Amine Gonca Toprak^1,*, Aytuğ Onan²

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.085268 - 13 August 2026

Abstract Biomedical texts present significant challenges for natural language processing (NLP) due to their complex terminology, intricate contextual dependencies, and highly domain-specific semantics. This study investigates the effectiveness of knowledge distillation (KD) for biomedical text classification, aiming to develop lightweight, resource-efficient models that remain competitive with larger architectures. A balanced dataset of 25,000 PubMed records was constructed, equally distributed across five biomedical domains. Two teacher models (BERT and PubMedBERT) and five student models (DistilBERT, BioClinicalBERT, BioBERT, DistilBioBERT, and DistilRoBERTa) were evaluated across ten distinct KD configurations. Each student model was also directly fine-tuned to serve as… More >

Manaswi Kulahara¹, Khadija Parwez², Faisal Alhwikem^3,*, Fawwad Hassan Jaskani⁴

CMC-Computers, Materials & Continua, Vol.89, No.1, 2026, DOI:10.32604/cmc.2026.084877 - 13 August 2026

Abstract Large Language Models (LLMs) have recently advanced in real-world commonsense reasoning, including understanding everyday object behaviors and inferring their attributes from text. However, they remain limited in reasoning about the real-world consequences of events, such as how object failures, obstructions, or structural changes affect the surrounding environment-especially without visual or sensorimotor input. Existing works like PIQA and NEWTON evaluate narrow sub-skills, such as whether an object action makes sense and whether object properties can be inferred, providing valuable benchmarks for commonsense and physical reasoning but offering limited evaluation of how events alter environmental functionality and downstream… More >

Wen Gao^1,2, Xingyu Zheng^1,2, Yanan Hu^1,2, Rui Zou³, Yongan Zhou⁴, Xiang Song^2,*

Oncology Research, Vol.34, No.9, 2026, DOI:10.32604/or.2026.082652 - 13 August 2026

Abstract Background: As a core component of the immunoproteasome, the β1i subunit (proteasome 20S subunit beta 9, PSMB9) is involved in antigen processing and presentation and regulates anti-tumor immune responses. PSMB9 is aberrantly overexpressed in colorectal cancer. However, the precise mechanisms through which PSMB9 contributes to the initiation, progression, and immune regulation of colorectal cancer remain unclear. This study aims to investigate the expression characteristics and biological functions of PSMB9 in colorectal cancer, and to further elucidate the molecular pathways underlying its role in colorectal cancer initiation and progression. The findings are expected to provide a theoretical… More >

Marco Ferreira^1,2,*

International Journal of Mental Health Promotion, Vol.28, No.7, 2026, DOI:10.32604/ijmhp.2026.080597 - 30 July 2026

Abstract Objectives: Teachers’ well-being significantly impacts schools, educators, and students. Many negative effects of low well-being are widely recognised, with stress and burnout linked to attrition and teacher shortages globally. In Portugal, a country with a severe lack of teachers, attention to teacher well-being is crucial for the long-term sustainability of the profession. This study aims to understand teachers’ professional well-being. Specifically, it seeks to (1) clarify well-being, the sense of belonging, and autonomy within the school community and (2) explore how teachers perceive the values and behaviours of schools that prioritise well-being. Methods: A descriptive qualitative… More >

Mihaela Jurdana^1,*, Lovro Ziberna^2,3

BIOCELL, Vol.50, No.8, 2026, DOI:10.32604/biocell.2026.079591 - 27 July 2026

Abstract Obesity and metabolic syndrome promote malignancies through chronic inflammation and sustained activation of insulin and insulin-like growth factor-1 (IGF-1) signaling. Skeletal muscle is central to this tumor-promoting milieu because it governs insulin-stimulated glucose disposal, lipid oxidation, and endocrine crosstalk. This narrative review explores whether melatonin signaling in skeletal muscle, particularly via melatonin receptor 2 (MT₂), represents a modifiable node within the obesity–cancer axis. Experimental evidence indicates that melatonin activates MT₂-linked Gi/o and calcium-sensitive pathways converging on phosphoinositide 3-kinase–protein kinase B (PI3K–Akt), extracellular signal-regulated kinases (ERK), and calcium/calmodulin-dependent protein kinase II–adenosine monophosphate-activated protein kinase–peroxisome proliferator-activated receptor gamma More >

Abdelkarim Hegab^1,*, Faisal Albatati¹, Ahmad Hussain², Asad A. Zaidi^3,*, Abdullah Abuhabaya¹, Ragab A. El-Sehiemy^4,5

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.6, 2026, DOI:10.32604/fdmp.2026.082520 - 30 June 2026

Abstract A combined asymptotic and characteristic-based computational framework is developed to investigate unsteady compressible flow response in solid rocket motor (SRM) chambers subjected to exit-plane disturbances and steady sidewall mass injection. The formulation integrates a low-Mach-number asymptotic reduction of the governing equations with a time-accurate numerical solution of the parabolized Navier–Stokes equations, employing characteristic-based boundary conditions to ensure physically consistent wave reflection and transmission at chamber boundaries. Controlled exit-plane pressure forcing is imposed under non-resonant and near-resonant conditions to examine acoustic–vorticity coupling mechanisms within slender SRM geometries. The computational framework is verified and validated against analytical… More >

Hao Jiang¹, Lucheng Sun², Liguo Shuai^1,*, Zhihan Li^3,*

FDMP-Fluid Dynamics & Materials Processing, Vol.22, No.6, 2026, DOI:10.32604/fdmp.2026.082152 - 30 June 2026

Abstract Underwater bio-inspired robots have emerged as a promising alternative to conventional propeller-driven autonomous underwater vehicles and remotely operated vehicles because of their potential for high propulsive efficiency, superior maneuverability, reduced acoustic signatures, and enhanced environmental adaptability. Unlike rigid propellers operating under approximately steady inflow conditions, bio-inspired propulsion relies on strongly unsteady hydrodynamic mechanisms, including vortex generation and shedding, added-mass effects, boundary-layer evolution, and flexible fluid–structure interaction (FSI). These processes fundamentally govern thrust production, energy conversion, and maneuvering performance, yet a systematic synthesis connecting hydrodynamic mechanisms with engineering implementation remains limited. This review addresses that gap… More >

Da Fang¹, Xianbing Chen^2,*, Chenxiao Chu^3,*, Xinhou Liu⁴, Mengyu Zhu⁵, Jinliang Zhu⁶

Frontiers in Heat and Mass Transfer, Vol.24, No.3, 2026, DOI:10.32604/fhmt.2026.079777 - 29 June 2026

Abstract A three-dimensional numerical model of a water-driven steam ejector was developed using the Euler-Euler two-fluid framework. A direct-contact condensation (DCC) heat and mass transfer model was employed to simulate the complex two-phase flow and energy exchange. The distributions of gas-liquid phases, pressure, and temperature were obtained to evaluate performance. Results indicate that within the investigated operating range (p_p = 140–160 kPa), the entrainment ratio (ER) and temperature rise (DT) are highly coupled, with DT varying from 5.33 to 11.49 K. The maximum temperature rise of 11.49 K was achieved at p_p = 140 kPa, T_p = 310 K,… More >

Si-Han Chen^1,#, Yun Song^2,#,*, Xian-Yin Li³, Jun-Ping Zhou², I-Hua Chen^3,*

International Journal of Mental Health Promotion, Vol.28, No.6, 2026, DOI:10.32604/ijmhp.2026.079774 - 23 June 2026

Abstract Backgrounds: In the digital era, smartphone-driven phubbing behavior has become increasingly prevalent among teachers and may contribute to insomnia. Psychological distress has been identified as a potential mechanism linking maladaptive technology use to sleep problems; however, this mediating pathway has not been examined longitudinally. Furthermore, gender differences in these associations remain unclear. This study aimed to examine the longitudinal relationship between phubbing behavior and insomnia, the mediating role of psychological distress, and the moderating role of gender. Methods: A two-wave longitudinal design with a four-month interval was employed. At Time 1 (T1), 1061 teachers participated, with… More >

Zhengzheng Li^1,2,#, Haitong Xie^1,2,#, Yujuan Chen^1,2, Qiuyan Li³, Xing Yuan⁴, Xinyue Dai³, Jie Chen^1,2,*

Oncology Research, Vol.34, No.7, 2026, DOI:10.32604/or.2026.081209 - 16 June 2026

Abstract Objectives: Triple-negative breast cancer (TNBC) is an aggressive subtype lacking targeted therapies. Phosphoglycerate kinase 1 (PGK1) drives TNBC progression, but mechanisms governing its protein stability remain unclear. This study aims to identify the E3 ubiquitin ligase responsible for PGK1 degradation and evaluate its therapeutic potential against metastasis. Methods: Clinical datasets and 50 human TNBC tissues were analyzed via multiplex immunohistochemistry. Co-immunoprecipitation, ubiquitination linkage assays, and structural modeling were utilized for in vitro mechanistic studies in TNBC cells. Additionally, functional impacts on epithelial-mesenchymal transition (EMT) and metastasis were evaluated using transwell assays and an in vivo mouse lung metastasis… More >