Angela Reynolds^∗,†, Kittisak Koombua^‡, Ramana M. Pidaparti^{†,‡, §}, Kevin R. Ward^†,¶

Molecular & Cellular Biomechanics, Vol.9, No.2, pp. 141-156, 2012, DOI:10.3970/mcb.2012.009.141

Abstract Better understanding of the acute/chronic inflammation in airways is very important in order to avoid lung injuries for patients undergoing mechanical ventilation for treatment of respiratory problems. Local lung inflammation is triggered by many mechanisms within the lung, including pathogens. In this study, a cellular automata based model (CA) for pulmonary inflammation that incorporates biophysical processes during inflammatory responses was developed. The developed CA results in three possible outcomes related to homeostasis (healing), persistent infection, and resolved infection with high inflammation (inflamed state). The results from the model are validated qualitatively against other existing computational models. A sensitivity analysis was… More >

Arthur J. Sit^*, John H.K. Liu^†

Molecular & Cellular Biomechanics, Vol.6, No.1, pp. 57-70, 2009, DOI:10.3970/mcb.2009.006.057

Abstract Glaucoma is a leading cause of visual impairment and blindness worldwide. The main risk factor for glaucoma is an elevated intraocular pressure (IOP), which is also the only currently treatable risk factor. Despite its importance, our understanding of IOP is incomplete and our ability to measure IOP is limited. IOP is known to undergo both random fluctuations as well as variations following a circadian pattern. In humans, IOP is highest at night and lower during the daytime, largely due to changes in body position, although other factors appear to contribute. In rabbits, IOP is also highest at night and lower… More >

Igor Grešovnik^1,2, Tadej Kodelja¹, Robert Vertnik^2,3, Bojan Senčič^3,2,3, Božidar Šarler^1,2,4

CMC-Computers, Materials & Continua, Vol.30, No.1, pp. 19-38, 2012, DOI:10.3970/cmc.2012.030.019

Abstract Artificial neural networks (ANNs) are employed as an alternative to physical modeling for calculation of the relations between the production path process parameters (melting of scrap steel and alloying, continuous casting, hydrogen removal, reheating, rolling, and cooling on a cooling bed) and the final product mechanical properties (elongation, tensile strength, yield stress, hardness after rolling, necking) of steel semi products. They provide a much faster technique of response evaluation complementary to physical modeling. The Štore Steel company process path for production of steel bars is used as an example for demonstrating the approach. The applied ANN is of a multilayer… More >

Deng Li¹, Shuwei Chang^1,*

CMES-Computer Modeling in Engineering & Sciences, Vol.120, No.2, pp. 305-318, 2019, DOI:10.32604/cmes.2019.06475

Abstract Mechanical force plays a critical role in the remodeling and degradation of cartilage tissues. The cartilage tissue generates, absorbs, and transmits mechanical force, enabling specific biological processes in our body. A moderate intensity mechanical force is necessary for cartilage tissue remodeling and the adaptation of biomechanical properties, but a high intensity mechanical force can lead to pathological degradation of cartilage tissue. However, the molecular mechanism of cartilage degradation is still unclear. We use full atomistic simulations with SMD simulations to investigate whether the magnitude of mechanical force affects the unbinding pathway of the MMP8-Aggrecan_IGD complex. We find that when the… More >

Long Deng¹, Xueying Huang^2,3,*, Heng Zuo⁴, Yuan Zheng², Chun Yang⁵, Yunhu Song¹, Dalin Tang⁶

CMES-Computer Modeling in Engineering & Sciences, Vol.116, No.2, pp. 115-125, 2018, DOI: 10.31614/cmes.2018.04076

Abstract The mechanisms of systolic anterior motion (SAM) of the mitral valve in hypertrophic obstructive cardiomyopathy (HOCM) remain unclear. To investigate the angle of attack between blood flow and mitral valve leaflets at pre-SAM time point, patient-specific CT-based computational models were constructed for 5 patients receiving septal myectomy surgery to obtain pre- and post-operative 2D vector flow mapping. The comparisons between pre- and post-operative angles of attack based on 2D vector flow mapping of 5 patients were performed. It was found that there was no statistically significant difference between pre- and post-operative angles of attack (61.1±t wao vs. 56.2±56.o, p=0.306, n=5).… More >

M.T.C. Araújo Fernandes¹, C.O. Cardoso², W.J. Mansur³

CMES-Computer Modeling in Engineering & Sciences, Vol.113, No.3, pp. 325-342, 2017, DOI:10.3970/cmes.2017.113.341

Abstract A new adaptive (automatic) time stepping algorithm, called RCA (Rate of Convergence Algorithm) is presented. The new algorithm was applied in nonlinear finite element analysis of path-dependent problems. The step size is adjusted by monitoring the estimated convergence rate of the nonlinear iterative process. The RCA algorithm is relatively simple to implement, robust and its performance is comparable to, and in some cases better than, the automatic load incrementaion algorithm existent in commercial codes. Discussions about the convergence rate of nonlinear iterative processes, an estimation of the rate and a study of the parameters of the RCA algorithm are presented.… More >

V.B.Shim ¹, K. Mithraratne ¹

CMES-Computer Modeling in Engineering & Sciences, Vol.98, No.3, pp. 279-294, 2014, DOI:10.32604/cmes.2014.098.279

Abstract The activation of NF-kB is an important precursor in developing melanoma. However the role of mechanical stimulation in the NF-kB activation has not been studied. We used a multiscale computational modeling approach to investigate the role of mechanical stimulation and the skin tissue internal structures in the activation of NF-kB. Our model is made up of three levels – 1) the macro level where a FE model of the Zygomaticus major muscle was developed; 2) the meso level where a micro FE model of the skin block using a sample from human cadaver was developed; 3) the cell level where… More >

E. Ferretti¹, E. Casadio, A. Di Leo¹

CMES-Computer Modeling in Engineering & Sciences, Vol.30, No.3, pp. 163-190, 2008, DOI:10.3970/cmes.2008.030.163

Abstract In this study, the Cell Method (CM) is applied in order to investigate the failure mechanisms of masonry walls under shear force. The direction of propagation is computed step-wise by the code, and the domain is updated by means of a propagation technique of intra-element nodal relaxation with re-meshing. The crack extension condition is studied in the Mohr/Coulomb plane, using the criterion of Leon. The main advantage of using the CM for numerical analyses of masonry is that the mortar, the bricks and the interfaces between mortar and bricks can be modeled without any need to use homogenization techniques, simply… More >

T. Nishioka¹, Y. Kobayashi¹, T. Fujimoto¹

CMES-Computer Modeling in Engineering & Sciences, Vol.17, No.3, pp. 231-238, 2007, DOI:10.3970/cmes.2007.017.231

Abstract First, for growing cracks in elastic-plastic materials, an incremental variational principle is developed to satisfy the boundary conditions near newly created crack surfaces. Then using this variational principle, a moving finite element method is formulated and developed, based on the Delaunay automatic triangulation. Furthermore, theoretical backgrounds on numerical prediction for fracture path of curving crack using T* integral are explained. Using the automatic moving finite element method, fracture-path prediction simulations are successfully carried out. More >

Toshihisa Nishioka ¹,

CMES-Computer Modeling in Engineering & Sciences, Vol.10, No.3, pp. 209-216, 2005, DOI:10.3970/cmes.2005.010.209

Abstract Recent Advances in Numerical Simulation Technologies for Various Dynamic Fracture Phenomena are summarized. First, the basic concepts of fracture simulations are explained together with pertinent simulation results. Next, Examples of dynamic fracture simulations are presented. More >