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  • Open Access

    ARTICLE

    Inhibition of Proteasome LMP2 Activity Suppresses Chil3 Expression in Mouse Colon Adenocarcinoma Tissue and Restrains Tumor Growth

    Tatiana M. Astakhova, Nikita S. Karpov, Nataliya O. Dashenkova, Elena V. Alpeeva, Mikhail V. Nesterchuk, Sergey B. Akopov, Arsen S. Mikaelyan, Anfisa S. Ryabchenko, Pavel A. Erokhov, Natalia P. Sharova*

    Oncology Research, Vol.33, No.9, pp. 2573-2595, 2025, DOI:10.32604/or.2025.066611 - 28 August 2025

    Abstract Objectives: Proteasomes, multi-subunit proteases, are key actors of cellular protein catabolism and a number of regulatory processes. The detection of subtle proteasome functioning in tumors may contribute to our understanding of the mechanisms of cancer development. The current study aimed to identify the role of low molecular mass protein 2 (LMP2), a proteasome immune subunit, in the development of mouse colon 26 (C26) adenocarcinoma. Methods: The functions of the LMP2 subunit in tumor development in Balb/c mice were studied using its irreversible inhibitor KZR-504. LMP2 activity was detected by the hydrolysis of the fluorogenic substrate… More >

  • Open Access

    ARTICLE

    A Non-Unit Protection Based on Propagation of Fault Traveling Wave for Transmission Line Connected to Wind Power Plant

    Hao Wang*, Wenyue Zhou, Yiping Luo

    Energy Engineering, Vol.122, No.9, pp. 3737-3752, 2025, DOI:10.32604/ee.2025.067938 - 26 August 2025

    Abstract Currently, renewable energy has been broadly implemented across diverse sectors, particularly evidenced by its substantially higher integration levels in power systems. The large-scale integration of renewable energy resources introduces distinct fault characteristics into power grids, potentially rendering traditional line protection schemes inadequate for transmission lines interfacing with these sources. Therefore, it is imperative to study line protection methods unaffected by the integration of renewable energy resources. After analyzing the propagation process of the fault traveling wave along the transmission line, a non-unit protection based on traveling wave distance measurement is proposed. The core principle of… More >

  • Open Access

    ARTICLE

    A Fault Location Method of Multi-Branch Distribution Line Based on MODWT Combined with Improved TEO

    Pan Duan*, Enze Peng

    Energy Engineering, Vol.122, No.9, pp. 3817-3838, 2025, DOI:10.32604/ee.2025.066491 - 26 August 2025

    Abstract To address the challenges of fault line identification and low detection accuracy of wave head in Fault Location (FL) research of distribution networks with complex topologies, this paper proposes an FL method of Multi-Branch distribution line based on Maximal Overlap Discrete Wavelet Transform (MODWT) combined with the improved Teager Energy Operator (TEO). Firstly, the current and voltage Traveling Wave (TW) signals at the head of each line are extracted, and the fault-induced components are obtained to determine the fault line by analyzing the polarity of the mutation amount of fault voltage and current TWs. Subsequently,… More >

  • Open Access

    ARTICLE

    Workplace territorial behaviors and employee knowledge sharing: Team identification mediation and task interdependence moderation

    Ziyuan Meng, Yongjun Chen, Hui Wang*

    Journal of Psychology in Africa, Vol.35, No.4, pp. 489-496, 2025, DOI:10.32604/jpa.2025.070068 - 17 August 2025

    Abstract This study tested a multilevel model of the workplace territorial behaviors and employees’ knowledge sharing relationship, with team identification serving as a mediator and task interdependence as a moderator. Data were collected from 253 employees (females = 128, mean age = 28.626, SD = 6.470) from 40 work teams from different industries in China. Path analysis results indicated that workplace territorial behaviors were associated with lower employee knowledge sharing. Team identification enhanced employee knowledge sharing and partially mediated the relationship between workplace territorial behaviors and employee knowledge sharing. Task interdependence enhanced knowledge sharing and strengthened More >

  • Open Access

    ARTICLE

    Teacher-student relationship quality effects on school students’ bullying victimization: A serial mediation model by student-student relationship and student engagement

    Yuan Yuan1, Yanfei Yang2,*

    Journal of Psychology in Africa, Vol.35, No.4, pp. 541-548, 2025, DOI:10.32604/jpa.2025.069551 - 17 August 2025

    Abstract This study examined the impact of teacher-student relationship quality on students’ risk of bullying victimization and the mediating roles of student-student relationships and student engagement in this relationship. A total of 656 Chinese junior high school students (females = 361, mean age = 13.75, SD = 0.98) completed validated measures of teacher-student relationship quality, student-student relationship quality, student engagement, and bullying victimization. Regression analysis results indicated that higher teacher-student relationship quality predicted a lower risk of student bullying victimization. Serial mediating effect testing of the student-student relationship quality and student engagement revealed that these factors More >

  • Open Access

    REVIEW

    Investigating Higher Education Teachers’ Well-Being and Its Influencing Multiple Factors: A Systematic Review Approach

    Jian Li1,*, Yunshu He2, Yahao Wang1, Eryong Xue2,*

    International Journal of Mental Health Promotion, Vol.27, No.7, pp. 901-928, 2025, DOI:10.32604/ijmhp.2025.066538 - 31 July 2025

    Abstract Background: Teachers from higher education commonly face substantial workloads, resulting in heightened stress and reduced well-being. This has spurred significant academic interest in the determinants of faculty well-being within higher education. Consequently, numerous studies have focused on both understanding these influencing factors and developing strategies to bolster teacher well-being, an area that has gained considerable traction as a research focus. Although systematic reviews have been conducted to elucidate the connections between well-being and particular attributes like emotional regulation, efficacy, and competency, there remains a paucity of reviews that holistically examine the multifaceted factors affecting the… More >

  • Open Access

    ARTICLE

    Sharp Interface Establishment through Slippery Fluid in Steady Exchange Flows under Stratification

    Mustafa Turkyilmazoglu1,2,*, Abdulaziz Alotaibi3

    CMES-Computer Modeling in Engineering & Sciences, Vol.143, No.3, pp. 2847-2865, 2025, DOI:10.32604/cmes.2025.068031 - 30 June 2025

    Abstract The variable salinity in stored reservoirs connected by a long channel attracts the attention of scientists worldwide, having applications in environmental and geophysical engineering. This study explores the impact of Navier slip conditions on exchange flows within a long channel connecting two large reservoirs of differing salinity. These horizontal density gradients drive the flow. We modify the recent one-dimensional theory, developed to avoid runaway stratification, to account for the presence of uniform slip walls. By adjusting the parameters of the horizontal density gradient based on the slip factor, we resolve analytically various flow regimes ranging… More >

  • Open Access

    ARTICLE

    The association between social support and decent work among rural primary school teachers: A chain mediation model

    Jiajian Wang1,2,*, Mansor Bin Abu Talib2, Biru Chang3, Jingwen Zhang2

    Journal of Psychology in Africa, Vol.35, No.2, pp. 223-230, 2025, DOI:10.32604/jpa.2025.068063 - 30 June 2025

    Abstract Amidst the unique challenges faced by rural educators is their sense of decent work influenced by levels of social support, career self-efficacy, and marginalization. To investigate these relationships, we surveyed 435 rural school teachers (females = 69.32%, mean years teaching experience = 13.6, SD = 7.7 years). The Structural Equation Modeling results indicated that social support positively predicts teachers’ perceptions of decent work. Career self-efficacy mediated the relationship between social support and a higher sense of decent work, while marginalization mediated the relationship such that lower social support predicted lower perceptions of decent work. Career… More >

  • Open Access

    ARTICLE

    Basic psychological needs satisfaction mediation of the relationship between kindergarten error management climate and creative teaching

    Jing Wang1, Ping Li2,*

    Journal of Psychology in Africa, Vol.35, No.2, pp. 167-172, 2025, DOI:10.32604/jpa.2025.065788 - 30 June 2025

    Abstract The present study aimed to examine the association between kindergarten error management climate and creative teaching and the mediating role of basic psychological needs satisfaction. A sample of 561 Chinese kindergarten teachers (females = 98%, Mage = 34.32, SD = 1.25) completed self-reported questionnaires on their work error management atmosphere, basic psychological needs satisfaction, and innovative teaching. The results structural equation modelling path analysis showed that high kindergarten error management climate was associated with higher innovative teaching. Moreover, the need for competence, but not the need for relatedness accounted for kindergarten error management atmosphere related to More >

  • Open Access

    CASE REPORT

    Teapot ureterocystoplasty in posterior urethral valve and chronic kidney disease: a case report

    Geemitha Ratnayake*, Yaqoub Jafar, Bruno Leslie, Luis Henrique Braga*

    Canadian Journal of Urology, Vol.32, No.3, pp. 209-212, 2025, DOI:10.32604/cju.2025.064122 - 27 June 2025

    Abstract Background: Bladder augmentation is often necessary to address poorly compliant and low-capacity bladders which can result from Posterior Urethral Valve. Traditional techniques are limited by complications from using bowel tissue, thus in the setting of a megaureter, ureterocystoplasty is favorable. Methods: We present a case of Teapot ureterocystoplasty, which improves vascular protection of the ureter by leaving the distal 3 cm of the ureter tubularized. Cystograms demonstrated bladder capacity improvement from 50 mL to 180 mL post-operatively. Additionally, creatinine stabilized after a peak of 250 µmol/L. Result and Conclusion: This patient is doing well at 4.5-year More >

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