Mukul Mishra¹, Deeba Khan², Sehbanul Islam^1,*

BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025

Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

LIUJIE CHEN^1,#, LILI DUAN^1,2,#, JIA LI^1,2, JUN CHEN^1,2, DUANFANG LIAO³, NONGYUE HE⁴, KAI LI^1,3, ZHENG HU^1,2,*

BIOCELL, Vol.49, No.1, pp. 21-43, 2025, DOI:10.32604/biocell.2024.056698 - 24 January 2025

Abstract Nucleic acid analysis is a key technique that enables accurate detection of various microorganisms. Conventional nucleic acid testing typically requires access to specialized laboratories, equipment, and trained personnel, which hinders the widespread use of on-site testing for DNA and RNA targets. However, integrating gene editing technology with traditional nucleic acid detection methods, especially isothermal amplification technology, can help overcome the limitations associated with on-site testing. This combination can accomplish precise and swift detection of nucleic acid sequences, offering a robust tool for on-site detection. The Clustered Regularly Interspaced Short Palindromic Repeats/CRISPR-associated proteins (CRISPR/Cas) technology, which More >

Dan Wang, Jihuan Song, Qiyuan Wang, Chenmeng Cui, Ying Yang^*

Journal of Renewable Materials, Vol.13, No.1, pp. 49-78, 2025, DOI:10.32604/jrm.2024.056644 - 20 January 2025

Abstract Upgrading of abundant cellulosic biomass to isosorbide can reduce the dependence on limited fossil resources and provide a sustainable way to produce isosorbide, utilized for polymers, medicine and health care product synthesis. This review comprehensively examines the key steps and catalytic systems involved in the conversion of cellulose to isosorbide. Initially, the reaction pathway from cellulose to isosorbide is elucidated, emphasizing three critical steps: cellulose hydrolysis, glucose hydrogenation, and the two-step dehydration of sorbitol to produce isosorbide. Additionally, the activation energy and acidic sites during cellulose hydrolysis, the impact of metal particle size and catalyst More > Graphic Abstract

Mustafa Youldash¹, Atta Rahman^2,*, Manar Alsayed¹, Abrar Sebiany¹, Joury Alzayat¹, Noor Aljishi¹, Ghaida Alshammari¹, Mona Alqahtani¹

Intelligent Automation & Soft Computing, Vol.40, pp. 125-143, 2025, DOI:10.32604/iasc.2025.058509 - 23 January 2025

Abstract Diabetic retinopathy (DR) is a complication of diabetes that can lead to reduced vision or even blindness if left untreated. Therefore, early and accurate detection of this disease is crucial for diabetic patients to prevent vision loss. This study aims to develop a deep-learning approach for the early and precise diagnosis of DR, as manual detection can be time-consuming, costly, and prone to human error. The classification task is divided into two groups for binary classification: patients with DR (diagnoses 1–4) and those without DR (diagnosis 0). For multi-class classification, the categories are no DR,… More >

Ghulam E Mustafa Abro^1,*, Ayman M Abdallah^1,2, Faizan Zahid³, Saleem Ahmed⁴

Intelligent Automation & Soft Computing, Vol.40, pp. 99-123, 2025, DOI:10.32604/iasc.2025.060364 - 23 January 2025

Abstract This review synthesises and assesses the most recent developments in Unmanned Aerial Vehicles (UAVs) and swarm robotics, with a specific emphasis on optimisation strategies, path planning, and formation control. The study identifies key methodologies that are driving progress in the field by conducting a comprehensive analysis of seven critical publications. The following are included: sensor-based platforms that facilitate effective obstacle avoidance, cluster-based hierarchical path planning for efficient navigation, and adaptive hybrid controllers for dynamic environments. The review emphasises the substantial contribution of optimisation techniques, including Max-Min Ant Colony Optimisation (MMACO), to the improvement of convergence… More >

NAIXIONG PENG, YUEFENG CAI, DONG CHEN, LING DENG, ZEJIAN ZHANG, WEI LI^*

Oncology Research, Vol.33, No.2, pp. 347-356, 2025, DOI:10.32604/or.2024.056039 - 16 January 2025

Abstract Background: Clear cell renal carcinoma (ccRCC), the leading histological subtype of RCC, lacks any targeted therapy options. Although some studies have shown that early growth response factor 1 (EGR1) has a significant role in cancer development and progression, its role and underlying mechanisms in ccRCC remain poorly understood. Methods: The Cancer Genome Atlas (TCGA) database was utilized to examine the expression of EGR1 in ccRCC. The expression of EGR1 in 55 ccRCC tissues was evaluated using immunohistochemistry. The link between EGR1 expression and clinicopathological variables was examined through an analysis. Gain-of-function assays were employed to… More >

HAIYING PANG^1,#, FENGBO WU^1,#, YU ZHANG¹, NAN ZHANG², CHUNTING WANG¹, QIU LI¹, GU HE^1,*, PENG ZHANG^3,*

Oncology Research, Vol.33, No.2, pp. 443-464, 2025, DOI:10.32604/or.2024.043948 - 16 January 2025

Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More > Graphic Abstract

Xianju Gao^*, Huachun Zhou, Weilin Wang, Jingfu Yan

Computer Systems Science and Engineering, Vol.49, pp. 19-48, 2025, DOI:10.32604/csse.2024.058327 - 03 January 2025

Abstract The network security knowledge base standardizes and integrates network security data, providing a reliable foundation for real-time network security protection solutions. However, current research on network security knowledge bases mainly focuses on their construction, while the potential to optimize intelligent security services for real-time network security protection requires further exploration. Therefore, how to effectively utilize the vast amount of historical knowledge in the field of network security and establish a feedback mechanism to update it in real time, thereby enhancing the detection capability of security services against malicious traffic, has become an important issue. Our… More >

TAO SUN^1,2, QINGHUA SONG³, HUA LIU^1,*

Oncology Research, Vol.33, No.1, pp. 133-148, 2025, DOI:10.32604/or.2024.054141 - 20 December 2024

Abstract Background: Lung cancer is a life-threatening disease that occurs worldwide, but is especially common in China. The crucial role of the tumour microenvironment (TME) in non-small cell lung cancer (NSCLC) has attracted recent attention. Cancer-associated fibroblasts (CAFs) are the main factors that contribute to the TME function, and CAF exosomes are closely linked to NSCLC. Methods: The expression levels of miR-3124-5p and Toll-interacting protein (TOLLIP) were analysed by bioinformatics prediction combined with RT-qPCR/Western Blot detection. Fibroblasts were isolated and identified from clinical NSCLC tissues. Transmission electron microscopy and Western Blot were used to identify exosomes… More >

ENRICO CALIMAN^1,2, SARA FANCELLI^1,2, FEDERICO SCOLARI³, ADRIANO PASQUI⁴, CLARA MANNESCHI⁴, DANIELE LAVACCHI¹, FRANCESCA MAZZONI⁴, FRANCESCA GENSINI⁵, VALERIA PASINI⁶, CAMILLA EVA COMIN^2,7, LUCA VOLTOLINI^2,8, SERENA PILLOZZI^1,2,*, LORENZO ANTONUZZO^1,2,4

Oncology Research, Vol.33, No.1, pp. 45-55, 2025, DOI:10.32604/or.2024.050161 - 20 December 2024

Abstract Background: Platinum chemotherapy (CT) remains the backbone of systemic therapy for patients with small-cell lung cancer (SCLC). The nucleotide excision repair (NER) pathway plays a central role in the repair of the DNA damage exerted by platinum agents. Alteration in this repair mechanism may affect patients’ survival. Materials and Methods: We conducted a retrospective analysis of data from 38 patients with extensive disease (ED)-SCLC who underwent platinum-CT at the Clinical Oncology Unit, Careggi University Hospital, Florence (Italy), from 2015 to 2020. mRNA expression analysis and single nucleotide polymorphism (SNP) characterization of three NER pathway genes—namely ERCC1, ERCC2,… More >