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  • Open Access

    ARTICLE

    AGPAT3 Regulates Immune Microenvironment in Osteosarcoma via Lysophosphatidic Acid Metabolism

    Shenghui Su, Yu Zeng, Jiaxin Chen, Xieping Dong*

    Oncology Research, Vol.34, No.1, 2026, DOI:10.32604/or.2025.070558 - 30 December 2025

    Abstract Background: Recent studies have shown glycerolipid metabolism played an essential role in multiple tumors, however, its function in osteosarcoma is unclear. This study aimed to explore the role of glycerolipid metabolism in osteosarcoma. Methods: We conducted bioinformatics analysis using data from the Therapeutically Applicable Research to Generate Effective Treatments (TARGET) database and single-cell RNA sequencing. Least Absolute Shrinkage and Selection Operator (LASSO) regression was used to identify the Glycerolipid metabolism-related genes associated with the clinical outcome of osteosarcoma. Tumor-associated macrophages (TAMs) and their interactions with immune cells were examined through single-cell analysis and co-culture experiments.… More >

  • Open Access

    ARTICLE

    BMP-2 Inhibits the Inflammatory Response and Promotes Bone Formation in Rats with Femoral Fracture by Activating the AMPK Signaling Pathway

    Yong Huang1, Xiandeng Li1, Qingling Jing1, Qin Zhang1, Chungui Huang2,*

    BIOCELL, Vol.49, No.11, pp. 2195-2216, 2025, DOI:10.32604/biocell.2025.072716 - 24 November 2025

    Abstract Objective: Mesenchymal stem cells (MSCs) are important cells in bone tissue engineering. Bone morphogenetic protein-2 (BMP-2) effectively treats bone defects and nonunion. The purpose of this study is to investigate whether BMP-2 promotes bone formation and femoral fracture healing by inhibiting inflammation and promoting osteogenic differentiation of MSCs, in order to provide an experimental basis for developing more efficient fracture treatment strategies. Methods: Bone marrow-derived MSCs (BMSCs) were isolated from rats and treated with OE-BMP-2, the 5-adenosine monophosphate-activated protein kinase (AMPK) signal agonist 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), and the inhibitor Compound C. Osteogenic differentiation was evaluated through… More >

  • Open Access

    ARTICLE

    Early Development and Phosphorus Use Efficiency Response to Phosphate Fertilizer Rates Associated with Phosphate-Solubilizing Bacteria in Contrasting Corn Hybrids

    Gilciany Ribeiro Soares1, Jiovana Kamila Vilas Boas1, Fábio Steiner1,2, Jorge González Aguilera2,*, Alan Mario Zuffo3, José Vitor Marçal do Prado2, Wellingthon da Silva Guimarães Júnnyor2, Leandris Argentel- Martínez4, Luis Morales-Aranibar5

    Phyton-International Journal of Experimental Botany, Vol.94, No.8, pp. 2347-2363, 2025, DOI:10.32604/phyton.2025.066264 - 29 August 2025

    Abstract Corn (Zea mays L.) is a very sensitive crop to phosphorus (P) deficiency during the early development phase, which may be a limiting factor for the sustainable production of this crop in P-deficient tropical soils. However, scientific evidence indicates that inoculation with phosphate-solubilizing bacteria can improve the development, uptake, and P-use efficiency of corn plants. In the present study, two contrasting corn hybrids were investigated for their responsiveness to multiple inoculations of Bacillus subtilis, B. megaterium, B. velezencis, and Pseudomonas fluorescens and application of phosphate fertilizer rates in the sandy soil of the Brazilian Cerrado. Plants from stable (DKB 360… More >

  • Open Access

    ARTICLE

    Mechanistic Investigation of Capacity Degradation in Lithium Iron Phosphate Batteries under Low Temperature Cycling Conditions

    Jianwei Sun, Shuqing Guo*, Shikai Li

    Energy Engineering, Vol.122, No.9, pp. 3625-3646, 2025, DOI:10.32604/ee.2025.067159 - 26 August 2025

    Abstract Since lithium-ion batteries have been put into use, the recession of work cycle efficiency at low temperatures has received widespread attention. In this paper, we investigated the effect of low temperature (−5°C, 0°C, 5°C) environments on the performance of lithium-ion batteries, which are well-known for their excellent discharge performance, cycle life, and safety. However, lithium-ion batteries exhibit significant capacity degradation at low temperatures, especially at 0°C, losing availability after only 10 cycles. Therefore, we conducted cycle degradation tests at 1C discharge and 100% charge-discharge conditions. In this paper, we analyzed the surface morphology, structure, and More > Graphic Abstract

    Mechanistic Investigation of Capacity Degradation in Lithium Iron Phosphate Batteries under Low Temperature Cycling Conditions

  • Open Access

    ARTICLE

    Synergistic Effect of Silicone Macromolecular Charring Agent and Ammonium Polyphosphate on Improving Flame Retardancy and Mechanical Properties of Ethylene-Butyl Acrylate Copolymer Composites

    Xuan Huo1, Bingchen Wu1, Yuanmeng Lou1, Junlin Zhu1, Cui Li1, Lili Ma1, Ye-Tang Pan2, Chuncheng Hao1,*, Xin Wen1,*

    Journal of Polymer Materials, Vol.42, No.2, pp. 517-530, 2025, DOI:10.32604/jpm.2025.065320 - 14 July 2025

    Abstract Power cables are important pieces of equipment for energy transmission, but achieving a good balance between flame retardancy and mechanical properties of cable sheaths remains a challenge. In this work, a novel intumescent flame retardant (IFR) system containing silicone-containing macromolecular charring agent (Si-MCA) and ammonium polyphosphate (APP) was designed to synergistically improve the flame retardancy and mechanical properties of ethylene-butyl acrylate copolymer (EBA) composites. The optimal mass ratio of APP/Si-MCA was 3/1 in EBA composites (EBA/APP-Si-31), corresponding to the best flame retardancy with 31.2% of limited oxygen index (LOI), V-0 rating in UL-94 vertical burning More > Graphic Abstract

    Synergistic Effect of Silicone Macromolecular Charring Agent and Ammonium Polyphosphate on Improving Flame Retardancy and Mechanical Properties of Ethylene-Butyl Acrylate Copolymer Composites

  • Open Access

    ARTICLE

    Tailored Phosphate Glass Powders for Augmented Flame Retardancy and Ceramicization in Silicone Rubber

    Yanbei Hou1,2, Xu Chang1, Shuming Liu1, Huimin Zhang3, Jianwei Fu3, Jianbin Wu3, Zhiyong Li3, Guoqiang Tang3, Weizhao Hu1,*

    Journal of Polymer Materials, Vol.42, No.2, pp. 531-548, 2025, DOI:10.32604/jpm.2025.065040 - 14 July 2025

    Abstract Silicone rubber (SR) exhibits superior breathability and high-temperature resistance. However, SR is prone to degradation under extreme heat or combustion, limiting its effectiveness in mitigating secondary hazards. In this study, phosphate glass powder was used to calcinate zinc borate, lanthanum oxide, and cerium oxide. Methylphenyl polysiloxane was then grafted onto the surface of the glass powder, resulting in the modified powders designated as Methylphenyl polysiloxane-grafted zinc borate-modified phosphate glass powder (GF-ZnBM), Methylphenyl polysiloxane-grafted lanthanum oxide-modified phosphate glass powder (GF-LaM), and Methylphenyl polysiloxane-grafted cerium oxide-modified phosphate glass powder (GF-CeM). The modified powders were subsequently incorporated into… More > Graphic Abstract

    Tailored Phosphate Glass Powders for Augmented Flame Retardancy and Ceramicization in Silicone Rubber

  • Open Access

    ARTICLE

    Thermal Behavior of a LFP Battery for Residential Applications: Development of a Multi-Physical Numerical Model

    Michela Costa1,*, Adolfo Palombo2, Andrea Ricci2, Ugo Sorge3

    Energy Engineering, Vol.122, No.5, pp. 1629-1643, 2025, DOI:10.32604/ee.2025.062613 - 25 April 2025

    Abstract Effective thermal management is paramount for successfully deploying lithium-ion batteries in residential settings as storage systems for the exploitation of renewable sources. Uncontrolled temperature increases within battery packs can lead to critical issues such as cell overheating, potentially culminating in thermal runaway events and, in extreme cases, leading to fire or explosions. This work presents a comprehensive numerical thermal model of a battery pack made of prototype pouch cells based on lithium ferrophosphate (LFP) chemistry. The multi-physical model is specifically developed to investigate real-world operating scenarios and to assess safety considerations. The considered energy storage… More >

  • Open Access

    ARTICLE

    Synergistic Effect of Piperazine Pyrophosphate (PAPP)/Melamine Polyphosphate (MPP)/ZnO Halogen-Free Flame Retardant System in PPC-P/PBAT Blends

    Yuxin Zheng, Ke Xu, Baicheng Zhang, Shengxin Guan, Lin Xia, Zhaoge Huang*

    Journal of Polymer Materials, Vol.42, No.1, pp. 237-253, 2025, DOI:10.32604/jpm.2025.059622 - 27 March 2025

    Abstract In this manuscript, we conveniently prepared a series of polyester-polycarbonate copolymer (PPC-P)/polybutylene adipate terephthalate (PBAT) blends that exhibit both flame-retardant properties and toughness. Piperazine pyrophosphate (PAPP), melamine phosphate (MPP) and ZnO were used as synergistic flame retardants for PPC-P/PBAT blends. The effects of synergistic flame retardants on thermal stability, combustion behavior and flame retardancy of PPC-P/PBAT blends were investigated. The results showed that when the ratio of PAPP/MPP/ZnO was 18.4:9.2:2.4, the LOI of PPC-P/PBAT composite was 42.8%, and UL-94 reached V-0 level. The results of cone calorimetry showed that the mass loss rate (MLR), the… More >

  • Open Access

    ARTICLE

    Investigation and structural of phosphate glasses at low photon energy through: optical and attenuation properties

    L. Alelyania, T. A. Ghawb,*, N. A. Asirib, N. A. Abdullahb, K. I. Husseinb, M. S. Alqahtanib

    Chalcogenide Letters, Vol.21, No.4, pp. 319-326, 2024, DOI:10.15251/CL.2024.214.319

    Abstract This paper presents a novel low-cost phosphate glass preparation by using the melt quenching technique. It was investigated for use in diagnostic protective applications. The range of UV-VIS wavelength is used to estimate the optical energy gap. The MAC denotes the mass attenuation coefficients of the present glass were computed at low photon energies between 15 and 200 KeV using the MIKE program. The manufactured glasses parameters viz; the mean free path, half value layer, tenth value layer, effective atomic number, effective electron density, and linear attenuation coefficient denotes as follows; MFP, HVL, TVL, Zeff, Neff, More >

  • Open Access

    ARTICLE

    Optimization of Phosphate Adsorption Using Activated Carbon Derived from Pangium edule Shell

    Rachmannu Ilham1, Fataty Kurnia Rahmah1, Nurul Faradilah Said2, Mohamad Buang Budiono2, Suprapto Suprapto1,*

    Journal of Renewable Materials, Vol.12, No.11, pp. 1895-1909, 2024, DOI:10.32604/jrm.2024.055602 - 22 November 2024

    Abstract This study investigated the efficiency of activated carbon from Pangium edule shells for removing phosphate from aqueous solution. The adsorption capacity of the synthesized activated carbon was determined to be 19.8392 mg g−1. Various isotherm models were used to analyze the adsorption process, Henry, Freundlich, SIP, and Halsey isotherm fitting showed r2 values close to 1.0. These isotherms indicated a combination of physisorption and chemisorption mechanisms, with heterogeneity and multilayer formation playing important roles. A pseudo-second-order model described the adsorption kinetics well, suggesting chemisorption as the dominant mechanism with an r2 value of 1.0 and a rate constant… More >

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