Joong-Hyun Park¹, Jiho Choi², Libor Mesicek³, Hoon Ko^2,*

CMC-Computers, Materials & Continua, Vol.88, No.3, 2026, DOI:10.32604/cmc.2026.084659 - 23 July 2026

Abstract With the rapid expansion of the Internet of Medical Things (IoMT), the importance of digital identity–based security has significantly increased. However, conventional static authentication mechanisms are insufficient to effectively address various identity misuse and abuse attacks. In this study, we model digital identity as a dynamic security entity and propose an AI-based framework that integrates a risk scoring model—combining unsupervised anomaly detection with context-aware analysis—and a multi-level risk-adaptive access control mechanism (Permit, Step-Up, Restrict). Experimental results using an extended version of the CERT Insider Threat Dataset tailored for IoMT environments provide proof-of-concept evidence that the More >

Kuldashbay Avazov¹, Kudratjon Zohirov², Alpamis Kutlimuratov³, Charos Khidirova⁴, Jasur Sevinov^5,6, Urishev Omadjon⁷, Adilbek Dauletov⁸, Akmalbek Abdusalomov^4,5,9, Young Im Cho^1,*

CMC-Computers, Materials & Continua, Vol.88, No.3, 2026, DOI:10.32604/cmc.2026.083828 - 23 July 2026

Abstract Unmanned aerial vehicles (UAVs) are becoming a common solution to urban mobility, and traffic monitoring as well, owing to their ability to be deployed flexibly, ability to see a broader area and real-time sensing. However, the reliability of UAV-assisted traffic systems can be compromised through identity spoofing, Sybil attacks, false data injection, and trajectory manipulation. Current authentication techniques primarily verify cryptographic identities but often cannot detect when a claimed identity is inconsistent with physical movement patterns and settings. To overcome this drawback, this paper presents a context-aware identity validation system, CIV-UAV, for UAV-based urban traffic… More >

Xianhui Fan¹, Zongwei Li^1,*, Yuxuan Zhai¹, Zhenyu Li²

CMC-Computers, Materials & Continua, Vol.88, No.3, 2026, DOI:10.32604/cmc.2026.083491 - 23 July 2026

Abstract Single-wave order picking in dynamic warehouses is a sequential multi-goal navigation problem. A robot must visit an ordered set of shelves and then a delivery station while avoiding moving obstacles under partial observability. Existing approaches either entangle long-horizon task logic with low-level obstacle avoidance or rely on static-environment assumptions that limit responsiveness in dynamic settings. This paper proposes the Single-Wave Dynamic Warehouse Navigation System (SW-DWNS), a lightweight scheduling framework that extends a pretrained ColorDynamic point-to-point local planner to ordered warehouse picking without retraining. The scheduler maintains a shelf queue, exposes only the active subgoal to… More >

Ganxin Wang¹, Zhongan Liu¹, Tian Zhou², Boting Yang^1,3,4, Jiaqin Chen^1,3,4, Jing Chen², Kai Huang⁵, Yunqing Xu⁵, Quan Tang⁶, Xiangqian Yin⁵, Guangqin Xiao^1,*, Sijia Zhang^1,3,4,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.083840 - 16 July 2026

Abstract Objectives: Ferroptosis resistance may contribute to tumor progression and immune escape. This study evaluated the prognostic and immunological significance of glutathione peroxidase 4 (GPX4), a core ferroptosis-suppressive enzyme, in surgically resected lung adenocarcinoma. Methods: We retrospectively analyzed 104 patients with primary lung adenocarcinoma who underwent curative resection. GPX4 protein expression was assessed by immunohistochemistry (IHC) using the histological score (H-score), and patients were classified as GPX4-low (n = 54) or GPX4-high (n = 50). Intratumoral immune contexture was quantified using CD3, CD4, CD8, CD68, programmed cell death protein 1 (PD-1), and programmed death-ligand 1 (PD-L1) staining.… More > Graphic Abstract

Hui Zhou^1,2, Jiarui Wang³, Zhili Qiao⁴, Xin Liao^1,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.082613 - 16 July 2026

Abstract Objectives: Uncoupling protein 2 (UCP2) has been extensively studied as a metabolic regulator in glioma; however, its relationship with the tumour immune microenvironment and the cellular source of its expression within the glioma tumour microenvironment (TME) remains poorly understood. This study aimed to characterise UCP2 expression at single-cell resolution and evaluate its immunological significance in glioma. Methods: This study employed an integrative multi-omics approach incorporating bulk transcriptomics, scRNA-seq (GSE70630, GSE84465, and GSE89567; n = 13,216 cells), immune deconvolution, immunohistochemistry (n = 96 glioma patients), and immunofluorescence co-staining (n = 6). Results: Pan-cancer analysis confirmed UCP2… More >

Zixin Wan^1,2,#, Jingdan Quan^1,2,#, Yue Qiu^1,2, Zhiwei Zhang^1,2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.082561 - 16 July 2026

Abstract Gastric cancer (GC) is one of the malignant tumors with high incidence and mortality worldwide. It has concealed early symptoms, poor prognosis for advanced patients, and limited efficacy of conventional treatments. Metabolic reprogramming is a core hallmark of cancer, among which amino acid metabolic reprogramming plays a critical regulatory role in the initiation and progression of GC. By linking intracellular energy supply, biosynthetic demands, and tumor microenvironment remodeling, it participates in immune escape, redox homeostasis maintenance, and therapeutic resistance. Dysregulation of key amino acids, including arginine, tryptophan, glutamine, branched-chain amino acids, serine/glycine, and aspartic acid,… More >

Liu Liu^1,2, Jie Liu^1,2, Shuangchen Ning³, Jin Wang³, Yingchun He^1,2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.081869 - 16 July 2026

Abstract Objectives: Nasopharyngeal carcinoma (NPC) is an aggressive head and neck malignancy in which post-treatment recurrence and distant metastasis remain major contributors to poor clinical outcomes. Although microRNAs are important post-transcriptional regulators of tumor progression, the role of miR-320d in NPC remains incompletely understood. This study evaluated the biological role of miR-320d and explored whether it is involved in regulating neutrophil extracellular trap (NET) formation through the nuclear factor kappa-B (NF-κB)/interleukin-8 (IL-8) signaling axis. Methods: miR-320d was overexpressed in NPC cell lines S18 and 5-8F, and cell viability, migration, and invasion were evaluated. Integrated transcriptomic and proteomic… More >

Shijia Lu^1,#, Yanmin Wang^1,#, Han Zhang¹, Mengjia Yan¹, Mengdan Sang², Jinle Wang¹, Huaying Du³, Jinwen Sima³, Yiran Zhen², Xue Yang², Yutong Zhang¹, Hongwei Zhou^1,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.079988 - 16 July 2026

Abstract Proliferating Cell Nuclear Antigen (PCNA) is a core protein in DNA replication and repair. Its functional dysregulation drives tumorigenesis and therapeutic resistance, making it a critical anticancer target. However, the fundamental conflict between PCNA’s indispensable “guardian” function in normal cells and its hijacked “accomplice” role in cancer cells constitutes the central challenge for targeted intervention: how to eradicate tumors while avoiding severe toxicity to normal tissues. This review aims to systematically review the latest advances and translational dilemmas in the field of PCNA-targeted therapy. It outlines various intervention strategies, including small-molecule inhibitors, proteolysis-targeting chimeras, post-translational More > Graphic Abstract

Yaqi Xu¹, Jia Zhao², Xiaowen Mao^1,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.079562 - 16 July 2026

Abstract Extracellular vesicles (EVs) are actively secreted, membrane-enclosed nanoparticles that serve as pivotal mediators of intercellular communication. They function as key mediators of intercellular communication by transporting diverse biomolecules, including proteins, nucleic acids, and metabolites. Within the tumor microenvironment, EVs drive complex cellular crosstalk and critically regulate tumor progression by remodeling the extracellular matrix, conferring drug resistance, and reprogramming immune responses. Given their natural biocompatibility, tissue tropism, and ability to cross biological barriers, EVs have emerged as promising platforms for immunotherapy, tumor vaccines and targeted drug delivery system. Moreover, the rapid expansion of EV-based clinical trials… More > Graphic Abstract

Yiming Ma^1,2,#, Zhihan Zhang^1,2,#, Hongli Pan³, Hailin Jiang^1,2, Lili Guo^4,*, Fengjie Guo^1,2,*

Oncology Research, Vol.34, No.8, 2026, DOI:10.32604/or.2026.079515 - 16 July 2026

Abstract Objectives: Lung adenocarcinoma (LUAD) has a poor prognosis, and effective metabolic biomarkers are still few. Glutamine metabolism is one of the central features of tumor metabolic reprogramming, but the cellular heterogeneity and clinical significance of glutamine metabolism in the LUAD tumor microenvironment (TME) remain unknown. The goal of this paper was to define glutamine metabolism on a single-cell basis and determine major regulators that have predictive value. Methods: A single-cell RNA sequencing dataset (GSE149655) was combined with The Cancer Genome Atlas Lung Adenocarcinoma (TCGA-LUAD) and Gene Expression Omnibus (GEO) datasets in order to evaluate the… More >