CHUN-HUA WANG^1,2, LU-KAI WANG³, RONG-YAUN SHYU⁴, FU-MING TSAI^5,*

BIOCELL, Vol.48, No.9, pp. 1285-1297, 2024, DOI:10.32604/biocell.2024.053746 - 04 September 2024

Abstract Tazarotene-induced gene 1 (TIG1) is induced by a derivative of vitamin A and is known to regulate many important biological processes and control the development of cancer. TIG1 is widely expressed in various tissues; yet in many cancer tissues, it is not expressed because of the methylation of its promoter. Additionally, the expression of TIG1 in cancer cells inhibits their growth and invasion, suggesting that TIG1 acts as a tumor suppressor gene. However, in some cancers, poor prognosis is associated with TIG1 expression, indicating its protumor growth characteristics, especially in promoting the invasion of inflammatory breast cancer More >

WEIGANG REN^1,#, JING LI^2,#, RUIJIANG ZENG^3,4, LIANG ZHU^3,4,*

BIOCELL, Vol.48, No.9, pp. 1323-1330, 2024, DOI:10.32604/biocell.2024.051747 - 04 September 2024

Abstract Background: Clear cell renal cell carcinoma (ccRCC) stands as the most prevalent form of kidney cancer, accounting for a significant proportion of malignancies affecting the kidneys. ccRCC is well known as a type of tumour with immunogenicity. Immune checkpoint inhibitors (ICIs) aim to enhance the anticancer immune response in ccRCC by blocking programmed cell death 1 ligand 1/programmed death 1 (PD-L1/PD-1) pathways. In a previous study, we showed that RING finger protein 26 (RNF26) degrades chromobox 7 (CBX7) to activate the tumor necrosis factor (TNF) in ccRCC. Methods: We analyzed The Cancer Genome Atlas (TCGA)… More > Graphic Abstract

Lijun Zhang, Ying Liu^*, Yushou Ma^*, Xinyou Wang

Phyton-International Journal of Experimental Botany, Vol.93, No.8, pp. 1913-1941, 2024, DOI:10.32604/phyton.2024.052621 - 30 August 2024

Abstract Perennial grasses have developed intricate mechanisms to adapt to diverse environments, enabling their resistance to various biotic and abiotic stressors. These mechanisms arise from strong natural selection that contributes to enhancing the adaptation of forage plants to various stress conditions. Methods such as antisense RNA technology, CRISPR/Cas9 screening, virus-induced gene silencing, and transgenic technology, are commonly utilized for investigating the stress response functionalities of grass genes in both warm-season and cool-season varieties. This review focuses on the functional identification of stress-resistance genes and regulatory elements in grasses. It synthesizes recent studies on mining functional genes, regulatory More >

Oncology Research Editorial Office

Oncology Research, Vol.32, No.9, pp. 1525-1525, 2024, DOI:10.32604/or.2024.056119 - 23 August 2024

Abstract This article has no abstract. More >

Pengcheng Li^1,2,#, Tianze Zhu^1,#, Yunyun Wang^1,2, Shuangyi Yin¹, Xinjie Zhu¹, Minggang Ji¹, Wenye Rui¹, Houmiao Wang¹, Zefeng Yang^1,2,*, Chenwu Xu^1,2,*

Phyton-International Journal of Experimental Botany, Vol.93, No.7, pp. 1441-1453, 2024, DOI:10.32604/phyton.2024.052219 - 30 July 2024

Abstract The nutritional composition and overall quality of maize kernels are largely determined by the key chemical components: protein, oil, and starch. Nevertheless, the genetic basis underlying these nutritional quality traits during grain filling remains poorly understood. In this study, the concentrations of protein, oil, and starch were studied in 204 recombinant inbred lines resulting from a cross between DH1M and T877 at four different stages post-pollination. All the traits exhibited considerable phenotypic variation. During the grain-filling stage, the levels of protein and starch content generally increased, whereas oil content decreased, with significant changes observed between… More >

Adelya Khayrova^*, Sergey Lopatin, Valery Varlamov

Journal of Renewable Materials, Vol.12, No.5, pp. 923-950, 2024, DOI:10.32604/jrm.2024.050033 - 17 July 2024

Abstract Due to the expected rise in the world population, an increase in the requirements for quality and safety of food and feed is expected, which leads to the growing demand for new sources of sustainable and renewable protein. Insect protein is gaining importance as a renewable material for several reasons, reflecting its potential contributions to sustainability, resource efficiency, and environmental conservation. Some insect species are known to be able to efficiently convert organic waste into high-value products such as protein, requiring less land and water compared to traditional livestock. In addition, insect farming produces fewer… More > Graphic Abstract

RUIFANG LI¹, XINRONG NAN^2,*, MING LI^3,*, OMAR RAHHAL³

Oncology Research, Vol.32, No.8, pp. 1323-1334, 2024, DOI:10.32604/or.2024.046965 - 17 July 2024

Abstract Background: Fibroblast activation protein (FAP), a cell surface serine protease, plays roles in tumor invasion and immune regulation. However, there is currently no pan-cancer analysis of FAP. Objective: We aimed to assess the pan-cancer expression profile of FAP, its molecular function, and its potential role in head and neck squamous cell carcinoma (HNSC). Methods: We analyzed gene expression, survival status, immune infiltration, and molecular functional pathways of FAP in The Cancer Genome Atlas (TCGA) and Genotype Tissue Expression (GTEx) tumors. Furthermore, to elucidate the role of FAP in HNSC, we performed proliferation, migration, and invasion assays… More >

SIYUAN LIU, YUAN ZHAO, YU YU, DOU YE, QIAN WANG, ZHAOYAN WANG, ZUO LUAN^*

BIOCELL, Vol.48, No.7, pp. 1115-1126, 2024, DOI:10.32604/biocell.2024.050493 - 03 July 2024

Abstract Introduction: Transplantation of mesenchymal stromal cells (MSCs) is a promising therapy for type 1 diabetes (T1D). However, whether the infused MSCs affect the endoplasmic reticulum stress or subsequent unfolded protein response in β cells remains unclear. Methods: To investigate this, we induced early-onset T1D in non-obese diabetic mice using streptozotocin. Subsequently, T1D mice were randomly assigned to receive either MSCs or phosphate-buffered saline. We observed the in vivo homing of MSCs and assessed their effectiveness by analyzing blood glucose levels, body weight, histopathology, pancreatic protein expression, and serum levels of cytokines, proinsulin, and C-peptide. Results: Infused MSCs… More > Graphic Abstract

Zhengyang Zhang^#, Weixue Liu^#, Yinran Huang^*, Ping Li^*

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1263-1274, 2024, DOI:10.32604/phyton.2024.050755 - 27 June 2024

Abstract Plant antifreeze proteins (AFPs) are special proteins that can protect plant cells from ice crystal damage in low-temperature environments, and they play a crucial role in the process of plants adapting to cold environments. Proteins with these characteristics have been found in fish living in cold regions, as well as many plants and insects. Although research on plant AFPs started relatively late, their application prospects are broad, leading to the attention of many researchers to the isolation, cloning, and genetic improvement of plant AFP genes. Studies have found that the distribution of AFPs in different species… More >

Abdul Momin¹, Amana Khatoon^1,*, Wajahat Khan¹, Dilsat Bozdoğan Konuşkan², Muhammad Mudasar Aslam³, Muhammad Jamil⁴, Shafiq Ur Rehman⁵, Baber Ali⁶, Alevcan Kaplan⁷, Sana Wahab⁸, Muhammad Nauman Khan^9,*, Sezai Ercisli^10,11, Mohammad Khalid Al-Sadoon¹²

Phyton-International Journal of Experimental Botany, Vol.93, No.6, pp. 1117-1128, 2024, DOI:10.32604/phyton.2024.048994 - 27 June 2024

Abstract Sprouts are ready-to-eat and are recognized worldwide as functional components of the human diet. Recent advances in innovative agricultural techniques could enable an increase in the production of healthy food. The use of light-emitting diode (LED) in indoor agricultural production could alter the biological feedback loop, increasing the functional benefits of plant foods such as wheat and lentil sprouts and promoting the bioavailability of nutrients. The effects of white (W), red (R), and blue (B) light were investigated on the growth parameters and nutritional value of wheat and lentil sprouts. In the laboratory, seeds were… More >