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Search Results (19)
  • Open Access

    REVIEW

    Pathogenic genes associated with Parkinson’s disease: molecular mechanism overview

    TINGTING LIU1,#, YIWEI HAO2,#, LIFENG ZHAO2,*

    BIOCELL, Vol.48, No.5, pp. 707-729, 2024, DOI:10.32604/biocell.2024.049130 - 06 May 2024

    Abstract Parkinson’s disease (PD) is a common neurodegenerative disease in the elderly, accounting for more than 1% of the population aged 65 years. Monogenic inheritance is relatively rare in PD, accounting for approximately 5% to 10% of PD patients, and there is a growing body of evidence suggesting that multiple genetic risk factors play a significant role in the pathogenesis of PD. Several groups have identified and reported a number of genes carrying mutations associated with affected family members. Mutated genes associated with PD are also candidates for idiopathic PD, and these genes may also carry… More >

  • Open Access

    REVIEW

    Exploring the molecular mechanisms and potential therapeutic strategies of ferroptosis in ovarian cancer

    LISHA MA1,#, WANQI SHAO1,#, WEILI ZHU2,*

    BIOCELL, Vol.48, No.3, pp. 379-386, 2024, DOI:10.32604/biocell.2024.047812 - 15 March 2024

    Abstract The morbidity rate of ovarian cancer, a malignant tumour in gynaecological tumours, is rising, and it is considered to be the most lethal cancer. The majority of patients are typically diagnosed during the advanced stages of the illness due to the elusive characteristics of ovarian cancer and an absence of highly sensitive and specific diagnostic indicators. Surgical excision of the lesions, along with chemotherapy, is the conventional treatment for ovarian cancer; however, resistance to platinum-based chemotherapeutic drugs and molecular targeted therapies frequently arises. Improving the survival rate and prognosis of patients with end-stage or recurring… More >

  • Open Access

    ARTICLE

    Physiological and Transcriptome Analysis Illuminates the Molecular Mechanisms of the Drought Resistance Improved by Alginate Oligosaccharides in Triticum aestivum L.

    Yunhong Zhang1,2,*, Yonghui Yang1,2, Jiawei Mao1,2

    Phyton-International Journal of Experimental Botany, Vol.93, No.2, pp. 185-212, 2024, DOI:10.32604/phyton.2023.046811 - 27 February 2024

    Abstract Alginate oligosaccharides (AOS) enhance drought resistance in wheat (Triticum aestivum L.), but the definite mechanisms remain largely unknown. The physiological and transcriptome responses of wheat seedlings treated with AOS were analyzed under drought stress simulated with polyethylene glycol-6000. The results showed that AOS promoted the growth of wheat seedlings and reduced oxidative damage by improving peroxidase and superoxide dismutase activities under drought stress. A total of 10,064 and 15,208 differentially expressed unigenes (DEGs) obtained from the AOS treatment and control samples at 24 and 72 h after dehydration, respectively, were mainly enriched in the biosynthesis of… More >

  • Open Access

    ARTICLE

    Knockdown Annexin A8 inhibits the proliferation and invasion of cervical cancer cells

    WEILING ZHANG1,2, YONG LI2, CAN ZHANG2, QING HAN2, YU ZHANG2, AIQIN HE2, WEIPEI ZHU1,*

    BIOCELL, Vol.47, No.12, pp. 2697-2708, 2023, DOI:10.32604/biocell.2023.044314 - 27 December 2023

    Abstract Background: This study aimed to explore the expression, function, and molecular mechanism of ANXA8, the gene for annexin 8, in cervical cancer. Methods: The gene expression of the ANX family members in cervical cancer tissues was classified via The Cancer Genome Atlas (TCGA) database. The expression of ANXA8 in paracancerous tissues, cervical cancer tissues, and cell lines was identified by fluorescence quantitative polymerase chain reaction (PCR) and immunohistochemistry. The effects of ANXA8 knockdown on the cellular growth and cell invasion of cervical cancer were examined by MTT, clone-formation assay, scratch test, and Transwell assay. The effect of ANXA8 knockdown… More >

  • Open Access

    REVIEW

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

    AMYLLY SANUELLY DA PAZ MARTINS1,#, MARLA DE CERQUEIRA ALVES2,#, ORLANDO ROBERTO PIMENTEL DE ARAÚJO3, FABIANA OLIVEIRA DOS SANTOS CAMATARI4, MARÍLIA OLIVEIRA FONSECA GOULART1,3,5, FABIANA ANDRÉA MOURA2,6,*

    BIOCELL, Vol.47, No.11, pp. 2547-2566, 2023, DOI:10.32604/biocell.2023.043253 - 27 November 2023

    Abstract

    Curcumin, a natural product, has exhibited promising effects in both animal models and clinical trials, interacting with a multitude of factors linked to Inflammatory Bowel Disease (IBD). These factors encompass cytokines, oxidative stress-associated enzymes, and modulation of the intestinal microbiota. Notably, curcumin has demonstrated therapeutic potential in animal models of colitis, wherein it exerts a negative regulatory influence on pivotal signaling pathways such as PI3/Akt, JAK/STAT, and β-catenin. Moreover, it inhibits the expression of pro-inflammatory enzymes and co-stimulatory molecules (including RANKL, ICAM-1, CD205, CD256, TLR4, among others), while curbing immune cell chemotaxis, thereby attenuating the characteristic

    More > Graphic Abstract

    Curcumin in inflammatory bowel diseases: Cellular targets and molecular mechanisms

  • Open Access

    ARTICLE

    Transcriptome Analysis of Molecular Mechanisms Underlying Phenotypic Variation in Phaseolus vulgaris Mutant ‘nts’

    Limin Yin#, Chang Liu#, Zicong Liang, Dajun Liu, Guojun Feng, Zhishan Yan*, Xiaoxu Yang*

    Phyton-International Journal of Experimental Botany, Vol.92, No.11, pp. 2981-2998, 2023, DOI:10.32604/phyton.2023.043151 - 24 October 2023

    Abstract The phenotype of a common bean plant is often closely related to its yield, and the yield of plants with reduced height or poor stem development during growth is low. Mutants serve as an essential gene resource for common bean breeding genetic research. Although model plants and crops are studied to comprehend the molecular mechanisms and genetic basis of plant phenotypes, the molecular mechanism of phenotypic variation in common beans remains underexplored. We here used the mutant ‘nts’ as material for transcriptome sequencing analysis. This mutant was obtained through 60Co-γ irradiation from the common bean variety… More >

  • Open Access

    ARTICLE

    Comparative transcriptome analysis provides insights into the molecular mechanism of the anti-nematode role of Arachis hypogaea (Fabales: Fabaceae) against Meloidogyne incognita (Tylenchida: Heteroderidae)

    XUEJIN YANG1,2,#, YUANYUAN ZHOU1,#, XINYI PENG1, XIAOHONG FU1, JIANQING MA1, JIANFENG LIU1,*, DANDAN CAO1,2,*

    BIOCELL, Vol.47, No.9, pp. 2101-2113, 2023, DOI:10.32604/biocell.2023.029581 - 28 September 2023

    Abstract Background: Plant root-knot nematode (RKN) disease is a serious threat to agricultural production across the world. Meloidogyne incognita is the most prominent pathogen to the vegetables and cash crops cultivated. Arachis hypogaea can effectively inhibit M. incognita, but the underlying defense mechanism is still unclear. Methods: In our study, the chemotaxis and infestation of the second-stage juveniles (J2s) of M. incognita to A. hypogaea root tips were observed by the Pluronic F-127 system and stained with sodium hypochlorite acid fuchsin, respectively. The transcriptome data of A. hypogaea roots with non-infected or infected by J2s were analyzed. Results: The J2s could approach and infect… More >

  • Open Access

    ARTICLE

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

    XIANBAO FANG1,#, MINGYAN TANG1,#, ZIYANG YU1,#, JIAQI DING1, CHONG CUI2, HONG ZHANG1,*

    BIOCELL, Vol.47, No.9, pp. 2059-2068, 2023, DOI:10.32604/biocell.2023.030565 - 28 September 2023

    Abstract Objective: Key genes were screened to analyze molecular mechanisms and their drug targets of endometriosis by applying a bioinformatics approach. Methods: Gene expression profiles of endometriosis and healthy controls were obtained from the Gene Expression Omnibus database. Significant differentially expressed genes were screened using the limma package. Correlation pathways were screened by Spearman correlation analysis on the echinoderm microtubule-associated protein-like 4 (EML4) and enrichment in endometriosis pathways and estimated by the GSVA package. Immune characteristics were assessed by the “ESTIMATE” R package. Potential regulatory pathways were determined by enrichment analysis. The SWISS-MODE website was used in… More > Graphic Abstract

    Identification of EML4 as a key hub gene for endometriosis and its molecular mechanism and potential drug prediction based on the GEO database

  • Open Access

    REVIEW

    Adventitious Root Regeneration: Molecular Basis and Influencing Factors

    Lulu Zhi, Xiangyang Hu*

    Phyton-International Journal of Experimental Botany, Vol.92, No.10, pp. 2825-2840, 2023, DOI:10.32604/phyton.2023.030912 - 15 September 2023

    Abstract Plant regeneration is a self-repair of the plant body in response to adverse conditions or damaged structures, and root regeneration allows the plant body to better adapt to its environment by supplementing the roots’ structure. Previous research has shown that adventitious roots can be made to occur from scratch in two ways. Studies that simulate adventitious root regeneration through natural conditions allow the regeneration process to be broadly divided into three stages: the perception of early signals, the massive accumulation of auxin, and the transformation of cell fate. The strength of regeneration, in turn, is More >

  • Open Access

    ARTICLE

    Study of molecular mechanisms underlying the medicinal plant Tripterygium wilfordii-derived compound celastrol in treating diabetic nephropathy based on network pharmacology and molecular docking

    FENGMEI QIAN1,2, PEIYAO REN2, LI ZHAO2, DANNA ZHENG2, WENFANG HE3, JUAN JIN3,*

    BIOCELL, Vol.47, No.8, pp. 1853-1867, 2023, DOI:10.32604/biocell.2023.029353 - 28 August 2023

    Abstract Background: Diabetic nephropathy (DN) is a serious complication of diabetes with rising prevalence worldwide. We aimed to explore the anti-DN mechanisms of the compound celastrol derived from the medicinal plant Tripterygium wilfordii. Methods: Celastrol-related targets were obtained from Herbal Ingredients’ Targets (HIT) and GeneCards databases. DN-related targets were retrieved from GeneCards, DisGeNET, and Therapeutic Targets Database (TTD). A Protein-protein interaction (PPI) network was established using the Search Tool for the Retrieval of Interacting Genes (STRING) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed using ClusterProfiler. The cytoHubba plugin… More > Graphic Abstract

    Study of molecular mechanisms underlying the medicinal plant <i>Tripterygium wilfordii</i>-derived compound celastrol in treating diabetic nephropathy based on network pharmacology and molecular docking

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