex 3D components out of a matrix of photo-curable resin. Current VPP processes utilize single-wavelength light exposure, imposing limitations on print speed and throughput, especially in multi-material AM. This is attributed to delays in material switch-over mechanisms. Additionally, the resolution of conventional single-wavelength VPP is constrained by over-curing. Despite ongoing efforts and progress in VPP, there remains a need for effective approaches to address these persistent issues. In this work, we report our development of two-wavelength digital light processing-based… More >

YUAN YIN¹, ZHENGYIN WANG¹, YUJIE HU¹, JIA WANG¹, YI WANG^2,*, QUN LU^1,*

Oncology Research, Vol.32, No.12, pp. 1881-1890, 2024, DOI:10.32604/or.2024.048007 - 13 November 2024

Abstract Background: Caffeic acid (CA) is considered a promising phytochemical that has inhibited numerous cancer cell proliferation. Therefore, it is gaining increasing attention due to its safe and pharmacological applications. In this study, we investigated the role of CA in inhibiting the Interleukin-6 (IL-6)/Janus kinase (JAK)/Signal transducer and activator of transcription-3 (STAT-3) mediated suppression of the proliferation signaling in human prostate cancer cells. Materials and Methods: The role of CA in proliferation and colony formation abilities was studied using 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay and colony formation assays. Tumour cell death and cell cycle arrest were… More >

ZHIGUO WANG^1,2,#, KUNLIN LI^2,#, CONGHUA LU², MINGXIA FENG², CAIYU LIN², GUOFANG YIN¹, DAN LUO¹, WENYI LIU³, KAIYU JIN⁴, YUANYAO DOU², DI WU², JIE ZHENG², KEJUN ZHANG⁵, LI LI^2,*, XIANMING FAN^1,*

Oncology Research, Vol.32, No.10, pp. 1637-1648, 2024, DOI:10.32604/or.2024.052664 - 18 September 2024

Abstract Background: Metformin has pleiotropic effects beyond glucose reduction, including tumor inhibition and immune regulation. It enhanced the anti-tumor effects of programmed cell death protein 1 (PD-1) inhibitors in serine/threonine kinase 11 (STK11) mutant non-small cell lung cancer (NSCLC) through an axis inhibition protein 1 (AXIN1)-dependent manner. However, the alterations of tumor metabolism and metabolites upon metformin administration remain unclear. Methods: We performed untargeted metabolomics using liquid chromatography (LC)-mass spectrometry (MS)/MS system and conducted cell experiments to verify the results of bioinformatics analysis. Results: According to the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway database, most… More > Graphic Abstract

Feiyu Yan^1,2, Xin Chen¹, Zhenzhen Wang¹, Yuxuan Xia¹, Dehui Zheng¹, Sirui Xue¹, Hongliang Zhao^1,2, Zhiwei Huang^1,2, Yuan Niu^1,2, Guoliang Zhang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1421-1440, 2024, DOI:10.32604/phyton.2024.053914 - 30 July 2024

Abstract Melatonin and abscisic acid, as major plant hormones, play important roles in the physiological and biochemical activities of crops, but the interaction between the two under salt stress is not yet clear. This study investigated the endogenous levels of melatonin and abscisic acid in rice by using exogenous melatonin, abscisic acid, and their synthetic inhibitors, and examined their interactions under salt stress. The research results indicate that melatonin and abscisic acid can improve rice salt tolerance. Melatonin alleviated the salt sensitivity caused by abscisic acid deficiency, increased antioxidant enzyme activity and antioxidant content in rice More >