Haibo Jia^1,*, Bo Yu¹

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 23-24, 2019, DOI:10.32604/mcb.2019.05708

Abstract Coronary angiography is the traditional standard imaging modality for visual evaluation of coronary anatomy and guidance of percutaneous coronary interventions (PCI). However, the 2-dimensional lumenogram cannot depict the arterial vessel per se and plaque characteristics, or directly assess the stenting result. Intracoronary imaging by means of intravascular ultrasound (IVUS) and optical coherence tomography (OCT) provides valuable incremental information that can be used clinically to optimize stent implantation and thereby minimize stent-related problems. Beyond guidance of stent selection and optimisation, imaging provides critical insights into the pathophysiology of acute coronary syndrome (ACS), greater clarity when confronted… More >

J. J. Wentzel^1,*

Molecular & Cellular Biomechanics, Vol.16, Suppl.1, pp. 7-8, 2019, DOI:10.32604/mcb.2019.05696

Abstract The pathophysiology of atherosclerosis is complex and multifactorial, involving systemic risk factors and biomechanical stimuli. Atherosclerotic plaques predominantly form in regions that are exposed to low shear stress of the blood at the vessel wall, whereas regions of moderate and high shear stress are generally protected. For more than 20 years, my research group performs studies to investigate the role of shear stress in atherosclerotic plaque formation and rupture in coronary and carotid arteries of patients and laboratory animals. For that reason, new technology was developed to 3D reconstruct arteries based on fusion of multiple… More >

Mingchao Cai, Chun Yang, Mehmet H. Kural, Richard Bach, David Muccigrosso, Deshan Yang, Jie Zheng, Kristen L. Billiar, Dalin Tang

The International Conference on Computational & Experimental Engineering and Sciences, Vol.19, No.4, pp. 97-104, 2011, DOI:10.3970/icces.2011.019.097

Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better risk assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. We propose a procedure where intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling are combined together to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. More >

Masahiko Demura^1,*, Junya Sakurai^1,2, Masayoshi Yamazaki¹, Junya Inoue^1,2

The International Conference on Computational & Experimental Engineering and Sciences, Vol.22, No.2, pp. 123-123, 2019, DOI:10.32604/icces.2019.05303

Abstract Creep is a complicated and time-dependent phenomenon, which is affected by the initial state and the degradation of microstructures. It is thus considered that the information about the microstructure is essential to predict the creep rupture time. On the other hand, there is a strong, practical need for the prediction without the investigation of microstructures nor the disclosure of the detailed process that should control the initial microstructures. In this study, we examined how modern machine learning technique can help to predict the creep rupture time in heat-resistant ferrite-type steels without the direct information about… More >

I.A. Miklashevich¹

The International Conference on Computational & Experimental Engineering and Sciences, Vol.15, No.4, pp. 145-152, 2010, DOI:10.3970/icces.2010.015.145

Abstract The simple analytical model for the energy flux by the earthquake is proposed. The energy flux can be evaluated through the Umov-Pointing vector by the rupture propagation in media. Discontinuity of vector components is found. This discontinuity cause the change of an energy flow direction and localization of the energy field. More >

Hongjian Wang^*, Jie Zheng^†, LiangWang^‡, Akiko Maehara^§, Chun Yang^II, David Muccigrosso^†, Richard Bachk^II, Jian Zhu^**, Gary S. Mintz^§, Dalin Tang^*,‡,††

Molecular & Cellular Biomechanics, Vol.12, No.2, pp. 107-122, 2015, DOI:10.3970/mcb.2015.012.107

Abstract Computational modeling has been used extensively in cardiovascular and biological research, providing valuable information. However, 3D vulnerable plaque model construction with complex geometrical features and multicomponents is often very time consuming and not practical for clinical implementation. This paper investigated if 2D atherosclerotic plaque models could be used to replace 3D models to perform correlation analysis and achieve similar results. In vivo intravascular ultrasound (IVUS) coronary plaque data were acquired from a patient follow-up study to construct 2D structure-only and 3D FSI models to obtain plaque wall stress (PWS) and strain (PWSn) data. One hundred… More >

Molecular & Cellular Biomechanics, Vol.9, No.1, pp. 77-94, 2012, DOI:10.3970/mcb.2012.009.077

Abstract Image-based computational modeling has been introduced for vulnerable atherosclerotic plaques to identify critical mechanical conditions which may be used for better plaque assessment and rupture predictions. In vivo patient-specific coronary plaque models are lagging due to limitations on non-invasive image resolution, flow data, and vessel material properties. A framework is proposed to combine intravascular ultrasound (IVUS) imaging, biaxial mechanical testing and computational modeling with fluid-structure interactions and anisotropic material properties to acquire better and more complete plaque data and make more accurate plaque vulnerability assessment and predictions. Impact of pre-shrink-stretch process, vessel curvature and high More >

J.S. Ren^*

Molecular & Cellular Biomechanics, Vol.7, No.4, pp. 213-224, 2010, DOI:10.3970/mcb.2010.007.213

Abstract Dynamic analysis of an axially stretched arterial wall with collagen fibers distributed in two preferred directions under a suddenly applied constant internal pressure along with the possibility of the formation and rupture of aneurysm are examined within the framework of nonlinear dynamics. A two layer tube model with the fiber-reinforced composite-based incompressible anisotropic hyper-elastic material is employed to model the mechanical behavior of the arterial wall. The maximum amplitudes and the phase diagrams are given by numerical computation of the differential relation. It is shown that the arterial wall undergoes nonlinear periodic oscillation and no More >

Chun Yang^∗,†, Dalin Tang^∗,‡, Shunichi Kobayashi^§, Jie Zheng^¶, Pamela K. Woodard^§, Zhongzhao Teng^*, Richard Bach^||, David N. Ku^∗∗

Molecular & Cellular Biomechanics, Vol.5, No.4, pp. 259-274, 2008, DOI:10.3970/mcb.2008.005.259

Abstract Many acute cardiovascular syndromes such as heart attack and stroke are caused by atherosclerotic plaque ruptures which often happen without warning. MRI-based models with fluid-structure interactions (FSI) have been introduced to perform flow and stress/strain analysis for atherosclerotic plaques and identify possible mechanical and morphological indices for accurate plaque vulnerability assessment. In this paper, cyclic bending was added to 3D FSI coronary plaque models for more accurate mechanical predictions. Curvature variation was prescribed using the data of a human left anterior descending (LAD) coronary artery. Five computational models were constructed based on ex vivo MRI… More >

Yuliya Vengrenyuk^*, Luis Cardoso^*, Sheldon Weinbaum^∗,†

Molecular & Cellular Biomechanics, Vol.5, No.1, pp. 37-48, 2008, DOI:10.3970/mcb.2008.005.037

Abstract In this paper, we further investigate the new paradigm for the rupture of thin cap fibroatheroma (TCFA) proposed in Vengrenyuk et al. (2006 PNAS 103:14678) using a multilevel micro-CT based 3D numerical modeling. The new paradigm proposes that the rupture of TCFA is due to stress-induced interfacial debonding of cellular - level, 10 -- 20 μm microcalcifications in the fibrous cap proper. Such microcalcifications, which lie below the visibility of current in vivo imaging techniques, were detected for the first time using confocal microscopy and high resolution microcomputed tomography (micro-CT) imaging in Vengrenyuk et al. (2006) In the present… More >