RENLONG ZHOU^1,2,#, SHUANG LI^3,#, XILIN XIAO^1,*

BIOCELL, Vol.47, No.11, pp. 2397-2408, 2023, DOI:10.32604/biocell.2023.030281

Abstract Background: In many cancer types, aryl hydrocarbon receptor nuclear translocator 2 (ARNT2) has been found to be associated with tumor cell proliferation and prognosis. However, the role of ARNT2 in clear cell renal cell carcinoma (ccRCC) has not been completely elucidated. In this study, the potential role of ARNT2 in ccRCC development was characterized. Methods: A pan-cancer dataset (TCGA-TARGET-GTEx) was accessed from UCSC Xena Data Browser. ARNT2 expression in normal and tumor samples was compared. Univariate Cox regression was performed to evaluate the prognostic value of ARNT2. Single sample gene set enrichment analysis (ssGSEA) was used to estimate the enrichment… More >

HAOSHENG ZHENG^1,#, RUIJUN LIN^2,#, WEIJIE CAI¹, YUZHEN ZHENG¹, XINGPING YANG¹, ZUI LIU¹, FEI QIN¹, YONGJIE CAI³, XIANYU QIN^1,*, HONGYING LIAO^1,*

BIOCELL, Vol.47, No.11, pp. 2453-2469, 2023, DOI:10.32604/biocell.2023.030032

Abstract Introduction: The difficulty in treating lung adenocarcinoma (LUAD) is caused by a shortage of knowledge about the biological mechanisms and a lack of treatment choices. Objectives: The aim of this study was to identify a valuable molecular target for the treatment of LUAD. Methods: Using multiple databases, we screened for hub genes in LUAD using Cytoscape and explored the expression and prognosis of DLG associated protein 5 (DLGAP5) in LUAD. We investigated the genetic variation, functional enrichment, and epigenetic activity of DLGAP5. Furthermore, we evaluated the relationship between the tumor microenvironment (TME) and DLGAP5. Results: Our study identified 10 hub… More > Graphic Abstract

Jacob Thottathil Varghese^a,*, Sat Ghosh^a,b

Frontiers in Heat and Mass Transfer, Vol.7, pp. 1-7, 2016, DOI:10.5098/hmt.7.34

Abstract Nature has its own astonishing capabilities to cleanse polluted environment. Living green drapes on buildings look elegant providing sustainable solutions in congested metropolises. VIT University promotes green values within the country. The walls of a subway connecting the main campus and hostel premises are draped with Vernonia elaeagnifolia, which was found to be efficient in capturing vehicular pollution. An experimental study established deposition patterns of pollutants. Thereafter, diffusive uptake modelling elucidated the mechanistic details of mass transport through the plant tissues. It is expected that the results of this paper will promote the use of green facades within built environment. More >

JINHUI LIU^1,*, JIAHENG XIE^2,*, PEIXIN DONG³

Oncology Research, Vol.32, No.1, pp. 99-100, 2024, DOI:10.32604/or.2023.045719

Abstract This article has no abstract. More >

GERWIN HELLER^1,*, THORSTEN FUEREDER¹, ALEXANDER MICHAEL GRANDITS¹, ROTRAUD WIESER^1,2,*

Oncology Research, Vol.32, No.1, pp. 1-17, 2024, DOI:10.32604/or.2023.044774

Abstract Head and neck squamous cell carcinoma (HNSCC) is one of the most frequent cancers worldwide. The main risk factors are consumption of tobacco products and alcohol, as well as infection with human papilloma virus. Approved therapeutic options comprise surgery, radiation, chemotherapy, targeted therapy through epidermal growth factor receptor inhibition, and immunotherapy, but outcome has remained unsatisfactory due to recurrence rates of ~50% and the frequent occurrence of second primaries. The availability of the human genome sequence at the beginning of the millennium heralded the omics era, in which rapid technological progress has advanced our knowledge of the molecular biology of… More >

HEE JU SONG, TAEHEE KIM, HAN NA CHOI, SOO JIN KIM, SANG DO LEE^*

Oncology Research, Vol.32, No.1, pp. 151-161, 2024, DOI:10.32604/or.2023.030690

Abstract Lung cancer has the highest mortality rate among all cancers, in part because it readily metastasizes. The tumor microenvironment, comprising blood vessels, fibroblasts, immune cells, and macrophages [including tumor-associated macrophages (TAMs)], is closely related to cancer cell growth, migration, and invasion. TAMs secrete several cytokines, including interleukin (IL)-1β, which participate in cancer migration and invasion. p21-activated kinase 1 (PAK1), an important signaling molecule, induces cell migration and invasion in several carcinomas. Tonicity-responsive enhancer-binding protein (TonEBP) is also known to participate in cancer cell growth, migration, and invasion. However, the mechanisms by which it increases lung cancer migration remain unclear. Therefore,… More > Graphic Abstract

QIUQIANG CHEN^1,*, XUEJUN GUO², WENXUE MA^3,*

Oncology Research, Vol.32, No.1, pp. 49-60, 2024, DOI:10.32604/or.2023.042383

Abstract Cancer immunotherapy has emerged as a promising strategy for the treatment of cancer, with the tumor microenvironment (TME) playing a pivotal role in modulating the immune response. CD47, a cell surface protein, has been identified as a crucial regulator of the TME and a potential therapeutic target for cancer therapy. However, the precise functions and implications of CD47 in the TME during immunotherapy for cancer patients remain incompletely understood. This comprehensive review aims to provide an overview of CD47’s multifaced role in TME regulation and immune evasion, elucidating its impact on various types of immunotherapy outcomes, including checkpoint inhibitors and… More > Graphic Abstract

Salma Khan¹, Muhammad Gulistan¹, Nasreen Kausar², Seifedine Kadry^3,4,5, Jungeun Kim^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1951-1979, 2024, DOI:10.32604/cmes.2023.030896

Abstract Tourism is a popular activity that allows individuals to escape their daily routines and explore new destinations for various reasons, including leisure, pleasure, or business. A recent study has proposed a unique mathematical concept called a q−Rung orthopair fuzzy hypersoft set (ROFHS) to enhance the formal representation of human thought processes and evaluate tourism carrying capacity. This approach can capture the imprecision and ambiguity often present in human perception. With the advanced mathematical tools in this field, the study has also incorporated the Einstein aggregation operator and score function into the ROFHS values to support multi-attribute decision-making algorithms. By implementing… More >

Mohamed Zarouan¹, Ibrahim M. Mehedi^1,2,*, Shaikh Abdul Latif³, Md. Masud Rana⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1341-1364, 2024, DOI:10.32604/cmes.2023.030037

Abstract Failure detection is an essential task in industrial systems for preventing costly downtime and ensuring the seamless operation of the system. Current industrial processes are getting smarter with the emergence of Industry 4.0. Specifically, various modernized industrial processes have been equipped with quite a few sensors to collect process-based data to find faults arising or prevailing in processes along with monitoring the status of processes. Fault diagnosis of rotating machines serves a main role in the engineering field and industrial production. Due to the disadvantages of existing fault, diagnosis approaches, which greatly depend on professional experience and human knowledge, intellectual… More >

Shibo Wu¹, Weidong Chen^1,*, Jingxin Ma², Lan Liu¹, Shengzhuo Lu¹, Honglin Meng¹, Xiquan Song³

CMES-Computer Modeling in Engineering & Sciences, Vol.138, No.2, pp. 1207-1236, 2024, DOI:10.32604/cmes.2023.029471

Abstract Launch safety of explosive charges has become an urgent problem to be solved by all countries in the world as launch situation of ammunition becomes consistently worse. However, the existing numerical models have different defects. This paper formulates an efficient computational model of the combustion of an explosive charge affected by a bottom gap in the launch environment in the context of the material point method. The current temperature is computed accurately from the heat balance equation, and different physical states of the explosive charges are considered through various equations of state. Microcracks in the explosive charges are described with… More > Graphic Abstract