JINGLONG CAO^1,#, SHUMEI LI^2,#, TONG ZHANG^1,#, JIAN LIU¹, WENSHUANG HOU¹, ANQI WANG¹, CHANG WANG^3,4,*, CHENGHAO JIN^1,3,5,*

BIOCELL, Vol.48, No.2, pp. 313-325, 2024, DOI:10.32604/biocell.2023.043474

Abstract Background: Valtrate (Val) was extracted from the Valeriana jatamansi Jones plant, had good antitumor activity. However, its precise molecular mechanism in cancer cells was still unclear. This study investigated the effect of Val on gastric cancer (GC) cells and its potential molecular mechanism. Methods: Cell viability was examined by CCK-8 assay. Cell cycle, apoptosis, and Reactive oxygen species (ROS) level were analyzed by flow cytometry. The migration effect of Val on AGS cells was analyzed by transwell and wound-healing assay. The expression levels of proteins were analyzed by western blot. Results: The cell viability assay results demonstrated that Val significantly… More > Graphic Abstract

HUI SUN, MASANORI KAWANO^*, TATSUYA IWASAKI, ICHIRO ITONAGA, YUTA KUBOTA, HIROSHI TSUMURA, KAZUHIRO TANAKA

Oncology Research, Vol.32, No.3, pp. 463-476, 2024, DOI:10.32604/or.2023.044085

Abstract An important factor in the emergence and progression of osteosarcoma (OS) is the dysregulated expression of microRNAs (miRNAs). Transcription factor 7-like 1 (TCF7L1), a member of the T cell factor/lymphoid enhancer factor (TCF/LEF) transcription factor family, interacts with the Wnt signaling pathway regulator β-catenin and acts as a DNA-specific binding protein. This study sought to elucidate the impact of the interaction between miR-329-3p and TCF7L1 on the growth and apoptosis of OS and analyze the regulatory expression relationship between miRNA and mRNA in osteosarcoma cells using a variety of approaches. MiR329-3p was significantly downregulated, while TCF7L1 was considerably up-regulated in… More > Graphic Abstract

YUANYUAN XU, XIAOKE CHEN^*

Oncology Research, Vol.32, No.3, pp. 517-528, 2024, DOI:10.32604/or.2023.030293

Abstract Background: The aberrant intracellular expression of a mitochondrial aspartyl-tRNA synthetase 2 (DARS2) has been reported in human cancers. Nevertheless, its critical role and detailed mechanism in lung adenocarcinoma (LUAD) remain unexplored. Methods: Initially, The Cancer Genome Atlas (TCGA)-based Gene Expression Profiling Interactive Analysis (GEPIA) database () was used to analyze the prognostic relevance of DARS2 expression in LUAD. Further, cell counting kit (CCK)-8, immunostaining, and transwell invasion assays in LUAD cell lines in vitro, as well as DARS2 silence on LUAD by tumorigenicity experiments in vivo in nude mice, were performed. Besides, we analyzed the expression levels of p-PI3K (phosphorylated-Phosphotylinosital3… More >

YANG LI^1,2, JIAN LIU^1,3,*, YUEDI HU^1,2, CHENGZHI CONG^1,2, YIMING CHEN^1,2, QIAO ZHOU^1,2

BIOCELL, Vol.48, No.1, pp. 9-19, 2024, DOI:10.32604/biocell.2023.045862

Abstract Rheumatoid arthritis (RA) is a prevalent autoimmune disease whose main features include chronic synovial inflammation, bone destruction, and joint degeneration. Neutrophils are often considered to be the first responders to inflammation and are a key presence in the inflammatory milieu of RA. Neutrophil extracellular traps (NETs), a meshwork of DNA-histone complexes and proteins released by activated neutrophils, are widely involved in the pathophysiology of autoimmune diseases, especially RA, in addition to playing a key role in the neutrophil innate immune response. NETs have been found to be an important source of citrullinated autoantigen antibodies and inflammatory factor release, which can… More > Graphic Abstract

JIANHONG LIU^1,#, KAI HE^2,#, HAN WANG^3,#, XIAOHONG CHENG^1,*

BIOCELL, Vol.48, No.1, pp. 21-32, 2024, DOI:10.32604/biocell.2023.045631

Abstract Exosomes, nanoscale extracellular vesicles (EVs) derived from the invagination of the endosomal membrane, are secreted by a majority of cell types. As carriers of DNA, mRNA, proteins, and microRNAs, exosomes are implicated in regulating biological activities under physiological and pathological conditions. Kidney-derived exosomes, which vary in origin and function, may either contribute to the pathogenesis of disease or represent a potential therapeutic resource. Membranous nephropathy (MN), an autoimmune kidney disease characterized by glomerular damage, is a predominant cause of nephrotic syndrome. Notably, MN, especially idiopathic membranous nephropathy (IMN), often results in end-stage renal disease (ESRD), affecting approximately 30% of patients… More > Graphic Abstract

Kun Yang^1,2,3, Shilong Chang¹, Yucheng Wang¹, Minghui Wang¹, Jiahui Yang¹, Shuang Liu^1,2,3, Kun Liu^1,2,3, Linyan Xue^1,2,3,*

CMC-Computers, Materials & Continua, Vol.78, No.1, pp. 393-410, 2024, DOI:10.32604/cmc.2023.044994

Abstract Clear cell renal cell carcinoma (ccRCC) represents the most frequent form of renal cell carcinoma (RCC), and accurate International Society of Urological Pathology (ISUP) grading is crucial for prognosis and treatment selection. This study presents a new deep network called Multi-scale Fusion Network (MsfNet), which aims to enhance the automatic ISUP grade of ccRCC with digital histopathology pathology images. The MsfNet overcomes the limitations of traditional ResNet50 by multi-scale information fusion and dynamic allocation of channel quantity. The model was trained and tested using 90 Hematoxylin and Eosin (H&E) stained whole slide images (WSIs), which were all cropped into 320… More >

Zhiwei Lin¹, Hui Wang^1,*, Tianding Chen¹, Yingtao Jiang², Jianmei Jiang³, Yingpin Chen¹

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1357-1379, 2024, DOI:10.32604/cmes.2023.045990

Abstract In the domain of autonomous industrial manipulators, precise positioning and appropriate posture selection in path planning are pivotal for tasks involving obstacle avoidance, such as handling, heat sealing, and stacking. While Multi-Degree-of-Freedom (MDOF) manipulators offer kinematic redundancy, aiding in the derivation of optimal inverse kinematic solutions to meet position and posture requisites, their path planning entails intricate multi-objective optimization, encompassing path, posture, and joint motion optimization. Achieving satisfactory results in practical scenarios remains challenging. In response, this study introduces a novel Reverse Path Planning (RPP) methodology tailored for industrial manipulators. The approach commences by conceptualizing the manipulator’s end-effector as an… More > Graphic Abstract

Xiaoge Wei^1,2,*, Yuming Zhang^1,2, Huaitao Song^1,2, Hengjie Qin^1,2, Guanjun Zhao³

CMES-Computer Modeling in Engineering & Sciences, Vol.139, No.2, pp. 1295-1316, 2024, DOI:10.32604/cmes.2023.045096

Abstract Reducing casualties and property losses through effective evacuation route planning has been a key focus for researchers in recent years. As part of this effort, an enhanced sparrow search algorithm (MSSA) was proposed. Firstly, the Golden Sine algorithm and a nonlinear weight factor optimization strategy were added in the discoverer position update stage of the SSA algorithm. Secondly, the Cauchy-Gaussian perturbation was applied to the optimal position of the SSA algorithm to improve its ability to jump out of local optima. Finally, the local search mechanism based on the mountain climbing method was incorporated into the local search stage of… More >

Maha Ouazzani^1,2,*, Zineb El Khammar², Nawal Oubelkacem², Youssef Aboussaleh¹, Hajar Masrour², Moncef Maiouak³, Rhizlane Berrady²

Psycho-Oncologie, Vol.17, No.4, pp. 235-244, 2023, DOI:10.32604/po.2023.044831

Abstract Introduction : la qualité de vie des patients suivis pour une hémopathie maligne dépend non seulement du type de la maladie, de ses caractéristiques cliniques, biologiques et thérapeutiques, mais aussi de la santé mentale du patient. L’objectif de notre étude est d’évaluer l’état psychologique des patients au diagnostic, de rechercher les facteurs associés à son altération et de préciser son impact sur la qualité de vie des patients. Méthode : nous avons mené une étude monocentrique transversale qui évalue la dépression, l’anxiété et la qualité de vie d’une population de patients atteints de syndromes lymphoprolifératifs sur une période de 22mois.… More >

Ke Jia, Xiuli Liu^*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1265-1285, 2023, DOI:10.32604/ijmhp.2023.043430

Abstract Empathy is a complex emotional phenomenon that plays a crucial role in promoting cooperation and social cohesion within human society. However, there is ongoing debate regarding the mechanisms that underlie the generation of empathy. While the importance of biological emotional resonance in empathy is widely recognized, the influence of cognitive regulation on empathetic responses cannot be disregarded. This article seeks to review the agents and strategies involved in regulating empathy to construct a dynamic model depicting the process. The model highlights that the impact of specific goals on empathy regulation is not definitive; rather, it depends on an individual’s interpretation… More >