Yiteng Zang¹, Biyun Xu², Sizhen Chen¹, Grace Mutale¹, Qiuyun Cao^3,*, Bingwei Chen^1,*

International Journal of Mental Health Promotion, Vol.25, No.12, pp. 1287-1302, 2023, DOI:10.32604/ijmhp.2023.042584

Abstract Psychosis has increasingly become a social problem, emphasizing the need to understand the relationship between mental disorders and personality. This study aimed to investigate the relationship between mental disorders and personality among psychiatric outpatients based on real-world data. Symptom Checklist 90 (SCL-90) and Eysenck Personality Questionnaire (EPQ) were used to evaluate the personality and psychopathological symptoms of patients (n = 8409) in the Psychiatric Outpatient Department at Nanjing Drum Tower Hospital. t-test was used to compare scores between patients and national norms. Pearson’s correlation coefficient and path analysis were used to explore the relationship between mental health status and personality.… More >

MINJI PARK¹, CHULHWAN BANG², WON-SOO YUN³, YUN-MI JEONG^3,*

Oncology Research, Vol.32, No.2, pp. 273-282, 2024, DOI:10.32604/or.2023.044362

Abstract Fucoidan, a sulfate polysaccharide obtained from brown seaweed, has various bioactive properties, including anti-inflammatory, anti-cancer, anti-viral, anti-oxidant, anti-coagulant, anti-thrombotic, anti-angiogenic, and anti-Helicobacter pylori properties. However, the effects of low-molecular-weight fucoidan (LMW-F) on melanoma cell lines and three dimensional (3D) cell culture models are not well understood. This study aimed to investigate the effects of LMW-F on A375 human melanoma cells and cryopreserved biospecimens derived from patients with advanced melanoma. Ultrasonic wave was used to fragment fucoidan derived from Fucus vesiculosus into smaller LMW-F. MTT and live/dead assays showed that LMW-F inhibited cell proliferation in both A375 cells and patient-derived melanoma… More >

BEHROOZ JOHARI^1,2,#,*, MILAD PARVINZAD LEILAN^1,#, MAHMOUD GHARBAVI³, YOUSEF MORTAZAVI¹, ALI SHARAFI², HAMED REZAEEJAM⁴

Oncology Research, Vol.32, No.2, pp. 309-323, 2024, DOI:10.32604/or.2023.043576

Abstract The Myc gene is the essential oncogene in triple-negative breast cancer (TNBC). This study investigates the synergistic effects of combining Myc decoy oligodeoxynucleotides-encapsulated niosomes-selenium hybrid nanocarriers with X-irradiation exposure on the MDA-MB-468 cell line. Decoy and scramble ODNs for Myc transcription factor were designed and synthesized based on promoter sequences of the Bcl2 gene. The nanocarriers were synthesized by loading Myc ODNs and selenium into chitosan (Chi-Se-DEC), which was then encapsulated in niosome-nanocarriers (NISM@Chi-Se-DEC). FT-IR, DLS, FESEM, and hemolysis tests were applied to confirm its characterization and physicochemical properties. Moreover, cellular uptake, cellular toxicity, apoptosis, cell cycle, and scratch repair… More > Graphic Abstract

ZHI ZHANG^1,#, XIAOSONG LI^1,2,#, YING ZHANG^1,2,#, HAO ZHU^1,2, ZHENGUO QIAO³, YANG LU⁴, XIUWEI MI⁴, HUIHUA CAO⁵, GENHAI SHEN^1,*, SONGBING HE^4,*

Oncology Research, Vol.32, No.2, pp. 353-360, 2024, DOI:10.32604/or.2023.042986

Abstract Colorectal cancer (CRC) stands among the top prevalent cancers worldwide and holds a prominent position as a major contributor to cancer-related mortality globally. Absent in melanoma 2 (AIM2), a constituent of the interferon-inducible hematopoietic interferon-inducible nuclear antigens with 200 amino acid repeats protein family, contributes to both cancer progression and inflammasome activation. Despite this understanding, the precise biological functions and molecular mechanisms governed by AIM2 in CRC remain elusive. Consequently, this study endeavors to assess AIM2’s expression levels, explore its potential antitumor effects, elucidate associated cancer-related processes, and decipher the underlying signaling pathways in CRC. Our findings showed a reduced… More > Graphic Abstract

Abdulwahab Ali Almazroi^1,*, Nasir Ayub²

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3921-3942, 2023, DOI:10.32604/cmc.2023.046602

Abstract Effectively managing complex logistics data is essential for development sustainability and growth, especially in optimizing distribution routes. This article addresses the limitations of current logistics path optimization methods, such as inefficiencies and high operational costs. To overcome these drawbacks, we introduce the Hybrid Firefly-Spotted Hyena Optimization (HFSHO) algorithm, a novel approach that combines the rapid exploration and global search abilities of the Firefly Algorithm (FO) with the localized search and region-exploitation skills of the Spotted Hyena Optimization Algorithm (SHO). HFSHO aims to improve logistics path optimization and reduce operational costs. The algorithm’s effectiveness is systematically assessed through rigorous comparative analyses… More >

Shuqin Zhang, Xinyu Su^*, Yunfei Han, Tianhui Du, Peiyu Shi

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3993-4023, 2023, DOI:10.32604/cmc.2023.044526

Abstract Advanced Persistent Threat (APT) is now the most common network assault. However, the existing threat analysis models cannot simultaneously predict the macro-development trend and micro-propagation path of APT attacks. They cannot provide rapid and accurate early warning and decision responses to the present system state because they are inadequate at deducing the risk evolution rules of network threats. To address the above problems, firstly, this paper constructs the multi-source threat element analysis ontology (MTEAO) by integrating multi-source network security knowledge bases. Subsequently, based on MTEAO, we propose a two-layer threat prediction model (TL-TPM) that combines the knowledge graph and the… More >

Manas Ranjan Prusty¹, Rishi Dinesh², Hariket Sukesh Kumar Sheth², Alapati Lakshmi Viswanath², Sandeep Kumar Satapathy^2,3,*

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3077-3094, 2023, DOI:10.32604/cmc.2023.042718

Abstract This paper presents a novel computerized technique for the segmentation of nuclei in hematoxylin and eosin (H&E) stained histopathology images. The purpose of this study is to overcome the challenges faced in automated nuclei segmentation due to the diversity of nuclei structures that arise from differences in tissue types and staining protocols, as well as the segmentation of variable-sized and overlapping nuclei. To this extent, the approach proposed in this study uses an ensemble of the UNet architecture with various Convolutional Neural Networks (CNN) architectures as encoder backbones, along with stain normalization and test time augmentation, to improve segmentation accuracy.… More >

Wen Sun¹, Meijing Li², Guoxiang Li¹, Ke Sun^1,*, Shuzhan Bai^1,*

Energy Engineering, Vol.121, No.1, pp. 95-110, 2024, DOI:10.32604/ee.2023.042096

Abstract Proton exchange membrane fuel cells are widely regarded as having the potential to replace internal combustion engines in vehicles. Since fuel cells cannot recover energy and have a slow dynamic response, they need to be used with different power sources. Developing efficient energy management strategies to achieve excellent fuel economy is the goal of research. This paper proposes an adaptive equivalent fuel minimum consumption strategy (AECMS) to solve the problem of the poor economy of the whole vehicle caused by the wrong selection of equivalent factors (EF) in traditional ECMS. In this method, the kinematics interval is used to update… More >

JIWEI SUN^1,2,#, LIANG XU^1,#, YESEN ZHANG², HAORAN LI¹, JIE FENG², XUEFENG LU², JUN DONG^1,*

BIOCELL, Vol.47, No.12, pp. 2721-2733, 2023, DOI:10.32604/biocell.2023.043869

Abstract Objective: This investigation aimed to unveil new prospective diagnosis-related biomarkers together with treatment targets against glioblastoma. Methods: The expression levels of long non-coding RNA (lncRNA) DPP10-AS1 were assessed using real-time quantitative polymerase chain reaction (RT-qPCR) within both the patient tissue specimens and glioblastoma cell lines. The relationship between lncRNA DPP10-AS1 expression in glioblastoma and patient prognosis was investigated. Cell Counting Kit-8 (CCK-8), transwell, and clonogenic experiments were utilized to assess tumor cells’ proliferation, invasiveness, and migratory potentials after lncRNA DPP10-AS1 expression was up or down-regulated. Using an online bioinformatics prediction tool, the intracellular localization of lncRNA DPP10-AS1 and its target… More >

FATEMEH HEIDARI^1,2, REIHANEH SEYEDEBRAHIMI^1,2, PIAO YANG³, MOHSEN ESLAMI FARSANI^1,2, SHIMA ABABZADEH^2,4, NASER KALHOR⁵, HAMED MANOOCHEHRI⁶, MOHSEN SHEYKHHASAN^7,*, MARYAM AZIMZADEH^8,9,*

BIOCELL, Vol.47, No.12, pp. 2597-2608, 2023, DOI:10.32604/biocell.2023.043351

Abstract Exosomes are small vesicles that carry molecules from one cell to another. They have many features that make them interesting for research, such as their stability, low immunogenicity, size of the nanoscale, toxicity, and selective delivery. Exosomes can also interact with viruses in diverse ways. Emerging research highlights the significant role of exosomes in viral infections, particularly in the context of diseases like COVID-19, HIV, HBV and HCV. Understanding the intricate interplay between exosomes and the human immune system holds great promise for the development of effective antiviral therapies. An important aspect is gaining clarity on how exosomes influence the… More >