JIE ZHAO^1,#, XUANTAO YANG^2,#, HAIXI ZHANG¹, XUEZHONG GU^1,*

Oncology Research, Vol.32, No.2, pp. 325-337, 2024, DOI:10.32604/or.2023.030770 - 28 December 2023

Abstract Multiple myeloma (MM) is a hematological tumor with high mortality and recurrence rate. Carfilzomib is a new-generation proteasome inhibitor that is used as the first-line therapy for MM. However, the development of drug resistance is a pervasive obstacle to treating MM. Therefore, elucidating the drug resistance mechanisms is conducive to the formulation of novel therapeutic therapies. To elucidate the mechanisms of carfilzomib resistance, we retrieved the GSE78069 microarray dataset containing carfilzomib-resistant LP-1 MM cells and parental MM cells. Differential gene expression analyses revealed major alterations in the major histocompatibility complex (MHC) and cell adhesion molecules.… More >

WEI HU^1,#, THOMAS WARTMANN^2,#, MARCO STRECKER², ARISTOTELIS PERRAKIS², ROLAND CRONER², ARPAD SZALLASI³, WENJIE SHI^2,*, ULF D. KAHLERT^2,*

Oncology Research, Vol.32, No.1, pp. 227-239, 2024, DOI:10.32604/or.2023.043053 - 15 November 2023

Abstract Transient receptor potential (TRP) channels are strongly associated with colon cancer development and progression. This study leveraged a multivariate Cox regression model on publicly available datasets to construct a TRP channels-associated gene signature, with further validation of signature in real world samples from our hospital treated patient samples. Kaplan-Meier (K-M) survival analysis and receiver operating characteristic (ROC) curves were employed to evaluate this gene signature’s predictive accuracy and robustness in both training and testing cohorts, respectively. Additionally, the study utilized the CIBERSORT algorithm and single-sample gene set enrichment analysis to explore the signature’s immune infiltration… More > Graphic Abstract

SAYAKA IMATSUJI^1,#, YUKIKO UJIE^1,#, HIROYUKI ODAKE¹, MASAYA IMOTO^1,2, SUSUMU ITOH³, ETSU TASHIRO^1,3,*

Oncology Research, Vol.32, No.1, pp. 139-150, 2024, DOI:10.32604/or.2023.030190 - 15 November 2023

Abstract Growing evidence suggests an association between epithelial-mesenchymal transition (EMT), a hallmark of tumor malignancy, and chemoresistance to a number of anti-cancer drugs. However, the mechanism of EMT induction in the process of acquiring anti-cancer drug resistance remains unclear. To address this issue, we obtained a number of cisplatin-resistant clones from LoVo cells and found that almost all of them lost cell-cell contacts. In these clones, the epithelial marker E-cadherin was downregulated, whereas the mesenchymal marker N-cadherin was upregulated. Moreover, the expression of EMT-related transcription factors, including Slug, was elevated. On the other hand, the upregulation More >

Wei Shi^1,2, Zhengyi Li¹, Xiaobing Xu¹, Yingshui Yu¹, Xiaofei Ding¹, Heng Ju^1,*

FDMP-Fluid Dynamics & Materials Processing, Vol.20, No.1, pp. 97-108, 2024, DOI:10.32604/fdmp.2023.029028 - 08 November 2023

Abstract Two-dimensional carbon/carbon (2D C/C) composites are a special class of carbon/carbon composites, generally obtained by combining resin-impregnated carbon fiber clothes, which are then cured and carbonized. This study deals with the preparation of a protective coating for these materials. This coating, based on graphite, was prepared by the slurry method. The effect of graphite and phenolic resin powders with different weight ratios was examined. The results have shown that the coating slurry can fill the pores and cracks of the composite surface, thereby densifying the surface layer of the material. With the increase of the… More >

Van Thao Le¹

Revista Internacional de Métodos Numéricos para Cálculo y Diseño en Ingeniería, Vol.39, No.2, pp. 1-3, 2023, DOI:10.23967/j.rimni.2023.06.007 - 30 June 2023

Abstract The suffusion susceptibility of the soil samples is evaluated through an erosion resistance index. Thanks to existing statistical analyses, the erosion resistance index is estimated from several soil parameters. In actual exploitation, the soil properties with the input parameters related to the grain distribution of the soil… vary greatly from the original design value due to the influence of many factors. One of the factors is the inherent variability. Inherent soil variability is modelled as a random field. The usual problems used to assess the suffusion susceptibility may be not give accurate results or fully… More >

Yangao Hu^1,*

The International Conference on Computational & Experimental Engineering and Sciences, Vol.27, No.3, pp. 1-1, 2023, DOI:10.32604/icces.2023.09773

Abstract This paper investigates the effects of graphene oxide (GO), notch depth, rebar, and load on the resistivity of cement paste and mortar. The electrical conductivity of GO/cement composite reaches its maximum value when the GO content is 0.03%, which is approximately 50% higher compared to the composite without GO. The resistivity of GO/cement composite shows significant changes with increasing load from 0 to 40 kN. The gauge factor for compressive loading varies from about 26 to 73 for different GO contents. Moreover, the resistivity variation with the notch depth in GO/cement is found to be More >

Chaoqian He^1,2, Runfang Hao^1,2,*, Kun Yang^1,2, Zhongyun Yuan^1,2, Shengbo Sang^1,2, Xiaorui Wang^1,2

CMC-Computers, Materials & Continua, Vol.77, No.3, pp. 3423-3442, 2023, DOI:10.32604/cmc.2023.045718 - 26 December 2023

Abstract Intelligent fault diagnosis in modern mechanical equipment maintenance is increasingly adopting deep learning technology. However, conventional bearing fault diagnosis models often suffer from low accuracy and unstable performance in noisy environments due to their reliance on a single input data. Therefore, this paper proposes a dual-channel convolutional neural network (DDCNN) model that leverages dual data inputs. The DDCNN model introduces two key improvements. Firstly, one of the channels substitutes its convolution with a larger kernel, simplifying the structure while addressing the lack of global information and shallow features. Secondly, the feature layer combines data from More >

JIAZHUANG LI^*, WEI ZHANG, SHOUBAO GAO, LI SUN, QINGYANG TAI, YING LIU

BIOCELL, Vol.47, No.10, pp. 2313-2320, 2023, DOI:10.32604/biocell.2023.029860 - 08 November 2023

Abstract Background: Trastuzumab resistance accounts for chemotherapy failure in gastric cancer patients in clinical practice. The significance of long non-coding RNAs (lncRNAs) in the maintenance of drug resistance in gastric cancer has been already underlined. Method: This study aimed to identify the specific role of lncRNA-ATB in gastric cancer progression and trastuzumab resistance. The downstream miRs of lncRNA-ATB and target genes of miRs were predicted by bioinformatics analysis and verified using dual luciferase reporter assay. Loss- and gain-function assays were performed to explore the roles of lncRNA-ATB, miR-200c, and zinc-finger protein 217 (ZNF217) in the cell functions More >

LIANLI NI^1,2,#, YUN YU^1,2,#, HAN LIN^1,2, WEISHAN ZHUGE², LU TAO², YIWEI SHEN², RI CUI^2,*, SHAOTANG LI^1,2,*

BIOCELL, Vol.47, No.10, pp. 2245-2254, 2023, DOI:10.32604/biocell.2023.030147 - 08 November 2023

Abstract Background: Homeobox B8 (HOXB8), a member of HOX family, plays a key role in the development of colorectal cancer (CRC). However, the function of HOXB8 in oxaliplatin (OXA) resistance in CRC is still unclear. This study investigated the role and precise molecular mechanism of HOXB8 in OXA-resistant CRC cells. Methods: The cell viability was measured by the 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide (MTT) assay, and the colony forming ability was determined by colony formation assay. The silencing RNA (siRNA) approach was used to knockdown HOXB8 in CRC cells while the lentiviral transfection system was used to establish… More >

Dengyun Li, Baiwen Du, Kai Zhu, Jicheng Yu^*, Siyuan Liang, Changxi Yue

Energy Engineering, Vol.120, No.11, pp. 2611-2628, 2023, DOI:10.32604/ee.2023.028282 - 31 October 2023

Abstract Self-heating and electric field distribution are the primary factors affecting the accuracy of the Ultra High Voltage Direct Current (UHVDC) resistive divider. Reducing the internal temperature rise of the voltage divider caused by self-heating, reducing the maximum electric field strength of the voltage divider, and uniform electric field distribution can effectively improve the UHVDC resistive divider’s accuracy. In this paper, thermal analysis and electric field distribution optimization design of 1200 kV UHVDC resistive divider are carried out: (1) Using the proposed iterative algorithm, the heat dissipation and temperature distribution of the high voltage DC resistive… More >