BINWU BAO, JINPENG WANG, YANXIA LI, FEN FENG, ZHONGXIANG JI, ZHUOMA LUORENG^*, XINGPING WANG^*

BIOCELL, Vol.47, No.7, pp. 1509-1518, 2023, DOI:10.32604/biocell.2023.028646

Abstract Bovine oocytes are one of the indispensable cells in cattle reproduction and have become a research hot spot in cattle reproduction in recent years. The maturation process of oocytes is mainly regulated by enzymes, hormones, cytokines, and other molecules. The factors affecting cattle oocyte maturation have been previously studied to clarify the molecular mechanisms of cattle oocyte maturation. In this review article, phospholipid protein-3-kinase/protein kinase B, mitogen-activated protein kinase/extracellular signal-regulated kinase, Janus kinase/signal transducer and activator of transcription, epidermal growth factor receptor/extracellular signal-regulated kinase, and other signaling pathways related to oocyte maturation are discussed. In addition, the molecular mechanisms of… More >

MARGARIDA LORIGO^1,2, ELISA CAIRRAO^1,2,*

BIOCELL, Vol.46, No.6, pp. 1383-1389, 2022, DOI:10.32604/biocell.2022.018895

Abstract Cardiovascular diseases (CVD) are one of the leading causes of death worldwide. The knowledge and understanding of CVD are based on the study of vascular physiology and how the smooth muscle cells and tissues perform their different functions. Exposure to endocrine disruptors (EDCs), such as phytoestrogens, polycyclic aromatic hydrocarbons, flame retardants, plasticizers, pesticides, and cosmetics, is an integral and fundamental part of human exposure. Humans are exposed to EDCs by multiple pathways including air, food, water, and consumer products. However, this exposure can lead to several adverse effects on human health, including on the cardiovascular (CV) system. The negative impact… More >

Lu Cao, Li Huang, Penghe Zhao, Yuling Liu^*

CMES-Computer Modeling in Engineering & Sciences, Vol.129, No.2, pp. 787-803, 2021, DOI:10.32604/cmes.2021.016226

Abstract In view of the frequent waterlogging caused by rapid urbanization and the public’s dissatisfaction with the drainage system, the article based on the concept of the green ecological drainage system, constructed the urban green ecological drainage comprehensive simulation research system, and quickly evaluated pipe network operation and surface water of an industrial park under typical rainfall conditions. The results showed that the drainage capacity of the designed green ecological rainwater drainage system reached 100%, and there was no ponding phenomenon, which indicated that the green ecological rainwater drainage system could effectively solve the practical problems of urban drainage. The green… More >

MAURA BENEDETTI, MARIA ELISA GIULIANI, MARICA MEZZELANI, ALESSANDRO NARDI, LUCIA PITTURA, STEFANIA GORBI, FRANCESCO REGOLI

BIOCELL, Vol.46, No.1, pp. 37-49, 2022, DOI:10.32604/biocell.2022.017507

Abstract Oxidative stress is a critical condition derived from the imbalance between the generation of reactive oxygen species and the sophisticated network of antioxidant mechanisms. Several pollutants and environmental factors can affect this system through connected mechanisms, indirect relationships, and cascade effects from pre-transcriptional to catalytic level, by either enhancing intracellular ROS formation or impairing antioxidant defenses. This review summarizes the current knowledge on the pro-oxidant challenges from emerging environmental stressors threatening marine organisms, such as pharmaceuticals, microplastics and climate-related ocean changes. Emphasis will be placed on oxidative pathways, including signaling proteins and transcription factors involved in regulation of antioxidant responsiveness.… More >

Shaoguan Huang¹, Rong Zhang², Lizhen Liu^3,*

Oncologie, Vol.23, No.1, pp. 159-171, 2021, DOI:10.32604/Oncologie.2021.012489

Abstract Breast cancer is one of malignant severe diseases that cause cancer death in women. Although research about the pathogenesis and studies about treatment mechanisms in breast cancer have become clear focuses, we have no clear conclusion yet. Therefore, this research is based on a modular approach to explore key factors and molecular mechanisms that affect breast cancer metastasis. First of all, it is necessary to download breast cancer-related data on the GEO database, and we analyzed the difference between primary tumors and metastatic lesions to obtain differential gene expression profiles. On this basis, a series of bioinformatics analyses were performed… More >

Gongyu Hou¹, Zhedong Xu^1,*, Xin Liu¹, Cong Jin¹

CMES-Computer Modeling in Engineering & Sciences, Vol.118, No.2, pp. 317-337, 2019, DOI:10.31614/cmes.2019.04693

Abstract This article proposes an exponential adjustment inertia weight immune particle swarm optimization (EAIW-IPSO) to enhance the accuracy and reliability regarding the selection of shield tunneling parameter values. According to the iteration changes and the range of inertia weight in particle swarm optimization algorithm (PSO), the inertia weight is adjusted by the form of exponential function. Meanwhile, the self-regulation mechanism of the immune system is combined with the PSO. 12 benchmark functions and the realistic cases of shield tunneling parameter value selection are utilized to demonstrate the feasibility and accuracy of the proposed EAIW-IPSO algorithm. Comparison with other improved PSO indicates… More >