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  • Open Access


    A novel prognostic gene signature, nomogram and immune landscape based on tanshinone IIA drug targets for hepatocellular carcinoma: Comprehensive bioinformatics analysis and in vitro experiments


    BIOCELL, Vol.47, No.7, pp. 1519-1535, 2023, DOI:10.32604/biocell.2023.027026

    Abstract Background: Tanshinone IIA, one of the main ingredients of Danshen, is used to treat hepatocellular carcinoma (HCC). However, potential targets of the molecule in the therapy of HCC are unknown. Methods: In this study, we collected the tanshinone IIA targets from public databases for investigation. We screened differentially expressed genes (DEGs) across HCC and normal tissues using mRNA expression profiles from The Cancer Genome Atlas (TCGA). Univariate Cox regression analysis and least absolute shrinkage and selection operator (LASSO) Cox regression models were used to identify and construct the prognostic gene signature. Results: Finally, we discovered common genes across tanshinone IIA… More >

  • Open Access


    Repellent and Insecticidal Activity of Naphthoquinones from the Heartwood of Tectona grandis on Incisitermes marginipennis (Latreille)

    Crisanto Velázquez-Becerra1,*, Gu Yen Ambriz-Ortiz1, Rafael Torres-Martínez2, Mauro Manuel Martínez-Pacheco3

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2165-2181, 2023, DOI:10.32604/phyton.2023.026954

    Abstract Wood is a lignocellulosic material that, because of its organic nature, is a source of nutrients for bacteria, fungi, and insects. Incisitermes marginipennis (Latreille) is an interesting dry wood-boring termite. Because it is an extremely destructive pest, difficult to control due to its cryptic lifestyle, and for its role in the biogeochemical cycle of carbon and other elements; it is a fundamental organism. The use of less toxic and eco-friendly substances is important for protecting domestic, cultural, and historical heritage made of wood or lignocellulosic materials. The aim of this study was to evaluate the biological activity of various naphthoquinones… More >

  • Open Access


    Tanshinone IIA protects intestinal epithelial cells from ferroptosis through the upregulation of GPX4 and SLC7A11


    BIOCELL, Vol.47, No.5, pp. 1107-1115, 2023, DOI:10.32604/biocell.2023.027131

    Abstract Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract. The destruction of the intestinal epithelial barrier is one of the major pathological processes in IBD pathology. Growing evidence indicated that epithelial cell ferroptosis is linked to IBD and is considered a target process. Methods: RAS-selective lethal 3 (RSL3) was used to induce ferroptosis in intestinal epithelial cell line No. 6 (IEC-6) cells, and cell ferroptosis and the effects of tanshinone IIA (Tan IIA) were determined by cell counting kit-8 (CCK-8), reactive oxygen species (ROS) staining, Giemsa staining and transmission electron microscope (TEM). The cell viability… More >

  • Open Access


    Valorization of Aloe barbadensis Miller. (Aloe vera) Processing Waste

    Jeltzlin Semerel1, Nigel John1, Wim Dehaen2, Pedro Fardim3,*

    Journal of Renewable Materials, Vol.11, No.3, pp. 1031-1061, 2023, DOI:10.32604/jrm.2022.023449

    Abstract Aloe vera plant is known worldwide for its medicinal properties and application in gel-based products such as shampoo, soap, and sunscreen. However, the demand for these gel-based products has led to a surplus production of Aloe vera processing waste. An Aloe vera gel processing facility could generate up to 4000 kg of Aloe vera waste per month. Currently the Aloe vera waste is being disposed to the landfill or used as fertilizer. A sustainable management system for the Aloe vera processing waste should be considered, due to the negative societal and environmental impacts of the currents waste disposal methods. Therefore,… More > Graphic Abstract

    Valorization of <i>Aloe barbadensis</i> Miller. (<i>Aloe vera</i>) Processing Waste

  • Open Access


    Computational docking and in vitro analysis identifies novel arylidene analogue FPMXY-14 against renal cancer cells by attenuating Akt


    Oncology Research, Vol.29, No.3, pp. 217-227, 2021, DOI:10.32604/or.2022.03570

    Abstract Targeted therapies are gaining global attention to tackle Renal Cancer (RC). This study aims to screen FPMXY- 14 (novel arylidene analogue) for Akt inhibition by computational and in vitro methods. FPMXY-14 was subjected to proton NMR analysis and Mass spectrum analysis. Vero, HEK-293, Caki-1, and A498 cell lines were used. Akt enzyme inhibition was studied with the fluorescent-based kit assay. Modeller 9.19, Schrodinger 2018-1, LigPrep module, and Glide docking were used in computational analysis. The nuclear status was assessed by PI/Hoechst- 333258 staining, cell cycle, and apoptosis assays were performed using flow cytometry. Scratch wound and migrations assays were performed.… More >

  • Open Access


    Use of the Naphthoquinone YM155 (Sepantronium Bromide) in the Treatment of Cancer: A Systematic Review and Meta-Synthesis

    Dariimaa Ganbat1,2, Bat-Erdene Jugder3, Lkhamaa Ganbat4, Miki Tomoeda5, Erdenetsogt Dungubat2,6, Ambaga Miyegombo7, Gantsetseg Garmaa8, Yoshihisa Takahashi6, Ryuji Fukuzawa6, Ichiro Mori6, Takayuki Shiomi6, Akinori Nakata9, Yasuhiko Tomita6,*

    Oncologie, Vol.24, No.2, pp. 195-225, 2022, DOI:10.32604/oncologie.2022.022299

    Abstract Most cancer cells overexpress the anti-apoptotic protein survivin and display redox dysregulation originating from genotypic and phenotypic alterations. These disturbances contribute to the uncontrolled proliferation, invasion, and chemoresistance of cancer cells, yet they also represent a specific vulnerability that could be exploited therapeutically in selected tumors. YM155 (sepantronium bromide) is a naphthoquinone-containing imidazolebased compound that selectively inhibits survivin expression at the transcriptional and post-transcriptional levels. Here, we performed a systematic review and meta-analysis of clinical studies in which YM155 was administered as monotherapy or combination therapy for patients with cancer. We assessed fully or partially reported clinical outcomes and pharmacological… More >

  • Open Access


    Molecular Interaction Study to Explore the Nigella sativa Bioactive Components as an Inhibitor of Peptide Deformylase to Inhibit the Xanthomonas oryzae pv. oryzae via Applying Computational Approach

    Pravej Alam*, Thamer H. Al balawi

    Phyton-International Journal of Experimental Botany, Vol.91, No.9, pp. 1923-1931, 2022, DOI:10.32604/phyton.2022.021334

    Abstract Bacterial leaf blight (BLB) caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most damaging diseases to rice across the world. Various chemicals have been employed so far for the management of bacterial leaf blight. On the other hand, these compounds are damaging to the ecosystem and have an impact on non-target species such as humans and animals. As a result, there is a need to create a new natural inhibitor for BLB management. Deformylase (PDF) enzyme is present in all eubacteria and its necessity in bacterial protein synthesis reveals it as an attractive target for drug development.… More >

  • Open Access


    Antifungal Activity of Crude Extracts of Tectona grandis L.f. against Wood Decay Fungi

    Enrique Cárcamo-Ibarra1, Mauro Manuel Martínez-Pacheco2, Abril Munro-Rojas1, Jorge Enrique Ambriz-Parra1, Crisanto Velázquez-Becerra1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.8, pp. 1795-1808, 2022, DOI:10.32604/phyton.2022.020578

    Abstract Wood is mainly made up of cellulose, hemicelluloses, lignin polymers and other organic and inorganic substances, making it susceptible to deteriorate by various biological agents. Tectona grandis L.f. (Teak) is a timber species with high resistance to biological deterioration, valued for its durability, beauty, and mechanical resistance. The purpose of this work was to evaluate the antifungal activity of crude extracts from teak on various fungi that cause wood deterioration. For this, Teak heartwood was obtained, then fragmented and pulverized until obtaining a flour which was used for compounds extraction using the Soxhlet technique coupled to a rotary evaporator through… More >

  • Open Access


    Embedded Coded Relay System for Molecular Communications

    Eman S. Attia1, Ashraf A. M. Khalaf1, Fathi E. Abd El-Samie2, Saied M. Abd El-atty2, Konstantinos A. Lizos3, Osama Alfarraj4, Farid Shawki2, Imran Khan5, Ki-Il Kim6,*

    CMC-Computers, Materials & Continua, Vol.72, No.2, pp. 2729-2748, 2022, DOI:10.32604/cmc.2022.026197

    Abstract With the emergence of the COVID-19 pandemic, the World Health Organization (WHO) has urged scientists and industrialists to explore modern information and communication technology (ICT) as a means to reduce or even eliminate it. The World Health Organization recently reported that the virus may infect the organism through any organ in the living body, such as the respiratory, the immunity, the nervous, the digestive, or the cardiovascular system. Targeting the abovementioned goal, we envision an implanted nanosystem embedded in the intra living-body network. The main function of the nanosystem is either to perform diagnosis and mitigation of infectious diseases or… More >

  • Open Access


    Rapid Profiling and Characterization of the Multicomponents from the Root and Rhizome of Salvia miltiorrhiza by Ultra-High Performance Liquid Chromatography/Ion Mobility-Quadrupole Time-of-Flight Mass Spectrometry in Combination with Computational Peak Annotation Workflows

    Boxue Chen1,#, Hongda Wang1,#, Meiyu Liu1, Wandi Hu1, Yuexin Qian1, Jiali Wang1, Jie Liu1, Xue Li1, Jing Wang2, Wenzhi Yang1,*

    Phyton-International Journal of Experimental Botany, Vol.91, No.5, pp. 1073-1088, 2022, DOI:10.32604/phyton.2022.019399

    Abstract Herbal components characterization represents a challenging task because of the co-existing of multiple classes of naturally occurring compounds with wide spans of polarity, molecular mass, and the ubiquitous isomerism. The root and rhizome of Salvia miltiorrhiza have been utilized as a reputable traditional Chinese medicine Salviae Miltiorrhizae Radix et Rhizoma (Dan-Shen) in the treatment of cardiovascular disease. Herein, a dimension-enhanced ultra-high performance liquid chromatography/ion mobility/quadrupole time-of-flight mass spectrometry approach in combination with intelligent peak annotation workflows was established aimed to rapidly characterize the multicomponents from S. miltiorrhiza. Due to the sufficient optimization, satisfactory chromatography separation was enabled on an HSS… More >

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