Xin Zhang^1,*, Shixing Zhang¹, Lina Chen², Jihong Zhang¹, Peihong Yang¹, Zilei Zhang¹, Xiaoming Zhang¹

Energy Engineering, Vol.122, No.9, pp. 3647-3679, 2025, DOI:10.32604/ee.2025.067035 - 26 August 2025

Abstract A park hydrogen-doped integrated energy system (PHIES) can maximize energy utilization as a system with multiple supplies. To realize win-win cooperation between the PHIES and active distribution network (ADN), the cooperative operation problem of multi-PHIES connected to the same ADN is studied. A low-carbon hybrid game coordination strategy for multi-PHIES accessing ADN based on dynamic carbon base price is proposed in the paper. Firstly, multi-PHIES are constructed to form a PHIES alliance, including a hydrogen-doped gas turbine (HGT), hydrogen-doped gas boiler (HGB), power to gas and carbon capture system (P2G-CCS), and other equipment. Secondly, a… More > Graphic Abstract

Dong Hwan Ho^1,*, Minhyung Lee^2,3, Daleum Nam¹, Hyejung Kim¹, Janghwan Kim^2,3, Mi Kyoung Seo^4,5, Sung Woo Park^4,5, Ilhong Son^1,6,*

BIOCELL, Vol.49, No.7, pp. 1225-1244, 2025, DOI:10.32604/biocell.2025.065486 - 25 July 2025

Abstract Background: Parkinson’s disease (PD) is a common neurodegenerative disease, characterized by symptoms like tremors, muscle rigidity, and slow movement. The main cause of these symptoms is the loss of dopamine-producing neurons in a brain area called the substantia nigra. Various genetic and environmental factors contribute to this neuronal loss. Once symptoms of PD begin, they worsen with age, which also impacts several critical cellular processes. Leucine-rich repeat kinase 2 (LRRK2) is a gene associated with PD. Certain mutations in LRRK2, such as G2019S, increase its activity, disrupting cellular mechanisms necessary for healthy neuron function, including… More >

Yanjie Liu, Ximin Cao^*, Yanchi Zhang

Energy Engineering, Vol.122, No.8, pp. 3377-3398, 2025, DOI:10.32604/ee.2025.066577 - 24 July 2025

Abstract Under the “dual carbon” goals, this paper constructs an optimization model of the comprehensive energy system in the park. A stepwise carbon excess rate mechanism and an electric vehicle coupling strategy are proposed: A carbon quota trading system is established based on the baseline method, and the stepwise function is adopted to quantify the cost of excess carbon emissions; Introduce the price demand response and the two-way interaction mechanism of electric Vehicle vehicle-to-grid (V2G) to enhance the flexible regulation ability. Aiming at the uncertainty of wind and solar output, a typical scene set is generated… More >

Yiqin He^1,2, Chenhan Hu^1,2, Xiangshu Meng^1,2, Rundong Ma^1,2, Kexin Duan^1,2, Yu Guo^2,3, Changqing Liu^1,2, Caiyun Ma^1,2, Gaofeng Liu^1,2,*, Chunjing Wang^1,2,*

BIOCELL, Vol.49, No.6, pp. 1037-1055, 2025, DOI:10.32604/biocell.2025.064633 - 24 June 2025

Abstract Background: Mesenchymal stem cells (MSCs) have shown great potential in treating neurodegenerative diseases, including Parkinson’s disease (PD), due to their ability to differentiate into neurons and secrete neurotrophic factors. Genetic modification of MSCs for PD treatment has become a research focus. Methods: In this study, rat pulmonary mesenchymal stem cells (PMSCs) were transduced with lentiviral vectors carrying Lmx1a/NeuroD1 to establish genetically engineered PMSCs (LN-PMSCs) and induce their differentiation into dopaminergic neurons. The LN-PMSCs were then transplanted into the right medial forebrain bundle region of PD model rats prepared using the 6-Hydroxydopamine (6-OHDA) method. Four weeks… More >

Mohammed Al-Jabbar¹, Mohammed Alshahrani^1,*, Ebrahim Mohammed Senan^2,3, Ibrahim Abunadi⁴, Sultan Ahmed Almalki¹, Eman A Alshari^3,5

CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.2, pp. 2429-2457, 2025, DOI:10.32604/cmes.2025.063938 - 30 May 2025

Abstract Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by tremors, rigidity, and decreased movement. PD poses risks to individuals’ lives and independence. Early detection of PD is essential because it allows timely intervention, which can slow disease progression and improve outcomes. Manual diagnosis of PD is problematic because it is difficult to capture the subtle patterns and changes that help diagnose PD. In addition, the subjectivity and lack of doctors compared to the number of patients constitute an obstacle to early diagnosis. Artificial intelligence (AI) techniques, especially deep and automated learning models, provide promising… More >

Chuan Li, Xuanlin Wen^*

CMC-Computers, Materials & Continua, Vol.83, No.3, pp. 3843-3875, 2025, DOI:10.32604/cmc.2025.063047 - 19 May 2025

Abstract Spark performs excellently in large-scale data-parallel computing and iterative processing. However, with the increase in data size and program complexity, the default scheduling strategy has difficulty meeting the demands of resource utilization and performance optimization. Scheduling strategy optimization, as a key direction for improving Spark’s execution efficiency, has attracted widespread attention. This paper first introduces the basic theories of Spark, compares several default scheduling strategies, and discusses common scheduling performance evaluation indicators and factors affecting scheduling efficiency. Subsequently, existing scheduling optimization schemes are summarized based on three scheduling modes: load characteristics, cluster characteristics, and matching More >

Zhiyuan Zhang¹, Yongjun Wu¹, Xiqin Li¹, Minghui Song¹, Guangwu Zhang², Ziren Wang^3,*, Wei Li³

Energy Engineering, Vol.122, No.5, pp. 1919-1948, 2025, DOI:10.32604/ee.2025.063178 - 25 April 2025

Abstract The park-level integrated energy system (PIES) is essential for achieving carbon neutrality by managing multi-energy supply and demand while enhancing renewable energy integration. However, current carbon trading mechanisms lack sufficient incentives for emission reductions, and traditional optimization algorithms often face challenges with convergence and local optima in complex PIES scheduling. To address these issues, this paper introduces a low-carbon dispatch strategy that combines a reward-penalty tiered carbon trading model with P2G-CCS integration, hydrogen utilization, and the Secretary Bird Optimization Algorithm (SBOA). Key innovations include: (1) A dynamic reward-penalty carbon trading mechanism with coefficients (μ = 0.2,… More >

Abdel Aziz Osseni¹, Hubert Olivier Dossou-Yovo^2,*, Apollon D.M.T. Hegbe³, Muhammad Nauman Khan⁴, Brice Sinsin²

Revue Internationale de Géomatique, Vol.34, pp. 209-234, 2025, DOI:10.32604/rig.2025.061448 - 14 April 2025

Abstract Today, environmental studies based on satellite imagery are known as making valuable contributions to the dynamics and spatial prediction of sensitive or complex ecosystems such as wide protected areas and represent sustainable decision tools. The Pendjari and W Transboundary Reserves which constitute biodiversity reservoirs, habitats for wildlife conservation lack substantial investigations on the vegetation dynamics. Despite the protection measures they benefit from, these reserves remain dependent on climatic hazards that can influence their stability. The present study is innovative since it applied remote sensing techniques combined with climate records from the last thirty years to… More >

Ziwen Cai^1,2, Yun Zhao^1,2, Zongyi Wang^1,2, Tonghe Wang^3,*, Yunfeng Li^1,2, Hao Wang³

Energy Engineering, Vol.122, No.4, pp. 1221-1248, 2025, DOI:10.32604/ee.2025.061452 - 31 March 2025

Abstract With the severe challenges brought by global climate change, exploring and developing clean and renewable energy systems to upgrade the energy structure has become an inevitable trend in related research. The comprehensive park systems integrated with photovoltaic, energy storage, direct current, and flexible loads (PEDF) is able to play an important role in promoting energy transformation and achieving sustainable development. In order to fully understand the advantages of PEDF parks in energy conservation and carbon reduction, this paper summarizes existing studies and prospects future research directions on the low-carbon operation of the PEDF park. This… More >

Kristina A. Kritskaya, Evgeniya I. Fedotova, Alexander D. Nadeev^*, Alexey V. Berezhnov^*

BIOCELL, Vol.49, No.3, pp. 451-464, 2025, DOI:10.32604/biocell.2025.061624 - 31 March 2025

Abstract Objective: Activation of mitophagy is a promising option to overcome the mitochondrial malfunction that accompanies many diseases. Herein, we investigate the mechanisms underlying the ability of sodium lactate and pyruvate to initiate mitophagy, from the perspective of action on mitochondrial network and expression levels. Methods: Fluorescent and confocal microscopy was used to assess key cell parameters characterizing the state of the mitochondrial network and the level of mitophagy in human fibroblasts carrying mutations in genes encoding LRRK2 and PINK1 after the combined application of lactate and pyruvate and after direct acidification. qRT-PCR was used to… More >