Yuen Lo Yau¹, Matthew S. Purlee², Lindsey M. Brinkley², Dipankar Gupta¹, David M. Saulino³, Dalia Lopez-Colon¹, John-Anthony Coppola¹, Dhanashree Rajderkar⁴, Himesh Vyas^1,*

Congenital Heart Disease, Vol.20, No.2, pp. 265-272, 2025, DOI:10.32604/chd.2025.065661 - 30 April 2025

Abstract Background: Patients with Fontan physiology are predisposed to congestive hepatopathy, progressive liver fibrosis, and end-stage liver disease. Ultrasound-based shear wave elastography (SWE) is a non-invasive tool to diagnose and monitor liver fibrosis. We sought to determine whether the degree of hemodynamic derangement prior to and after the Fontan operation is associated with increased liver stiffness measured by SWE. Methods: A single-center retrospective study of patients with Fontan circulation who underwent ultrasound elastography between 2008 and 2024 was conducted. Liver stiffness was measured by SWE and reported as velocity in m/s. Hemodynamic assessment with cardiac catheterization and… More >

Juan Yang^1,2,#, Jiahui Zhang^3,#, Le Zhang^1,2,*, Zhenshan Yang^4,*

BIOCELL, Vol.49, No.3, pp. 399-417, 2025, DOI:10.32604/biocell.2025.059908 - 31 March 2025

Abstract With the prevalence of obesity, metabolic dysfunction-associated steatotic liver disease (MASLD) has become the most common chronic liver disease worldwide and can cause a series of serious complications. The pathogenesis of MASLD is complex, characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Mitochondrial biology and function are central to the physiology of the liver. It has been suggested that mitochondrial oxidative stress plays a crucial role in MASLD progression. Excessive oxidative stress response is an important trigger for the occurrence and development of MASLD. In this review, we aim to More >

Sumaiya Noor¹, Salman A. AlQahtani², Salman Khan^3,*

CMC-Computers, Materials & Continua, Vol.83, No.1, pp. 1435-1450, 2025, DOI:10.32604/cmc.2025.061700 - 26 March 2025

Abstract The liver is a crucial gland and the second-largest organ in the human body and also essential in digestion, metabolism, detoxification, and immunity. Liver diseases result from factors such as viral infections, obesity, alcohol consumption, injuries, or genetic predispositions. Pose significant health risks and demand timely diagnosis and treatment to enhance survival rates. Traditionally, diagnosing liver diseases relied heavily on clinical expertise, often leading to subjective, challenging, and time-intensive processes. However, early detection is essential for effective intervention, and advancements in machine learning (ML) have demonstrated remarkable success in predicting various conditions, including Chronic Obstructive… More >

QIN LIU^1,#, CHUNYAN NIU^2,#,*, QIANG ZHANG³, SHIQIN SUN⁴, YUE CHEN², YONGQIANG SHI²

BIOCELL, Vol.48, No.5, pp. 759-769, 2024, DOI:10.32604/biocell.2024.048551 - 06 May 2024

Abstract Background: Nonalcoholic fatty liver disease (NAFLD) is a global health concern with the acid sphingomyelinase (ASM)/ceramide (CE) pathway and the NOD-like receptor family, pyrin domain-containing protein 3 (NLRP3) inflammasome identified as pivotal players in lipid disorders and inflammation. This study explores the interaction mechanism between the ASM/CE pathway and NLRP3 in NAFLD cell models, aiming to understand the impact of amitriptyline (Ami), an ASM inhibitor, on lipid deposition and hepatocyte injury by regulating the ASM/CE-NLRP3 pathway. Methods: HepG2 and HL-7702 cells were exposed to free fatty acids (FFAs) to establish the NAFLD model. The cells… More >

Srilekha Muthukaruppankaruppiah^1,*, Shanker Rajendiran Nagalingam², Priya Murugasen³, Rajesh Nandaamarnath⁴

Intelligent Automation & Soft Computing, Vol.35, No.2, pp. 2309-2323, 2023, DOI:10.32604/iasc.2023.029598 - 19 July 2022

Abstract Malfunction of human liver happens due to non-alcoholic fatty liver. Fatty liver measurement is used for grading hepatic steatosis, fibrosis and cirrhosis. The various imaging techniques for measuring fatty liver are Magnetic Resonance Imaging, Ultrasound and Computed Tomography. Imaging modalities lead to the exposure of harmful radiation of electromagnetic waves because of frequent measurement. The continuous monitoring of fatty liver is never achieved through imaging techniques. In this paper, the human fatty liver measured through a Fatty Liver Sensor (FLS). The continuous monitoring of the fatty liver is achieved through the FLS. FLS is fabricated… More >

Mounita Ghosh¹, Md. Mohsin Sarker Raihan¹, M. Raihan², Laboni Akter¹, Anupam Kumar Bairagi³, Sultan S. Alshamrani⁴, Mehedi Masud^5,*

Intelligent Automation & Soft Computing, Vol.30, No.3, pp. 917-928, 2021, DOI:10.32604/iasc.2021.017989 - 20 August 2021

Abstract The liver is considered an essential organ in the human body. Liver disorders have risen globally at an unprecedented pace due to unhealthy lifestyles and excessive alcohol consumption. Chronic liver disease is one of the principal causes of death affecting large portions of the global population. An accumulation of liver-damaging factors deteriorates this condition. Obesity, an undiagnosed hepatitis infection, alcohol abuse, coughing or vomiting blood, kidney or hepatic failure, jaundice, liver encephalopathy, and many more disorders are responsible for it. Thus, immediate intervention is needed to diagnose the ailment before it is too late. Therefore,… More >

Pushpendra Kumar^1,2,*, Ramjeevan Singh Thakur³

CMC-Computers, Materials & Continua, Vol.68, No.3, pp. 3513-3529, 2021, DOI:10.32604/cmc.2021.016957 - 06 May 2021

Abstract The aim of this research is to develop a mechanism to help medical practitioners predict and diagnose liver disease. Several systems have been proposed to help medical experts by diminishing error and increasing accuracy in diagnosing and predicting diseases. Among many existing methods, a few have considered the class imbalance issues of liver disorder datasets. As all the samples of liver disorder datasets are not useful, they do not contribute to learning about classifiers. A few samples might be redundant, which can increase the computational cost and affect the performance of the classifier. In this… More >

Yuguo YI, Jiamin ZHENG, Yang ZHOU, Zhiqin LIU, Dan WENG^*

BIOCELL, Vol.44, No.1, pp. 7-11, 2020, DOI:10.32604/biocell.2020.08686 - 01 March 2020

Abstract Nonalcoholic fatty liver disease (NAFLD) represents a huge threat to public health of the whole world. Around 25% of NAFLD patients will progress to nonalcoholic steatohepatitis (NASH), which has been predicted to be the main reason for liver transplantation in the United States in 2020. Extensive effort has been devoted to investigating the underlying molecular mechanisms of NASH pathogenesis and developing new promising treatments. Recent studies have demonstrated that pyroptosis, an inflammatory programmed cell death mediated by inflammasome and gasdermin-D (GSDMD), is involved in the development and progression of NASH. This review aims to summarize More >

Sara Youssry¹, Maher A. Kamel²

European Cytokine Network, Vol.30, No.4, pp. 135-143, 2019, DOI:10.1684/ecn.2019.0437

Abstract Background and aims: Chronic hepatic inflammation is an important pathogenic mediator of nonalcoholic fatty liver disease (NAFLD) that contributes to disease severity. It is commonly suggested that autophagy dysfunction may be an underlying cause of nonalcoholic fatty liver disease. However, the exact role of autophagy in lipid metabolism remains controversial. There has been a growing interest in the role of folate supplementation for the treatment and/or prevention of NAFLD. We aimed in this study to investigate the effects of different doses of folate supplementation on several immune markers and autophagy trying to explore the complex… More >

Jose A. Silva‐Sepulveda¹, Yudy Fonseca², Irine Vodkin³, Gabrielle Vaughn¹, Robert Newbury⁴, Vera Vavinskaya⁵, Jerry Dwek⁶, James C. Perry¹, Preeti Reshamwala⁷, Cynthia Baehling⁸, James Lyon⁹, Christopher Davis¹, Jesse W. Lee¹, Hannah El‐Sabrout¹⁰, Doaa Shahbah¹¹, Laith Alshawabkeh¹², John W Moore¹, Howaida El‐Said¹

Congenital Heart Disease, Vol.14, No.4, pp. 600-608, 2019, DOI:10.1111/chd.12770

Abstract Introduction: Liver fibrosis and cirrhosis are late complications in Fontan palliation. Liver biopsy is the gold standard. The goal of this study is to correlate transjugular liver biopsy (TJLB) in the setting of Fontan palliation with noninvasive testing and hemodynamics.
Methods: Between August 2014 and July 2017, 49 Fontan patients underwent TJLB. All the patients had hemodynamic evaluation, 28 patients had MRE (magnetic reso‐ nance elastography) and 40 patients had cardiopulmonary exercise test. Histologic liver fibrosis was quantitated using traditional histologic scoring systems and a modi‐ fied Ishak congestive hepatic fibrosis score.
Results: Median age 17.8 years, median… More >