HAISU LIANG1,2,#, WEI YAN3,#, ZHI LIU1,4, YUNBO HE1,2,5, JIAO HU1, ZHIWEI SHU1, HUIHUANG LI1, BELAYDI OTHMANE1, WENBIAO REN1,6, CHAO QUAN1, DONGXU QIU1, MINFENG CHEN1, WEI XIONG5, BINGNAN ZHANG1,*, PEIHUA LIU1,2,*
Oncology Research, Vol.33, No.5, pp. 1105-1119, 2025, DOI:10.32604/or.2024.054623
- 18 April 2025
Abstract Circular RNAs (circRNAs) are a type of non coding RNA that possess unique single stranded circular structures formed through reverse splicing mechanisms. Due to the lack of a free end that is typically susceptible to degradation by nucleases, circular RNAs exhibit resistance to ribonuclease R, making them highly stable in eukaryotic cells. The complex relationship between circRNA dysregulation and various pathophysiological conditions, especially cancer. Tumor microenvironment (TME) is a collective term for various components surrounding tumors and is an important factor affecting tumor development. Simultaneous infiltration of TME by different types of immune cells; These… More >