Sheng Dong^*, Feihu Fan, Yinuo Chen, Shangpeng Guo, Jiayu Liu

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.1, pp. 1-50, 2025, DOI:10.32604/cmes.2025.062113 - 11 April 2025

Abstract Legged robots have always been a focal point of research for scholars domestically and internationally. Compared to other types of robots, quadruped robots exhibit superior balance and stability, enabling them to adapt effectively to diverse environments and traverse rugged terrains. This makes them well-suited for applications such as search and rescue, exploration, and transportation, with strong environmental adaptability, high flexibility, and broad application prospects. This paper discusses the current state of research on quadruped robots in terms of development status, gait trajectory planning methods, motion control strategies, reinforcement learning applications, and control algorithm integration. It More >

Chen Lin^1,*, Zidan Zhang¹, Zhao Zhang¹, Yuxiang Long¹, Xuwen Shen¹, Jinghao Zhang¹, Youping Wang^1,2,*

Phyton-International Journal of Experimental Botany, Vol.94, No.3, pp. 583-601, 2025, DOI:10.32604/phyton.2025.063086 - 31 March 2025

Abstract Glutathione S-transferases (GSTs) represent a large and diverse enzyme family ubiquitously distributed across the plant kingdom. These proteins catalyze the conjugation of glutathione (GSH) with electrophilic substrates in response to various stress conditions. Beyond their role in stress adaptation, certain GSTs are integral regulators of plant growth and development, contributing to a range of physiological processes. Most GST proteins exhibit dual enzymatic activities, functioning as both transferases and peroxidases, which enables their involvement in diverse cellular processes, including detoxification and stress responses. Recent advancements, particularly in X-ray crystallography, have enabled detailed structural analysis of GST More >

Surajudeen Sikiru^1,*, Yusuf Olanrewaju Busari^2,3, John Oluwadamilola Olutoki⁴, Mohd Muzamir Mahat¹, Sanusi Yekinni Kolawole⁵

Journal of Polymer Materials, Vol.42, No.1, pp. 1-31, 2025, DOI:10.32604/jpm.2025.058936 - 27 March 2025

Abstract Photocatalysis is a crucial technique for environmental cleanup and renewable energy generation. Polymer-based photocatalysts have attracted interest due to their adaptability, adjustable chemical characteristics, and enhanced light absorption efficiency. Unlike traditional inorganic photocatalysts, we can optimize polymeric systems to enhance photocatalytic efficiency and yield significant advantages in environmental remediation and energy conversion applications. This study talks about the latest developments in polymer-based photocatalysts and how important they are for cleaning water, breaking down pollutants, and making renewable energy through processes like hydrogen production and CO₂ reduction. These materials are proficient in degrading harmful pollutants such as… More >

Hafiz Zain Ul Aabidin¹, Muhammad Inam Ul Hassan², Tariq Yasin², Muhammad Zubair Rahim¹, Asif Raza^1,*

Journal of Polymer Materials, Vol.42, No.1, pp. 141-150, 2025, DOI:10.32604/jpm.2024.057423 - 27 March 2025

Abstract Geological samples often contain significant amounts of iron, which, although not typically the target element, can substantially interfere with the analysis of other elements of interest. To mitigate these interferences, amidoxime-based radiation grafted adsorbents have been identified as effective for iron removal. In this study, an amidoxime-functionalized, radiation-grafted adsorbent synthesized from polypropylene waste (PPw-g-AO-10) was employed to remove iron from leached geological samples. The adsorption process was systematically optimized by investigating the effects of pH, contact time, adsorbent dosage, and initial ferric ion concentration. Under optimal conditions—pH 1.4, a contact time of 90 min, and More >

Zhaohui An, Changyong Li^*, Yong Han, Mengru Niu

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1347-1366, 2025, DOI:10.32604/cmc.2025.059037 - 26 March 2025

Abstract This paper introduces an Improved Bidirectional Jump Point Search (I-BJPS) algorithm to address the challenges of the traditional Jump Point Search (JPS) in mobile robot path planning. These challenges include excessive node expansions, frequent path inflexion points, slower search times, and a high number of jump points in complex environments with large areas and dense obstacles. Firstly, we improve the heuristic functions in both forward and reverse directions to minimize expansion nodes and search time. We also introduce a node optimization strategy to reduce non-essential nodes so that the path length is optimized. Secondly, we… More >

SHUANG ZHAO^1,#, HONGYONG WEN^2,#, BAIQI WANG², QINGLIN XIONG¹, LANXIN LI¹, AILAN CHENG^1,*

Oncology Research, Vol.33, No.4, pp. 795-810, 2025, DOI:10.32604/or.2025.057317 - 19 March 2025

Abstract Approximately half of all cancers have p53 inactivating mutations, in addition to which most malignancies inactivate the p53 pathway by increasing p53 inhibitors, decreasing p53 activators, or inactivating p53 downstream targets. A growing number of researches have demonstrated that p53 can influence tumor progression through the tumor microenvironment (TME). TME is involved in the process of tumor development and metastasis and affects the clinical prognosis of patients. p53 participates in host immunity and engages in the immune landscape of the TME, but the specific mechanisms remain to be investigated. This review briefly explores the More >

CHRISTINA LOH¹, YUQI ZHENG¹, ISLAM ALZOUBI², KIMBERLEY L. ALEXANDER^3,4, MAGGIE LEE⁴, WEI-DONG CAI², YANG SONG⁵, KERRIE MCDONALD⁶, ANNA K. NOWAK⁷, RICHARD B. BANATI^8,9, MANUEL B. GRAEBER^1,4,10,*

Oncology Research, Vol.33, No.4, pp. 937-950, 2025, DOI:10.32604/or.2024.056436 - 19 March 2025

Abstract Background: Microglia and brain macrophages contribute significantly to the tumor microenvironment in highly malignant glioblastoma where they are considered important drivers of tumor progression. A better understanding of the role of the brain macrophages present in glioblastoma appears crucial for improving therapeutic outcomes, especially in the context of novel immunotherapeutic approaches. Methods: We investigated the regulation of two well-established markers for microglia and brain macrophages, IBA1 and CD163, in relation to glioblastoma tumor necrosis using immunohistochemistry and modality fusion heatmaps of whole slide images obtained from adjacent tissue sections. Results: IBA1 and CD163 showed remarkable differences… More >

GUANTING PANG^1,4,#, YAOHAN LI^2,4,#, QIWEN SHI³, JINGKUI TIAN⁴, HANMEI LOU^4,5,*, YUE FENG^4,5,*

Oncology Research, Vol.33, No.4, pp. 821-836, 2025, DOI:10.32604/or.2024.053772 - 19 March 2025

Abstract Immunotherapies have demonstrated notable clinical benefits in the treatment of cervical cancer (CC). However, the development of therapeutic resistance and diverse adverse effects in immunotherapy stem from complex interactions among biological processes and factors within the tumor immune microenvironment (TIME). Advanced omic technologies offer novel insights into a more expansive and thorough layer of the TIME. Furthermore, integrating multidimensional omics within the frameworks of systems biology and computational methodologies facilitates the generation of interpretable data outputs to characterize the clinical and biological trajectories of tumor behavior. In this review, we present advanced omics technologies that More >

JIYUN PANG^1,2,#, WEIGANG XIU^1,#, YUEYUN CHEN⁴, WENJING LIAO^1,2, QIN ZHANG^3,*, HUASHAN SHI^4,*

Oncology Research, Vol.33, No.4, pp. 895-904, 2025, DOI:10.32604/or.2024.053363 - 19 March 2025

Abstract Background: Non-small cell lung cancer (NSCLC) is often accompanied by brain metastasis (BM), and the prognosis of patients with BM is poor. This study assesses the prognostic impact of BM in NSCLC patients with epidermal growth factor receptor (EGFR) mutations. Methods: We retrospectively evaluated 692 advanced NSCLC patients with EGFR mutations treated with tyrosine kinase inhibitors (TKIs) at West China Hospital from 2015 to 2019. The overall survival rate (OS), progression-free survival rate (PFS), objective response rate (ORR), disease control rate (DCR), and clinical parameters of the BM and non-BM groups were compared. Univariable and multivariable… More >

Tarak Dhaouadi¹, Hichem Mrabet^1,2,*, Adeeb Alhomoud³, Abderrazak Jemai^1,4

CMC-Computers, Materials & Continua, Vol.82, No.3, pp. 4535-4554, 2025, DOI:10.32604/cmc.2025.060935 - 06 March 2025

Abstract The increasing adoption of Industrial Internet of Things (IIoT) systems in smart manufacturing is leading to raise cyberattack numbers and pressing the requirement for intrusion detection systems (IDS) to be effective. However, existing datasets for IDS training often lack relevance to modern IIoT environments, limiting their applicability for research and development. To address the latter gap, this paper introduces the HiTar-2024 dataset specifically designed for IIoT systems. As a consequence, that can be used by an IDS to detect imminent threats. Likewise, HiTar-2024 was generated using the AREZZO simulator, which replicates realistic smart manufacturing scenarios.… More >