LIWEN FENG^1,2,#,*, YUTING CHEN^3,#, WENYI JIN⁴

Oncology Research, Vol.33, No.5, pp. 1091-1103, 2025, DOI:10.32604/or.2024.054207 - 18 April 2025

Abstract Osteosarcoma (OS) is a prevalent primary bone malignancy with limited treatment options. Therefore, it is imperative to investigate and understand the mechanisms underlying OS pathogenesis. Cancer-associated fibroblasts (CAFs) are markedly abundant in tumor stromal cells and are essentially involved in the modulation of tumor occurrence and development. In recent years, CAFs have become a hotspot as researchers aim to elucidate CAF mechanisms that regulate tumor progression. However, most studies on CAFs are limited to a few common cancers, and their association with OS remains elusive. This review describes the role and current knowledge of CAFs More >

Ilesanmi Afolabi Daniyan^1,*, Rumbidzai Muvunzi², Festus Fameso³, Julius Ndambuki³, Williams Kupolati³, Jacques Snyman³

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 1623-1648, 2025, DOI:10.32604/cmc.2025.062092 - 16 April 2025

Abstract This study evaluates the Fuzzy Analytical Hierarchy Process (FAHP) as a multi-criteria decision (MCD) support tool for selecting appropriate additive manufacturing (AM) techniques that align with cleaner production and environmental sustainability. The FAHP model was validated using an example of the production of aircraft components (specifically fuselage) employing AM technologies such as Wire Arc Additive Manufacturing (WAAM), laser powder bed fusion (L-PBF), Binder Jetting (BJ), Selective Laser Sintering (SLS), and Laser Metal Deposition (LMD). The selection criteria prioritized eco-friendly manufacturing considerations, including the quality and properties of the final product (e.g., surface finish, high strength,… More >

Lieping Zhang^1,2, Hao Ma¹, Jiancheng Huang³, Cui Zhang^4,*, Xiaolin Gao²

CMC-Computers, Materials & Continua, Vol.83, No.2, pp. 2245-2265, 2025, DOI:10.32604/cmc.2025.061519 - 16 April 2025

Abstract Detecting individuals wearing safety helmets in complex environments faces several challenges. These factors include limited detection accuracy and frequent missed or false detections. Additionally, existing algorithms often have excessive parameter counts, complex network structures, and high computational demands. These challenges make it difficult to deploy such models efficiently on resource-constrained devices like embedded systems. Aiming at this problem, this research proposes an optimized and lightweight solution called FGP-YOLOv8, an improved version of YOLOv8n. The YOLOv8 backbone network is replaced with the FasterNet model to reduce parameters and computational demands while local convolution layers are added.… More >

Sheng Dong^*, Feihu Fan, Yinuo Chen, Shangpeng Guo, Jiayu Liu

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 1-50, 2025, DOI:10.32604/cmes.2025.062113 - 11 April 2025

Abstract Legged robots have always been a focal point of research for scholars domestically and internationally. Compared to other types of robots, quadruped robots exhibit superior balance and stability, enabling them to adapt effectively to diverse environments and traverse rugged terrains. This makes them well-suited for applications such as search and rescue, exploration, and transportation, with strong environmental adaptability, high flexibility, and broad application prospects. This paper discusses the current state of research on quadruped robots in terms of development status, gait trajectory planning methods, motion control strategies, reinforcement learning applications, and control algorithm integration. It More >

Chen Lin^1,*, Zidan Zhang¹, Zhao Zhang¹, Yuxiang Long¹, Xuwen Shen¹, Jinghao Zhang¹, Youping Wang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 583-601, 2025, DOI:10.32604/phyton.2025.063086 - 31 March 2025

Abstract Glutathione S-transferases (GSTs) represent a large and diverse enzyme family ubiquitously distributed across the plant kingdom. These proteins catalyze the conjugation of glutathione (GSH) with electrophilic substrates in response to various stress conditions. Beyond their role in stress adaptation, certain GSTs are integral regulators of plant growth and development, contributing to a range of physiological processes. Most GST proteins exhibit dual enzymatic activities, functioning as both transferases and peroxidases, which enables their involvement in diverse cellular processes, including detoxification and stress responses. Recent advancements, particularly in X-ray crystallography, have enabled detailed structural analysis of GST More >

Surajudeen Sikiru^1,*, Yusuf Olanrewaju Busari^2,3, John Oluwadamilola Olutoki⁴, Mohd Muzamir Mahat¹, Sanusi Yekinni Kolawole⁵

Journal of Polymer Materials, Vol.42, No.1, pp. 1-31, 2025, DOI:10.32604/jpm.2025.058936 - 27 March 2025

Abstract Photocatalysis is a crucial technique for environmental cleanup and renewable energy generation. Polymer-based photocatalysts have attracted interest due to their adaptability, adjustable chemical characteristics, and enhanced light absorption efficiency. Unlike traditional inorganic photocatalysts, we can optimize polymeric systems to enhance photocatalytic efficiency and yield significant advantages in environmental remediation and energy conversion applications. This study talks about the latest developments in polymer-based photocatalysts and how important they are for cleaning water, breaking down pollutants, and making renewable energy through processes like hydrogen production and CO₂ reduction. These materials are proficient in degrading harmful pollutants such as… More >

Hafiz Zain Ul Aabidin¹, Muhammad Inam Ul Hassan², Tariq Yasin², Muhammad Zubair Rahim¹, Asif Raza^1,*

Journal of Polymer Materials, Vol.42, No.1, pp. 141-150, 2025, DOI:10.32604/jpm.2024.057423 - 27 March 2025

Abstract Geological samples often contain significant amounts of iron, which, although not typically the target element, can substantially interfere with the analysis of other elements of interest. To mitigate these interferences, amidoxime-based radiation grafted adsorbents have been identified as effective for iron removal. In this study, an amidoxime-functionalized, radiation-grafted adsorbent synthesized from polypropylene waste (PPw-g-AO-10) was employed to remove iron from leached geological samples. The adsorption process was systematically optimized by investigating the effects of pH, contact time, adsorbent dosage, and initial ferric ion concentration. Under optimal conditions—pH 1.4, a contact time of 90 min, and More >

Zhaohui An, Changyong Li^*, Yong Han, Mengru Niu

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1347-1366, 2025, DOI:10.32604/cmc.2025.059037 - 26 March 2025

Abstract This paper introduces an Improved Bidirectional Jump Point Search (I-BJPS) algorithm to address the challenges of the traditional Jump Point Search (JPS) in mobile robot path planning. These challenges include excessive node expansions, frequent path inflexion points, slower search times, and a high number of jump points in complex environments with large areas and dense obstacles. Firstly, we improve the heuristic functions in both forward and reverse directions to minimize expansion nodes and search time. We also introduce a node optimization strategy to reduce non-essential nodes so that the path length is optimized. Secondly, we… More >

SHUANG ZHAO^1,#, HONGYONG WEN^2,#, BAIQI WANG², QINGLIN XIONG¹, LANXIN LI¹, AILAN CHENG^1,*

Oncology Research, Vol.33, No.4, pp. 795-810, 2025, DOI:10.32604/or.2025.057317 - 19 March 2025

Abstract Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. A growing number of researches have demonstrated that p53 can influence tumor progression through the tumor microenvironment (TME). TME is involved in the process of tumor development and metastasis and affects the clinical prognosis of patients. p53 participates in host immunity and engages in the immune landscape of the TME, but the specific mechanisms remain to be investigated. This review briefly explores the More >

CHRISTINA LOH¹, YUQI ZHENG¹, ISLAM ALZOUBI², KIMBERLEY L. ALEXANDER^3,4, MAGGIE LEE⁴, WEI-DONG CAI², YANG SONG⁵, KERRIE MCDONALD⁶, ANNA K. NOWAK⁷, RICHARD B. BANATI^8,9, MANUEL B. GRAEBER^1,4,10,*

Oncology Research, Vol.33, No.4, pp. 937-950, 2025, DOI:10.32604/or.2024.056436 - 19 March 2025

Abstract Background: Microglia and brain macrophages contribute significantly to the tumor microenvironment in highly malignant glioblastoma where they are considered important drivers of tumor progression. A better understanding of the role of the brain macrophages present in glioblastoma appears crucial for improving therapeutic outcomes, especially in the context of novel immunotherapeutic approaches. Methods: We investigated the regulation of two well-established markers for microglia and brain macrophages, IBA1 and CD163, in relation to glioblastoma tumor necrosis using immunohistochemistry and modality fusion heatmaps of whole slide images obtained from adjacent tissue sections. Results: IBA1 and CD163 showed remarkable differences… More >