Shaimaa R. Ahmed^1,*, Omnia M. Hendawy², Sumera Qasim², Hanan Khojah³, Ambreen Malik Uttra⁴

Phyton-International Journal of Experimental Botany, Vol.95, No.2, 2026, DOI:10.32604/phyton.2026.075718 - 28 February 2026

Abstract The study evaluated the skin anti-aging activity of Astragalus sarcocolla leaves extract (ASE) by assessing its antioxidant and inhibitory effect activity on matrix metalloproteinase (MMP), collagenase, elastase, hyaluronidase, and tyrosinase in relation to its chemical composition. Ultra Performance Liquid Chromatography-Mass Spectrometry (UPLC-MS) identified 27 metabolites (15 flavonoids, 8 phenolic acids and their derivatives, and 4 coumarins). ASE showed strong antioxidant capacity in DPPH (IC₅₀ value of 26.05 µg/mL) and FRAP (2433 µM FeSO₄/g extract) assays. The extract inhibited MMP-1 and MMP-9 in a concentration-dependent manner and suppressed collagenase, elastase, hyaluronidase, and tyrosinase activities (IC₅₀ = 35.038, 40.748, 61.389,… More > Graphic Abstract

Jo-Yu Lin^1,#, Tien-Huang Lin^2,3,#, Ya-Jing Jiang⁴, Liang-Wei Lin⁴, Kuan-Ying Lai⁵, Yi-Chin Fong^6,7,8, Chih-Chuang Liaw^5,9,*, Chih-Hsin Tang^1,4,10,11,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.074202 - 24 February 2026

Abstract Background: Prostate cancer (PCa) is the most prevalent malignancy in men and often correlates with distant metastasis in its advanced stages. The study aimed to investigate the effects of Ugonin J, a natural compound isolated from Helminthostachys zeylanica, on PCa metastasis. Methods: The effects of Ugonin J on cell motility were assessed using migration and invasion assays. Reverse Transcription Quantitative PCR (RT-qPCR) and Western blotting were used to evaluate the impact of Ugonin J on mRNA and protein expression. RNA sequencing (RNA-seq) analysis was performed to investigate candidate mechanisms. Differential gene expression analysis in PCa patients… More >

Myeong Ryeo Kim^1,*, Jae Rim Lee¹, Xiaohan Zhang², Kwang Won Jeong^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072592 - 24 February 2026

Abstract Objectives: Tamoxifen is a key drug that provides endocrine therapy for estrogen receptor (ER) α-positive breast cancer; however, resistance remains a significant clinical challenge. This study aims to investigate the molecular mechanisms of tamoxifen resistance in ERα-positive breast cancer, with particular focus on the role of SET Domain Containing 1A (SETD1A)-driven forkhead box A2 (FOXA2) as a key regulator of this resistance. Methods: FOXA2 expression and its regulation by SETD1A were assessed via (quantitative polymerase chain reaction), western blotting, transcriptome profiling, and chromatin immunoprecipitation analyses. The effects of FOXA2 on cell proliferation, migration, invasion, and cancer… More >

Marcia Eduarda Viana Luna^1,2, Gustavo Jacob Lourenço², Juliana Carron^2,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.072133 - 24 February 2026

Abstract This literature review explores the complex interaction between p53 and microRNAs (miRNAs) in the occurrence and progression of breast cancer (BC), the most common and lethal tumor type among women. BC is a multifactorial disease resulting from a combination of genetic and epigenetic alterations in cell DNA, influencing proliferation, differentiation, and migration. TP53 gene, which codifies p53 protein, is a known tumor suppressor, and it plays an important role in cell maintenance as DNA repair, cell proliferation control, and apoptosis activation. TP53 expression can be modulated by several miRNAs, as miR-30c, miR-34a, and the miR-200 family, More >

Guojian Zhou^1,2,#, Rui Zhang^1,#, Lei Nie^1,#, Yi Si¹, Ting Liu¹, Jing Wang¹, Shuangshuang Han¹, Mingda Xuan¹, Jia Wang^3,*, Weifang Yu^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.070333 - 24 February 2026

Abstract Objectives: Gastric cancer (GC) is among the most prevalent malignancies worldwide, ranking as the fifth most common cancer and the fifth leading cause of cancer-related mortality. This study intends to investigate how Inhibin subunit beta A (INHBA) promotes the progression of GC by activating the mitogen-activated protein kinase (MAPK) signaling pathway via targeting Integrin alpha-6 (ITGA6). Methods: Quantitative reverse transcription-Polymerase Chain Reaction (qRT-PCR) and Immunohistochemistry (IHC) were utilised to validate the expression levels of INHBA in GC, which were subsequently correlated with the clinicopathological factors and outcomes. Cellular and animal studies were conducted to ascertain… More >

Min Dong^1,#, Zongchang Song^2,#, Xiaohui Lu^1,3,#, Minxue Lu^4,*, Chen Zhong^1,*

Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2026.068508 - 24 February 2026

Abstract Background: Gastric cancer (GC) remains highly lethal, with metabolic reprogramming as a key hallmark. This study explores Centromere Protein F (CENPF)’s role in GC pathogenesis, specifically its regulation of glutamine metabolism. Methods: The Cancer Genome Atlas–Stomach Adenocarcinoma (TCGA-STAD), GSE19826, and GSE27342 datasets were analyzed by bioinformatics to identify key candidate genes in GC. The function of CENPF was assessed by flow cytometry, colony formation assays, and Cell Counting Kit-8 (CCK-8). RNA sequencing, metabolic profiling, chromatin immunoprecipitation (ChIP), western blot (WB), and luciferase reporter assay were employed to investigate the fundamental mechanisms. Results: CENPF was upregulated in GC… More >

Egor A. Turovsky^*, Elena G. Varlamova

BIOCELL, Vol.50, No.2, 2026, DOI:10.32604/biocell.2025.073728 - 14 February 2026

Abstract Objectives: Glioblastoma multiforme (GBM) is highly resistant to apoptosis. This study investigates the role of Selenoprotein M (SELENOM), a redox-regulating protein, in the response of human glioblastoma A-172 cells to staurosporine (STS) and hyperthermia. Methods: A stable SELENOM-knockdown (SELENOM-KD) cell line was created. We measured reactive oxygen species (ROS), mitochondrial membrane potential (ΔΨm), cell death, and apoptotic gene expression. Results: SELENOM-KD increased basal ROS levels and induced mitochondrial dysfunction. It sensitized cells to STS-induced apoptosis, enhancing the upregulation of pro-apoptotic genes. Conversely, under hyperthermia (42°C), SELENOM-KD cells exhibited significant thermoresistance, with 52% survival vs. 99% death More > Graphic Abstract

Kirti A. Yadav¹, Yachana Jha¹, Haiam O. Elkatry², Heba I. Mohamed^3,*, Ahmed Mahmoud Ismail⁴, Abdelrahman R. Ahmed^2,*

Phyton-International Journal of Experimental Botany, Vol.95, No.1, 2026, DOI:10.32604/phyton.2026.074570 - 30 January 2026

Abstract Phytophthora blight is a devastating disease of pigeon pea (Cajanus cajan) that severely impacts plant growth and productivity. This study investigates the morphological, anatomical, and biochemical responses of a susceptible variety (ICPL 11260) and a resistant variety (IPAC-02) following infection by Phytophthora. Morphological analyses showed that infection caused a drastic reduction in root length, shoot length, leaf number, fresh weight, and dry weight in the susceptible ICPL 11260 variety, with reductions ranging from 0.5- to 2-fold compared to non-infected controls. Anatomical observations revealed pronounced cellular damage and mycelial invasion in infected ICPL 11260 plants by 30… More >

SHAOFENG XIONG^1,2, WENKAI LV³, GUOSHENG CAO⁴, LONGSHENG FU¹, WEN LIU³, MENGFAN LEI², YANNI LV^1,5,*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.073401 - 23 January 2026

Abstract Objective: Leucine-rich alpha-2 glycoprotein 1 (Lrg1) could regulate diverse cells in cerebral ischemia-reperfusion. Our study seeks to uncover Lrg1’s impact on endothelial cell heterogeneity via differentiation pathways and transcription factors. Method: The CSOmap model measured cell-to-brain-center distances using single-cell RNA sequencing (scRNA-seq) data in middle cerebral artery occlusion reperfusion (MCAO/R). Monocle2 mapped endothelial differentiation paths. Gene set enrichment analysis (GSEA) analyzed endothelial subcluster variations. Database searches revealed a zinc finger MIZ-type containing 1 protein-frizzled 3 (Zmiz1-Fzd3) promoter interaction. Endothelial cells were transfected with a Fzd3 promoter-luciferase plasmid. Polymerase chain reaction (PCR) and western blotting assessed… More >

TOSHIYUKI HABU^*

BIOCELL, Vol.50, No.1, 2026, DOI:10.32604/biocell.2025.071798 - 23 January 2026

Abstract RING protein 213 (RNF213), the susceptibility gene for Moyamoya disease (MMD), possesses two active AAA+ ATPase (ATPases Associated with diverse cellular Activities) modules, a RING, and RNF213-ZNFX1 finger (RZ finger) domains. Several RNF213 variants have been reported in MMD patients, including the p.R4810K variant (rs112735431), which is a founder polymorphism associated with MMD in East Asia. To elucidate the function of RNF213 and its variant, we investigated the localization of RNF213 and the R4810K variant in this study. RNF213 induced circular hole structures near the nucleus, similar to lipid droplets (LDs), in U-2 OS cells. More >