Chang-Eui Hong^1,2,3, Su-Yun Lyu^1,2,3,*

BIOCELL, Vol.49, No.12, pp. 2377-2397, 2025, DOI:10.32604/biocell.2025.072360 - 24 December 2025

Abstract Objective: Triple-negative breast cancer (TNBC) remains a major therapeutic challenge with limited treatment options and poor prognosis. This study aimed to investigate the synergistic anticancer effects of doxorubicin (DOX) combined with Viscum album L. var. coloratum agglutinin (VCA) and to elucidate the underlying molecular mechanisms in TNBC cells. Methods: This study evaluated the synergistic effects and mechanisms of doxorubicin (DOX) and Viscum album L. var. coloratum agglutinin (VCA) combination in MDA-MB231 TNBC cells. Cell viability, oxidative stress markers, apoptosis-related proteins, cell migration, and proliferative recovery were assessed using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, superoxide dismutase (SOD) and nitric oxide… More >

Damodharan Palaniappan¹, Tan Kuan Tak², K. Vijayan³, Balajee Maram⁴, Pravin R Kshirsagar⁵, Naim Ahmad^6,*

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4107-4127, 2025, DOI:10.32604/cmes.2025.073387 - 23 December 2025

Abstract A phase-aware cross-modal framework is presented that synthesizes UWF_FA from non-invasive UWF_RI for diabetic retinopathy (DR) stratification. A curated cohort of 1198 patients (2915 UWF_RI and 17,854 UWF_FA images) with strict registration quality supports training across three angiographic phases (initial, mid, final). The generator is based on a modified pix2pixHD with an added Gradient Variance Loss to better preserve microvasculature, and is evaluated using MAE, PSNR, SSIM, and MS-SSIM on held-out pairs. Quantitatively, the mid phase achieves the lowest MAE (98.76 ± 42.67), while SSIM remains high across phases. Expert review shows substantial agreement (Cohen’s More >

Rytis Maskeliūnas¹, Robertas Damaševičius^1,*, Audrius Kulikajevas¹, Kipras Pribuišis², Nora Ulozaitė-Stanienė², Virgilijus Uloza²

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4203-4223, 2025, DOI:10.32604/cmes.2025.072790 - 23 December 2025

Abstract This study introduces a novel voice cloning framework driven by Mordukhovich Subdifferential Optimization (MSO) to address the complex multi-objective challenges of pathological speech synthesis in under-resourced Lithuanian language with unique phonemes not present in most pre-trained models. Unlike existing voice synthesis models that often optimize for a single objective or are restricted to major languages, our approach explicitly balances four competing criteria: speech naturalness, speaker similarity, computational efficiency, and adaptability to pathological voice patterns. We evaluate four model configurations combining Lithuanian and English encoders, synthesizers, and vocoders. The hybrid model (English encoder, Lithuanian synthesizer, English More >

Rıdvan Yayla, Hakan Üçgün^*, Onur Ali Korkmaz

CMES-Computer Modeling in Engineering & Sciences, Vol.145, No.3, pp. 4055-4087, 2025, DOI:10.32604/cmes.2025.072703 - 23 December 2025

Abstract Recent advancements in autonomous vehicle technologies are transforming intelligent transportation systems. Artificial intelligence enables real-time sensing, decision-making, and control on embedded platforms with improved efficiency. This study presents the design and implementation of an autonomous radio-controlled (RC) vehicle prototype capable of lane line detection, obstacle avoidance, and navigation through dynamic path planning. The system integrates image processing and ultrasonic sensing, utilizing Raspberry Pi for vision-based tasks and Arduino Nano for real-time control. Lane line detection is achieved through conventional image processing techniques, providing the basis for local path generation, while traffic sign classification employs a… More > Graphic Abstract

Fu Zhang^1,2, Miao Lin^1,2, Yuancong Jiang³, Fangjian Zhou^1,2,*

European Cytokine Network, Vol.36, No.1, pp. 1-5, 2025, DOI:10.1684/ecn.2025.0500

Abstract Interleukin-33 (IL-33), a key member of the IL-1 family, plays a significant role in inflammation and cancer. Its classic receptors, ST2 and IL-1 receptor accessory protein (IL-1RAcP), are predominantly expressed in immune cells such as T helper 2 (Th2) cells and mast cells. Recent studies have highlighted the involvement of IL-33 in breast cancer, demonstrating its ability to exert dual functional effects by modulating both innate and adaptive immune responses within the tumour microenvironment. However, the precise molecular mechanisms linking IL-33 to breast cancer pathogenesis and its potential as a target for molecularly targeted therapies More >

C. M. Fu^a, M. Z. Ge^b, X. Q. Zhang^c, W. Yan^c,*

Chalcogenide Letters, Vol.22, No.8, pp. 665-677, 2025, DOI:10.15251/CL.2025.228.665

Abstract Constructing heterojunctions represents a crucial strategy for enhancing semiconductor photocatalysts. In this study, the C-MoO₂/Cd_0.9Zn_0.1S S-scheme heterojunction composite was successfully fabricated through a self-assembly approach. XPS analysis confirmed the spontaneous transfer of intrinsic electrons from Cd_0.9Zn_0.1S to C-MoO₂ in the dark, establishing an internal electric field at the C-MoO2/Cd_0.9Zn_0.1S interface. Under visible light irradiation, the C-MoO₂/Cd_0.9Zn_0.1S composite exhibited significantly enhanced hydrogen evolution activity, achieving a 6.3-fold improvement compared to pristine Cd_0.9Zn_0.1S. PL, TRPL, and electrochemical measurements collectively demonstrated that the incorporation of C-MoO₂ effectively suppressed the recombination of photogenerated electrons in Cd_0.9Zn_0.1S. The outstanding photocatalytic performance and improved charge More >

Fang Liao, Xiurong Wang^*, Muyan Xie, Lixin Duan

Phyton-International Journal of Experimental Botany, Vol.94, No.11, pp. 3667-3686, 2025, DOI:10.32604/phyton.2025.069653 - 01 December 2025

Abstract Bryophytes play important ecological roles in terrestrial ecosystems, but their growth is often influenced by environmental factors and chemical interactions with surrounding vegetation. Fallen leaves are an important source of allelopathic substances, yet little is known about their impact on mosses. This study investigates the allelopathic effects of fallen leaves from Cinnamomum camphora, Pinus massoniana, and Bambusa emeiensis on the bryophyte Thuidium kanedae in Guiyang. The litter aqueous extract (0.0125 g/mL (T1), 0.025 g/mL (T2), 0.05 g/mL (T3), 0.1 g/mL (T4) and distilled water control (CK)) was used to regularly water and culture T. kanedae. During the 120-day test period,… More >

Jun He¹, Jianli Luo¹, Yanling Wang^1,*, Dai Zhou^1,*, Shuanglin Xiang^2,*

Congenital Heart Disease, Vol.20, No.5, pp. 613-623, 2025, DOI:10.32604/chd.2025.071773 - 30 November 2025

Abstract Pediatric congenital heart disease (CHD) pharmacotherapy faces three fundamental barriers: developmental pharmacokinetic complexity, anatomic-genetic heterogeneity, and evidence chain gaps. Traditional agents exhibit critical limitations: digoxin’s narrow therapeutic index (0.5–0.9 ng/mL) is exacerbated by ABCB1 mutations (toxicity risk increases 4.1-fold), furosemide efficacy declines by 35% in neonates due to NKCC2 immaturity, and β-blocker responses vary by CYP2D6 polymorphisms (poor metabolizers require 50–75% dose reduction). Novel strategies demonstrate transformative potential—CRISPR editing achieves 81% reversal of BMPR2-associated pulmonary vascular remodeling, metabolically matured cardiac organoids replicate adult myocardial energy metabolism for drug screening, and SGLT2 inhibitors activate triple mechanisms (calcium overload More >

Hiroshi Yoshida^1,*, Mayumi Kobayashi Kato²

Oncology Research, Vol.33, No.12, pp. 3701-3730, 2025, DOI:10.32604/or.2025.068432 - 27 November 2025

Abstract Ovarian endometrioid carcinoma (OEC) accounts for ~10% of epithelial ovarian cancers and displays broad morphologic diversity that complicates diagnosis and grading. Recent data show that the endometrial cancer molecular taxonomy (DNA polymerase epsilon, catalytic subunit [POLE]-ultramutated, mismatch repair-deficient [MMRd], p53-abnormal, no specific molecular profile [NSMP]) also applies to OEC, and that OEC is enriched for Lynch syndrome–associated tumors, supporting routine MMR testing. We aimed to synthesize contemporary evidence spanning epidemiology, histopathology and immunophenotype, diagnostic pitfalls and differential diagnosis, and to evaluate the clinical utility of The Cancer Genome Atlas (TCGA)-surrogate molecular classification for risk stratification; More >

Si Qin, Shu Tang, Lijiao Xie, Jianbo Zhu, Jianguo Sun^*

Oncology Research, Vol.33, No.12, pp. 4145-4154, 2025, DOI:10.32604/or.2025.068300 - 27 November 2025

Abstract Background: Primary pulmonary lymphoepithelioma-like carcinoma (PPLELC) is a rare subtype of primary non-small cell lung cancer (NSCLC), with no established treatment guidelines. We present a case of a young female with PPLELC who achieved a pathological complete response (pCR) in both primary and metastatic lesions after receiving combined immunotherapy and radiotherapy. Case description: We present a 33-year-old female patient with stage IVa (cT2bN0M1b) PPLELC. As a first-line treatment, the patient received seven cycles of nab-paclitaxel combined with toripalimab (a PD-1 inhibitor) and achieved stable disease. This was followed by toripalimab maintenance therapy for nearly 30 months.… More >