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  • Open Access

    ARTICLE

    Chemical Characterization of Jarilla caudata Seeds from Mexico

    Juan Francisco Zamora Natera1,*, Mario Felipe González González1, Javier Vioque2, Julio Girón-Calle2, Manuel Alaiz2

    Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1533-1544, 2025, DOI:10.32604/phyton.2025.064966 - 29 May 2025

    Abstract Jarilla caudata Standl. (Caricaceae) is a wild herbaceous plant native to Mexico recognized for its edible fruits. It is considered to be the closest taxonomically species to Carica papaya L. (Caricaceae), whose seeds have good nutritional and functional properties. This study analyzes and compares the seed chemical compositions of J. caudata and C. papaya to study the nutritional and functional potential of J. caudata seeds. The analysis of the proximate composition was based on standard methods. High-performance liquid chromatography was used to determine the free amino acid profile, gas chromatography to quantify the fatty acid content, and inductively coupled plasma–optical… More > Graphic Abstract

    Chemical Characterization of <i>Jarilla caudata</i> Seeds from Mexico

  • Open Access

    SHORT COMMUNICATION

    A Gel-Free Budget-Friendly Approach to GFP-Tagged Viruses Quantification in Plant Samples

    Rohith Grandhi, Mélodie B. Plourde, Aditi Balasubramani, Hugo Germain*

    Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1497-1504, 2025, DOI:10.32604/phyton.2025.063974 - 29 May 2025

    Abstract Viral diseases are an important threat to crop yield, as they are responsible for losses greater than US$30 billion annually. Thus, understanding the dynamics of virus propagation within plant cells is essential for devising effective control strategies. However, viruses are complex to propagate and quantify. Existing methodologies for viral quantification tend to be expensive and time-consuming. Here, we present a rapid cost-effective approach to quantify viral propagation using an engineered virus expressing a fluorescent reporter. Using a microplate reader, we measured viral protein levels and we validated our findings through comparison by western blot analysis More >

  • Open Access

    REVIEW

    Cell cycle proteins: Linking the cell cycle to tumors

    JIE ZHONG1, JUE LIU1, XING TANG2, WENCHAO ZHOU2, GUANGMING SONG1, YUHUAN ZENG1, XIAODI ZHANG1, JIANBIN ZHOU1, JieZhou1, LU CAO1, QUNFENG ZHANG1,*, YUKUN LI2,*

    Oncology Research, Vol.33, No.6, pp. 1335-1346, 2025, DOI:10.32604/or.2025.058760 - 29 May 2025

    Abstract The cell cycle is a tightly coupled series of events that enable cells to grow and proliferate. Cyclin-dependent kinases (CDKs) play crucial roles in the cell cycle by enabling cells to transition between different phases when they are activated. Cell cycle proteins enhance the activity of CDKs, while natural CDK inhibitors (CDKIs) suppress them. The cell cycle continues in cycles under normal conditions, but when conditions change, cells halt or terminate the cell cycle. Tumors are tissues that grow out of control, and the mechanisms of various types of tumors are different; however, almost… More > Graphic Abstract

    Cell cycle proteins: Linking the cell cycle to tumors

  • Open Access

    REVIEW

    From Model Organism to Pharmaceutical Powerhouse: Innovative Applications of Yeast in Modern Drug Research

    Xiaobing Li1,2, Yongsheng Liu1, Limin Wei1, Li Rao1, Jingxin Mao1,*, Xuemei Li3,*

    BIOCELL, Vol.49, No.5, pp. 813-832, 2025, DOI:10.32604/biocell.2025.062124 - 27 May 2025

    Abstract Yeast-based models have become a powerful platform in pharmaceutical research, offering significant potential for producing complex drugs, vaccines, and therapeutic agents. While many current drugs were discovered before fully understanding their molecular mechanisms, yeast systems now provide valuable insights for drug discovery and personalized medicine. Recent advancements in genetic engineering, metabolic engineering, and synthetic biology have improved the efficiency and scalability of yeast-based production systems, enabling more sustainable and cost-effective manufacturing processes. This paper reviews the latest developments in yeast-based technologies, focusing on their use as model organisms to study disease mechanisms, identify drug targets,… More >

  • Open Access

    ARTICLE

    Bioinformatics and In-Silico Findings Reveal Candidate Genes for Tetralogy of Fallot via Integrative Multi-Omics Data

    Jiawei Shi1,2,3,#, Zhen Wang1,2,3,#, Ying Bai1,2,3, Shiying Li1,2,3, Xin Zhang1,2,3, Tianshu Liu1,2,3, Liu Hong1,2,3, Li Cui1,2,3, Yi Zhang1,2,3, Jing Ma1,2,3, Juanjuan Liu1,2,3, Jing Zhang1,2,3, Haiyan Cao1,2,3,*, Jing Wang1,2,3,*

    Congenital Heart Disease, Vol.20, No.2, pp. 213-229, 2025, DOI:10.32604/chd.2025.064950 - 30 April 2025

    Abstract Background: Tetralogy of Fallot (TOF), the predominant cyanotic congenital heart defect, arises from multifactorial gene-environment interactions disrupting cardiac developmental networks. This study investigated TOF-specific transcriptional alterations and identified high-confidence candidate genes. Methods: Based on GSE36761 transcriptome data, a weighted gene co-expression network analysis (WGCNA) and protein-protein interaction (PPI) network were conducted to identify TOF-related sub-network and Hub genes. The potential biological functions among these genes were revealed by enrichment analysis. Genetic, epigenetic and transcriptional alteration in the Hub genes were analyzed with leveraged public resources: a methylation dataset (GSE62629) and two single-cell datasets (EGAS00001003996 and GSE126128). Results:More >

  • Open Access

    CORRECTION

    Correction: Silencing of the long non-coding RNA LINC00265 triggers autophagy and apoptosis in lung cancer by reducing protein stability of SIN3A oncogene

    XIAOBI HUANG1, CHUNYUAN CHEN2, YONGYANG CHEN1, HONGLIAN ZHOU1, YONGHUA CHEN1, ZHONG HUANG1, YULIU XIE1, BAIYANG LIU1, YUDONG GUO1, ZHIXIONG YANG1, GUANGHUA CHEN3, WENMEI SU1,4

    Oncology Research, Vol.33, No.5, pp. 1249-1250, 2025, DOI:10.32604/or.2024.061822 - 18 April 2025

    Abstract This article has no abstract. More >

  • Open Access

    VIEWPOINT

    The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma

    GAVIN M. ANCHONDO, KYRA PARKER, ALEXIS BRUCE, ELIZABETH CORTEZ, LE SU*

    Oncology Research, Vol.33, No.5, pp. 1001-1005, 2025, DOI:10.32604/or.2025.060573 - 18 April 2025

    Abstract Synovial sarcoma is a high-grade soft tissue malignancy characterized by a unique fusion gene known as SS18-SSX. The SS18-SSX fusion protein acts as an oncogenic driver of synovial sarcoma, and it has thus been commonly accepted that disruption of SS18-SSX function represents a therapeutic means of treating synovial sarcoma, but emerging evidence suggests that upon depletion of SS18-SSX, an anti-apoptotic signal surprisingly arises to protect synovial sarcoma cell survival. In this article, we discuss the controversial roles of SS18-SSX’s transcriptional activity in synovial sarcoma biology and outline a synergistic strategy for overcoming the resistance of More > Graphic Abstract

    The SS18-SSX fusion oncoprotein: Friend and foe in targeted therapy for synovial sarcoma

  • Open Access

    REVIEW

    Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy

    MOEKA NAKASHIMA, NAOKO SUGA, AKARI FUKUMOTO, SAYURI YOSHIKAWA, SATORU MATSUDA*

    Oncology Research, Vol.33, No.5, pp. 1007-1017, 2025, DOI:10.32604/or.2025.059657 - 18 April 2025

    Abstract Malignant tumors are heterogeneous diseases characterized by uncontrolled cell proliferation, invasion, metastasis, and/or recurrence of their malignancies. In particular, cancer stem cells (CSCs) within these tumors might be responsible for the property of invasiveness and/or therapies-resistance. CSCs are a self-renewing, awfully tumorigenic subpopulation of cancer cells, which are notorious for strong chemoresistance and are frequently responsible the aggravated invasion, metastasis, and/or recurrence. Developing targeting therapies against CSCs, therefore, may be deliberated a more encouraging mission for the greater cancer therapy. Innovation for a more potent anti-CSC treatment has been required as soon as possible.… More > Graphic Abstract

    Promising roles of vitamin D receptor and APRO family proteins for the development of cancer stem cells targeted malignant tumor therapy

  • Open Access

    ARTICLE

    Mycobacterial antigen Ag85B restrains Hodgkin lymphoma tumor growth by inhibiting autophagy

    YONGFENG CHENG1, YIPING SHEN2, YUNFEI ZHANG1, HAILIQIGULI NURIDING1, XUEMEI WANG1, CHUNYAN FAN1, GULIBAHA MAIMAITI1, YU LIU1, YINGBIN YUE1, DANLU LI1, MEI YAN1,*

    Oncology Research, Vol.33, No.5, pp. 1173-1187, 2025, DOI:10.32604/or.2025.057842 - 18 April 2025

    Abstract Background: The growth of the B-cell lymphoma subtype, Hodgkin lymphoma (HL), is associated with increased autophagy. A mycobacterial antigen, Ag85, has been reported to inhibit cell autophagy under a variety of conditions. Whether Ag85 could inhibit autophagy in HL is unknown. Methods: Lymph node samples from patients with HL and healthy controls were collected to assess proliferation and autophagy. The human HL cell line, L-428, was cultured and subjected to Ag85B treatment. Autophagy in L-428 cells was evaluated through western blotting analysis, immunohistochemistry, and transmission electron microscopy. Apoptosis in these cells was measured using flow… More >

  • Open Access

    ARTICLE

    Oncolytic adenovirus H101 enhances the anti-tumor effects of PD-1 blockade via CD47 downregulation in tumor cells

    CHENXIAO QIAO1, YIPENG XU2, YEDIE HE2, ZHIJIAN CAI1,*, HUA WANG2,*

    Oncology Research, Vol.33, No.5, pp. 1161-1172, 2025, DOI:10.32604/or.2024.055746 - 18 April 2025

    Abstract Objective: To investigate the anti-tumor effects of an E1B55KD-deleted oncolytic adenovirus, H101, in combination with a humanized anti-PD-1 (Programmed cell death protein 1) monoclonal antibody, Camrelizumab. Methods: Anti-tumor efficacy of intratumoral injection of H101 or/and intraperitoneal injection of Camrelizumab were evaluated in an immune system humanized NOD Prkdcscid Il2rg-/- mice subcutaneous (S.C.) tumor model, established with human glioblastoma of unknown origin cell line U87-MG, and human bladder cancer cell line T24 and YTS-1. The mechanism by which H101 induced anti-tumor immunity were also investigated. Results: Combining H101 with Camrelizumab demonstrated more potent anti-tumor effects than monotherapy in… More >

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