Home / Advanced Search

  • Title/Keywords

  • Author/Affliations

  • Journal

  • Article Type

  • Start Year

  • End Year

Update SearchingClear
  • Articles
  • Online
Search Results (263)
  • Open Access

    PROCEEDINGS

    Multiscale Structural Design and Fracture Control of High-Performance Biomimetic Materials

    Kaijin Wu1,*, Yong Ni1

    The International Conference on Computational & Experimental Engineering and Sciences, Vol.26, No.3, pp. 1-2, 2023, DOI:10.32604/icces.2023.09028

    Abstract Bioinspired architectural design for composites with much higher impact-resistance and fracture-resistance than that of individual constituent remains a major challenge for engineers and scientists. Inspired by the survival war between the mantis shrimps and abalones, we develop multiscale mechanical methods to design structures and control fractures in high-performance biomimetic materials. The first point is the optimization design of impact-resistant nacre-like materials [1-4]. By a combination of simulation, additive manufacturing, and drop tower testing we revealed that, at a critical interfacial strength or a critical prestress, the competition between intralayer cracks and interlayer delamination, or the… More >

  • Open Access

    ARTICLE

    Developing a Breast Cancer Resistance Protein Substrate Prediction System Using Deep Features and LDA

    Mehdi Hassan1,2, Safdar Ali3, Jin Young Kim2,*, Muhammad Sanaullah4, Hani Alquhayz5, Khushbakht Safdar6

    CMC-Computers, Materials & Continua, Vol.76, No.2, pp. 1643-1663, 2023, DOI:10.32604/cmc.2023.038578 - 30 August 2023

    Abstract Breast cancer resistance protein (BCRP) is an important resistance protein that significantly impacts anticancer drug discovery, treatment, and rehabilitation. Early identification of BCRP substrates is quite a challenging task. This study aims to predict early substrate structure, which can help to optimize anticancer drug development and clinical diagnosis. For this study, a novel intelligent approach-based methodology is developed by modifying the ResNet101 model using transfer learning (TL) for automatic deep feature (DF) extraction followed by classification with linear discriminant analysis algorithm (TLRNDF-LDA). This study utilized structural fingerprints, which are exploited by DF contrary to conventional More >

  • Open Access

    ARTICLE

    Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage

    TONG WANG1,4,#, JINHUAN HONG1,5,#, JIAJIE XIE1,5, QIAN LIU4, JINRUI YUE1,5, XUTING HE1,5, SHIYU GE4, TAO LI4, GUOXIN LIU4, BENZHI CAI1,3,5, LINQIANG LI2,*, YE YUAN1,3,5,*

    BIOCELL, Vol.47, No.8, pp. 1811-1820, 2023, DOI:10.32604/biocell.2023.029120 - 28 August 2023

    Abstract Background: Phototherapies based on sunlight, infrared, ultraviolet, visible, and laser-based treatments present advantages like high curative effects, small invasion, and negligible adverse reactions in cancer treatment. We aimed to explore the potential therapeutic effects of blue light emitting diode (LED) in human hepatoma cells and decipher the underlying cellular and molecular mechanisms. Methods: Wound healing and transwell assays were employed to probe the inhibition of the invasion and migration of hepatocellular carcinoma cells in the presence of blue LED. The sphere-forming test was used to evaluate the effect of LED blue light irradiation on cancer… More > Graphic Abstract

    Blue LED promotes the chemosensitivity of human hepatoma to Sorafenib by inducing DNA damage

  • Open Access

    ARTICLE

    Preliminary Study on the Treatment Efficiency of Pasteurized Lime Thermal Alkaline Hydrolysis for Excess Activated Sludge and Reduction of Tetracycline Resistance Genes

    Maoxia Chen1,2,*, Qixuan Zhou1, Jiayue Zhang1, Jiaoyang Li1, Wei Zhang1, Huan Liu1

    Journal of Renewable Materials, Vol.11, No.10, pp. 3711-3723, 2023, DOI:10.32604/jrm.2023.027826 - 10 August 2023

    Abstract Thermal alkaline hydrolysis is a common pretreatment method for the utilization of excess activated sludge (EAS). Owing to strict environment laws and need for better energy utilization, new methods were developed in this study to improve the efficiency of pretreatment method. Direct thermal hydrolysis (TH), pasteurized thermal hydrolysis (PTH), and alkaline pasteurized thermal hydrolysis (PTH + CaO and PTH + NaOH) methods were used to treat EAS. Each method was compared and analyzed in terms of dissolution in ammonium nitrogen (NH4 + -N) and soluble COD (SCOD) in EAS. Furthermore, the removal of tetracycline resistance genes… More >

  • Open Access

    ARTICLE

    Effects of Filler-Asphalt Ratio on the Properties of Lignin and Polyester Fiber Reinforced SMPU/SBS Modified Asphalt Mortar

    Wenjing Xia1,*, JinHui Wang1, Tao Xu1, Nan Jiang2

    Journal of Renewable Materials, Vol.11, No.8, pp. 3387-3402, 2023, DOI:10.32604/jrm.2023.026971 - 26 June 2023

    Abstract To understand the effects of filler-asphalt ratio on different properties of lignin and polyester fiber reinforced shape memory polyurethane (SMPU)/styrene butadiene styrene (SBS) composite modified asphalt mortar (PSAM), as well as to reveal the reinforcing and toughening mechanisms of lignin and polyester fibers on PSAM, SMPU, SBS and mineral powder were first utilized to prepare PSAM. Then the conventional, rheological and anticracking properties of lignin fiber reinforced PSAM (LFAM) and polyester fiber reinforced PSAM (PFAM) at different filler-asphalt ratios were characterized. Test results indicate that the shear strength, deformation resistance and viscosity are increased after… More > Graphic Abstract

    Effects of Filler-Asphalt Ratio on the Properties of Lignin and Polyester Fiber Reinforced SMPU/SBS Modified Asphalt Mortar

  • Open Access

    REVIEW

    The Mechanisms of Trichoderma Species to Reduce Drought and Salinity Stress in Plants

    Mohammad Reza Boorboori, Haiyang Zhang*

    Phyton-International Journal of Experimental Botany, Vol.92, No.8, pp. 2261-2281, 2023, DOI:10.32604/phyton.2023.029486 - 25 June 2023

    Abstract Environmental stresses caused by climate change have severely affected agriculture in the present century; Salinity and drought have challenged most forecasts for increased agricultural production in the past few decades, therefore, different methods that reduce the effect of these stresses on plants have attracted scientists’ attention. The effect of beneficial soil microorganisms on soil health and increasing plants’ resistance to stresses is one of the solutions that researchers have paid attention to. This study investigated how Trichoderma species can be affected by the molecular and morphophysiological mechanisms of plants and improve their salt and drought resistance. More >

  • Open Access

    ARTICLE

    mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance

    CHIWEN BU1,2, LIGANG ZHAO1, LISHAN WANG1, ZEQIAN YU1, JIAHUA ZHOU1,*

    Oncology Research, Vol.31, No.4, pp. 495-503, 2023, DOI:10.32604/or.2023.029309 - 25 June 2023

    Abstract Pancreatic cancer is one of the most aggressive cancers with a median survival time of less than 5 months, and conventional chemotherapeutics are the main treatment strategy. Poly(ADP-ribose) polymerase (PARP) inhibitors have been recently approved for BRCA1/2-mutant pancreatic cancer, opening a new era for targeted therapy for this disease. However, most pancreatic cancer patients carry wild-type BRCA1/2 with resistance to PARP inhibitors. Here, we reported that mammalian target of rapamycin complex 2 (mTORC2) kinase is overexpressed in pancreatic cancer tissues and promotes pancreatic cancer cell growth and invasion. Moreover, we found that knockdown of the More > Graphic Abstract

    mTORC2 promotes pancreatic cancer progression and parp inhibitor resistance

  • Open Access

    ARTICLE

    Zinc alpha 2 glycoprotein (ZAG): A potential novel pharmacological target in diabetic retinopathy

    UMAPATHY PRAKASH1, SUBRAMANIAM RAJESH BHARATHIDEVI1,*, RAMYA R. NADIG2, RAJIV RAMAN2, GIRISH SHIV RAO2, MUNA BHENDE2

    BIOCELL, Vol.47, No.7, pp. 1473-1482, 2023, DOI:10.32604/biocell.2023.027804 - 21 June 2023

    Abstract Zinc alpha 2 glycoprotein (ZAG) is a 41 KDa secretory soluble glycoprotein found in different body fluids like the serum, saliva, sweat, breast milk, and urine. It is also found in tissues like the testis, epididymis, kidney, spleen, liver, lungs, heart, and brain. ZAG is an adipokine with multiple roles, including lipid mobilization, modulating glucose metabolisms, improving insulin sensitivity, inhibiting tumor proliferation through RNAse activity, and suppressing inflammation. Low levels of zinc and ZAG are linked to metabolic syndrome and are also reported as potential biomarkers for diabetic nephropathy. Interestingly zinc has been found to More >

  • Open Access

    REVIEW

    In vitro Mutagenesis for the Improvement of Agave Genus

    Sugey Vásquez-Hernández, Joaquín Adolfo Montes-Molina*, Federico Antonio Gutiérrez-Miceli, Sheila Jazmín Reyes-Zambrano, Carlos Alberto Lecona-Guzmán*

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2065-2078, 2023, DOI:10.32604/phyton.2023.028784 - 29 May 2023

    Abstract Biotechnological techniques provide a viable alternative to help improve and increase the production of plant species of agricultural and economic importance, which have been affected over the years by climate change, increasing their susceptibility to pests and/or diseases, generating losses in production as well as a decrease in their regenerative and genetic diversity. The application of biotechnological techniques such as in vitro mutagenesis offers a viable option for the generation of crops that are resistant to the different factors caused by abiotic and biotic stress. In vitro mutagenesis has been used in an efficient way to generate… More >

  • Open Access

    ARTICLE

    Intron Retention Fine-Tunes the Resistance of the Rice Mutant pls4 to Rice Sheath Blight (Rhizotonia solani AG I.1a)

    Shaochun Liu, Jiamin Hu, Haohua He, Junru Fu, Xu Jie, Dahu Zhou*, Haihui Fu*

    Phyton-International Journal of Experimental Botany, Vol.92, No.7, pp. 2035-2049, 2023, DOI:10.32604/phyton.2023.028296 - 29 May 2023

    Abstract OsPLS4 encodes a β-ketoacyl carrier protein reductase (KAR). The role of OsPLS4 in rice sheath blight (Rhizoctonia solani) remains unclear. Our preliminary studies showed that premature leaf senescence mutants (pls4) were highly susceptive to sheath blight in the early stage of rice development. To explore the role of this gene in the development of rice sheath blight, the transcriptome profiles of the rice pls4 mutant and wild type were compared by RNA-seq. The results revealed 2,569 differentially expressed genes (DEGs). The down-regulated genes were significantly enriched in the defense response-related biological processes. These down-regulated genes included the chitinase… More >

Displaying 51-60 on page 6 of 263. Per Page