Xinxin Hu^1,2,#, Yuye Xue^3,#, Fei Fang⁴, Jie Li², Xiaofeng Yuan², Guang Cheng⁵, Hailong Yuan³, Yongqiang Zhang², Yuefei Zhou⁵, Shuangwu Yang⁵, Pengcheng Qiu^2,*, Yunyang Lu², Haifeng Tang^2,*

Oncology Research, Vol.33, No.9, pp. 2491-2506, 2025, DOI:10.32604/or.2025.064454 - 28 August 2025

Abstract Objectives: The Sorbin and SH3 domain containing 1 (SORBS1), a protein linked to insulin signaling CBL interaction, was investigated for its role in pancreatic cancer apoptosis. This study explored polyphyllin H (PPH)’s ability to restore SORBS1-knockdown-mediated repair functions. Methods: PANC-1 cells were divided into Blank, overexpression (OE), and knockdown groups. CCK-8 assays assessed proliferation and drug toxicity. Western blot and flow cytometry analyzed SORBS1 levels and PPH effects. Comet assays quantified DNA damage. Subcutaneous xenograft tumors in nude mice (Blank vs. knockdown) were treated with PPH to evaluate in vivo efficacy. SORBS1-H2AX gene correlation was analyzed… More > Graphic Abstract

Ibrahim T. Teke^1,2, Ahmet H. Ertas^2,*

CMES-Computer Modeling in Engineering & Sciences, Vol.144, No.1, pp. 201-237, 2025, DOI:10.32604/cmes.2025.066644 - 31 July 2025

Abstract Fatigue failure continues to be a significant challenge in designing structural and mechanical components subjected to repeated and complex loading. While earlier studies mainly examined material properties and how stress affects lifespan, this review offers the first comprehensive, multiscale comparison of strategies that optimize geometry to improve fatigue performance. This includes everything from microscopic features like the shape of graphite nodules to large-scale design elements such as fillets, notches, and overall structural layouts. We analyze and combine various methods, including topology and shape optimization, the ability of additive manufacturing to fine-tune internal geometries, and reliability-based More >

Gracia Cristina Villodres^1,#,*, Federico Salvador-Pérez², José Joaquín Muros¹, Rocío Vizcaíno-Cuenca^3,4,#

International Journal of Mental Health Promotion, Vol.27, No.7, pp. 877-899, 2025, DOI:10.32604/ijmhp.2025.066137 - 31 July 2025

Abstract Background: University students face significant challenges in maintaining healthy physical activity (PA) and dietary habits, and they often fall short of global health recommendations. Psychological factors such as social physique anxiety, body image concerns, and self-objectification may act as barriers to PA engagement, influencing both mental and physical health. The present study constructed a structural equation model (SEM) to examine the relationship between body image-related psychological factors and resistance to PA in university students from southern Spain. Methods: A cross-sectional and correlational study was conducted with 519 university students (74% females, 26% males; Mean age… More >

Adnan Amin, Wajid Zaman^*

Phyton-International Journal of Experimental Botany, Vol.94, No.7, pp. 1973-1996, 2025, DOI:10.32604/phyton.2025.067885 - 31 July 2025

Abstract Plant-pathogen interactions involve complex biological processes that operate across molecular, cellular, microbiome, and ecological levels, significantly influencing plant health and agricultural productivity. In response to pathogenic threats, plants have developed sophisticated defense mechanisms, such as pattern-triggered immunity (PTI) and effector-triggered immunity (ETI), which rely on specialized recognition systems such as pattern recognition receptors (PRRs) and nucleotide-binding leucine-rich repeat (NLR) proteins. These immune responses activate intricate signaling pathways involving mitogen-activated protein kinase cascades, calcium fluxes, reactive oxygen species production, and hormonal cross-talk among salicylic acid, jasmonic acid, and ethylene. Furthermore, structural barriers such as callose deposition… More >

Filomena Emanuela Laddaga¹, Pamela Pinto², Bruna Daraia², Antonio D’amato^3,4, Stella D’oronzo^3,5, Stefano Martinotti^3,6,*, Francesco Gaudio^2,3,*

BIOCELL, Vol.49, No.7, pp. 1185-1206, 2025, DOI:10.32604/biocell.2025.063572 - 25 July 2025

Abstract Checkpoint inhibitors, particularly programmed cell death-1/programmed death-ligand 1 (PD-1/PD-L1) inhibitors, have significantly advanced the treatment of Hodgkin lymphoma (HL), especially in relapsed or refractory cases. However, challenges such as resistance, immune-related adverse events (irAEs), and the need for effective patient selection remain. This review aims to explore the mechanisms of resistance to checkpoint inhibitors, including alterations in the tumor microenvironment, loss of antigen presentation, and T-cell exhaustion. Overcoming resistance may involve combination therapies, such as pairing PD-1 inhibitors with other immune checkpoint inhibitors or targeted therapies like Brentuximab vedotin. Additionally, next-generation inhibitors targeting molecules like More >

FLáVIA ALVES VERZA^1,#,*, GUILHERME CARVALHO DA SILVA^2,#, FELIPE GARCIA NISHIMURA²

Oncology Research, Vol.33, No.8, pp. 1819-1834, 2025, DOI:10.32604/or.2025.065755 - 18 July 2025

Abstract Cancer remains a major global health burden, with rising incidence and mortality linked to aging populations and increased exposure to genotoxic agents. Oxidative stress plays a critical role in cancer development, progression, and resistance to therapy. The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-associated protein 1 (KEAP1)-antioxidant response element (ARE) signaling pathway is central to maintaining redox balance by regulating the expression of antioxidant and detoxification genes. Under physiological conditions, this pathway protects cells from oxidative damage, however, sustained activation of NRF2 in cancer, often due to mutations in KEAP1, supports tumor cell survival, More > Graphic Abstract

Chengquan Wang^1,2, Rongyang Liu¹, Xinquan Wang^1,2,*, Boyan Ping³, Haimin Qian^1,2, Xiao Li¹, Yuhan Liang¹

Structural Durability & Health Monitoring, Vol.19, No.4, pp. 819-850, 2025, DOI:10.32604/sdhm.2025.060580 - 30 June 2025

Abstract This article provides an overview of the current development status of prestressed segmental precast and assembled piers, Emphasis was placed on analyzing the stress characteristics of bridge piers under impact. The concept of recoverable functional design and its application prospects were elaborated, and finally, the research on the impact resistance performance of prestressed segmental precast and assembled piers was discussed. Research has shown that optimizing design and material selection can effectively enhance the impact resistance and structural durability of bridge piers. At the same time, the introduction of the concept of recoverable functionality provides new More >

Xingjie Ren^1,2,#,*, Jianrong Zhang^3,4,#, Qingfeng Tang³, Heng Zhang³, Yaling Zhang^3,4,*

Frontiers in Heat and Mass Transfer, Vol.23, No.3, pp. 881-897, 2025, DOI:10.32604/fhmt.2025.066302 - 30 June 2025

Abstract This paper investigates interfacial heat transfer characteristics in a multi-layer structure under ultra-high heat flux conditions, focusing on thermal contact resistance (TCR) between adjacent layers. A three-layer computational model with dual rough interfaces was developed to systematically analyze the synergistic effects of interfacial pressure, surface emissivity, and thermal interface materials (TIMs). Surface reconstruction using experimental measurement data generated two representative roughness models to quantify the impact of surface roughness on heat dissipation. Numerical simulations demonstrate that the absence of TIMs leads to insufficient thermal dissipation capacity under ultra-high heat flux conditions. Compared to TIM application, More >

Ali Salehi Sardoei^1,*, Bahman Fazeli-Nasab²

Phyton-International Journal of Experimental Botany, Vol.94, No.6, pp. 1601-1630, 2025, DOI:10.32604/phyton.2025.064729 - 27 June 2025

Abstract The ability of plants to tolerate cold is a complex process. When temperatures drop or freeze, plant tissues can develop ice, which dehydrates the cells. However, plants can protect themselves by preventing ice formation. This intricate response to cold stress is regulated by hormones, photoperiod, light, and various factors, in addition to genetic influences. In autumn, plants undergo morphological, physiological, biochemical, and molecular changes to prepare for the low temperatures of winter. Understanding cellular stress responses is crucial for genetic manipulation aimed at enhancing cold resistance. Early autumn frosts or late spring chills can cause… More >

Sajid Ali^*, Yong-Sun Moon^*

Phyton-International Journal of Experimental Botany, Vol.94, No.5, pp. 1419-1451, 2025, DOI:10.32604/phyton.2025.064284 - 29 May 2025

Abstract This review focused on the role of plant growth-promoting rhizobacteria (PGPR) in enhancing plant growth and protecting against pathogens, highlighting their mechanisms of action, ecological benefits, and challenges. PGPR mediate plant growth through several mechanisms, including nutrient acquisition, production of antimicrobial compounds and induction of systemic resistance. These mechanisms are critical in improving crop yields, especially under stressful conditions. This review examines the molecular mechanisms of PGPR-mediated plant pathogen control, cellular mechanisms of PGPR in plant pathogen control, ecological and environmental benefits of PGPR application. Despite their potential, PGPR application is limited by environmental variability,… More >