Roberta Giorgione1,#, Daniela Grasso2,#, Elisabetta Gambale1, Federico Scolari3, Virginia Rossi1, Fabrizio Di Maida4, Marinella Micol Mela1, Barbara Marzocchi2, Laura Doni1, Adriano Pasqui1, Andrea Minervini4, Enrico Caliman1, Sergio Serni4,5,6, Andrea Bernini2, Serena Pillozzi3, Lorenzo Antonuzzo1,5,*
Oncology Research, Vol.34, No.4, 2026, DOI:10.32604/or.2026.068896
- 23 March 2026
Abstract Objectives: To date, predictive and prognostic biomarkers for Bladder Cancer (BC) remain lacking. Existing literature underscores the potential of metabolomics as a valuable tool for biomarker identification. The primary objective of this study is to characterize the serum metabolic profile of BC patients undergoing platinum-based chemotherapy (Pt-CT) to identify potential biomarkers. Methods: In this pilot study, we investigated the metabolomic profiles of 14 BC patients undergoing Pt-CT in different settings. We compared their baseline profiles with those of healthy controls and tracked key metabolites throughout chemotherapy cycles. Metabolomics profiling was conducted using nuclear magnetic resonance… More >