Jo-Yu Lin1,#, Tien-Huang Lin2,3,#, Ya-Jing Jiang4, Liang-Wei Lin4, Kuan-Ying Lai5, Yi-Chin Fong6,7,8, Chih-Chuang Liaw5,9,*, Chih-Hsin Tang1,4,10,11,*
Oncology Research, Vol.34, No.3, 2026, DOI:10.32604/or.2025.074202
- 24 February 2026
Abstract Background: Prostate cancer (PCa) is the most prevalent malignancy in men and often correlates with distant metastasis in its advanced stages. The study aimed to investigate the effects of Ugonin J, a natural compound isolated from Helminthostachys zeylanica, on PCa metastasis. Methods: The effects of Ugonin J on cell motility were assessed using migration and invasion assays. Reverse Transcription Quantitative PCR (RT-qPCR) and Western blotting were used to evaluate the impact of Ugonin J on mRNA and protein expression. RNA sequencing (RNA-seq) analysis was performed to investigate candidate mechanisms. Differential gene expression analysis in PCa patients… More >