MOHAMMAD ABOHASSAN, MESFER MOHAMMAD AL SHAHRANI, SARAH KHALED ALOUDA, PRASANNA RAJAGOPALAN^*

Oncology Research, Vol.33, No.3, pp. 675-685, 2025, DOI:10.32604/or.2024.056256 - 28 February 2025

Abstract Background: The JAK2^V617F mutation plays a crucial part in the pathogenesis of myeloproliferative neoplasms (MPN), which includes polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF) leading to aberrant proliferation and survival of hematopoietic cells. Alongside the challenges of drug resistance and side effects, identifying novel compounds that selectively target JAK2^V617F could provide more effective and safer therapeutic options for patients with MPNs. Materials and Methods: We employed computational approaches like high-throughput virtual screening, molecular dynamics simulations (MDS), and binding free energy calculations to identify inhibitors targeting wild and mutant JAK2 kinases. JAK2^V617F positive HEL, wild… More >

Djordje Spasojević^1,*, Sanja Janićević², Svetislav Mijatović¹, Bosiljka Tadić^3,4

CMES-Computer Modeling in Engineering & Sciences, Vol.142, No.2, pp. 1021-1107, 2025, DOI:10.32604/cmes.2024.057884 - 27 January 2025

Abstract Disordered ferromagnets with a domain structure that exhibit a hysteresis loop when driven by the external magnetic field are essential materials for modern technological applications. Therefore, the understanding and potential for controlling the hysteresis phenomenon in these materials, especially concerning the disorder-induced critical behavior on the hysteresis loop, have attracted significant experimental, theoretical, and numerical research efforts. We review the challenges of the numerical modeling of physical phenomena behind the hysteresis loop critical behavior in disordered ferromagnetic systems related to the non-equilibrium stochastic dynamics of domain walls driven by external fields. Specifically, using the extended… More >

Parul Verma¹, Sana Choudhary¹, Neha Naaz^1,*, Nidhi Sharma¹, Nora M. Al Aboud², Fatmah Ahmed Safhi³, Diaa Abd El Moneim^4,*

Phyton-International Journal of Experimental Botany, Vol.93, No.12, pp. 3347-3372, 2024, DOI:10.32604/phyton.2024.057592 - 31 December 2024

Abstract Cadmium (Cd) is a highly toxic heavy metal pollutant primarily introduced into the environment through anthropogenic activities. In plants, the absorption and retention of Cd lead to a cascade of morphological, physiological, and cytological alterations. Nigella sativa L., also known as black cumin, is an annual herb with important commercial and medicinal uses. Thymoquinone, the primary bioactive compound in Nigella sativa L., is renowned for its potential health benefits. The current experiment aimed to ascertain the effects of various concentrations (10, 20, 30, 40 and 50 ppm) of cadmium nitrate (Cd(NO₃₊)₂) on two Nigella sativa cultivars (AN20 and… More >

Chongdong Lin^1,2,3,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.29, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.011631

Abstract In many real-world scenarios, such as high-speed combustion processes and re-entry flows in aerospace vehicles, the flow conditions often involve complex interactions between multiple chemical species and energy modes, leading to thermodynamic nonequilibrium effects. Traditional computational fluid dynamics (CFD) methods struggle to accurately capture these phenomena due to their simplifying assumptions regarding equilibrium thermodynamics. To solve this issue, the Multicomponent Discrete Boltzmann Method (MDBM) is proposed as a numerical approach to simulate compressible reactive flows with thermodynamic nonequilibrium effects. Based on kinetic theory, this method can capture the complex interactions between different species and energy… More >

MIN LIU^1,*, XIA LI², JUN LIU¹, YU LIU¹

BIOCELL, Vol.48, No.10, pp. 1475-1487, 2024, DOI:10.32604/biocell.2024.053227 - 02 October 2024

Abstract Background: Alveolar macrophage pyroptosis exacerbates inflammatory lung diseases, and tanshinone IIA is known for its anti-inflammatory properties. Thus, understanding how tanshinone IIA affects alveolar macrophage pyroptosis is essential. Methods: NR8383 cells were exposed to lipopolysaccharide (LPS) and adenosine triphosphate (ATP). We assessed cell viability, pyroptosis, and the expression of triggering receptors expressed on myeloid cells 2 (TREM2), p-β-catenin, β-catenin, and pyroptosis-related factors. We also examined the interaction between tanshinone IIA and TREM2. Results: Co-stimulation with LPS and ATP significantly reduced NR8383 cell viability, increased pyroptosis, and upregulated pyroptosis-associated factors. Treatment with tanshinone IIA mitigated these effects.… More >

Agatha E. R. Prado Gárate^1,2, Fernando E. Felissia², María Cristina Area², Teresa Suirezs³, María Evangelina Vallejos^2,*

Journal of Renewable Materials, Vol.12, No.9, pp. 1541-1555, 2024, DOI:10.32604/jrm.2024.052481 - 25 September 2024

Abstract Non-traditional lignocellulosic materials are a significant resource for producing high-value products, including nanocellulose. This work studied the nanocellulose obtention from chemical pulps of the two fast-growing bamboo species, Guadua trinii, and Guadua angustifolia. Chemical pulps were produced by soda-anthraquinone (S) pulping from both autohydrolysis-pretreated (H) and unpretreated bamboo chips. Autohydrolysis-pretreated (SHP) and unpretreated soda-anthraquinone (AQ) (SP) pulps were characterized by yield, Kappa number, alpha, beta, and gamma cellulose, degree of polymerization, water retention value, and crystallinity. The nanocellulose was produced by a sequential chemical oxidation treatment (2,2,6,6-tetramethylpiperidine-1-oxyl, TEMPO reagent) and mechanical nanofibrillation. Nanocellulose was characterized by carboxylic… More > Graphic Abstract

BOWEN PENG¹, YUN GE¹, GANG YIN^2,3,*

BIOCELL, Vol.47, No.7, pp. 1519-1535, 2023, DOI:10.32604/biocell.2023.027026 - 21 June 2023

Abstract Background: Tanshinone IIA, one of the main ingredients of Danshen, is used to treat hepatocellular carcinoma (HCC). However, potential targets of the molecule in the therapy of HCC are unknown. Methods: In this study, we collected the tanshinone IIA targets from public databases for investigation. We screened differentially expressed genes (DEGs) across HCC and normal tissues using mRNA expression profiles from The Cancer Genome Atlas (TCGA). Univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) Cox regression models were used to identify and construct the prognostic gene signature. Results: Finally, we discovered common… More >

Crisanto Velázquez-Becerra^1,*, Gu Yen Ambriz-Ortiz¹, Rafael Torres-Martínez², Mauro Manuel Martínez-Pacheco³

Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2165-2181, 2023, DOI:10.32604/phyton.2023.026954 - 29 May 2023

Abstract Wood is a lignocellulosic material that, because of its organic nature, is a source of nutrients for bacteria, fungi, and insects. Incisitermes marginipennis (Latreille) is an interesting dry wood-boring termite. Because it is an extremely destructive pest, difficult to control due to its cryptic lifestyle, and for its role in the biogeochemical cycle of carbon and other elements; it is a fundamental organism. The use of less toxic and eco-friendly substances is important for protecting domestic, cultural, and historical heritage made of wood or lignocellulosic materials. The aim of this study was to evaluate the biological… More >

HAN WANG^1,2,#, YANG SUN^1,2,#, XIAOXU ZHANG^2,3, XIAOYING WANG⁴, YUJUN XIA^1,*, LISHENG WANG^1,2,*

BIOCELL, Vol.47, No.5, pp. 1107-1115, 2023, DOI:10.32604/biocell.2023.027131 - 10 April 2023

Abstract Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The destruction of the intestinal epithelial barrier is one of the major pathological processes in IBD pathology. Growing evidence indicated that epithelial cell ferroptosis is linked to IBD and is considered a target process. Methods: RAS-selective lethal 3 (RSL3) was used to induce ferroptosis in intestinal epithelial cell line No. 6 (IEC-6) cells, and cell ferroptosis and the effects of tanshinone IIA (Tan IIA) were determined by cell counting kit-8 (CCK-8), reactive oxygen species (ROS) staining, Giemsa staining and transmission electron microscope… More >

Jeltzlin Semerel¹, Nigel John¹, Wim Dehaen², Pedro Fardim^3,*

Journal of Renewable Materials, Vol.11, No.3, pp. 1031-1061, 2023, DOI:10.32604/jrm.2022.023449 - 31 October 2022

Abstract Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo, soap, and sunscreen. However, the demand for these gel-based products has led to a surplus production of Aloe vera processing waste. An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month. Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer. A sustainable management system for the Aloe vera processing waste should be considered, due to the negative societal and environmental impacts of the currents waste disposal methods. Therefore, this… More > Graphic Abstract