GUANTING PANG^1,4,#, YAOHAN LI^2,4,#, QIWEN SHI³, JINGKUI TIAN⁴, HANMEI LOU^4,5,*, YUE FENG^4,5,*

Oncology Research, Vol.33, No.4, pp. 821-836, 2025, DOI:10.32604/or.2024.053772 - 19 March 2025

Abstract Immunotherapies have demonstrated notable clinical benefits in the treatment of cervical cancer (CC). However, the development of therapeutic resistance and diverse adverse effects in immunotherapy stem from complex interactions among biological processes and factors within the tumor immune microenvironment (TIME). Advanced omic technologies offer novel insights into a more expansive and thorough layer of the TIME. Furthermore, integrating multidimensional omics within the frameworks of systems biology and computational methodologies facilitates the generation of interpretable data outputs to characterize the clinical and biological trajectories of tumor behavior. In this review, we present advanced omics technologies that More >

JIYUN PANG^1,2,#, WEIGANG XIU^1,#, YUEYUN CHEN⁴, WENJING LIAO^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.33, No.4, pp. 895-904, 2025, DOI:10.32604/or.2024.053363 - 19 March 2025

Abstract Background: Non-small cell lung cancer (NSCLC) is often accompanied by brain metastasis (BM), and the prognosis of patients with BM is poor. This study assesses the prognostic impact of BM in NSCLC patients with epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively evaluated 692 advanced NSCLC patients with EGFR mutations treated with tyrosine kinase inhibitors (TKIs) at West China Hospital from 2015 to 2019. The overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), disease control rate (DCR), and clinical parameters of the BM and non-BM groups were compared. Univariable and multivariable… More >

Tarak Dhaouadi¹, Hichem Mrabet^1,2,*, Adeeb Alhomoud³, Abderrazak Jemai^1,4

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4535-4554, 2025, DOI:10.32604/cmc.2025.060935 - 06 March 2025

Abstract The increasing adoption of Industrial Internet of Things (IIoT) systems in smart manufacturing is leading to raise cyberattack numbers and pressing the requirement for intrusion detection systems (IDS) to be effective. However, existing datasets for IDS training often lack relevance to modern IIoT environments, limiting their applicability for research and development. To address the latter gap, this paper introduces the HiTar-2024 dataset specifically designed for IIoT systems. As a consequence, that can be used by an IDS to detect imminent threats. Likewise, HiTar-2024 was generated using the AREZZO simulator, which replicates realistic smart manufacturing scenarios.… More >

Arif Ullah¹, Siti Fatimah Abdul Razak^2,*, Sumendra Yogarayan², Md Shohel Sayeed²

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 5185-5204, 2025, DOI:10.32604/cmc.2025.059355 - 06 March 2025

Abstract Networking, storage, and hardware are just a few of the virtual computing resources that the infrastructure service model offers, depending on what the client needs. One essential aspect of cloud computing that improves resource allocation techniques is host load prediction. This difficulty means that hardware resource allocation in cloud computing still results in hosting initialization issues, which add several minutes to response times. To solve this issue and accurately predict cloud capacity, cloud data centers use prediction algorithms. This permits dynamic cloud scalability while maintaining superior service quality. For host prediction, we therefore present a… More >

Sally Negm¹, Badwy Mohdly², Motrih Al-Mutiry³, Wael Shehata⁴, Karima Ahmed⁵, Mohamed Abou-Zeid^2,*, Rana Elessawy⁶, Ashgan Abdel-Azim⁵, Amr Abdel-Fattah², Amani Omar Abuzaid⁷, Enas A. Almanzalawi⁷, Tahani M. Alqahtani⁷, Shouaa A. Alrobaish⁸, Diaa Abd El Moneim⁹, Ahmed M. Abbas^10,11, Mohammed O. Alshaharni¹⁰, Huda Alghamdi¹⁰, Shaimaa G. Salama¹², Kairy Amer⁵

Phyton-International Journal of Experimental Botany, Vol.94, No.2, pp. 347-377, 2025, DOI:10.32604/phyton.2025.057448 - 06 March 2025

Abstract Barley (Hordeum vulgare L.) is a significant global crop that thrives in various climatic and drought-stress conditions. Furthermore, increased drought intervals and more significant weather variability resulting from climate change can affect the severity of plant diseases. Therefore, two primary objectives of integrated disease management regarding climate change are identifying cultivars resistant to foliar diseases and understanding disease progression under abiotic stress. In the current study, we assessed the quantitative foliar disease resistance of 17 commercial barley cultivars under both normal and water stress conditions over two growing seasons (from 2020/21 to 2021/22). The findings demonstrated… More >

Fengbo Guo^1,2,3,#, Leru Zhong^1,#, Xingru Huang¹, Zewei Chen¹, Xiaoyuan Sun^1,3,*

International Journal of Mental Health Promotion, Vol.27, No.2, pp. 111-124, 2025, DOI:10.32604/ijmhp.2025.058874 - 03 March 2025

Abstract Background: Childhood environmental unpredictability (CEU) is crucial to personal development, profoundly influence physical and psychological growth particularly, and psychopathy is recognized as a dark personality trait. The aim of this study is to investigate the effects of insecure attachment and life history strategy (LHS) on the relationship between CEU and psychopathy by establishing a sequential mediation model based on evolutionary life history theory and cognitive-affective personality system. Methods: A group of 532 undergraduates completed the measurements for CEU, insecure attachment, LHS, and psychopathy, and Bootstrap mediation test through SPSS 25.0 and PROCESS macro tool was… More >

Ferzat Anka¹, Ghanshyam G. Tejani^2,3,*, Sunil Kumar Sharma⁴, Mohammed Baljon⁵

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 2691-2724, 2025, DOI:10.32604/cmes.2025.061522 - 03 March 2025

Abstract Due to the intense data flow in expanding Internet of Things (IoT) applications, a heavy processing cost and workload on the fog-cloud side become inevitable. One of the most critical challenges is optimal task scheduling. Since this is an NP-hard problem type, a metaheuristic approach can be a good option. This study introduces a novel enhancement to the Artificial Rabbits Optimization (ARO) algorithm by integrating Chaotic maps and Levy flight strategies (CLARO). This dual approach addresses the limitations of standard ARO in terms of population diversity and convergence speed. It is designed for task scheduling… More >

Abdullah M. Alqahtani^1,*, Kamran Ahmad Awan², Abdulaziz Almaleh³, Osama Aletri⁴

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.3, pp. 3155-3179, 2025, DOI:10.32604/cmes.2025.061472 - 03 March 2025

Abstract Efficient resource management within Internet of Things (IoT) environments remains a pressing challenge due to the increasing number of devices and their diverse functionalities. This study introduces a neural network-based model that uses Long-Short-Term Memory (LSTM) to optimize resource allocation under dynamically changing conditions. Designed to monitor the workload on individual IoT nodes, the model incorporates long-term data dependencies, enabling adaptive resource distribution in real time. The training process utilizes Min-Max normalization and grid search for hyperparameter tuning, ensuring high resource utilization and consistent performance. The simulation results demonstrate the effectiveness of the proposed method, More >

HYE IN KA^#, SE HWAN MUN^#, SORA HAN^#, YOUNG YANG^*

Oncology Research, Vol.33, No.3, pp. 519-531, 2025, DOI:10.32604/or.2024.056860 - 28 February 2025

Abstract Osteosarcoma is a bone malignancy characterized by strong invasiveness and rapid disease progression. The tumor microenvironment of osteosarcoma contains various types of immune cells, including myeloid-derived suppressor cells, macrophages, T cells, and B cells. Imbalances of these immune cells can promote the proliferation and metastasis of osteosarcoma. Recent studies have indicated a substantial increase in the levels of myeloid-derived suppressor cells, an immune cell associated with immunosuppressive and pro-cancer effects, in the peripheral blood of patients with osteosarcoma. Moreover, the levels of the pro-inflammatory cytokine interleukin 18 are positively correlated with those of myeloid-derived suppressor More >

Abiodun Abdulhameed Amusa^1,*, Anwar Johari¹, Kamil Kayode Katibi^2,3, Ibrahim Garba Shitu^4,5, Abdulrahman Oyekanmi Adeleke⁶, Mohd Fairus Mohd Yasin⁷, Muhammad Thalhah Zainal⁸

Journal of Renewable Materials, Vol.13, No.2, pp. 251-272, 2025, DOI:10.32604/jrm.2025.057487 - 20 February 2025

Abstract The increasing severity of air pollution necessitates more effective and sustained air filtration technology. Concurrently, the desire for more environmentally friendly, sustainable materials with better filtering performance and less environmental impact drives the move away from conventional synthetic membranes. This review presents lignocellulosic biocomposite (LigBioComp) membranes as an alternative to traditional synthetic membranes. It focuses on their materials, fabrication, and functionalization techniques while exploring challenges and proposing methods for resourceful utilization. Renowned for their abundance and renewable nature, lignocellulosic materials consist of cellulose, hemicellulose, and lignin. Various applications can benefit from their antibacterial properties,… More > Graphic Abstract