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  • Open Access

    REVIEW

    Monocyte Phenotypic Plasticity in Peripheral Artery Disease: From Pathophysiology to Therapeutic Targets

    Gizem Kaynar Beyaz1,*, Ahmet Kirbas2, Sevgi Kalkanli Tas1

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.072368 - 23 January 2026

    Abstract Peripheral artery disease (PAD) remains a significant global health issue, with current treatments primarily focused on relieving symptoms and addressing macrovascular issues. However, critical immunoinflammatory mechanisms are often overlooked. Recent evidence suggests that monocyte phenotypic plasticity plays a central role in PAD development, affecting atherogenesis, plaque progression, ischemia-reperfusion injury, and chronic ischemic remodeling. This narrative review aims to summarize the latest advances (2023–2025) in understanding monocyte diversity, functional states, and their changes throughout different stages of PAD. We discuss both established and emerging biomarkers, such as circulating monocyte subset proportions, functional assays, immune checkpoint expression, More >

  • Open Access

    REVIEW

    The Warburg Effect Beyond Cancer: Melatonin as a Metabolic Modulator in Non-Neoplastic Disorders

    JOSé A. BOGA1,2, ANA COTO-MONTES2,3,*, RUSSEL J. REITER4

    BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.068245 - 23 January 2026

    Abstract Aerobic glycolysis, also known as the Warburg effect, and the accumulation of lactate that it causes, are increasingly recognized outside the field of oncology as triggers of chronic non-neoplastic disorders. This review integrates preclinical and clinical evidence to evaluate the ability of melatonin to reverse Warburg-effect-like metabolic reprogramming. Literature on neurodegeneration, age-related sarcopenia, type 2 diabetes, chronic kidney disease, heart failure and pulmonary arterial hypertension (PAH) has been reviewed and synthesised. In all of these conditions, hypoxia-inducible factor 1α (HIF-1α) and pyruvate dehydrogenase kinase 4 (PDK4) inhibit the pyruvate dehydrogenase complex. This diverts pyruvate away… More >

  • Open Access

    ARTICLE

    Research on Deformation Mechanism of Rolled AZ31B Magnesium Alloy during Tension by VPSC Model Computational Simulation

    Xun Chen1, Jinbao Lin1,2,*, Zai Wang1

    CMC-Computers, Materials & Continua, Vol.86, No.3, 2026, DOI:10.32604/cmc.2025.072495 - 12 January 2026

    Abstract This work investigates the effects of deformation mechanisms on the mechanical properties and anisotropy of rolled AZ31B magnesium alloy under uniaxial tension, combining experimental characterization with Visco-Plastic Self Consistent (VPSC) modeling. The research focuses particularly on anisotropic mechanical responses along transverse direction (TD) and rolling direction (RD). Experimental measurements and computational simulations consistently demonstrate that prismatic <a> slip activation significantly reduces the strain hardening rate during the initial stage of tensile deformation. By suppressing the activation of specific deformation mechanisms along RD and TD, the tensile mechanical behavior of the magnesium alloy was further investigated. More >

  • Open Access

    ARTICLE

    A Temperature-Indexed Concrete Damage Plasticity Model Incorporating Bond-Slip Mechanism for Thermo-Mechanical Analysis of Reinforced Concrete Structures

    Wu Feng1,2,*, Tengku Anita Raja Hussin1, Xu Yang3

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071664 - 08 January 2026

    Abstract This study investigates the thermo–mechanical behavior of C40 concrete and reinforced concrete subjected to elevated temperatures up to 700°C by integrating experimental testing and advanced numerical modeling. A temperature-indexed Concrete Damage Plasticity (CDP) framework incorporating bond–slip effects was developed in Abaqus to capture both global stress–strain responses and localized damage evolution. Uniaxial compression tests on thermally exposed cylinders provided residual strength data and failure observations for model calibration and validation. Results demonstrated a distinct two-stage degradation regime: moderate stiffness and strength reduction up to ~400°C, followed by sharp deterioration beyond 500°C–600°C, with residual capacity at… More >

  • Open Access

    ARTICLE

    Revisiting Nonlinear Modelling Approaches for Existing RC Structures: Lumped vs. Distributed Plasticity

    Hüseyin Bilgin*, Bredli Plaku

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.071007 - 08 January 2026

    Abstract Nonlinear static procedures are widely adopted in structural engineering practice for seismic performance assessment due to their simplicity and computational efficiency. However, their reliability depends heavily on how the nonlinear behaviour of structural components is represented. The recent earthquakes in Albania (2019) and Türkiye (2023) have underscored the need for accurate assessment techniques, particularly for older reinforced concrete buildings with poor detailing. This study quantifies the discrepancies between default and user-defined component modelling in pushover analysis of pre-modern reinforced concrete structures, analysing two representative low- and mid-rise reinforced concrete frame buildings. The lumped plasticity approach… More > Graphic Abstract

    Revisiting Nonlinear Modelling Approaches for Existing RC Structures: Lumped vs. Distributed Plasticity

  • Open Access

    REVIEW

    Recent Efforts on the Compressive and Tensile Strength Behavior of Thermoplastic-Based Recycled Aggregate Concrete toward Sustainability in Construction Materials

    Mahmoud Alhashash1, Abdullah Alariyan2, Ameen Mokhles Youns3, Favzi Ghreivati4, Ahed Habib5,*, Maan Habib6

    Structural Durability & Health Monitoring, Vol.20, No.1, 2026, DOI:10.32604/sdhm.2025.070194 - 08 January 2026

    Abstract Concrete production often relies on natural aggregates, which can lead to resource depletion and environmental harm. In addition, improper disposal of thermoplastic waste exacerbates ecological problems. Although significant attention has recently been given to recycling various waste materials into concrete, studies specifically addressing thermoplastic recycled aggregates are still trending. This underscores the need to comprehensively review existing literature, identify research trends, and recognize gaps in understanding the mechanical performance of thermoplastic-based recycled aggregate concrete. Accordingly, this review summarizes recent investigations focused on the mechanical properties of thermoplastic-based recycled aggregate concrete, emphasizing aspects such as compressive… More >

  • Open Access

    PROCEEDINGS

    A New Analytical Method for Strength Prediction of Injection Molded Fiber Reinforced Thermoplastics Based on Progressive Delamination Failure Principle

    Dayong Huang1,2,*, Wenjun Wang1,2, Xiaofu Tang1,2, Pengfei Zhu3, Xianqiong Zhao3,*

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.34, No.1, pp. 1-1, 2025, DOI:10.32604/icces.2025.012063

    Abstract Accurate prediction for the tensile properties (tensile modulus and strength) of injection molded fiber-reinforced thermoplastics (IMFT) plays an important role in the design of structures made with such composites. Based on the Laminate analogy approach (LAA), a unified distribution function (UDF) of tensile properties is derived by introducing the assumption that the fiber length distribution (FLD) and fiber orientation distribution (FOD) are independent of each other. The UDF of tensile properties is simplified by introducing the modified monotonic functions of fiber length and orientation factors (λL and λO). Compared with the tensile modulus and strength… More >

  • Open Access

    ARTICLE

    Influence of Honey on Structural, Morphology and Thermal Behavior of Zein-Based Polymer Systems

    Nurrul Asyiqin K. Shamsuri1, Shujahadeen B. Aziz2, Siti Nadiah Halim3, Hashlina Rusdi4, Mohd Fakhrul Zamani Kadir1,5,*

    Journal of Polymer Materials, Vol.42, No.4, pp. 1111-1123, 2025, DOI:10.32604/jpm.2025.070939 - 26 December 2025

    Abstract This study investigates the effects of honey concentration on the crystallinity, morphology, and thermal behavior of zein-based polymer systems, aiming to assess honey’s role as a natural plasticizer. Fourier transform infrared spectroscopy (FTIR) analysis confirmed the presence of strong intermolecular interactions and hydrogen bonding between zein and honey, indicating good miscibility. X-ray diffraction (XRD) patterns revealed a significant reduction in crystallinity with increasing honey concentration up to 25 wt.%, with the ZH5 (75 wt.% zein-25 wt.% honey) sample exhibiting the smallest crystallite size (4.23 nm), suggesting enhanced amorphous character suitable for ionic mobility. Field emission… More >

  • Open Access

    ARTICLE

    Behavior of Sandwich Glued Laminated Bamboo Structures with a Core Formed by Bioplastic Fiber Using 3D Printing Technology

    Nattawat Mahasuwanchai, Thippakorn Udtaranakron, Kasan Chanto, Tawich Pulngern*

    Journal of Renewable Materials, Vol.13, No.12, pp. 2453-2478, 2025, DOI:10.32604/jrm.2025.02025-0137 - 23 December 2025

    Abstract This research investigates the behavior of sandwich glued laminated bamboo (Glubam) structures with a core formed by biodegradable plastic fibers, specifically polylactic acid (PLA), fabricated using 3D printing technology. The influence of various fiber printing orientations (0° and 45/135°) on tensile and compressive properties was investigated. The experimental results indicated that polylactic acid with calcium carbonate (PLA+) printed unidirectionally and aligned with the loading direction (0°) exhibits superior tensile and compressive strengths compared to specimens printed bidirectionally at 45/135°. Furthermore, the effect of additives on bioplastics of carbon fiber (PLA-CF) and glass fiber (PLA-GF) additives… More > Graphic Abstract

    Behavior of Sandwich Glued Laminated Bamboo Structures with a Core Formed by Bioplastic Fiber Using 3D Printing Technology

  • Open Access

    ARTICLE

    Characteristics of Food Packaging Bioplastics with Nanocrystalline Cellulose (NCC) from Oil Palm Empty Fruit Bunches (OPEFB) as Reinforcement

    Maryam1,*, Rahayu Puji2, Luthfi Muhammad Zulfikar2, Ikhsandy Ferry2, Nadiyah Khairun1, Hidayat3, Ilyas Rushdan Ahmad4, Syafri Edi5

    Journal of Renewable Materials, Vol.13, No.12, pp. 2431-2451, 2025, DOI:10.32604/jrm.2025.02024-0063 - 23 December 2025

    Abstract The development of the bioplastics industry addresses critical issues such as environmental pollution and food safety concerns. However, the industrialization of bioplastics remains underdeveloped due to challenges such as high production costs and suboptimal material characteristics. To enhance these characteristics, this study investigates bioplastics reinforced with Nanocrystalline Cellulose (NCC) derived from Oil Palm Empty Fruit Bunches (OPEFB), incorporating dispersing agents. The research employs a Central Composite Design from the Response Surface Methodology (RSM) with two factors: the type of dispersing agent (KCl and NaCl) and the NCC concentration from OPEFB (1%–5%), along with the dispersing… More >

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