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  • Open Access

    ARTICLE

    Associations of Physical Activity and Sedentary Behavior with Internalizing Problems among Youth with Chronic Pain

    Lingling Yu1,2, Yanxia Chen3,*, Jinming Li2, André O. Werneck4, Fabian Herold5, Alyx Taylor6, Benjamin Tari7, Liye Zou2

    International Journal of Mental Health Promotion, Vol.27, No.2, pp. 97-110, 2025, DOI:10.32604/ijmhp.2025.061237 - 03 March 2025

    Abstract Background: Taking actions to maintain a healthy lifestyle, including regular engagement in physical activity (PA) and reducing sedentary behavior (SB), may protect against the development of internalizing problems among healthy youth. However, it remains unclear whether such associations exist among youth with chronic pain who often report symptoms of depression and anxiety. To this end, we aimed to investigate the associations between independent and combined PA and/or SB patterns with indicators of internalizing problems in this vulnerable population. Methods: Data used in this cross-sectional study were retrieved from the U.S. National Survey of Children’s Health… More >

  • Open Access

    ARTICLE

    Terpinen-4-ol suppresses proliferation and motility of cutaneous squamous cell carcinoma cells by enhancing calpain-2 expression

    DONGYUN RONG1,2,#, YUSHEN SU1,#, ZHIRUI ZENG3, YAN YANG4, HONGUAN LU1,*, YU CAO1,*

    Oncology Research, Vol.33, No.3, pp. 605-616, 2025, DOI:10.32604/or.2024.050661 - 28 February 2025

    Abstract Background: Terpinen-4-ol (T4O), a key constituent of tea tree essential oil and various aromatic plants, has shown promising antiproliferative and pro-apoptotic effects in melanoma and other cancer types. However, its efficacy against cutaneous squamous cell carcinoma (cSCC) remains unclear. Thus, in this study, we investigated the in vivo and in vitro effects of T4O on cSCC cell lines and preliminarily explored its impacting pathways. Methods: Using CCK8 and assay colony formation, we assessed the viability of cSCC A431, SCL-1, and COLO-16 cells treated with T40 at varying concentrations (0, 1, 2, and 4 μM). Flow cytometry was… More >

  • Open Access

    ARTICLE

    Amniotic bladder therapy: six-month follow up treating interstitial cystitis/bladder pain syndrome

    Jack Considine1, Kyle O'Hollaren1, Codrut Radoiu1, Raghav Madan1, Aron Liaw1,2, Nivedita Dhar2,3

    Canadian Journal of Urology, Vol.31, No.3, pp. 11898-11903, 2024

    Abstract Introduction: Interstitial cystitis/bladder pain syndrome (IC/BPS) is characterized by chronic pelvic pain and usually accompanies lower urinary tract symptoms. We have previously reported that amniotic bladder therapy (ABT) provides symptomatic improvement in refractory IC/BPS patients for up to 3 months. Herein, we evaluated the durability of ABT up to 6 months.
    Materials and methods: Consecutive IC/BPS patients received intra-detrusor injections of 100 mg micronized amniotic membrane. Clinical evaluation and patient reported outcome measurements including Interstitial Cystitis Symptom Index (ICSI), Interstitial Cystitis Problem Index (ICPI), Bladder Pain/ Interstitial Cystitis Symptom Score (BPIC-SS) and Overactive Bladder Assessment Tool (OAB)… More >

  • Open Access

    ARTICLE

    Outcomes of sacral neuromodulation in male patients with overactive bladder, chronic pelvic pain, and fecal incontinence

    Roseanne Ferreira1, Emad Alwashmi1,2, Samuel Otis-Chapados1, Naeem Bhojani3, Kevin C. Zorn4, Bilal Chughtai5, Dean S. Elterman1

    Canadian Journal of Urology, Vol.31, No.4, pp. 11943-11949, 2024

    Abstract Introduction: Despite the growing body of literature on sacral neuromodulation (SNM) outcomes, research focusing on male patients remains limited and often represented by small cohorts nested within a larger study of mostly women. Herein, we evaluated the outcomes of SNM in a male-only cohort with overactive bladder (OAB), fecal incontinence (FI), chronic bladder pain, and neurogenic lower urinary tract dysfunction (NLUTD).
    Materials and methods: This retrospective cohort study included 64 male patients who underwent SNM insertion between 2013 and 2021 at a high-volume tertiary center. Indications for SNM therapy included OAB, FI, chronic pelvic pain, and NLUTD.… More >

  • Open Access

    ARTICLE

    Clinical Effect Observation of Constructing PERMA Model in Psychological Intervention for Patients with Chronic Cancer Pain

    Yu-Feng Ren, Dong-Li Ji*, Yu Wu, Ru-Qin Ben, Hai-Xia Wei

    Psycho-Oncologie, Vol.18, No.4, pp. 329-336, 2024, DOI:10.32604/po.2024.053098 - 04 December 2024

    Abstract Background: The constructing PERMA model in psychological intervention was applied to patients with chronic cancer pain to provide data reference for reducing pain, fear of cancer recurrence, and improving the level of psychological capital. Aim: To explore the clinical effects of constructing PERMA model in psychological intervention for patients with chronic cancer pain. Methods: A total of 98 patients with chronic cancer pain admitted to our hospital from March 2021 to March 2023 were randomly divided into two groups, 49 cases in each group. The control group received routine intervention, while the research group constructed PERMA… More >

  • Open Access

    PROCEEDINGS

    Mechanism Analysis of Thermal Pain and Mechanical Matching of Stretchable Bio-Integrated Devices Integrated on Biological Tissues

    Yuhang Li1,*, Jin Nan1, Yang Wang1, Yafei Yin1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.31, No.1, pp. 1-1, 2024, DOI:10.32604/icces.2024.013412

    Abstract As a new type of electronic device, stretchable bio-integrated devices are generally composed of inorganic functional components, stretchable interconnected structures, soft biocompatible substrates and encapsulations, and have wide adaptability to a variety of complex surfaces of soft biological tissues. The small size of functional components, the thin substrate thickness, and poor thermal conductivity can easily lead to thermal burns caused by local temperature concentration in biological tissues. The unique microstructure characteristics and biological thermal characteristics of biological tissues make the heat transfer behavior of integrated devices in biological tissues significantly different from the traditional Fourier… More >

  • Open Access

    ARTICLE

    Investigation of the Film Formation in Dynamic Air Spray Painting

    Deqing Han, Yong Zeng*, Jintong Gu, Bin Yan

    FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.10, pp. 2393-2415, 2024, DOI:10.32604/fdmp.2024.053114 - 23 September 2024

    Abstract To accurately predict the film thickness distribution during dynamic spraying performed with air guns and support accordingly the development of intelligent spray painting, the spray problem was analyzed numerically. In particular, the Eulerian-Eulerian approach was employed to calculate the paint atomization and film deposition process. Different spray heights, spray angles, spray gun movement speeds, spray trajectory curvature radii, and air pressure values were considered. Numerical simulation results indicate that the angle of spray painting significantly affects the velocity of droplets near the spray surface. With an increase in the spraying angle, spraying height and spray… More >

  • Open Access

    ARTICLE

    Spatial and Contextual Path Network for Image Inpainting

    Dengyong Zhang1,2, Yuting Zhao1,2, Feng Li1,2, Arun Kumar Sangaiah3,4,*

    Intelligent Automation & Soft Computing, Vol.39, No.2, pp. 115-133, 2024, DOI:10.32604/iasc.2024.040847 - 21 May 2024

    Abstract Image inpainting is a kind of use known area of information technology to repair the loss or damage to the area. Image feature extraction is the core of image restoration. Getting enough space for information and a larger receptive field is very important to realize high-precision image inpainting. However, in the process of feature extraction, it is difficult to meet the two requirements of obtaining sufficient spatial information and large receptive fields at the same time. In order to obtain more spatial information and a larger receptive field at the same time, we put forward… More >

  • Open Access

    ARTICLE

    Image Inpainting Technique Incorporating Edge Prior and Attention Mechanism

    Jinxian Bai, Yao Fan*, Zhiwei Zhao, Lizhi Zheng

    CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 999-1025, 2024, DOI:10.32604/cmc.2023.044612 - 30 January 2024

    Abstract Recently, deep learning-based image inpainting methods have made great strides in reconstructing damaged regions. However, these methods often struggle to produce satisfactory results when dealing with missing images with large holes, leading to distortions in the structure and blurring of textures. To address these problems, we combine the advantages of transformers and convolutions to propose an image inpainting method that incorporates edge priors and attention mechanisms. The proposed method aims to improve the results of inpainting large holes in images by enhancing the accuracy of structure restoration and the ability to recover texture details. This… More >

  • Open Access

    ARTICLE

    Minimizing opioids after gender affirming orchiectomy – a multimodal pain pathway

    Eric Robinson1, Alex Wang2, Solange Bassale3, Jyoti D. Chouhan2

    Canadian Journal of Urology, Vol.30, No.1, pp. 11414-11418, 2023

    Abstract Introduction: To evaluate the effectiveness of a standardized multimodal pain pathway for gender affirming orchiectomy (GAO) in adequately addressing postoperative pain while reducing the prescribing of unnecessary opioids.
    Materials and methods: A standardized discharge pain pathway for GAO +/- scrotectomy or testicular implants was implemented between May 2020 and March 2022. A retrospective analysis was performed on all consecutive patients who underwent GAO with a single surgeon. Patients answered five questions on postoperative pain management at their 3 week follow up.
    Results: A total of 69 patients were included in the study. Mean age was 34.3 years (SD… More >

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