Xiaomei He¹, Xiaoting Wan¹, Muhammad Arif ², Ziyang Hu¹, Haiyu Wang¹, Muhammad Aamir Manzoor^3,*, Cheng Song^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 2985-3002, 2025, DOI:10.32604/phyton.2025.070697 - 29 October 2025

Abstract Melatonin is a multifunctional molecule found in all organisms that has been shown to play a crucial role in plant growth, development, and stress response. Plant melatonin is typically synthesized in organelles termed chloroplasts, and the mechanisms of its synthesis and metabolic pathways have been extensively studied. Melatonin serves a significant regulatory function in plant growth and development, influencing the morphological and physiological characteristics of plants by modulating biological processes. While studies on plant melatonin receptors are in their early stages compared to studies in animal receptors, the binding mechanism with melatonin is now recognized… More >

Ivica Delic¹, Goran Jukic², Ivan Varnica², Valentina Spanic^3,*

Phyton-International Journal of Experimental Botany, Vol.94, No.10, pp. 3189-3203, 2025, DOI:10.32604/phyton.2025.070489 - 29 October 2025

Abstract This study evaluated agro-morphological traits, grain quality traits, and phenotypic stability of nine soybean genotypes across four environments over two growing seasons (2022–2023). Traits such as days to flowering, days to maturity, and disease symptoms were monitored throughout the season. At maturity, parameters including grain yield, grain oil and protein content, 1000-seed weight, test weight, scores of lodgings, shattering, plant height, and first pod height were evaluated. In addition, 18 morphological traits were scored, of which eight were sufficiently variable for further analysis. In terms of environmental stability, genotypes 2 and 13 excelled, while genotypes… More >

J. E. López-Gil¹, J. F. Ituna-Yudonago^1,*, V. Pérez-García², V. Martínez-Calzada³, J. L. Rodríguez-Muñoz⁴, J. Serrano-Arellano⁵

Frontiers in Heat and Mass Transfer, Vol.23, No.5, pp. 1365-1393, 2025, DOI:10.32604/fhmt.2025.068100 - 31 October 2025

Abstract This paper presents a thermophysical study approach for a pure environmental control system (ECS), incorporating the geometric dimensions of heat exchangers, ram air duct, and air cycle machine (ACM) blades of the Sabreliner’s environmental control system. Real flight scenarios are simulated by considering flight input variables such as altitude, aircraft speed, compression ratio of the air cycle machine, and the mass flow rate of bleed air. The study evaluates the coefficient of performance (COP) of the environmental control system, the heat exchanger efficiencies, and the work distribution of the air cycle machine based on five… More >

Hongle Li¹, SeongKi Kim^2,*

CMC-Computers, Materials & Continua, Vol.85, No.3, pp. 5571-5594, 2025, DOI:10.32604/cmc.2025.067424 - 23 October 2025

Abstract Path planning is a fundamental component in robotics and game artificial intelligence that considerably influences the motion efficiency of robots and unmanned aerial vehicles, as well as the realism and immersion of virtual environments. However, traditional algorithms are often limited to single-objective optimization and lack real-time adaptability to dynamic environments. This study addresses these limitations through a proposed real-time dynamic multiobjective (RDMO) path-planning algorithm based on an enhanced A* framework. The proposed algorithm employs a queue-based structure and composite multiheuristic functions to dynamically manage game tasks and compute optimal paths under changing-map-connectivity conditions in real… More >

Robyn Lesch¹, Evan David Visser¹, Ntalane Sello Seroka^1,2,*, Lindiwe Khotseng^1,*

Journal of Renewable Materials, Vol.13, No.10, pp. 1935-1977, 2025, DOI:10.32604/jrm.2025.02025-0026 - 22 October 2025

Abstract The review investigates the use of biomass-derived carbon as precursors for nanomaterials, acknowledging their sustainability and eco-friendliness. It examines various types of biomasses, such as agricultural residues and food byproducts, focussing on their transformation via environmentally friendly methods such as pyrolysis and hydrothermal carbonisation. Innovations in creating porous carbon nanostructures and heteroatom surface functionalisation are identified, enhancing catalytic performance. The study also explores the integration of biomass-derived carbon with nanomaterials for energy storage, catalysis, and other applications, noting the economic and environmental benefits. Despite these advantages, challenges persist in optimising synthesis methods and scaling production. More > Graphic Abstract

Amber Hassan¹, Badr Hafiz², Taghreed Alsinani³, Rakan Bokhari⁴, Dahlia Mirdad⁵, Awab Tayyib⁵, Alaa Alkhotani⁶, Ahmad Fallata⁷, Iman Mirza⁸, Eyad Faizo^9,10, Saleh Baeesa², Huda Alghefari¹¹, Maher Kurdi^11,*

Oncology Research, Vol.33, No.11, pp. 3293-3325, 2025, DOI:10.32604/or.2025.070031 - 22 October 2025

Abstract Background: Glioblastoma (GBM) remains the most aggressive primary brain tumour in adults, marked by pronounced cellular heterogeneity, diffuse infiltration, and resistance to conventional treatment. In recent years, transcriptomic profiling has provided valuable insights into the molecular mechanisms that govern the progression of glioblastoma. This systematic review aims to synthesise the current literature on dysregulated gene expression in GBM, focusing on gene signatures associated with stemness, immune modulation, extracellular matrix remodelling, metabolic adaptation, and therapeutic resistance. Methods: We conducted a systematic search of PubMed, The Cancer Genome Atlas (TCGA), Chinese Glioma Genome Atlas (CGGA), and the GlioVis… More >

Bruno Špiljak^1,#, Bojan Poposki^2,#, Stjepanka Lešić^3,*

Oncology Research, Vol.33, No.11, pp. 3269-3292, 2025, DOI:10.32604/or.2025.068395 - 22 October 2025

Abstract Head and neck squamous cell carcinoma (HNSCC) is an aggressive cancer with high recurrence rates and prevalent resistance to therapeutic interventions. Tumor behavior is largely dependent on the tumor microenvironment (TME) that includes immune cells, stromal components, cancer-associated fibroblasts (CAFs), the extracellular matrix (ECM), and an associated cytokine network. In this review, we examine principal mechanisms of the tumorigenic transformation, encompassing immune checkpoint disruption, therapy resistance mediated through CAFs, the contribution of hypoxic niches, and several metabolic dependencies that hold potential as future targets. Novel therapeutics developed and/or repurposed, such as immune checkpoint inhibitors (ICIs),… More >

Ana Clara Ciglioni Salustiano^1,2, Gabriela Barbosa^1,3,4, Rodolfo Borges dos Reis^2,4, Amílcar Castro de Mattos^5,6, Athanase Billis⁶, Leonardo O. Reis^1,3,4,*

Oncology Research, Vol.33, No.11, pp. 3417-3428, 2025, DOI:10.32604/or.2025.068023 - 22 October 2025

Abstract Objective: The tumor microenvironment plays a pivotal role in prostate cancer progression and may differ across metastatic sites. This study aimed to evaluate and compare the primary and metastatic prostate adenocarcinoma tumor microenvironment. Methods: A total of 27 formalin-fixed paraffin-embedded tissue samples derived from 17 patients diagnosed with prostate adenocarcinoma, including the primary tumors, and the corresponding metastatic lymphatic and hematogenous lesions from various anatomical sites. Immunohistochemical labeling was performed using antibodies against Cluster of Differentiation 3 epsilon chain (CD3e), CD8 alpha chain (CD8a), Cluster of Differentiation 68 (CD68), Cluster of Differentiation 163 (CD163), Forkhead… More > Graphic Abstract

Xiangnan Feng^1,#, Dayong Li^2,#, Pingyu Wang¹, Xinyu Li², Guangyao Li^2,*

Oncology Research, Vol.33, No.11, pp. 3327-3346, 2025, DOI:10.32604/or.2025.067343 - 22 October 2025

Abstract Lactylation, a post-translational modification process that adds lactate groups to lysine residues, plays a crucial role in cancer biology, especially in drug resistance. However, the specific molecular mechanisms of lactylation in cancer progression and drug resistance are still unclear, and therapeutic strategies targeting the lactylation pathway are expected to overcome metabolic reprogramming and immune evasion. Therefore, this article provides a comprehensive description and summary of lactylation modification and tumor drug resistance. Numerous studies have shown that, due to the Warburg effect, there is an abnormally high level of lactate in tumor cells. Elevated levels of… More >

Jun Li¹, Kangmin Yu¹, Zhiyong Chen¹, Dan Xing², Binshan Zha¹, Wentao Xie¹, Huan Ouyang¹, Changjun Yu^3,*

Oncology Research, Vol.33, No.11, pp. 3469-3492, 2025, DOI:10.32604/or.2025.066193 - 22 October 2025

Abstract Objectives: Colorectal cancer (CRC) remains a major contributor to global cancer mortality, ranking second worldwide for cancer-related deaths in 2022, and is characterized by marked heterogeneity in prognosis and therapeutic response. We sought to construct a machine-learning prognostic model based on a complement-related risk signature (CRRS) and to situate this signature within the CRC immune microenvironment. Methods: Transcriptomic profiles with matched clinical annotations from TCGA and GEO CRC cohorts were analyzed. Prognostic CRRS genes were screened using Cox proportional hazards modeling alongside machine-learning procedures. A random survival forest (RSF) predictor was trained and externally validated.… More >