Eun-Jeong Jeong^1,2,#, Yeon Soo Kim^2,#, Yujin Lee³, Jae-Sung Ryu⁴, Yung Hyun Choi^5,6, Eunjeong Kim^3,7,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078376 - 21 May 2026

Abstract Objective: The systematic evaluation of expansive genomic databases facilitates the discovery of clinically vital biomarkers. While Sideroflexin 3 (SFXN3) consistently displays elevated expression in head and neck squamous cell carcinoma (HNSCC), its specific pathobiological functions and prognostic value remain insufficiently characterized. This study aims to delineate the clinical and functional significance of SFXN3 in HNSCC. Methods: We interrogated SFXN3 expression patterns, patient survival outcomes, and immune cell infiltration characteristics utilizing multiple independent repositories, including the cancer genome atlas (TCGA) and gene expression omnibus (GEO). The prognostic independence of SFXN3 was verified via multivariate Cox regression. These… More > Graphic Abstract

Wei Jiang¹, You Zheng¹, Zhouhong Jing², Xiangling Yu¹, Huiying Fang^2,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078278 - 21 May 2026

Abstract Background: Breast cancer treatment is often hampered by the immunosuppressive tumor microenvironment (TME). To improve therapeutic efficacy, this study developed a folic acid-chitosan (FA-CS)-modified liposomal formulation co-delivering doxorubicin (DOX) and resiquimod (R848) for combined chemotherapy and immune modulation. Methods: The FA-CS-R848/DOX@Lip liposomes were prepared by rotary evaporation and characterized for morphology, particle size, zeta potential, drug encapsulation efficiency (EE), drug loading (DL) capacity, and drug release profiles. Cellular uptake and cytotoxicity were determined to assess the biological effects of the formulation. Antitumor efficacy and biosafety were assessed in an EO771 tumor-bearing mouse model. The macrophage phenotype,… More >

Pei-Yu Kao¹, Jie-Hong Chen², Kuo-Hu Chen^1,3,*

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.078219 - 21 May 2026

Abstract Cervical cancer remains a major global health challenge despite advances in human papillomavirus (HPV) vaccination, screening, and treatment. Persistent infection with high-risk HPV types, particularly HPV16 and HPV18, is a necessary cause of cervical cancer; however, only a small fraction of infections progress to malignancy, indicating the importance of additional cofactors. Increasing evidence identifies estrogen signaling as a critical modifier of HPV-driven carcinogenesis. Estrogen acts synergistically with HPV oncogenes E6 and E7 to promote genomic instability, immune evasion, and tumor progression, largely through effects on the tumor microenvironment (TME). This review aims to clarify and… More >

Elena Matei^1,*, Ionuț Ciprian Iorga^2,3, Mariana Deacu^2,4, Georgeta Camelia Cozaru^1,4, Gabriela Isabela Băltățescu^1,4,#, Manuela Enciu^2,4,#

Oncology Research, Vol.34, No.6, 2026, DOI:10.32604/or.2026.072421 - 21 May 2026

Abstract Objectives: Deregulated plasticity is involved in initiation, progression, metastasis, and resistance to therapy of various cancers. Our study aimed to present new checkpoints involved in complex biological processes that sustain epithelial-mesenchymal transition (EMT) variability and heterogeneity in prostate tumor cell plasticity. Methods: Dysregulated cell signaling pathways involved in prostate EMT heterogeneity were analyzed by intrinsic and extrinsic factors such as cell cycle phases by propidium iodide (PI) stain, apoptosis by caspase-3/7 biochemical cascade DEVDase enzyme activity by Magic Red stain (DEVD-MR)/propidium iodide stain, autophagy and nuclear shrinkage by Hoechst/acridine orange stain, evasion of immune surveillance by… More >

Feng-Cheng Lin^*, Bo-Chiao Jan, Hui-An Wu

CMC-Computers, Materials & Continua, Vol.88, No.1, 2026, DOI:10.32604/cmc.2026.079393 - 08 May 2026

Abstract With the increasing refinement of ornamental fish culture, understanding fish behavioral patterns has become critical. Fish movements not only reflect daily activity ranges but also reveal responses to environmental changes such as water currents and obstacles. However, traditional manual observation is limited by manpower and time, making it difficult to record fish behaviors over long periods stably. Existing automated tracking techniques often suffer from ID switches and track interruptions caused by rapid fish movement, occlusions, or intermingling, which in turn degrade the reliability of subsequent analyses. This paper proposes a deep learning-based multi-object fish tracking… More >

Pablo Luna^1,*, Lidia Losada², Débora Rodrigo-Ruiz³, Alba Rodríguez-Donaire¹, Javier Cejudo¹

International Journal of Mental Health Promotion, Vol.28, No.4, 2026, DOI:10.32604/ijmhp.2026.078092 - 28 April 2026

Abstract Objectives: There is a growing global concern regarding mental health and well-being in educational settings, especially in contexts of socio-educational exclusion. Active educational interventions offer an effective approach to enhance students’ mental health and personal and social well-being. This study aimed to evaluate the effects of a psychosocial intervention program based on the Sports Education model (SEM) on subjective well-being (positive and negative affect) and externalizing problems (aggressiveness, hyperactivity, and behavioral problems) in youth students from a highly vulnerable socio-cultural community belonging to an ethnic minority with significant socio-educational support needs associated with socio-educational exclusion. Methods:… More >

Zhengliang Zhang¹, Shijian Wu², Xinna Tang³, Haowen Wu^3,*

International Journal of Mental Health Promotion, Vol.28, No.4, 2026, DOI:10.32604/ijmhp.2025.071999 - 28 April 2026

Abstract Objectives: Amid accelerating urbanization, digitalization, and population aging, mental health issues have become increasingly salient among urban community residents. This study aims to examine how community environmental governance influences mental health (MH) by conceptualizing the community environment as comprising social capital (SC) and environmental perception (EP). Aging anxiety (AA) and digital usage tendency (DUT) are introduced as psychosocial background variables to analyze MH pathways under multifactor influences. Methods: Using data from the 2021 Chinese General Social Survey (CGSS), this study constructed a structural equation model (SEM) based on 362 urban residents from the Yangtze River Delta.… More >

Lihua Xu^1,2, Jinmei Liu³, Yan Wang⁴, Wenfu Li^3,*

Journal of Psychology in Africa, Vol.36, No.2, pp. 239-248, 2026, DOI:10.32604/jpa.2026.078257 - 29 April 2026

Abstract This study investigated the association between helicopter parenting and malevolent creativity among college students, and the serial mediating roles of family environment and moral identity. The study sample comprised 489 Chinese college students (females = 56.2%, 18–23 years old = 87.1%). The students completed self-report measures assessing helicopter parenting, family environment, moral identity, and malevolent creativity. The results of serial mediation model showed that helicopter parenting was significantly associated with higher malevolent creativity. Moreover, family environment and moral identity sequentially mediated this relationship. Specifically, helicopter parenting may contribute to a negative family environment and undermine More >

Saddam Husain Dhobi^1,2,*, Kishori Yadav², Suresh Prasad Gupta^2,*, Jeevan Jyoti Nakarmi¹, Ajay Kumar Jha³

Energy Engineering, Vol.123, No.5, 2026, DOI:10.32604/ee.2026.076691 - 27 April 2026

Abstract Increasing requirements on clean, efficient, and sustainable energy technologies have raised interest in hydrogen fuel cells, particularly proton exchange membrane fuel cells (PEMFCs), which are operationally characterized by high efficiency with zero emissions. The objective of this work is to study the scattering behaviors of particles participating in scattering under various conditions (energy, efficiency, temperature, cell voltage) at/around the electrode of PEMFC theoretically. For this, we developed a model using a scattering matrix, the Kroll-Watson approximation, the thermal wave function of an electron in a laser field, interaction potential, and Bessel functions to study the… More > Graphic Abstract

Ju He^1,#, Peiwen Zhao^2,#, Dongyang Han³, Kexin Lv², Jiuping Rao^3,*, Xinqiang Ye⁴, Guodong Ruan⁴, Fei Guo³, Mizi Fan^3,*, Weigang Zhao^3,*

Journal of Renewable Materials, Vol.14, No.4, 2026, DOI:10.32604/jrm.2026.02026-0012 - 24 April 2026

Abstract This study presents a systematic evaluation of bamboo-derived activated carbons (ACs) prepared using three alkaline activating agents-KOH, KHCO₃, and K₂CO₃-for efficient formaldehyde adsorption. The pore structures of the resulting ACs were modulated by varying the alkali-to-carbon (A/C) ratio from 1:1 to 4:1, and the effects on microstructure and adsorption performance were thoroughly investigated. Among all samples, AC-MB@KOH(3) demonstrated superior performance, featuring a high specific surface area of 2141.77 m²/g and a removal efficiency of 90%, attributed to its rich microporous texture and well-developed hierarchical porosity. Comparative analysis revealed that the activation strength and decomposition behavior of different More > Graphic Abstract