Recep Bentli1, Osman Ciftci2, Asli Cetin3, Merve Unlu2, Nese Basak2, Mahmut Çay4
European Cytokine Network, Vol.24, No.2, pp. 91-96, 2013, DOI:10.1684/ecn.2013.0337
Abstract The objective of the current study was to investigate the protective effects of hesperidin against oxidative
stress, altered cytokines levels and histological changes in rats induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin
(TCDD). Rats were divided randomly into four equal groups (Control, TCDD, hesperidin and TCDD+hesperidin).
TCDD and hesperidin were given by gavage, dissolved in corn oil at doses of 2 μ/kg/week and 50 mg/kg/day respectively.
The blood and tissue samples were taken from all rats on the 60th day, to be analyzed for the determination of
oxidative stress, histological changes and cytokine levels. The results indicated that hesperidin prevented More >