Chenglong Zhong¹, Xianfeng Hou^1,*, Shuai Peng¹, Zhenzhong Gao¹, Qiaofang Zhou¹, Shijing Yan²

Journal of Renewable Materials, Vol.13, No.2, pp. 297-310, 2025, DOI:10.32604/jrm.2024.049534 - 20 February 2025

Abstract The main raw material utilized in wood adhesives comes from petrochemical extractives. However, due to the excessive dependence on petrochemical resources and the adverse impact on the ecosystem and human well-being, there is an increasing trend to develop byproduct protein-based adhesives in the current global food safety context. In this research, flaxseed meal was subjected to pretreatment, and trimethylolpropane triglycidyl ether (TTE) and ethylenediamine (EN) were utilized as crosslinkers to establish a more compact adhesive layer and to prevent water intrusion. The pretreatment decreased the FM/UB viscosity by 60% compared to FM. The combination… More > Graphic Abstract

Hong Lei¹, Xiaojian Zhou², Antonio Pizzi^3,*, Guanben Du^2,*, Xuedong Xi²

Journal of Renewable Materials, Vol.13, No.2, pp. 199-249, 2025, DOI:10.32604/jrm.2025.02024-0048 - 20 February 2025

Abstract This review is composed of three main parts each of which is written by well-known top specialists that have been, in a way or other, also the main participants of the majority of the developments reported. Thus, after a general part covering the grand lines and more in-depth views of more recent tannin, lignin, carbohydrate and soy bioadhesives, some mix of the other bio raw materials with soy protein and soy flour and some other differently sourced bioadhesives for wood, this review presents a more in-depth part on starch-based wood adhesives and a more in-depth… More > Graphic Abstract

Mukul Mishra¹, Deeba Khan², Sehbanul Islam^1,*

BIOCELL, Vol.49, No.1, pp. 127-147, 2025, DOI:10.32604/biocell.2025.058038 - 24 January 2025

Abstract The COVID-19 pandemic, caused by the newly emerged coronavirus SARS-CoV-2, has resulted in unprecedented global health challenges, including millions of infections and deaths. While the direct effects of the virus are critical, the interplay between SARS-CoV-2 and cellular host factors significantly impacts the replication cycle of the virus and the clinical severity of COVID-19. This review provides a comprehensive analysis of host-pathogen interactions, focusing on the functional roles and regulatory mechanisms of SARS-CoV-2 viral proteins. We systematically review the literature to detail how SARS-CoV-2 engages with host cellular machinery, with a specific emphasis on their More >

Mengjie Xu, Anbin Wang, Tonghong Zuo, Hecui Zhang, Zhihao Hu, Liquan Zhu^*

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 157-179, 2025, DOI:10.32604/phyton.2025.060566 - 24 January 2025

Abstract Calmodulin-like (CMLs) proteins are critical in calcium signaling and essential for plant growth, development, and stress responses. In many species, the CMLs families have been identified and described. However, the characterization and expression profiling of CMLs genes in tobacco is retrievable. In this study, a comprehensive whole-genome identification and analysis, and 75 NtCML genes were identified in tobacco, each containing two to four EF-hand domains. Most NtCML proteins exhibited conserved gene structures and motifs. Notably, most NtCML proteins were intron-less and distributed across 18 chromosomes. Two pairs of tandemly duplicated genes and seven pairs of segmentally More >

Su-Ee Lau^1,2,*, Lucas Wei Tze Lim³, Mohd Fadhli Hamdan⁴, Colin Chan⁵, Noor Baity Saidi⁶, Janna Ong-Abdullah⁶, Boon Chin Tan^1,*

Phyton-International Journal of Experimental Botany, Vol.94, No.1, pp. 1-31, 2025, DOI:10.32604/phyton.2025.059930 - 24 January 2025

Abstract Abiotic stresses such as drought, heat, salinity, and heavy metal contamination severely affect global agricultural productivity. Between 2005 and 2015, droughts caused losses of approximately USD 29 billion in developing countries, and from 2008 to 2018, droughts accounted for over 34% of crop and livestock yield losses, totaling about USD 37 billion. To support the growing human population, agricultural output must increase substantially, necessitating a 60%–100% rise in crop productivity to meet the escalating demand. To address environmental challenges, organic, inorganic, and microbial biostimulants are increasingly employed to enhance plant resilience through various morphological, physiological,… More >

YARU DU^1,2,#, ZHIHUI PEI^1,3,#, SHUQIN HU⁴, CHUANWEN LIAO¹, SHUHAO LIU^1,*

Oncology Research, Vol.33, No.2, pp. 309-325, 2025, DOI:10.32604/or.2024.058273 - 16 January 2025

Abstract Objectives: KH-type splicing regulatory protein (KHSRP) is an RNA-binding protein involved in several cellular processes, including nuclear splicing, mRNA localization, and cytoplasmic degradation. While KHSRP’s role has been studied in other cancers, its specific involvement in gastric cancer remains poorly understood. This study aims to explore KHSRP expression in gastric cancer and its potential effects on tumor progression and immune response. Methods: KHSRP expression in gastric cancer tissues and normal tissues was analyzed using data from The Cancer Genome Atlas (TCGA) database. The correlation between KHSRP expression, patient survival, and immune response was also assessed.… More >

NAIXIONG PENG, YUEFENG CAI, DONG CHEN, LING DENG, ZEJIAN ZHANG, WEI LI^*

Oncology Research, Vol.33, No.2, pp. 347-356, 2025, DOI:10.32604/or.2024.056039 - 16 January 2025

Abstract Background: Clear cell renal carcinoma (ccRCC), the leading histological subtype of RCC, lacks any targeted therapy options. Although some studies have shown that early growth response factor 1 (EGR1) has a significant role in cancer development and progression, its role and underlying mechanisms in ccRCC remain poorly understood. Methods: The Cancer Genome Atlas (TCGA) database was utilized to examine the expression of EGR1 in ccRCC. The expression of EGR1 in 55 ccRCC tissues was evaluated using immunohistochemistry. The link between EGR1 expression and clinicopathological variables was examined through an analysis. Gain-of-function assays were employed to… More >

CANCAN HE^1,2,*, TINGTING ZHANG³, WEI XIONG⁴, SHENGYU WANG⁵, XIN SUN⁶

Oncology Research, Vol.33, No.2, pp. 421-429, 2025, DOI:10.32604/or.2024.049757 - 16 January 2025

Abstract Background: The outcomes of pediatric patients with acute lymphoblastic leukemia (ALL) remain far less than favorable. While apigenin is an anti-cancer agent, studies on the mechanism by which it regulates ALL cell cycle progression are inadequate. Ferroptosis and AMP-activated protein kinase (AMPK) signaling are important processes for ALL patients. However, it remains unclear whether apigenin works by affecting AMPK and apoptosis. Materials and Methods: SUP-B15 and T-cell Jurkat ALL cells were treated with apigenin, and cell viability and apoptosis were measured using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays, respectively.… More >

HAIYING PANG^1,#, FENGBO WU^1,#, YU ZHANG¹, NAN ZHANG², CHUNTING WANG¹, QIU LI¹, GU HE^1,*, PENG ZHANG^3,*

Oncology Research, Vol.33, No.2, pp. 443-464, 2025, DOI:10.32604/or.2024.043948 - 16 January 2025

Abstract Background: EMP2 is a tumor-associated membrane protein belonging to the GAS-3/PMP22 gene family. EMP2 expression demonstrates significant tissue specificity and heterogeneity in various human tissues and tumor tissues, where it may play a role in either promoting or inhibiting tumor growth. This study aimed to investigate the expression level, biological functions, and molecular mechanisms of EMP2 in liver cancer. Methods: we analyzed the mRNA expression levels of EMPs family genes in hepatocellular carcinoma (HCC) tissues and normal liver tissues based on the TCGA database and immunohistochemical analysis of tissue microarrays. Subsequently, we constructed HCC cell… More > Graphic Abstract

XIANG LI^1,#, WENKE JIN^2,#, LIFENG WU², HUAN WANG¹, XIN XIE¹, WEI HUANG^1,*, BO LIU^2,*

Oncology Research, Vol.33, No.1, pp. 67-81, 2025, DOI:10.32604/or.2024.055921 - 20 December 2024

Abstract Background: Triple-negative breast cancer (TNBC), characterized by its lack of traditional hormone receptors and HER2, presents a significant challenge in oncology due to its poor response to conventional therapies. Autophagy is an important process for maintaining cellular homeostasis, and there are currently autophagy biomarkers that play an effective role in the clinical treatment of tumors. In contrast to targeting protein activity, intervention with protein-protein interaction (PPI) can avoid unrelated crosstalk and regulate the autophagy process with minimal interference pathways. Methods: Here, we employed Naive Bayes, Decision Tree, and k-Nearest Neighbors to elucidate the complex PPI… More >